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ALL-RIC trial protocol: a comparison of reduced dose total body irradiation (TBI) and cyclophosphamide with fludarabine and melphalan reduced intensity conditioning in adults with acute lymphoblastic leukaemia (ALL) in complete remission
ALL-RIC trial protocol: a comparison of reduced dose total body irradiation (TBI) and cyclophosphamide with fludarabine and melphalan reduced intensity conditioning in adults with acute lymphoblastic leukaemia (ALL) in complete remission
IntroductionThe UKALL 141 2 trial prospectively studied reduced intensity conditioning (RIC) transplantation in adults wit...
Rubella seroprevalence among pregnant women in the region of Rabat, Morocco: a cross-sectional study
Rubella seroprevalence among pregnant women in the region of Rabat, Morocco: a cross-sectional study
Strengths and limitations of this studyThe findings from our local population may not be applicable at the national scale,...
Role of health facility governing committees in strengthening social accountability to improve the health system in Tanzania: protocol for a participatory action research study
Role of health facility governing committees in strengthening social accountability to improve the health system in Tanzania: protocol for a participatory action research study
Strengths and limitations of this studyThe study methodology is novel by adopting community-based participatory research t...
Investigating Clinical Excellence and Impact Awards (INCEA): a qualitative study into how current assessors and other key stakeholders define and score excellence
Investigating Clinical Excellence and Impact Awards (INCEA): a qualitative study into how current assessors and other key stakeholders define and score excellence
DesignSemistructured interviews were conducted with key informants of the NCEAs scheme, between July and August 2021. Repo...
Cost of surgical treatment for ulnar nerve entrapment in Finland, 2011-2015: a registry-based cost description study
Cost of surgical treatment for ulnar nerve entrapment in Finland, 2011-2015: a registry-based cost description study
STRENGTHS AND LIMITATIONS OF THIS STUDYThe data from the Finnish Care Register for Health Care and the Social Insurance In...
Age-specific and genotype-specific carcinogenic human papillomavirus prevalence in a country with a high cervical cancer burden: results of a cross-sectional study in Estonia
Age-specific and genotype-specific carcinogenic human papillomavirus prevalence in a country with a high cervical cancer burden: results of a cross-sectional study in Estonia
IntroductionHuman papillomavirus (HPV) is estimated to be one of the most common sexually transmitted infections worldwide...
Correction: Key factors for effective implementation of healthcare worker support interventions after patient safety incidents in health organisations: a protocol for a scoping review
Correction: Key factors for effective implementation of healthcare worker support interventions after patient safety incidents in health organisations: a protocol for a scoping review
Guerra-Paiva S, Lobão MJ, Simões JD, et al. Key factors for effective implementation of healthcare worker support interven...
Barriers and facilitators of family doctor contract services in caring for disabled older adults in Beijing, China: a mixed methods study
Barriers and facilitators of family doctor contract services in caring for disabled older adults in Beijing, China: a mixed methods study
IntroductionWith the global escalation of the ageing process and the extension of average life expectancy, more and more o...
Quality of life and associated factors among chronic kidney disease patients at Zewditu Memorial and Tikur Anbessa Specialised Hospitals, Ethiopia: a cross-sectional study design
Quality of life and associated factors among chronic kidney disease patients at Zewditu Memorial and Tikur Anbessa Specialised Hospitals, Ethiopia: a cross-sectional study design
STRENGTHS AND LIMITATIONS OF THIS STUDYThis study was conducted at two referral centres that provide chronic kidney diseas...
Burden of disease and barriers to comprehensive care for rheumatic heart disease in South Africa: an updated systematic review protocol
Burden of disease and barriers to comprehensive care for rheumatic heart disease in South Africa: an updated systematic review protocol
This review protocol was registered with the PROSPERO International Prospective Register of systematic reviews http://www....
Study protocol: pneumonia and inhaled corticosteroid treatment patterns in chronic obstructive pulmonary disease - a cohort study using sequence analysis (PICCS)
Study protocol: pneumonia and inhaled corticosteroid treatment patterns in chronic obstructive pulmonary disease - a cohort study using sequence analysis (PICCS)
IntroductionInhaled corticosteroid (ICS) treatment is one of the medical treatments used in chronic obstructive pulmonary ...
Impact of the COVID-19 pandemic on domiciliary care workers in Wales, UK: a data linkage cohort study using the SAIL Databank
Impact of the COVID-19 pandemic on domiciliary care workers in Wales, UK: a data linkage cohort study using the SAIL Databank
STRENGTHS AND LIMITATIONS OF THIS STUDYLinking registration data to electronic health records in Wales provided a unique o...
Novel application of multi-facility process map analysis for rapid injury care health system assessment in Northern Malawi
Novel application of multi-facility process map analysis for rapid injury care health system assessment in Northern Malawi
STRENGTHS AND LIMITATIONS OF THIS STUDYProcess mapping is a method with promise for application within rapid injury care h...
Protocol for the OCAY study: a cohort study of orphanhood and caregiver loss in the COVID-19 era to explore the impact on children and adolescents
Protocol for the OCAY study: a cohort study of orphanhood and caregiver loss in the COVID-19 era to explore the impact on children and adolescents
Strengths and limitations of this studyThis is the first empirical investigation of the impacts of COVID-19-associated car...
