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Neural underpinnings of open-label placebo effects in emotional distress
Neural underpinnings of open-label placebo effects in emotional distress
While placebo effects are well-known, research in the last decade revealed intriguing effects that placebos may have benef...
Comment on report of a large reduction in cortical GABA following ketone ingestion
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Essential role of P-glycoprotein in the mechanism of action of oliceridine
Essential role of P-glycoprotein in the mechanism of action of oliceridine
Mu opioid receptor (MOR) agonists comprise the most effective analgesics, but their therapeutic utility is limited by adve...
Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD
Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD
ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for ADHD, methylphenidate, can cause se...
Individualized functional connectome identified generalizable biomarkers for psychiatric symptoms in transdiagnostic patients
Individualized functional connectome identified generalizable biomarkers for psychiatric symptoms in transdiagnostic patients
Substantial clinical heterogeneity and comorbidity inherent amongst mental disorders limit the identification of neuroimag...
In Memoriam Donald S. Robinson, MD
Donald S Robinson MD, ACNP Fellow Emeritus, who passed away peacefully surrounded by family on September ...
The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia
The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia
Excess dopamine release in the dorsal striatum (DS) is linked to psychosis. Antipsychotics are thought to work by blocking...
Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios
Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios
As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce ...
The basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice
The basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice
The lateral septum (LS) is a basal forebrain GABAergic region that is implicated in social novelty. However, the neural ci...
Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula
Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula
Early life stress can result in depression in humans and depressive-like behaviour in rodents. In various animal models of...
Pramipexole modulates fronto-subthalamic pathway in sequential working memory
Pramipexole modulates fronto-subthalamic pathway in sequential working memory
Brain dopamine may regulate the ability to maintain and manipulate sequential information online. However, the precise rol...
Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction
Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction
Extinction training during the reconsolidation window following memory recall is an effective behavioral pattern for promo...
Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory
Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory
Delayed upregulation of the neuronal chloride extruder KCC2 underlies the progressive shift in GABA signaling polarity dur...
Reward-related predictors of symptom change in behavioral activation therapy for anhedonic adolescents: a multimodal approach
Reward-related predictors of symptom change in behavioral activation therapy for anhedonic adolescents: a multimodal approach
Anhedonia is a cardinal characteristic of depression which predicts worse treatment outcome and is among the most common r...
IN MEMORIAM - Irwin Feinberg, MD
IN MEMORIAM - Irwin Feinberg, MD
It is with great sadness that we share the news of the passing of Irwin (Bob) Fei...
Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their ...
Effects of lithium on aggression in Drosophila
Effects of lithium on aggression in Drosophila
Lithium is a common medication used to treat mania and bipolar disorder, but the mechanisms by which lithium stabilizes mo...
Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice
Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice
Memories allow past experiences to guide future decision making and behavior. Sparse ensembles of neurons, known as engram...