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The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs [In the Spotlight]
The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs [In the Spotlight]
Summary: Cancer-associated fibroblast (CAF) pro– and anti–pancreatic cancer functional dichotomy has been at the center of...
The CLIP1-LTK Fusion Is an Oncogenic Driver of NSCLC [Lung Cancer]
The CLIP1-LTK Fusion Is an Oncogenic Driver of NSCLC [Lung Cancer]
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Bispecific Antibody Takes Down FL [News in Brief]
Bispecific Antibody Takes Down FL [News in Brief]
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Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer [Microbiome]
Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer [Microbiome]
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Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells [Research Articles]
Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells [Research Articles]
Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblast...
Transition to NK-Like T Cells Is a Mechanism Behind CAR T-cell Exhaustion [Immunotherapy]
Transition to NK-Like T Cells Is a Mechanism Behind CAR T-cell Exhaustion [Immunotherapy]
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Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer [Research Articles]
Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer [Research Articles]
Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Activ...
"Very Compelling" Results for ADC in TNBC Trial [News in Brief]
"Very Compelling" Results for ADC in TNBC Trial [News in Brief]
In a phase I trial, the antibody–drug conjugate datopotamab deruxtecan demonstrated encouraging response rates and managea...
Novel SERD Has PFS Edge against Breast Cancer [News in Brief]
Novel SERD Has PFS Edge against Breast Cancer [News in Brief]
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Tumor Profiling Improves Breast Cancer PFS [News in Brief]
Tumor Profiling Improves Breast Cancer PFS [News in Brief]
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Navigating Cancer Care in the COVID-19 Era [News in Depth]
Navigating Cancer Care in the COVID-19 Era [News in Depth]
With the COVID-19 pandemic, clinicians, researchers, industry leaders, and federal regulators in oncology have had to adap...
Noted [News in Brief]
Noted [News in Brief]
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MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma [Research Articles]
MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma [Research Articles]
AbstractThe degree of metastatic disease varies widely among patients with cancer and affects clinical outcomes. However, ...
Pandemic Puts Telehealth to the Test [News in Depth]
Pandemic Puts Telehealth to the Test [News in Depth]
Access to telehealth in oncology rapidly expanded during the COVID-19 pandemic, and it has been widely touted as a way to ...
Improving the Affordability of Anticancer Medicines Demands Evidence-Based Policy Solutions [Science in Society]
Improving the Affordability of Anticancer Medicines Demands Evidence-Based Policy Solutions [Science in Society]
AbstractThe high cost of many new anticancer medicines significantly impedes breakthrough discoveries from reaching patien...
Shedding Light on ecDNA Behavior Using CRISPR-Based Live-Cell Imaging [In the Spotlight]
Shedding Light on ecDNA Behavior Using CRISPR-Based Live-Cell Imaging [In the Spotlight]
1Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.2Berlin Institute of Hea...
Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders [Research Articles]
Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders [Research Articles]
AbstractPersonalized medicine aims to match the right drug with the right patient by using specific features of the indivi...
A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era [Reviews]
A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era [Reviews]
Leukemias and LymphomasHematolymphoid neoplasms are the most prevalent group of cancers (38.7%) in CAYA. With increasing k...
An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML [Research Articles]
An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML [Research Articles]
AbstractCRISPR–Cas9-based genetic screens have successfully identified cell type–dependent liabilities in cancer, includin...
Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF/FGFR Aberrations: A Phase I Dose-Expansion Study [Research Articles]
Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF/FGFR Aberrations: A Phase I Dose-Expansion Study [Research Articles]
AbstractFutibatinib, a highly selective, irreversible FGFR1–4 inhibitor, was evaluated in a large multihistology phase I d...
B Cells Synthesize and Secrete GABA to Reduce Antitumor Immunity [Immunology]
B Cells Synthesize and Secrete GABA to Reduce Antitumor Immunity [Immunology]
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89Zr-pembrolizumab Uptake Predicts Survival and Immunotherapy Response [Immunotherapy]
89Zr-pembrolizumab Uptake Predicts Survival and Immunotherapy Response [Immunotherapy]
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Dual-Targeting Approach for CD40 and 4-1BB [News in Brief]
Dual-Targeting Approach for CD40 and 4-1BB [News in Brief]
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Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes [Research Articles]
Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes [Research Articles]
Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes Yasu...
Immunotherapy First for BRAF-Mutant Melanoma [News in Brief]
Immunotherapy First for BRAF-Mutant Melanoma [News in Brief]
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Lineage-Specific Clonal Hematopoiesis Predicts Hematologic Malignancy [Hematopoiesis]
Lineage-Specific Clonal Hematopoiesis Predicts Hematologic Malignancy [Hematopoiesis]
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Ibrutinib Treatment in Early Stage CLL Prolongs Time to Active Disease [Clinical Trials]
Ibrutinib Treatment in Early Stage CLL Prolongs Time to Active Disease [Clinical Trials]
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BRD4-cJUN-CCL2-TNF{alpha} Axis Maintains Basal-Like Pancreatic Cancer Subtype Identity [Pancreatic Cancer]
BRD4-cJUN-CCL2-TNF{alpha} Axis Maintains Basal-Like Pancreatic Cancer Subtype Identity [Pancreatic Cancer]
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Glycogen Accumulation Induces the Hippo Pathway and Liver Tumorigenesis [Tumorigenesis]
Glycogen Accumulation Induces the Hippo Pathway and Liver Tumorigenesis [Tumorigenesis]
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Peptide-Centric CAR-T Cells Target Unmutated Intracellular Oncoproteins [Immunotherapy]
Peptide-Centric CAR-T Cells Target Unmutated Intracellular Oncoproteins [Immunotherapy]
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