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Cannabinoid Receptor 2-Centric Molecular Feedback Loop Drives Necroptosis in Diabetic Heart Injuries
BACKGROUND: Diabetic heart dysfunction is a common complication of diabetes. Cell death is a core event that leads to diab...
Noninvasive Plaque Imaging to Accelerate Coronary Artery Disease Drug Development
Coronary artery disease (CAD) remains the leading cause of adult mortality globally. Targeting known modifiable risk facto...
Targeted Screening for Transthyretin Amyloid Cardiomyopathy in Patients With Atrial Fibrillation
Babak Nazer Correspondence to: Babak Nazer, MD, Knight Cardiovascular Institute, Oregon Health and Science University, 318...
The Future for Patients With Transthyretin Cardiac Amyloidosis Is Looking Brighter
Mathew S. Maurer Correspondence to: Mathew S. Maurer, MD, Columbia University, Irving Medical Center, 622 West 168th St, P...
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
BACKGROUND: Mechanical stress on the heart, such as high blood pressure, initiates inflammation and causes hypertrophic he...
Lipoprotein(a) in Youth and Prediction of Major Cardiovascular Outcomes in Adulthood
BACKGROUND: Elevated lipoprotein(a) [Lp(a)] is a common risk factor for cardiovascular disease outcomes with unknown mecha...
Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration
BACKGROUND: Cardiac regeneration after injury is limited by the low proliferative capacity of adult mammalian cardiomyocyt...
Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling
BACKGROUND: Cross-talk between sterol metabolism and inflammatory pathways has been demonstrated to significantly affect t...
Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity
BACKGROUND: Autoimmunity is increasingly recognized as a key contributing factor in heart muscle diseases. The functional ...
Dose-Blinded Myosin Inhibition in Patients with Obstructive HCM Referred for Septal Reduction Therapy: Outcomes Through 32-Weeks
Background: Septal reduction therapy (SRT) in patients with intractable symptoms from obstructive hypertrophic cardiomyopa...
Fitness—Rather Than BMI—Appears to Be a Better Predictor of Survival for Women With Heart Disease
"Fitness—Rather Than BMI—Appears to Be a Better Predictor of Survival for Women With Heart Disease." Circulation, 146(21),...
Increasing Societal Benefit From Cardiovascular Drugs
Increasing Societal Benefit From Cardiovascular Drugs
During the past few years, several innovative treatments for noncommunicable chronic disease have become available, includ...
From IMPERIALism to EMINENence: The Noble Rise of the Second-Generation Peripheral Drug-Eluting Stent
From IMPERIALism to EMINENence: The Noble Rise of the Second-Generation Peripheral Drug-Eluting Stent
Eric A. Secemsky Correspondence to: Eric A. Secemsky, MD, MSc, Director of Vascular Intervention, Beth Israel Deaconess Me...
Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension
BACKGROUND: Pulmonary hypertension (PH) is associated with increased expression of VEGF-A (vascular endothelial growth fac...
Apixaban for Patients with Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial
Background: There is no randomized data evaluating the safety or efficacy of apixaban for stroke prevention in patients wi...
Survival After Invasive or Conservative Management of Stable Coronary Disease
Background: The ISCHEMIA trial compared an initial invasive versus an initial conservative management strategy for patient...
If the Fates Allow: The Zero-Sum Game of ISCHEMIA-EXTEND
© American Heart Association, Inc. All rights reserved. Unauthorized ...
Aspirin vs. Clopidogrel for Chronic Maintenance Monotherapy after Percutaneous Coronary Intervention: the HOST-EXAM Extended Study
Background: Long term outcomes of antiplatelet monotherapy in patients who receive percutaneous coronary intervention (PCI...
Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs to Improve Statin Rates (NOTIFY-1 Project)
Background: Coronary artery calcium (CAC) can be identified on non-gated chest CTs, but this finding is not consistently i...
Empagliflozin in Black Versus White Patients with Heart Failure: Analysis of EMPEROR-Pooled
João Pedro Ferreira https://orcid.org/0000-0002-2304-6138 Université de Lorraine, Inserm, Centre d'Investigations Cliniqu...
The EMPEROR’s New Clothes: Aren’t We Just Treating Grades of Heart Failure With Reduced Ejection Fraction?
Robin A.P. Weir Correspondence to: Robin A.P. Weir, MD, Cardiology Department, University Hospital Hairmyres, Eaglesham Ro...