Objectives and outcomes of patient-driven innovations published in peer-reviewed journals: a qualitative analysis of publications included in a scoping review
Objectives and outcomes of patient-driven innovations published in peer-reviewed journals: a qualitative analysis of publications included in a scoping review
BackgroundMultiple policy documents emphasise the importance of involving patients in care decisions and processes.1–3 Als...
Shared characteristics of intervention techniques for oral vocabulary and speech comprehensibility in preschool children with co-occurring features of developmental language disorder and a phonological speech sound disorder: protocol for a systematic review with narrative synthesis
Shared characteristics of intervention techniques for oral vocabulary and speech comprehensibility in preschool children with co-occurring features of developmental language disorder and a phonological speech sound disorder: protocol for a systematic review with narrative synthesis
IntroductionWithin the field of child language disorders, there are often overlapping or co-occurring difficulties which c...
Paving the way for solutions improving access to kidney transplantation: a qualitative study from a multistakeholder perspective
Paving the way for solutions improving access to kidney transplantation: a qualitative study from a multistakeholder perspective
IntroductionOverview of the issueThe scientific literature regarding chronic kidney disease indicates that transplantation...
Consideration of sex and gender in European clinical practice guidelines in internal medicine: a systematic review protocol
Consideration of sex and gender in European clinical practice guidelines in internal medicine: a systematic review protocol
STRENGTHS AND LIMITATIONS OF THIS STUDYClinical practice guidelines (CPGs) in internal medicine and its subspecialties pro...
Oral-only antibiotics for bone and joint infections in children: study protocol for a nationwide randomised open-label non-inferiority trial
Oral-only antibiotics for bone and joint infections in children: study protocol for a nationwide randomised open-label non-inferiority trial
Methods and analysisStudy hypothesis and designWe hypothesise that oral-only antibiotic therapy is non-inferior (non-infer...
Pragmatic multicentre stepped-wedge cluster randomised trial to investigate the effectiveness of community-based falls prevention programme for older adults with falls risk in Singapore: a protocol paper
Pragmatic multicentre stepped-wedge cluster randomised trial to investigate the effectiveness of community-based falls prevention programme for older adults with falls risk in Singapore: a protocol paper
IntroductionFalls are a major public health concern as 30%–39% of community-dwelling adults above 60 years had a fall in a...
Testing the applicability and additional value of a consultation round after the consensus meeting in the development of two core outcome sets
Testing the applicability and additional value of a consultation round after the consensus meeting in the development of two core outcome sets
STRENGTHS AND LIMITATIONS OF THIS STUDYThe level of agreement was above the preset required level of 80%.Disagreement was ...
Association between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database
Association between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database
STRENGTHS AND LIMITATIONS OF THIS STUDYTo the best of our knowledge, this is the first study assessing the association bet...
Association between serum uric acid and measures of adiposity in Chinese adults: a cross-sectional study
Association between serum uric acid and measures of adiposity in Chinese adults: a cross-sectional study
IntroductionHyperuricaemia is a disorder of purine metabolism that affects approximately 120 million individuals in China,...
Pre-emptive coinfiltration of dexamethasone palmitate emulsion with ropivacaine for postoperative pain in patients undergoing major spine surgery: a study protocol for a prospective, randomised controlled, multicentre trial
Pre-emptive coinfiltration of dexamethasone palmitate emulsion with ropivacaine for postoperative pain in patients undergoing major spine surgery: a study protocol for a prospective, randomised controlled, multicentre trial
IntroductionPatients undergoing major spine surgery (such as laminoplasty, single laminectomy and fusion after laminectomy...
Time trends in the incidence of cardiovascular disease, hypertension and diabetes by sex and socioeconomic status in Catalonia, Spain: a population-based cohort study
Time trends in the incidence of cardiovascular disease, hypertension and diabetes by sex and socioeconomic status in Catalonia, Spain: a population-based cohort study
IntroductionCardiovascular disease (CVD) is the leading cause of death worldwide, being responsible for nearly 18.6 millio...
Medication use and comorbidities in an increasingly younger osteoarthritis population: an 18-year retrospective open-cohort study
Medication use and comorbidities in an increasingly younger osteoarthritis population: an 18-year retrospective open-cohort study
IntroductionOsteoarthritis (OA) is a severe disease resulting in substantial clinical and economic burden to society and l...
Mapping the evidence on assessment of fitness to work at heights: a scoping review protocol
Mapping the evidence on assessment of fitness to work at heights: a scoping review protocol
RationaleFalls from height are a leading cause of serious occupational injury and fatality globally.1–7 In 2013 alone, fal...
Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers
Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers
Strengths and limitations of this studyAs a participant and observer blinded randomised control trial this study will prov...
Initial characteristics and course of disease in patients with suspected COVID-19 managed in general practice: a prospective, multicentre cohort study
Initial characteristics and course of disease in patients with suspected COVID-19 managed in general practice: a prospective, multicentre cohort study
BackgroundThe first wave of COVID-19 in France prompted a lockdown from mid-March to mid-May 2020. General practitioners (...
Train Smart Study: protocol for a randomised trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults
Train Smart Study: protocol for a randomised trial investigating the role of exercise training dose on markers of brain health in sedentary middle-aged adults
Experimental design and overviewThis randomised trial will follow a two-group parallel design. Participants will be assign...
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