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Biological and molecular profile of fracture non‐union tissue: A systematic review and an update on current insights
Biological and molecular profile of fracture non‐union tissue: A systematic review and an update on current insights
Abstract Fracture non-union represents a common complication, seen in 5%–10% of all acute fractures. Despite the en...
FGF21 alleviates acute liver injury by inducing the SIRT1‐autophagy signalling pathway
FGF21 alleviates acute liver injury by inducing the SIRT1‐autophagy signalling pathway
Abstract Liver injury can lead to different hepatic diseases, which are the mainly causes of high global mortality and mor...
Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition
Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition
Abstract Berberine (BBR), an isoquinoline alkaloid, is used to treat gastrointestinal disorders as an herbal medicine in C...
The emerging roles of exosomal long non‐coding RNAs in bladder cancer
The emerging roles of exosomal long non‐coding RNAs in bladder cancer
Abstract Extracellular vesicles (EVs), especially exosomes, have been reported to play essential roles as extracellular me...
Comparative proteome analysis identified CD44 as a possible serum marker for docetaxel resistance in castration‐resistant prostate cancer
Comparative proteome analysis identified CD44 as a possible serum marker for docetaxel resistance in castration‐resistant prostate cancer
Abstract Baseline or acquired resistance to docetaxel (DOC) represents a significant risk for patients with metastatic pro...
Uridine alleviates carbon tetrachloride‐induced liver fibrosis by regulating the activity of liver‐related cells
Uridine alleviates carbon tetrachloride‐induced liver fibrosis by regulating the activity of liver‐related cells
Abstract At present, liver fibrosis is a major challenge of global health. When hepatocyte regeneration cannot compensate ...
Bioactive polypeptide improves neuroinflammation by regulating microglia polarization
Bioactive polypeptide improves neuroinflammation by regulating microglia polarization
1 BACKGROUND Toll-like receptor (TLR) was first discovered during a research of embryonic development i...
Cardiovascular and haematological events post COVID‐19 vaccination: A systematic review
Cardiovascular and haematological events post COVID‐19 vaccination: A systematic review
Abstract Since COVID-19 took a strong hold around the globe causing considerable morbidity and mortality, a lot of effort ...
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy
Abstract Glioblastoma multiforme (GBM) is a primary tumour of the central nervous system (CNS) that exhibits the highest d...
Cinnamic Aldehyde, the main monomer component of Cinnamon, exhibits anti‐inflammatory property in OA synovial fibroblasts via TLR4/MyD88 pathway
Cinnamic Aldehyde, the main monomer component of Cinnamon, exhibits anti‐inflammatory property in OA synovial fibroblasts via TLR4/MyD88 pathway
Abstract Cinnamon is a wildly used traditional Chinese herbal medicine for osteoarthritis (OA) treatment, but the underlyi...
Roles of mesenchymal stem cells and exosomes in interstitial cystitis/bladder pain syndrome
Roles of mesenchymal stem cells and exosomes in interstitial cystitis/bladder pain syndrome
Abstract Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by several symptoms of higher sensitivity o...
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1‐RAGE/TLR4‐NF‐κB/AKT pathway
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1‐RAGE/TLR4‐NF‐κB/AKT pathway
Abstract To investigate the role of glycyrrhizin on the progression of temporomandibular joint osteoarthritis (TMJOA) and ...
Studying the mechanism of sperm DNA damage caused by folate deficiency
Studying the mechanism of sperm DNA damage caused by folate deficiency
Abstract Sperm DNA injury is one of the common causes of male infertility. Folic acid deficiency would increase the methyl...
Thymoquinone ameliorates pressure overload‐induced cardiac hypertrophy by activating the AMPK signalling pathway
Thymoquinone ameliorates pressure overload‐induced cardiac hypertrophy by activating the AMPK signalling pathway
Abstract Prolonged pathological myocardial hypertrophy leads to end-stage heart failure. Thymoquinone (TQ), a bioactive co...
