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Assessment of QRISK3 as a predictor of cardiovascular disease events in type 2 diabetes mellitus
Assessment of QRISK3 as a predictor of cardiovascular disease events in type 2 diabetes mellitus
BackgroundThe risk of cardiovascular disease (CVD) in diabetes mellitus (DM) patients is two- to three-fold higher than in...
Circulating tumor DNA profile and its clinical significance in patients with hormone receptor-positive and HER2-negative mBC
Circulating tumor DNA profile and its clinical significance in patients with hormone receptor-positive and HER2-negative mBC
BackgroundAfter early-line (first- and second-line) endocrine therapy, hormone-receptor (HR)-positive and human epidermal ...
Exploration and validation of a combined immune and metabolism gene signature for prognosis prediction of colorectal cancer
Exploration and validation of a combined immune and metabolism gene signature for prognosis prediction of colorectal cancer
BackgroundColorectal cancer (CRC) is still one of the most frequently diagnosed malignancy around the world. The complex e...
Association of maternal triglyceride responses to thyroid function in early pregnancy with gestational diabetes mellitus
Association of maternal triglyceride responses to thyroid function in early pregnancy with gestational diabetes mellitus
IntroductionThe prevalence of Gestational Diabetes Mellitus (GDM) is increasing globally, and high levels of triglyceride ...
Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease
Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease
IntroductionThere is few effective biomarkers for diagnosing nonalcoholic fatty liver disease (NAFLD) in clinical practice...
The alterations of circulating mucosal-associated invariant T cells in polycystic ovary syndrome
The alterations of circulating mucosal-associated invariant T cells in polycystic ovary syndrome
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting reproductive age females and an...
Thyroid eye disease or Graves’ orbitopathy: What name to use, and why it matters
Thyroid eye disease or Graves’ orbitopathy: What name to use, and why it matters
There is currently no universally accepted name for inflammatory disease of the eye and orbit associated with thyroid auto...
Association of thyroid function, within the euthyroid range, with cardiovascular risk: The EPIPorto study
Association of thyroid function, within the euthyroid range, with cardiovascular risk: The EPIPorto study
BackgroundThyroid hormones are important modulators of cardiovascular function. Both hypothyroidism and hyperthyroidism ar...
Exploring risk factors of short-term readmission in heart failure patients: A cohort study
Exploring risk factors of short-term readmission in heart failure patients: A cohort study
BackgroundThe risk of all-cause mortality in patients with heart failure (HF) has been studied previously. Readmission ris...
Congenital adrenal hyperplasia due to P450 oxidoreductase deficiency
Congenital adrenal hyperplasia due to P450 oxidoreductase deficiency
ObjectiveTo raise awareness of Cytochrome P450 Oxidoreductase Deficiency (PORD, a rare form of congenital adrenal hyperpla...
Albinism in the largest extant amphibian: A metabolic, endocrine, or immune problem?
Albinism in the largest extant amphibian: A metabolic, endocrine, or immune problem?
BackgroundPigment regression is an intriguing phenomenon that can be caused by disorders in melanin metabolism or endocrin...
ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral...
Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice
Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice
Occludin (OCLN) is a tight junction protein and Ocln deletion mutation causes male infertility in mice. However, the role ...
Role of cytotoxic T cells and PD-1 immune checkpoint pathway in papillary thyroid carcinoma
Role of cytotoxic T cells and PD-1 immune checkpoint pathway in papillary thyroid carcinoma
BackgroundLymphocytic thyroiditis (LT) is frequently seen in the tumor microenvironment (TME) of papillary thyroid carcino...
Corrigendum: The association between normal serum sodium levels and bone turnover in patients with type 2 diabetes
Corrigendum: The association between normal serum sodium levels and bone turnover in patients with type 2 diabetes
Corrigendum on: Hai-yan Huang, Zhi-qi Huang, Ling-yan Hua, Wang-shu Liu, Feng Xu, Xiaoqin Ge, Chun-feng Lu, Jian-bin Su, X...
Secular trends in age at pubertal onset assessed by breast development among Chinese girls: A systematic review
Secular trends in age at pubertal onset assessed by breast development among Chinese girls: A systematic review
BackgroundThe average age at thelarche has trended downwards worldwide since 1970s; however, the onset age of “precocious ...
Vascular and hormonal interactions in the adrenal gland
Vascular and hormonal interactions in the adrenal gland
Primary aldosteronism is the most common form of secondary arterial hypertension, due to excessive aldosterone production ...
A nomogram model based on clinical markers for predicting malignancy of ovarian tumors
A nomogram model based on clinical markers for predicting malignancy of ovarian tumors
ObjectiveThe aim of this study was to build a nomogram based on clinical markers for predicting the malignancy of ovarian ...
Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome
Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome
ObjectiveTo investigate the efficacy of oral letrozole (LE) starting on day 3 or 5 of the menstrual cycle in patients with...
Global miRNA expression reveals novel nuclear and mitochondrial interactions in Type 1 diabetes mellitus
Global miRNA expression reveals novel nuclear and mitochondrial interactions in Type 1 diabetes mellitus
BackgroundConsidering the potential role of miRNAs as biomarkers and their interaction with both nuclear and mitochondrial...
Immunosuppressive environment in response to androgen deprivation treatment in prostate cancer
Immunosuppressive environment in response to androgen deprivation treatment in prostate cancer
RationaleTo invest the role of androgen deprivation therapy (ADT) on the tumor immune microenvironment of prostate cancer....
The polymorphisms of MIR31HG gene is correlated with alcohol-induced osteonecrosis of the femoral head in Chinese Han male population
The polymorphisms of MIR31HG gene is correlated with alcohol-induced osteonecrosis of the femoral head in Chinese Han male population
BackgroundAlcoholic osteonecrosis of the femoral head (ONFH) is a multifaceted illness that seriously disturbs the patient...
Wnt signaling pathway inhibitors, sclerostin and DKK-1, correlate with pain and bone pathology in patients with Gaucher disease
Wnt signaling pathway inhibitors, sclerostin and DKK-1, correlate with pain and bone pathology in patients with Gaucher disease
Patients with Gaucher disease (GD) have progressive bone involvement that clinically presents with debilitating bone pain,...
Health-related quality of life in boys with constitutional delay of growth and puberty
Health-related quality of life in boys with constitutional delay of growth and puberty
IntroductionConstitutional delay of growth and puberty (CDGP) is the most common reason for delayed puberty in healthy mal...