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Beyond quadruple therapy: the potential roles for ivabradine, vericiguat, and omecamtiv mecarbil in the therapeutic armamentarium
Beyond quadruple therapy: the potential roles for ivabradine, vericiguat, and omecamtiv mecarbil in the therapeutic armamentarium
Quadruple therapy is effective for patients with heart failure with reduced ejection fraction, providing significant clini...
Anti-obesity medications in the management of heart failure with preserved ejection fraction: available evidence and next STEPS
Anti-obesity medications in the management of heart failure with preserved ejection fraction: available evidence and next STEPS
Obesity is associated with an increased risk of incident heart failure with preserved ejection fraction (HFpEF) and, among...
Interplay of the heart, spleen, and bone marrow in heart failure: the role of splenic extramedullary hematopoiesis
Interplay of the heart, spleen, and bone marrow in heart failure: the role of splenic extramedullary hematopoiesis
Improvements in therapies for heart failure with preserved ejection fraction (HFpEF) are crucial for improving patient out...
Nexilin in cardiomyopathy: unveiling its diverse roles with special focus on endocardial fibroelastosis
Nexilin in cardiomyopathy: unveiling its diverse roles with special focus on endocardial fibroelastosis
Cardiac disorders exhibit considerable heterogeneity, and understanding their genetic foundations is crucial for their dia...
Acetazolamide therapy in patients with acute heart failure: a systematic review and meta-analysis of randomized controlled trials
Acetazolamide therapy in patients with acute heart failure: a systematic review and meta-analysis of randomized controlled trials
Acute heart failure (AHF) often leads to unfavorable outcomes due to fluid overload. While diuretics are the cornerstone t...
The significance of the apelinergic system in doxorubicin-induced cardiotoxicity
The significance of the apelinergic system in doxorubicin-induced cardiotoxicity
Cancer is the leading cause of death worldwide, and the number of cancer-related deaths is expected to increase. Common ty...
Extended thromboprophylaxis in heart failure patients; the unmet need
Extended thromboprophylaxis in heart failure patients; the unmet need
Heart failure (HF) is considered one of a leading cause of cardiovascular morbidity and mortality worldwide. The associati...
Biosensors with left ventricular assist devices
Biosensors with left ventricular assist devices
Heart failure imposes a significant global health burden, standing as a primary contributor to mortality. Various indicato...
New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy
New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy
Advances in the etiological classification of myocarditis and inflammatory cardiomyopathy (ICM) have reached a consensus. ...
Navigating the penetrance and phenotypic spectrum of inherited cardiomyopathies
Navigating the penetrance and phenotypic spectrum of inherited cardiomyopathies
Inherited cardiomyopathies are genetic diseases that can lead to heart failure and sudden cardiac death. These conditions ...
STEP HFpEF DM: a sweet sequel
STEP HFpEF DM: a sweet sequel
Kosiborod MN, Petrie MC, Borlaug BA et al (2024) Semaglutide in patients with obesity-related heart failure and type 2 dia...
The role of PCSK9 in heart failure and other cardiovascular diseases—mechanisms of action beyond its effect on LDL cholesterol
The role of PCSK9 in heart failure and other cardiovascular diseases—mechanisms of action beyond its effect on LDL cholesterol
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a protein that regulates low-density lipoprotein (LDL) cholestero...
Evaluating the role of interatrial shunt devices in heart failure management: insights from the RELIEVE-HF trial
Evaluating the role of interatrial shunt devices in heart failure management: insights from the RELIEVE-HF trial
McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M et al (2021) 2021 ESC Guidelines for the diagnosis and treat...
Pooled prevalences of obstructive sleep apnea and heart failure: a systematic review and meta-analysis
Pooled prevalences of obstructive sleep apnea and heart failure: a systematic review and meta-analysis
Obstructive sleep apnea (OSA) is a disease with intermittent hypoxemia during sleep. It has been shown that OSA is related...
Assessment of patient-reported outcomes measures in heart failure: a systematic review
Assessment of patient-reported outcomes measures in heart failure: a systematic review
Heart failure (HF) is a prevalent global disease, particularly impacting developed countries. With the world’s aging...
Resistance is not futile: a systematic review of the benefits, mechanisms and safety of resistance training in people with heart failure
Resistance is not futile: a systematic review of the benefits, mechanisms and safety of resistance training in people with heart failure
Exercise offers many physical and health benefits to people with heart failure (CHF), but aerobic training (AT) predominat...
Comparative analysis of treatment options for chronic heart failure and depression: a systematic review and Bayesian network meta-analysis
Comparative analysis of treatment options for chronic heart failure and depression: a systematic review and Bayesian network meta-analysis
Different interventions have been evaluated for the treatment of depression in heart failure (HF) patients. However, clear...
Current status and future directions in pediatric ventricular assist device
Current status and future directions in pediatric ventricular assist device
A ventricular assist device (VAD) is a form of mechanical circulatory support that uses a mechanical pump to partially or ...
New perspectives in the echocardiographic hemodynamics multiparametric assessment of patients with heart failure
New perspectives in the echocardiographic hemodynamics multiparametric assessment of patients with heart failure
International Guidelines consider left ventricular ejection fraction (LVEF) as an important parameter to categorize patien...
Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure
Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure
Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ cu...
Budget impact analyses for treatment of heart failure. A systematic review
Budget impact analyses for treatment of heart failure. A systematic review
Heart failure (HF) is increasing globally and turning out to be a serious worldwide public health problem with significant...
The prevalence of coronary microvascular dysfunction (CMD) in heart failure with preserved ejection fraction (HFpEF): a systematic review and meta-analysis
The prevalence of coronary microvascular dysfunction (CMD) in heart failure with preserved ejection fraction (HFpEF): a systematic review and meta-analysis
To date, studies on the prevalence of coronary microvascular dysfunction (CMD) in heart failure with preserved ejection fr...
Current perspectives of sudden cardiac death management in hypertrophic cardiomyopathy
Current perspectives of sudden cardiac death management in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by left ventricular hypertrophy. Sudden ...
Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry
Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry
Takotsubo syndrome (TTS) in the pediatric population is an infrequent but relevant cause of morbidity and mortality, with ...
Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography
Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography
Left atrium (LA) is a very important component of cardiovascular performance. The assessment of LA function has gathered t...
Electrocardiographic abnormalities in patients with cardiomyopathies
Electrocardiographic abnormalities in patients with cardiomyopathies
Abnormalities in impulse generation and transmission are among the first signs of cardiac remodeling in cardiomyopathies. ...
Diagnosis of heart failure with preserved ejection fraction: a systematic narrative review of the evidence
Diagnosis of heart failure with preserved ejection fraction: a systematic narrative review of the evidence
Heart failure (HF) with preserved ejection fraction (HFpEF) is a common condition in clinical practice, affecting more tha...
Heart failure with mildly reduced and preserved ejection fraction: A review of disease burden and remaining unmet medical needs within a new treatment landscape
Heart failure with mildly reduced and preserved ejection fraction: A review of disease burden and remaining unmet medical needs within a new treatment landscape
This review provides a comprehensive overview of heart failure with mildly reduced and preserved ejection fraction (HFmrEF...
Cardiac contractility modulation in patients with heart failure — A review of the literature
Cardiac contractility modulation in patients with heart failure — A review of the literature
Experimental in vivo and in vitro studies showed that electric currents applied during the absolute refractory period can ...
Latest pharmaceutical approaches across the spectrum of heart failure
Latest pharmaceutical approaches across the spectrum of heart failure
Despite major advances in prevention and medical therapy, heart failure (HF) remains associated with high morbidi...
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