The role of Cold‐Inducible RNA‐binding protein in respiratory diseases
The role of Cold‐Inducible RNA‐binding protein in respiratory diseases
Abstract Cold-inducible RNA-binding protein (CIRP) is a stress-response protein that is expressed in various types of cell...
Expression and significance of SOX B1 genes in glioblastoma multiforme patients
Expression and significance of SOX B1 genes in glioblastoma multiforme patients
Abstract The overall survival of glioblastoma multiforme (GBM) patients remains poor. To improve patient outcomes, effecti...
AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells
AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells
Abstract Both androgen receptor (AR) and the ZFHX3 transcription factor modulate prostate development. While AR drives pro...
ITGB3BP is a potential biomarker associated with poor prognosis of glioma
ITGB3BP is a potential biomarker associated with poor prognosis of glioma
Abstract Despite the growing recognition of ITGB3BP as an essential feature of various cancers, the relationship between I...
The G to A transformation of rs4702 polymorphism in 3’UTR of FURIN reduced the risk of radiotherapy‐induced cognitive impairment in glioma patients
The G to A transformation of rs4702 polymorphism in 3’UTR of FURIN reduced the risk of radiotherapy‐induced cognitive impairment in glioma patients
Abstract The G allele of rs4702 polymorphism has been reported to reduce the production of mature BDNF and FURIN, both of ...
Sparstolonin B suppresses free fatty acid palmitate‐induced chondrocyte inflammation and mitigates post‐traumatic arthritis in obese mice
Sparstolonin B suppresses free fatty acid palmitate‐induced chondrocyte inflammation and mitigates post‐traumatic arthritis in obese mice
Abstract Abnormal lipid metabolism, such as systemic increased free fatty acid, results in overproduction of pro-inflammat...
Gingival mesenchymal stem cell‐derived exosomes are immunosuppressive in preventing collagen‐induced arthritis
Gingival mesenchymal stem cell‐derived exosomes are immunosuppressive in preventing collagen‐induced arthritis
Abstract Due to the unsatisfied effects of clinical drugs used in rheumatoid arthritis (RA), investigators shifted their f...
Multi‐omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID‐19
Multi‐omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID‐19
Abstract Growing evidence has shown that Transmembrane Serine Protease 2 (TMPRSS2) not only contributes to the severe acut...
Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation
Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation
Abstract The microtubule-associated protein tau gene (MAPT) 10+16 intronic mutation causes frontotemporal lobar degenerati...
Curcumin modulates airway remodelling‐contributing genes—the significance of transcription factors
Curcumin modulates airway remodelling‐contributing genes—the significance of transcription factors
Abstract Bronchial epithelial cells and fibroblasts play an essential role in airway remodelling, due to their protective ...
SDF‐1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up‐regulating FoxO1 via binding to CXCR4
SDF‐1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up‐regulating FoxO1 via binding to CXCR4
Abstract Islet β cell dedifferentiation is one of the most important mechanisms in the occurrence and development of...
γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
Abstract The aggregation of β-amyloid peptide 42 results in the formation of toxic oligomers and plaques, which play...
Galangin as a direct inhibitor of vWbp protects mice from Staphylococcus aureus‐induced pneumonia
Galangin as a direct inhibitor of vWbp protects mice from Staphylococcus aureus‐induced pneumonia
Abstract The surge in multidrug resistance in Staphylococcus aureus (S. aureus) and the lag in antibiotic discovery n...
Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites
Abstract The present paper is a commentary to ‘Identification and characterization of hADSC-derived exosome protein...
C1632 suppresses the migration and proliferation of non‐small‐cell lung cancer cells involving LIN28 and FGFR1 pathway
C1632 suppresses the migration and proliferation of non‐small‐cell lung cancer cells involving LIN28 and FGFR1 pathway
Abstract Chemoresistance and migration represent major obstacles in the therapy of non-small-cell lung cancer (NSCLC), whi...
Effects of a short‐term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects
Effects of a short‐term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects
Abstract This discovery study investigated in healthy subjects whether a short-term cold exposure may alter circulating mi...
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