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A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2-specific immune responses in rhesus macaques
A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2-specific immune responses in rhesus macaques
Ad26.COV2.S has demonstrated durability and clinical efficacy against symptomatic COVID-19 in humans. In this study, we re...
Damp heat–stable perovskite solar cells with tailored-dimensionality 2D/3D heterojunctions
Damp heat–stable perovskite solar cells with tailored-dimensionality 2D/3D heterojunctions
In order for perovskite solar cells (PSCs) with high power conversion efficiencies (PCEs) to be commercialized, they must ...
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection
The waning efficacy of SARS-CoV-2 vaccines, combined with the continued emergence of variants resistant to vaccine-induced...
Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation
Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation
Bivalent genes are ready for activation upon the arrival of developmental cues. Here we report that BEND3 is a CpG island ...
Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination
Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination
Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinall...
Pebbles and sand on asteroid (162173) Ryugu: In situ observation and particles returned to Earth
Pebbles and sand on asteroid (162173) Ryugu: In situ observation and particles returned to Earth
The Hayabusa2 spacecraft investigated the C-type (carbonaceous) asteroid (162173) Ryugu. The mission performed two landing...
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
Broadly neutralizing antibodies (bnAbs) to coronaviruses (CoVs) are valuable in their own right as prophylactic and therap...
Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody
Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody
The SARS-CoV-2 Omicron variant has become the dominant infective strain. We report the structures of the Omicron spike tri...
Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients
Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients
The severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) Omicron variant (B.1.1.529) is spreading rapidly...
SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine
SARS-CoV-2 Omicron-neutralizing memory B-cells are elicited by two doses of BNT162b2 mRNA vaccine
Multiple SARS-CoV-2 variants possess mutations in the spike receptor-binding domain (RBD) with potential to evade neutrali...
Dynamics and mechanism of a light-driven chloride pump
Dynamics and mechanism of a light-driven chloride pump
Chloride transport by microbial rhodopsins is an essential process for which molecular details—such as the mechanisms that...
Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge to engineering cell-based ca...
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients
Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high cor...
Indirect protection of children from SARS-CoV-2 infection through parental vaccination
Indirect protection of children from SARS-CoV-2 infection through parental vaccination
Children unvaccinated against SARS-CoV-2 may still benefit through protection from vaccinated contacts. We estimated the p...
A single-cell atlas of the normal and malformed human brain vasculature
A single-cell atlas of the normal and malformed human brain vasculature
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanis...
SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies
SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies
SARS-CoV-2 Beta variant of concern (VOC) resists neutralization by major classes of antibodies from COVID-19 patients and ...
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, there remains a need for mor...
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants
Current COVID-19 vaccines significantly reduce overall morbidity and mortality and are vitally important to controlling th...
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
The SARS-CoV-2 Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or infection with ...
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannab...
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
The newly reported Omicron variant is poised to replace Delta as the most prevalent SARS-CoV-2 variant across the world. C...
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus disease 2019 (COVID-19), but mech...
Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera
Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera
The globally-circulating SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) has a large number of mutations especially in t...
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses
Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that possess mutations associated with incr...
Epstein-Barr virus and multiple sclerosis
Epstein-Barr virus and multiple sclerosis
Infection with Epstein-Barr virus is the trigger for the development of multiple sclerosis
Isospin magnetism and spin-polarized superconductivity in Bernal bilayer graphene
Isospin magnetism and spin-polarized superconductivity in Bernal bilayer graphene
In conventional superconductors, Cooper pairing occurs between electrons of opposite spin. We observe spin-polarized super...
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology....
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures against SARS-CoV-2...
COVID mortality in India: National survey data and health facility deaths
COVID mortality in India: National survey data and health facility deaths
India’s national COVID death totals remain undetermined. Using an independent nationally representative survey of 0.14 mil...
Attosecond coherent electron motion in Auger-Meitner decay
Attosecond coherent electron motion in Auger-Meitner decay
In quantum systems, coherent superpositions of electronic states evolve on ultrafast timescales (few femtosecond to attose...
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