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Electroacupuncture alleviates spatial memory deficits in METH withdrawal mice by enhancing astrocyte‐mediated glutamate clearance in the dCA1
Electroacupuncture alleviates spatial memory deficits in METH withdrawal mice by enhancing astrocyte‐mediated glutamate clearance in the dCA1
Abstract Methamphetamine (METH) elicits endogenous glutamate (Glu) in the brain, which could partially explain METH-induce...
Genetic liability for substance use associated with medical comorbidities in electronic health records of African‐ and European‐ancestry individuals
Genetic liability for substance use associated with medical comorbidities in electronic health records of African‐ and European‐ancestry individuals
Abstract Polygenic risk scores (PRS) represent an individual's summed genetic risk for a trait and can serve as biomarkers...
Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self‐administration in rats
Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self‐administration in rats
Abstract Early life stress presents an important risk factor for drug addiction and comorbid depression and anxiety throug...
Effects of substance misuse on inhibitory control in patients with attention‐deficit/hyperactivity disorder
Effects of substance misuse on inhibitory control in patients with attention‐deficit/hyperactivity disorder
Abstract Patients with attention-deficit/hyperactivity disorder (ADHD) are often diagnosed with comorbid substance misuse ...
Mu‐opioid receptors in septum mediate the development of behavioural sensitization to a single morphine exposure in male rats
Mu‐opioid receptors in septum mediate the development of behavioural sensitization to a single morphine exposure in male rats
Abstract Behavioural sensitization (BS) is characterized by enhanced psychomotor responses to a dose of substance of abuse...
Sex‐specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking
Sex‐specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking
Abstract Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1) antagonists to reg...
A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data
A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data
Abstract Ghrelin is a gastric-derived peptide hormone with demonstrated impact on alcohol intake and craving, but the reve...
The histone methyltransferase G9a mediates stress‐regulated alcohol drinking
The histone methyltransferase G9a mediates stress‐regulated alcohol drinking
Abstract The epigenetic enzyme G9a is a histone methyltransferase that dimethylates lysine 9 on histone H3 (H3K9me2), and ...
Closing the brain–heart loop: Towards more holistic models of addiction and addiction recovery
Closing the brain–heart loop: Towards more holistic models of addiction and addiction recovery
Abstract Much research seeks to articulate the brain structures and pathways implicated in addiction and addiction recover...
Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials
Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials
Abstract Some evidence suggests that males and females may differ in their responses to acute cannabis effects, including ...
Exercise can restore behavioural and molecular changes of intergenerational morphine effects
Exercise can restore behavioural and molecular changes of intergenerational morphine effects
Abstract In our previous studies, the offspring of morphine-exposed parents (MEO) showed pharmacological tolerance to the ...
Similarities and differences between internet gaming disorder and tobacco use disorder: A large‐scale network study
Similarities and differences between internet gaming disorder and tobacco use disorder: A large‐scale network study
Abstract Studies have shown that internet gaming disorder (IGD) has the potential to be a type of addiction; however, dire...
Altered neural responses to missed chance contribute to the risk‐taking behaviour in individuals with Internet gaming disorder
Altered neural responses to missed chance contribute to the risk‐taking behaviour in individuals with Internet gaming disorder
Abstract Missed chance is a powerful factor in shaping risk-taking behaviour. The abnormal risk-taking behaviour is an obv...
Differential brain responses to alcohol‐related and natural rewards are associated with alcohol use and problems: Evidence for reward dysregulation
Differential brain responses to alcohol‐related and natural rewards are associated with alcohol use and problems: Evidence for reward dysregulation
Abstract Multiple theoretical perspectives posit that drug use leads to biased valuation of drug-related reward, at the ex...
Baseline‐ and treatment‐associated pain in the X:BOT comparative effectiveness study of extended‐release naltrexone versus buprenorphine‐naloxone for OUD
Baseline‐ and treatment‐associated pain in the X:BOT comparative effectiveness study of extended‐release naltrexone versus buprenorphine‐naloxone for OUD
Abstract Chronic pain is highly prevalent among patients with opioid use disorder (OUD). However, little is known about ho...
