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Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice
Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice
Previous studies indicated that ASD-related olfactory dysfunctions are rooted in the piriform cortex. However, the direct ...
Chronic Δ9-tetrahydrocannabinol exposure in adolescent nonhuman primates: persistent abnormalities in economic demand and brain functional connectivity
Chronic Δ9-tetrahydrocannabinol exposure in adolescent nonhuman primates: persistent abnormalities in economic demand and brain functional connectivity
Although chronic cannabis use during adolescence can alter brain function and impair complex behavioral processes, it is u...
Mitogen-activated protein kinase dependent presynaptic potentiation in the lateral habenula mediates depressive-like behaviors in rats
Mitogen-activated protein kinase dependent presynaptic potentiation in the lateral habenula mediates depressive-like behaviors in rats
Emerging evidence suggests that the enhanced activity of lateral habenula (LHb) is involved in depressive disorders. This ...
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannab...
Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model
Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model
Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder with profoundly debilitating symptoms with no FDA-app...
Improved patient identification by incorporating symptom severity in deep learning using neuroanatomic images in first episode schizophrenia
Improved patient identification by incorporating symptom severity in deep learning using neuroanatomic images in first episode schizophrenia
Brain alterations associated with illness severity in schizophrenia remain poorly understood. Establishing linkages betwee...
Correction: Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex
Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex
Serotonin (5-hydroxytryptamine, 5-HT) is a powerful modulator of neuronal activity within the central nervous system and d...
PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus
PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide widely distributed in the brain including the...
Orexinergic modulation of chronic jet lag-induced deficits in mouse cognitive flexibility
Orexinergic modulation of chronic jet lag-induced deficits in mouse cognitive flexibility
Cognitive flexibility and working memory are important executive functions mediated by the prefrontal cortex and can be im...
Is the stereoisomer R-MDMA a safer version of MDMA?
There are many outstanding questions about the potential therapeutic use of 3,4-methylenedioxymethamp...
Phytocannabinoids restore seizure-induced alterations in emotional behaviour in male rats
Phytocannabinoids restore seizure-induced alterations in emotional behaviour in male rats
Epilepsy often presents with severe emotional comorbidities including anxiety and abnormal fear responses which impose a s...
Extended course accelerated intermittent theta burst stimulation as a substitute for depressed patients needing electroconvulsive therapy
Extended course accelerated intermittent theta burst stimulation as a substitute for depressed patients needing electroconvulsive therapy
In response to restrictions on electroconvulsive therapy (ECT) access during COVID-19, we designed a trial to assess the c...
NPP Editorial: tides of progress
Neuropsychopharmacology (NPP) was first published in 1987. Since then, there have been eight Editors ...
Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice
Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice
The co-chaperone FKBP51, encoded by FKBP5 gene, is recognized as a psychiatric risk factor for anxiety and depressive diso...
PET clinical study of novel antipsychotic LB-102 demonstrates unexpectedly prolonged dopamine receptor target engagement
PET clinical study of novel antipsychotic LB-102 demonstrates unexpectedly prolonged dopamine receptor target engagement
Regulation of dopamine activity has important clinical consequences, most notably in schizophrenia. LB-102, N-methyl amisu...
Efficacy and safety of JNJ-42165279, a fatty acid amide hydrolase inhibitor, in adolescents and adults with autism spectrum disorder: a randomized, phase 2, placebo-controlled study
Efficacy and safety of JNJ-42165279, a fatty acid amide hydrolase inhibitor, in adolescents and adults with autism spectrum disorder: a randomized, phase 2, placebo-controlled study
JNJ-42165279, a highly selective and orally bioavailable fatty acid amide (FAA) hydrolase inhibitor, was evaluated for eff...
Small-molecule natural product sophoricoside reduces peripheral neuropathic pain via directly blocking of NaV1.6 in dorsal root ganglion nociceptive neurons
Small-molecule natural product sophoricoside reduces peripheral neuropathic pain via directly blocking of NaV1.6 in dorsal root ganglion nociceptive neurons
Peripheral neuropathic pain poses a significant global health challenge. Current drugs for peripheral neuropathic pain oft...
Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors
Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors
Early Life Adversity (ELA) predisposes to stress hypersensitivity in adulthood, but neurobiological mechanisms that protec...
Neuroimaging in psychiatry: toward mechanistic insights and clinical utility
Neuroimaging has been a mainstay of psychiatric research for three decades, but in recent years, ther...
Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid
Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behaviors, social deficits, an...
Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses
Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses
Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefr...
Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample
Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample
Externalizing psychopathology in childhood is a predictor of poor outcomes across the lifespan. Children exhibiting elevat...
A digital intervention for cognitive deficits following COVID-19: a randomized clinical trial
A digital intervention for cognitive deficits following COVID-19: a randomized clinical trial
Post-COVID-19 cognitive deficits are common, persistent, and disabling. Evidence on effective treatments is limited. The g...
Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training
Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training
Increased brain levels of acetylcholine (ACh) have been observed in patients with depression, and increasing ACh levels ph...
Effects of intranasal oxytocin on fear extinction learning
Effects of intranasal oxytocin on fear extinction learning
Once a threat no longer exists, extinction of conditioned fear becomes adaptive in order to reduce allotted resources towa...
Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior
Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior
Schizophrenia is a neuropsychiatric disorder with postulated neurodevelopmental etiology. Genetic and imaging studies have...
Cathepsin B modulates microglial migration and phagocytosis of amyloid β in Alzheimer’s disease through PI3K-Akt signaling
Cathepsin B modulates microglial migration and phagocytosis of amyloid β in Alzheimer’s disease through PI3K-Akt signaling
The approval of anti-amyloid β (Aβ) monoclonal antibodies (lecanemab) for the treatment of patients with early p...
Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum
Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum
Understanding the neural basis of social play in juvenile rats may ultimately help restore social play deficits in autisti...
Memory engram stability and flexibility
Memory engram stability and flexibility
Many studies have shown that memories are encoded in sparse neural ensembles distributed across the brain. During the post...
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