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Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants
Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants
Critical period-like plasticity (iPlasticity) can be reinstated in the adult brain by several interventions, including dru...
Node of Ranvier remodeling in chronic psychosocial stress and anxiety
Node of Ranvier remodeling in chronic psychosocial stress and anxiety
Differential expression of myelin-related genes and changes in myelin thickness have been demonstrated in mice after chron...
Perspective on equitable translational studies and clinical support for an unbiased inclusion of the LGBTQIA2S+community
Research regarding the mental health of the Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, Asexual, 2 Spirit (LGBTQ...
Muscarinic receptor activation overrides boundary conditions on memory updating in a calcium/calmodulin-dependent manner
Muscarinic receptor activation overrides boundary conditions on memory updating in a calcium/calmodulin-dependent manner
Long-term memory storage is a dynamic process requiring flexibility to ensure adaptive behavioural responding in changing ...
Psychedelics: preclinical insights provide directions for future research
Psychedelics: preclinical insights provide directions for future research
Recently, psychedelics have emerged as promising therapeutics for numerous neuropsychiatric disorders. While their potenti...
Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice
Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice
A link between gut dysbiosis and the pathogenesis of brain disorders has been identified. A role for gut bacteria in drug ...
Pathways link environmental and genetic factors with structural brain networks and psychopathology in youth
Pathways link environmental and genetic factors with structural brain networks and psychopathology in youth
Adolescence is a period of significant brain development and maturation, and it is a time when many mental health problems...
In Memoriam—Robert M. A. Hirschfeld, MD, MSc
In Memoriam—Robert M. A. Hirschfeld, MD, MSc
Robert M. A. Hirschfeld, MD, MSc, ACNP Fellow Emeritus, and Professor of Psychiat...
BNST PKCδ neurons are activated by specific aversive conditions to promote anxiety-like behavior
BNST PKCδ neurons are activated by specific aversive conditions to promote anxiety-like behavior
The bed nucleus of the stria terminalis (BNST) is a critical mediator of stress responses and anxiety-like behaviors. Neur...
Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder
Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder
The amygdala is a key region in current neurocircuitry models of reactive aggression as it is crucially involved in detect...
Nicotine dependence and insula subregions: functional connectivity and cue-induced activation
Nicotine dependence and insula subregions: functional connectivity and cue-induced activation
Nicotine dependence is a major predictor of relapse in people with Tobacco Use Disorder (TUD). Accordingly, therapies that...
N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial
N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial
Current treatments for adolescent alcohol use disorder (AUD) are mainly psychosocial and limited in their efficacy. As suc...
IN MEMORIAM Barbara H. Stanley Ph.D
IN MEMORIAM Barbara H. Stanley Ph.D
Barbara H. Stanley was an ACNP Fellow and accepted into membership in 2014. Sadly, she died on Wednesday ...
For neuroscience, social history matters
Dwortz MF. et al. Neural systems that facilitate the representation of social rank. Philos Trans R Soc Lond B Biol Sci. 20...
Dona Lee Wong (1946–2022)
Dona Lee Wong (1946–2022)
Dona Lee Wong, PhD, an ACNP member since 2002 and Fellow Emerita, died of complic...
Retraction Note: Safety and efficacy of dapoxetine in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Acute psilocybin enhances cognitive flexibility in rats
Acute psilocybin enhances cognitive flexibility in rats
Psilocybin has been shown to improve symptoms of depression and anxiety when combined with psychotherapy or other clinicia...
Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms
Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms
Major depressive disorder (MDD) is a leading cause of disability worldwide. Individuals with MDD exhibit decreased motivat...
A pilot randomized controlled trial of ketamine in Borderline Personality Disorder
A pilot randomized controlled trial of ketamine in Borderline Personality Disorder
This study is the first randomized controlled trial to test the effects of ketamine in Borderline Personality Disorder (BP...
Plasma and cerebrospinal fluid inflammatory markers and human aggression
Plasma and cerebrospinal fluid inflammatory markers and human aggression
A growing body of work suggests that individuals with aggressive behavior and/or aggressive tendencies have evidence of ch...
Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice
Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice
Selective inhibition of kappa opioid receptors (KORs) is highly anticipated as a pharmacotherapeutic intervention for subs...
William T. McKinney, Jr., MD 1937–2022
Shortly after Bill McKinney joined the faculty of the Psychiatry Department at University of Wisconsin in...
Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis
Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis
Multiple psychiatric disorders are characterized by a failure to suppress default-mode network (DMN) activity during tasks...
mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior
mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior
Pharmacological manipulation of mGluR5 has showed that mGluR5 is implicated in the pathophysiology of anxiety and mGluR5 h...
Identifying novel proteins underlying loneliness by integrating GWAS summary data with human brain proteomes
Identifying novel proteins underlying loneliness by integrating GWAS summary data with human brain proteomes
Enduring loneliness is associated with mental disorders and physical diseases. Although genome-wide association studies (G...
Activation of GABAB receptors in central amygdala attenuates activity of PKCδ + neurons and suppresses punishment-resistant alcohol self-administration in rats
Activation of GABAB receptors in central amygdala attenuates activity of PKCδ + neurons and suppresses punishment-resistant alcohol self-administration in rats
Alcohol use despite negative consequences is a core phenomenon of alcohol addiction. We recently used alcohol self-adminis...
Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer’s disease
Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer’s disease
Alzheimer’s disease (AD) is the most prevalent age-related neurodegenerative disease, which has a high heritability ...
Controlled human drug administration studies are necessary to define the THC-sparing effects of CBD and other cannabis constituents
Cannabis is the most commonly used drug in the United States after alcohol and nicotine. With ongoing pol...
Neuroscience targets and human studies: future translational efforts in the stress system
FundingDr. Haass-Koffler is supported by the National Institute on Alcohol Abuse and Alcoholism (R01 AA026589; R01 AA02776...
DNA methylation GrimAge acceleration in US military veterans with PTSD
DNA methylation GrimAge acceleration in US military veterans with PTSD
Epigenetic alterations in DNA methylation might mediate gene expression effects of trauma underlying PTSD symptoms, or eff...
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