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Neural effects of psychedelics: Complexity the key word
BDMJ reports grants from the PSI Foundation, the University of Toronto and CIHR. MIH receives research support from the Br...
In vivo translocator protein in females with autism spectrum disorder: a pilot study
In vivo translocator protein in females with autism spectrum disorder: a pilot study
Sex-based differences in the prevalence of autism spectrum disorder (ASD) are well-documented, with a male-to-female ratio...
Rebound activation of 5-HT neurons following SSRI discontinuation
Rebound activation of 5-HT neurons following SSRI discontinuation
Cessation of therapy with a selective serotonin (5-HT) reuptake inhibitor (SSRI) is often associated with an early onset&a...
AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects
AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects
Preclinical research has demonstrated the efficacy of CB1 receptor (CB1R) antagonists in reducing drug-taking behavior. Ho...
Beyond traditional pharmacology: evaluating phosphodiesterase inhibitors in autism spectrum disorder
Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, et al. The Lancet Commission on the future of care and clin...
Author Correction: Sex differences in offspring risk and resilience following 11β-hydroxylase antagonism in a rodent model of maternal immune activation
Author Correction: Sex differences in offspring risk and resilience following 11β-hydroxylase antagonism in a rodent model of maternal immune activation
Correction to: Neuropsychopharmacology https://doi.org/10.1038/s41386-023-01771-5, published online 2...
The selective D3Receptor antagonist VK4-116 reverses loss of insight caused by self-administration of cocaine in rats
The selective D3Receptor antagonist VK4-116 reverses loss of insight caused by self-administration of cocaine in rats
Chronic psychostimulant use causes long-lasting changes to neural and cognitive function that persist after long periods o...
The rostromedial tegmental nucleus gates fat overconsumption through ventral tegmental area output in male rats
The rostromedial tegmental nucleus gates fat overconsumption through ventral tegmental area output in male rats
Excessive consumption of palatable foods that are rich in fats and sugars has contributed to the increasing prevalence of ...
Altered excitatory and inhibitory ionotropic receptor subunit expression in the cortical visuospatial working memory network in schizophrenia
Altered excitatory and inhibitory ionotropic receptor subunit expression in the cortical visuospatial working memory network in schizophrenia
Dysfunction of the cortical dorsal visual stream and visuospatial working memory (vsWM) network in individuals with schizo...
Retraction Note: Association between neuromelanin-sensitive MRI signal and psychomotor slowing in late-life depression
Author notesThese authors contributed equally: Guillermo Horga, Bret R. Rutherford.Authors and AffiliationsDepartment of P...
Kappa-opioid receptor stimulation in the nucleus accumbens shell and ethanol drinking: Differential effects by rostro-caudal location and level of drinking
Kappa-opioid receptor stimulation in the nucleus accumbens shell and ethanol drinking: Differential effects by rostro-caudal location and level of drinking
Although the kappa-opioid receptor (KOR) and its endogenous ligand, dynorphin, are believed to be involved in ethanol drin...
Does acute cannabidiol (CBD) use impair performance? A meta-analysis and comparison with placebo and delta-9-tetrahydrocannabinol (THC)
Does acute cannabidiol (CBD) use impair performance? A meta-analysis and comparison with placebo and delta-9-tetrahydrocannabinol (THC)
Cannabidiol (CBD) is widely used and believed to be non-intoxicating, lacking acute performance effects (e.g., non-impairi...
Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease
Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease
Meta-analysis of genome-wide association study data has implicated PDE4B in the pathogenesis of Alzheimer’s disease ...
Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system
Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system
The majority of lifetime smokers begin using nicotine during adolescence, a critical period of brain development wherein n...
Dorsal CA3 overactivation mediates witnessing stress-induced recognition memory deficits in adolescent male mice
Dorsal CA3 overactivation mediates witnessing stress-induced recognition memory deficits in adolescent male mice
Witnessing violent or traumatic events is common during childhood and adolescence and could cause detrimental effects such...
Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1
Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1
Epigenetic factors are well-established players in memory formation. Specifically, DNA methylation is necessary for the fo...
Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats
Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats
Evidence indicates that the anterior (aIC), but not posterior (pIC), insular cortex promotes cued reinstatement of cocaine...
Reply to Karadag: does steroid increase LPS-induced sickness behaviors?
Karadag K, Cimen B, Ertunc M, Sara Y. Does steroid increase LPS-induced sickness behaviors?Alexander B, Fewell JE. Metyrap...
Clinical decision support for bipolar depression using large language models
Clinical decision support for bipolar depression using large language models
Management of depressive episodes in bipolar disorder remains challenging for clinicians despite the availability of treat...
Elevated dorsal medial prefrontal cortex to lateral habenula pathway activity mediates chronic stress-induced depressive and anxiety-like behaviors
Elevated dorsal medial prefrontal cortex to lateral habenula pathway activity mediates chronic stress-induced depressive and anxiety-like behaviors
The medial prefrontal cortex (mPFC) sends projections to numerous brain regions and is believed to play a significant role...
Lifespan development of thalamic nuclei and characterizing thalamic nuclei abnormalities in schizophrenia using normative modeling
Lifespan development of thalamic nuclei and characterizing thalamic nuclei abnormalities in schizophrenia using normative modeling
Thalamic abnormalities have been repeatedly implicated in the pathophysiology of schizophrenia and other neurodevelopmenta...
Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome
Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome
Clinical assessments often fail to discriminate between unipolar and bipolar depression and identify individuals who will ...
IN MEMORIAM—Brian E. Leonard PhD DSc MRIA
IN MEMORIAM—Brian E. Leonard PhD DSc MRIA
With sadness, we mourn the passing of Prof. Brian E. Leonard, Emeritus Professor of Pharmacology at t...
Does steroid increase LPS-induced sickness behaviors?
Martz J, Shelton MA, Geist L, Seney ML, Kentner AC. Sex differences in offspring risk and resilience following 11β-hydroxy...
Critical review and recommendations for enhancement of the article on novel neurosteroid therapeutics for postpartum depression
The article authored by Patterson et al., titled “Novel neurosteroid therapeutics for postpartum depression: perspectives ...
Effect of serum concentrations of IL-6 and TNF-α on brain structure in anorexia nervosa: a combined cross-sectional and longitudinal study
Effect of serum concentrations of IL-6 and TNF-α on brain structure in anorexia nervosa: a combined cross-sectional and longitudinal study
Previous studies of brain structure in anorexia nervosa (AN) have reported reduced gray matter in underweight patients, wh...
Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior
Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior
Prefrontal cortex (PFC) maturation during adolescence is characterized by structural and functional changes, which involve...
Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations
Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations
Fear conditioning is encoded by strengthening synaptic connections between the neurons activated by a conditioned stimulus...
Developmental and molecular contributions to contextual fear memory emergence in mice
Developmental and molecular contributions to contextual fear memory emergence in mice
Cognitive impairment is a common phenotype of neurodevelopmental disorders, but how these deficits arise remains elusive. ...
Reply to Bisol: Critical review and recommendations for enhancement of the article on novel neurosteroid therapeutics for postpartum depression
SM-B has previously received research funding as an Investigator to UNC from Sage Therapeutics for other projects. SM-B ha...
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