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Hyaluronic acid-based supramolecular nanomedicine with optimized ratio of oxaliplatin/chlorin e6 for combined chemotherapy and O2-economized photodynamic therapy
Cancer is thus far one of the most challenging diseases, which has negatively affected the life expectancy and quality of ...
Oligochitosan-based nanovesicles for nonalcoholic fatty liver disease treatment via the FXR/miR-34a/SIRT1 regulatory loop
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases, affecting about 25% of the world's ...
An enzyme-instructed self-assembly system induces tumor acidosis via sequential-dual effect for cancer selective therapy
The reprogrammed energy metabolism pathway of tumor cells, also known as the Warburg effect, has become one of the most us...
A tumor microenvironment-responsive core-shell tecto dendrimer nanoplatform for magnetic resonance imaging-guided and cuproptosis-promoted chemo-chemodynamic therapy
As a principal modality for cancer treatment, chemotherapy could induce the regulated death of tumor cells in different su...
A pH-responsive magnetic resonance tuning probe for precise imaging of bacterial infection in vivo
Bacterial infections seriously threaten human health and safety [1], [2], [3], making the precise and rapid diagnosis of b...
Redox ferrocenylseleno compounds modulate longitudinal and transverse relaxation times of FNPs-Gd MRI contrast agents for multimodal imaging and photo-Fenton therapy
Developing a feasible way to feature longitudinal (T1) and transverse (T2) relaxation performance of contrast agents for m...
ROS-responsive self-activatable photosensitizing agent for photodynamic-immunotherapy of cancer
Cancer remains a global health concern [1]. Although many therapeutic methods have been developed for cancer treatment, su...
Multifunctional nanodrug performs sonodynamic therapy and inhibits TGF-β to boost immune response against colorectal cancer and liver metastasis
Developing a feasible way to feature longitudinal (T1) and transverse (T2) relaxation performance of contrast agents for m...
Modulating the local coordination environment of cobalt single-atomic nanozymes for enhanced catalytic therapy against bacteria
Enzymes participate in all biological processes in nature. For example, many proteases use non-metallic or metallic object...
Barium sulphate microparticles are taken up by three different cell types: HeLa, THP-1, and hMSC
The interaction of particles with cells is of considerable interest in biomedicine, particle toxicology, and occupational ...
Phase-field modeling of pitting and mechanically-assisted corrosion of Mg alloys for biomedical applications
A phase-field model is developed to simulate the corrosion of Mg alloys in body fluids. The model incorporates both Mg dis...
Bone and soft tissue reaction to Co(II)/Cr(III) ions stimulation in a murine calvaria model: A pioneering in vivo study
The utilization of cobalt-chromium alloy (CoCr alloy) in joint prostheses as a bearing material is prevalent due to its ex...
Biomaterials and tissue engineering approaches using glycosaminoglycans for tissue repair: Lessons learned from the native extracellular matrix
The extracellular matrix (ECM) is vital to tissue repair, regeneration, and homeostasis. It imparts physical cues, includi...
Superficial zone chondrocytes can get compacted under physiological loading: A multiscale finite element analysis
Articular cartilage is a specialized tissue lining diarthrodial joints in the body, where it serves to reduce friction whi...
Scaffold geometry modulation of mechanotransduction and its influence on epigenetics
The field of tissue engineering and regenerating medicine (TERM) is rapidly evolving with the overarching vision to provid...
Mechanical strain in the mouse astrocytic lamina increases after exposure to recombinant trypsin
Astrocytic glial cells support the retinal ganglion cell axons in the optic nerve head (ONH). In a mouse eye, the tissue i...
Dynamic biophysical responses of neuronal cell nuclei and cytoskeletal structure following high impulse loading
Biomechanical cues guide and regulate cellular behavior including nuclear mechanics, gene expression, and tissue homeostas...
Extracellular matrix mechanobiology in cancer cell migration
The global cancer burden has risen, with cases growing to 1.44 million between 2006 to 2016 [1]. This incidence is estimat...
Computational modeling reveals a vital role for proximity-driven additive and synergistic cell-cell interactions in increasing cancer invasiveness
A key process in metastasis, the typically lethal spread of cancer [1] to local or distant body-sites, is migration and in...
Glioblastoma spheroid growth and chemotherapeutic responses in single and dual-stiffness hydrogels
Glioblastoma multiforme (GBM) is a deadly brain tumor for which currently there is no cure and the median patient survival...
Structure-property relationships of velar bone tissue from the energy absorbing horncore of bighorn sheep rams
The bony horncore of bighorn sheep absorbs substantial energy during head-to-head impacts which reduces brain cavity accel...
Multicellular dynamics on structured surfaces: Stress concentration is a key to controlling complex microtissue morphology on engineered scaffolds
Available online 9 May 2023Author links open overlay panel, , , , , , , , , AbstractTissue engineers have utilized a varie...
CCR2-overexpressing Biomimetic Carrier-free Nanoplatform for Enhanced Cascade Ferroptosis Tumor Therapy
Therapeutic approaches targeting apoptosis have been the mainstream of antitumor therapy researches [1,2]. However, the th...
The Cell-Assembled extracellular Matrix: a focus on the storage stability and terminal sterilization of this human “bio” material.
Tissue-Engineered Products (TEPs) offer groundbreaking opportunities in healthcare and are the subject of thousands of res...
Staphylococcal protein A-modified hydrogel facilitates in situ immunomodulation by capturing anti-HMGB1 for islet grafts
Available online 5 May 2023Author links open overlay panel, , , , , , , , , , ABSTRACTIslet transplantation is regarded as...
Reversing Immune Evasion using a DNA Nano-orchestrator for Pancreatic Cancer Immunotherapy
Pancreatic adenocarcinoma (PAAD) is one of the most aggressive and lethal types of gastrointestinal cancer. Immunotherapie...
Slow hydrogel matrix degradation enhances salivary gland mimetic phenotype
Available online 5 May 2023Author links open overlay panel, , , , , , , , ABSTRACTWe recently developed a salivary gland t...
Strongly adhesive zwitterionic composite hydrogel paints for surgical sutures and blood-contacting devices
Over the past few decades, synthetic hydrogels have garnered significant attention in various fields such as tissue engine...
Cells Resident to Precision Templated 40-µm Pore Scaffolds Generate Small Extracellular Vesicles that Affect CD4+ T Cell Phenotypes Through Regulatory TLR4 Signaling
Unresolved (chronic) inflammation around implanted medical devices leads to reduced vascularization, formation of foreign ...
Mechanical Fatigue Testing in silico: Dynamic evolution of Material Properties of Nanoscale Biological Particles
Available online 2 May 2023Author links open overlay panel, , , , ABSTRACTBiological particles have evolved to possess mec...
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