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Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress
Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress
Oxidative stress, resulting from dysregulation in the secretion of adrenal hormones, represents a major concern in human h...
The obesogenic side of Genistein
The obesogenic side of Genistein
Genistein (GN) has been highly recommended for its medicinal properties like anticancer, antidiabetic, antihyperlipidemic,...
Editorial: Insights in cellular endocrinology: 2022
Editorial: Insights in cellular endocrinology: 2022
The first review article is related to metabolic diseases and focuses on the importance of the maintenance of the pancreat...
Brain and serum metabolomic studies reveal therapeutic effects of san hua decoction in rats with ischemic stroke
Brain and serum metabolomic studies reveal therapeutic effects of san hua decoction in rats with ischemic stroke
San Hua Decoction (SHD) is a traditional four-herbal formula that has long been used to treat stroke. Our study used a tra...
Employing fasting plasma glucose to safely limit the use of oral glucose tolerance tests in pregnancy: a pooled analysis of four Norwegian studies
Employing fasting plasma glucose to safely limit the use of oral glucose tolerance tests in pregnancy: a pooled analysis of four Norwegian studies
Background/objectiveThere is no international consensus about the optimal approach to screening and diagnosis of gestation...
PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome
PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome
BackgroundWe performed a transcriptomic analysis of adrenal signaling pathways in various forms of endogenous Cushing’s sy...
Association between serum uric acid level and bone mineral density in men more than 50 years of age
Association between serum uric acid level and bone mineral density in men more than 50 years of age
BackgroundThe results of previous studies on the association between serum uric acid levels and bone mineral density and t...
The adverse effect of gestational diabetes mellitus and hypertensive disorders of pregnancy on maternal–perinatal outcomes among singleton and twin pregnancies: a retrospective cohort study (2011–2019)
The adverse effect of gestational diabetes mellitus and hypertensive disorders of pregnancy on maternal–perinatal outcomes among singleton and twin pregnancies: a retrospective cohort study (2011–2019)
BackgroundGestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) are the predominant pregnancy ...
Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study
Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study
Background and aimsIncreasing evidence supports a causal relationship between lipoprotein(a) [Lp(a)] and atherosclerotic c...
Editorial: Current and future trends in gestational diabetes diagnosis, care and neonatal outcomes
Editorial: Current and future trends in gestational diabetes diagnosis, care and neonatal outcomes
Gestational diabetes mellitus (GDM) is defined in the World Health Organization guidelines as glucose intolerance or hyper...
Intestinal permeability is associated with aggravated inflammation and myofibroblast accumulation in Graves’ orbitopathy: the MicroGO study
Intestinal permeability is associated with aggravated inflammation and myofibroblast accumulation in Graves’ orbitopathy: the MicroGO study
BackgroundGraves’ disease (GD) and Graves’ orbitopathy (GO) result from ongoing stimulation of the TSH receptor due to aut...
Editorial: Adipokines and hormone-dependent cancers
Editorial: Adipokines and hormone-dependent cancers
Over the last two decades it has been progressively recognised the functional role of adipose tissue as an active and immu...
Prevalence and characteristics of thelarche variant
Prevalence and characteristics of thelarche variant
IntroductionGirls with early thelarche may show an intermediate clinical picture between isolated premature thelarche (PT)...
Total bilirubin and bilirubin-to-triglycerides ratio predict changes in glycated hemoglobin in healthy children
Total bilirubin and bilirubin-to-triglycerides ratio predict changes in glycated hemoglobin in healthy children
ObjectiveBilirubin and triglycerides can regulate insulin secretion and glucose uptake. The aim of our study is to analyze...
Causal effects of circulating lipids and lipid-lowering drugs on the risk of urinary stones: a Mendelian randomization study
Causal effects of circulating lipids and lipid-lowering drugs on the risk of urinary stones: a Mendelian randomization study
BackgroundPrevious studies have yielded conflicting findings regarding the association between circulating lipids and lipi...
Multiple myeloma following bone metastasis of renal cell carcinoma: a case report
Multiple myeloma following bone metastasis of renal cell carcinoma: a case report
BackgroundThe clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, whic...
