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Initiation and sequencing of guideline-directed medical therapy for heart failure across the ejection fraction spectrum
Initiation and sequencing of guideline-directed medical therapy for heart failure across the ejection fraction spectrum
Strong evidence supports the importance of rapid sequence or simultaneous initiation of quadruple guideline-directed medic...
Advanced Markers for Hemodynamic Monitoring in Cardiogenic Shock and End-Stage Heart Failure: A Mini Review
Advanced Markers for Hemodynamic Monitoring in Cardiogenic Shock and End-Stage Heart Failure: A Mini Review
Right heart catheterization (RHC) provides critical hemodynamic insights by measuring atrial, ventricular, and pulmonary a...
Lessons learned and future perspectives from the PRO-HF trial
Lessons learned and future perspectives from the PRO-HF trial
Conflict of interest Dr. Mario Enrico Canonico receives salary supp...
Focusing on microvascular function in heart failure with preserved ejection fraction
Focusing on microvascular function in heart failure with preserved ejection fraction
Heart failure is a prevalent global health issue. Heart failure with preserved ejection fraction (HFpEF), which already re...
Heart failure outpatient clinics resources in Italy: a viewpoint of Italian Society of Cardiology organization
Heart failure outpatient clinics resources in Italy: a viewpoint of Italian Society of Cardiology organization
The current paper reports the model organization, level of health care, and type of medical and research activities relate...
Sacubitril/valsartan in a wide spectrum of heart failure patients (from mechanisms of action to outcomes in specific populations)
Sacubitril/valsartan in a wide spectrum of heart failure patients (from mechanisms of action to outcomes in specific populations)
Heart failure (HF) represents a significant global health challenge, characterized by high morbidity and mortality rates, ...
Machine learning in predicting heart failure survival: a review of current models and future prospects
Machine learning in predicting heart failure survival: a review of current models and future prospects
Heart failure is a complex and prevalent condition with significant implications for patient management and survival predi...
Potential effects of beta-blockers in HFpEF
Potential effects of beta-blockers in HFpEF
Heart failure with preserved ejection fraction (HFpEF) poses a significant challenge in contemporary medicine, characteriz...
Hyperkalemia management: a multidisciplinary expert panel’s perspective on the role of new potassium binders
Hyperkalemia management: a multidisciplinary expert panel’s perspective on the role of new potassium binders
Hyperkalemia is a potentially life-threatening condition frequently encountered in clinical practice, particularly among p...
Epigenetics of cardiomyopathies: the next frontier
Epigenetics of cardiomyopathies: the next frontier
Cardiomyopathies (CMP) are a diverse group of myocardial diseases that cause structural, functional, and pathological chan...
Conduction system pacing in heart failure: Time for a paradigm shift?
Conduction system pacing in heart failure: Time for a paradigm shift?
Heart failure (HF) is a major clinical challenge characterized by significant morbidity and mortality. Electrical conducti...
Could SGLT2 inhibitors improve outcomes in patients with heart failure and significant valvular heart disease? Need for action
Could SGLT2 inhibitors improve outcomes in patients with heart failure and significant valvular heart disease? Need for action
Delivering valvular intervention for all eligible patients with valvular heart disease (VHD) in a timely manner remains a ...
Maternal heart failure: state-of-the-art review
Maternal heart failure: state-of-the-art review
Pregnancy is a period of substantial changes to the body’s normal physiology, and the failure to adapt to these chan...
Sodium-glucose co-transporter 2 inhibitors in left ventricular assist device and heart transplant recipients: a mini-review
Sodium-glucose co-transporter 2 inhibitors in left ventricular assist device and heart transplant recipients: a mini-review
In recent years, sodium-glucose co-transporter 2 inhibitors (SGLT2i) emerged as promising therapeutic agents in managing h...
Diagnosis and management of hypertrophic cardiomyopathy: European vs. American guidelines
Diagnosis and management of hypertrophic cardiomyopathy: European vs. American guidelines
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, affecting 1:200 to 1:500 individuals worldwide...
Adrenal crisis-induced cardiogenic shock (ACCS): a comprehensive review
Adrenal crisis-induced cardiogenic shock (ACCS): a comprehensive review
Adrenal insufficiency (AI) is a disorder in which inadequate glucocorticoid and mineralocorticoid hormone production leads...
The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined
The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined
Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established appro...
A fine addition: Finerenone in the evolving landscape of heart failure with preserved ejection fraction
A fine addition: Finerenone in the evolving landscape of heart failure with preserved ejection fraction
McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, C...
The many faces of SCN5A pathogenic variants: from channelopathy to cardiomyopathy
The many faces of SCN5A pathogenic variants: from channelopathy to cardiomyopathy
The SCN5A gene encodes the alpha subunit of the cardiac sodium channel, which plays a fundamental role in the generation a...
Sodium-glucose cotransporter-2 inhibitors in acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials
Sodium-glucose cotransporter-2 inhibitors in acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials
We aimed to assess the efficacy and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) versus placebo, initiated...
Noninvasive biometric monitoring technologies for patients with heart failure
Noninvasive biometric monitoring technologies for patients with heart failure
Heart failure remains one of the leading causes of mortality and hospitalizations in the US that not only impacts quality ...
The sympathetic nervous system in heart failure with preserved ejection fraction
The sympathetic nervous system in heart failure with preserved ejection fraction
The sympathetic nervous system (SNS) is a major mediator of cardiovascular physiology during exercise in healthy people. H...
Changing the paradigm in heart failure: shifting from treatment to prevention
Changing the paradigm in heart failure: shifting from treatment to prevention
Heart failure (HF) poses a major global health challenge with rising prevalence, significant morbidity and mortality, and ...
Heart failure with reduced ejection fraction and chronic kidney disease: a focus on therapies and interventions
Heart failure with reduced ejection fraction and chronic kidney disease: a focus on therapies and interventions
In heart failure with reduced ejection fraction (HFrEF), the presence of concomitant chronic kidney disease (CKD) predicts...
GLP-1 receptor agonists as promising anti-inflammatory agents in heart failure with preserved ejection fraction
GLP-1 receptor agonists as promising anti-inflammatory agents in heart failure with preserved ejection fraction
Heart Failure with Preserved Ejection Fraction (HFpEF) represents a significant challenge in modern cardiovascular medicin...
Dietary sodium intake restriction in patients with heart failure: an overview of systematic reviews
Dietary sodium intake restriction in patients with heart failure: an overview of systematic reviews
This study aimed to identify, assess, and summarize systematic reviews on dietary sodium intake restrictions for patients ...
In-hospital initiation of sodium-glucose co-transporter-2 inhibitors in patients with acute heart failure
In-hospital initiation of sodium-glucose co-transporter-2 inhibitors in patients with acute heart failure
Sodium-glucose cotransporter-2 (SGLT2) inhibitors provide cardiovascular and kidney benefits to patients with heart failur...
Harnessing the lymphatic system
Harnessing the lymphatic system
Heart failure (HF) is a growing concern, with significant implications for mortality, morbidity, and economic sustainabili...
Mineralocorticoid receptor antagonists and heart failure with preserved ejection fraction: current understanding and future prospects
Mineralocorticoid receptor antagonists and heart failure with preserved ejection fraction: current understanding and future prospects
The mineralocorticoid receptor (MR), part of the steroid hormone receptor subfamily within nuclear hormone receptors, is f...
The chronobiology of human heart failure: clinical implications and therapeutic opportunities
The chronobiology of human heart failure: clinical implications and therapeutic opportunities
Circadian variation in cardiovascular and metabolic dynamics arises from interactions between intrinsic rhythms and extrin...
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