Associations between electronic devices use and common mental traits: A gene–environment interaction model using the UK Biobank data
Associations between electronic devices use and common mental traits: A gene–environment interaction model using the UK Biobank data
Abstract Background Electronic devices use has been reported to be associated with depression. However, limited effort has...
Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor‐mediated upregulation of Cav1.2
Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor‐mediated upregulation of Cav1.2
Abstract The progressively increased motivation for cocaine during abstinence is closely associated with the dysfunction o...
Bipolar disorder and cannabis use: A bidirectional two‐sample Mendelian randomization study
Bipolar disorder and cannabis use: A bidirectional two‐sample Mendelian randomization study
Abstract Cannabis use is associated with a number of psychiatric disorders; however, the causal nature of these associatio...
Projection from the basolateral amygdala to the anterior cingulate cortex facilitates the consolidation of long‐term withdrawal memory
Projection from the basolateral amygdala to the anterior cingulate cortex facilitates the consolidation of long‐term withdrawal memory
Abstract The process through which early memories are transferred to the cerebral cortex to form long-term memories is ref...
Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence
Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence
Abstract Alcohol dependence (AD) is one of the most common and detrimental neuropsychological disorders. Recently, more an...
Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Abstract Chronic alcohol use increases risk of alcohol withdrawal symptoms (AW) and disrupts stress biology and resilient ...
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans
Abstract Preclinical studies have revealed robust and long-lasting alterations in dendritic spines in the brain following ...
Repetitive transcranial magnetic stimulation modulates coupling among large‐scale brain networks in heroin‐dependent individuals: A randomized resting‐state functional magnetic resonance imaging study
Repetitive transcranial magnetic stimulation modulates coupling among large‐scale brain networks in heroin‐dependent individuals: A randomized resting‐state functional magnetic resonance imaging study
Abstract The abnormal interactions of three key large-scale brain networks (default mode [DMN], salience and executive con...
Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain
Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain
Abstract Dopamine neurons in the substantia nigra (SN) and ventral tegmental area (VTA) play a central role in the reinfor...
Multimodal MRI data fusion reveals distinct structural, functional and neurochemical correlates of heavy cannabis use
Multimodal MRI data fusion reveals distinct structural, functional and neurochemical correlates of heavy cannabis use
Abstract Heavy cannabis use (HCU) is frequently associated with a plethora of cognitive, psychopathological and sensorimot...
Glucagon‐like peptide‐1 receptor agonist, liraglutide, reduces heroin self‐administration and drug‐induced reinstatement of heroin‐seeking behaviour in rats
Glucagon‐like peptide‐1 receptor agonist, liraglutide, reduces heroin self‐administration and drug‐induced reinstatement of heroin‐seeking behaviour in rats
Abstract Drug addiction is a chronic brain disease characterized by the uncontrolled use of a substance. Due to its relaps...
FGF2 is an endogenous regulator of alcohol reward and consumption
FGF2 is an endogenous regulator of alcohol reward and consumption
Abstract Alcohol use disorder (AUD) is a chronic, relapsing disorder, characterized by escalating alcohol drinking and los...
Dual methylation and hydroxymethylation study of alcohol use disorder
Dual methylation and hydroxymethylation study of alcohol use disorder
Abstract Using an integrative, multi-tissue design, we sought to characterize methylation and hydroxymethylation changes i...
A polygenic approach to the association between smoking and schizophrenia
A polygenic approach to the association between smoking and schizophrenia
Abstract Smoking prevalence in schizophrenia is considerably larger than in general population, playing an important role ...
Functional connectivity during feedback learning in smokers
Functional connectivity during feedback learning in smokers
Abstract Background Although it has been traditionally assumed that dysregulation of psychological processes in smokers re...
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