Single-cell profiling reveals transcriptomic signatures of vascular endothelial cells in non-healing diabetic foot ulcers
Single-cell profiling reveals transcriptomic signatures of vascular endothelial cells in non-healing diabetic foot ulcers
BackgroundThe treatment of diabetic foot ulcers (DFUs) poses a challenging medical problem that has long plagued individua...
Ghrelin misbalance affects mice embryo implantation and pregnancy success by uterine immune dysregulation and nitrosative stress
Ghrelin misbalance affects mice embryo implantation and pregnancy success by uterine immune dysregulation and nitrosative stress
IntroductionIn a previous study we found that ghrelin (Ghrl) misbalance during the peri-implantation period significantly ...
Diabetes status and cognitive function in middle-aged and older adults in the Canadian longitudinal study on aging
Diabetes status and cognitive function in middle-aged and older adults in the Canadian longitudinal study on aging
ObjectivesDiabetes is recognized as a significant risk factor for cognitive impairment. However, this association has not ...
The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1
The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1
IntroductionPluripotent stem cells can be generated from somatic cells by the Yamanaka factors Oct4, Sox2, Klf4 and c-Myc....
Osteocalcin has a muscle-protective effect during weight loss in men without metabolic syndrome: a multicenter, prospective, observational study
Osteocalcin has a muscle-protective effect during weight loss in men without metabolic syndrome: a multicenter, prospective, observational study
ObjectiveWeight reduction often accompanies muscle loss. Existing studies highlight the involvement of osteocalcin (OC) in...
A bibliometric analysis of PCSK9 inhibitors from 2007 to 2022
A bibliometric analysis of PCSK9 inhibitors from 2007 to 2022
BackgroundSince the approval of the proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies for market...
Association between dynamic fluctuations in triiodothyronine levels and prognosis among critically ill patients within comprehensive intensive care units
Association between dynamic fluctuations in triiodothyronine levels and prognosis among critically ill patients within comprehensive intensive care units
ObjectiveDecrease in free thyroid hormone T3 (FT3) can be used as an independent prognostic indicator for the risk of deat...
Family history of malignant or benign thyroid tumors: implications for surgical procedure management and disease-free survival
Family history of malignant or benign thyroid tumors: implications for surgical procedure management and disease-free survival
BackgroundCurrent guidelines lack a standardized management for patients with family history of thyroid carcinoma (fTC),pa...
Undiagnosed diabetic retinopathy in Northeast China: prevalence and determinants
Undiagnosed diabetic retinopathy in Northeast China: prevalence and determinants
ObjectiveTo report the prevalence and contributing factors of undiagnosed diabetic retinopathy (DR) in a population from N...
Overview of research progress on the association of dietary potassium intake with serum potassium and survival in hemodialysis patients, does dietary potassium restriction really benefit hemodialysis patients?
Overview of research progress on the association of dietary potassium intake with serum potassium and survival in hemodialysis patients, does dietary potassium restriction really benefit hemodialysis patients?
For the general population, increasing potassium intake can reduce the incidence of cardiovascular and cerebrovascular dis...
Association between urinary sodium and circulating lipid levels: a Mendelian randomization study
Association between urinary sodium and circulating lipid levels: a Mendelian randomization study
BackgroundUrinary sodium was indicated to be associated with dyslipidemia, but inconsistent conclusions for this associati...
Using feature optimization and LightGBM algorithm to predict the clinical pregnancy outcomes after in vitro fertilization
Using feature optimization and LightGBM algorithm to predict the clinical pregnancy outcomes after in vitro fertilization
BackgroundAccording to a recent report by the WHO, approximately 17.5\% (about one-sixth) of the global adult population i...
Clinical characteristics of male prolactinoma patients mainly presenting with severe obesity and the metabolic response to dopamine agonist therapy
Clinical characteristics of male prolactinoma patients mainly presenting with severe obesity and the metabolic response to dopamine agonist therapy
ObjectiveTo summarize the clinical characteristics of 4 male prolactinoma patients with severe obesity.MethodsThe clinical...
Thyroid dysfunction and risk of cutaneous malignant melanoma: a bidirectional two-sample Mendelian randomization study
Thyroid dysfunction and risk of cutaneous malignant melanoma: a bidirectional two-sample Mendelian randomization study
BackgroundEpidemiologic and observational data have found a risk association between thyroid dysfunction and cutaneous mal...
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