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Hepatitis-B virus: replication cycle, targets, and antiviral approaches
Hepatitis-B virus: replication cycle, targets, and antiviral approaches
Available online 10 September 2023, 101360Author links open overlay panel, , , Highlights•Hepatitis B is a major cause of ...
Genetic and pharmacological perturbation of hepatitis-C virus entry
Genetic and pharmacological perturbation of hepatitis-C virus entry
Hepatitis-C virus (HCV) chronically infects 58 million individuals worldwide with variable disease outcome. While a subfra...
Role of the viral polymerase during adaptation of influenza A viruses to new hosts
Role of the viral polymerase during adaptation of influenza A viruses to new hosts
As a group, influenza-A viruses (IAV) infect a wide range of animal hosts, however, they are constrained to infecting sele...
Editorial overview: Viruses and Cancer
Editorial overview: Viruses and Cancer
Volume 62, October 2023, 101364Author links open overlay panelEthel Cesarman, Jennifer TotonchyShow morePrevious article i...
The role of nuclear pores and importins for herpes simplex virus infection
The role of nuclear pores and importins for herpes simplex virus infection
Microtubule transport and nuclear import are functionally connected, and the nuclear pore complex (NPC) can interact with ...
The more the merrier? Gene duplications in the coevolution of primate lentiviruses with their hosts
The more the merrier? Gene duplications in the coevolution of primate lentiviruses with their hosts
Gene duplications are a major source of genetic diversity and evolutionary innovation. Newly formed, duplicated genes can ...
Antigenic evolution of SARS coronavirus 2
Antigenic evolution of SARS coronavirus 2
SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in December 2019. Vaccines developed we...
Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine
Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine
The effectiveness of early COVID-19 vaccines in reducing the severity of the disease has led to a focus on developing next...
Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines
Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines
Newcastle disease virus (NDV) is an avian pathogen with an unsegmented negative-strand RNA genome. Properties such as the ...
Structural basis for respiratory syncytial virus and human metapneumovirus neutralization
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) continue to be a global burden to infants, the elderly,...
Predicting zoonotic potential of viruses: where are we?
The prospect of identifying high-risk viruses and designing interventions to pre-empt their emergence into human populatio...
A review of broadly protective monoclonal antibodies to treat Ebola virus disease
The filovirus vaccine and the therapeutic monoclonal antibody (mAb) research have made substantial progress. However, exis...
Cryo-electron tomography of viral infection — from applications to biosafety
Cellular cryo-electron tomography (cryo-ET) offers 3D snapshots at molecular resolution capturing pivotal steps during vir...
Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: more than a key mediator of viral persistence
Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic herpesvirus. Its latency-associated ...
Hemagglutinin stability as a key determinant of influenza A virus transmission via air
To cause pandemics, zoonotic respiratory viruses need to adapt to replication in and spread between humans, either via (in...
Broadly neutralizing antibodies against COVID-19
The COVID-19 pandemic caused by SARS-CoV-2 has led to hundreds of millions of infections and millions of deaths, however, ...
Colonization of peripheral ganglia by herpes simplex virus type 1 and 2
Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) infect and establish latency in neurons of the peripheral nervous system...
Adenoviral-vectored next-generation respiratory mucosal vaccines against COVID-19
The world is in need of next-generation COVID-19 vaccines. Although first-generation injectable COVID-19 vaccines continue...
Diagnosis and monitoring of virus-associated cancer using cell-free DNA
Viral-associated cancers are a distinct group of malignancies with a unique pathogenesis and epidemiology. Liquid biopsy i...
The two faces of oligoadenylate synthetase-like: effective antiviral protein and negative regulator of innate immunity
The type I interferon response is critical for controlling viral infection and triggers the production of downstream-targe...
Deimmunization of flagellin adjuvant for clinical application
Flagellin is the cognate ligand for host pattern recognition receptors, toll-like receptor 5 (TLR5) in the cell surface, a...
Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children?
Cytomegalovirus (CMV) is a ubiquitous herpesvirus that has a profound impact on the host immune system. Congenital cytomeg...
The roles of nucleic acid editing in adaptation of zoonotic viruses to humans
Following spillover, viruses must adapt to new selection pressures exerted by antiviral responses in their new hosts. In m...
Viral determinants influencing intra- and intercellular communication in cytomegalovirus infection
KeywordsUL25 family proteinsCytomegalovirusesReprogramming signaling pathwaysRemodeling cell architectureMCMV M25 proteins...
The role of human lipoproteins for hepatitis C virus persistence
Hepatitis C virus (HCV) is a hepatotropic virus that establishes a chronic infection in most individuals. Effective treatm...
Does arbovirus emergence in humans require adaptation to domestic mosquitoes?
In the last few decades, several mosquito-borne arboviruses of zoonotic origin have established large-scale epidemic trans...
Gradual adaptation of animal influenza A viruses to human-type sialic acid receptors
Influenza A viruses (IAVs) originating from animal reservoirs pose continuous threats to human health as demonstrated by t...
Structural insights into hepatitis C virus neutralization
Inspite of the available antiviral therapy, hepatitis C virus (HCV) remains a global health burden and a prophylactic vacc...
Flavivirus nonstructural proteins and replication complexes as antiviral drug targets
Many flaviviruses are well-known pathogens, such as dengue, Zika, Japanese encephalitis, and yellow fever viruses. Among t...
MEK inhibitors as novel host-targeted antivirals with a dual-benefit mode of action against hyperinflammatory respiratory viral diseases
Acute hyperinflammatory virus infections, such as influenza or coronavirus disease-19, are still a major health burden wor...
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