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Development of hepatocellular carcinoma organoid model recapitulating HIF-1A metabolic signature
Development of hepatocellular carcinoma organoid model recapitulating HIF-1A metabolic signature
Hypoxia is one of the main hallmarks of hepatocellular carcinoma (HCC) resulting from improper oxygenation and insufficien...
Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk
Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk
Shift work, particularly night shifts, disrupts circadian rhythms and increases stroke risk. This manuscript explores the ...
Current biological implications and clinical relevance of metastatic circulating tumor cells
Current biological implications and clinical relevance of metastatic circulating tumor cells
Metastatic disease and cancer recurrence are the primary causes of cancer-related deaths. Circulating tumor cells (CTCs) a...
The prognostic implications and oncogenic role of NSUN5 in clear cell renal cell carcinoma
The prognostic implications and oncogenic role of NSUN5 in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC), a predominant form of urinary malignancy, requires the identification of reliable...
A systematic review and meta-analysis of the endothelial-immune candidate biomarker endoglin in rheumatic diseases
A systematic review and meta-analysis of the endothelial-immune candidate biomarker endoglin in rheumatic diseases
Existing challenges in accurately diagnosing various rheumatic diseases (RDs) have stimulated the search for novel biomark...
Clinical characteristics and prognosis analysis of pseudomonas aeruginosa bloodstream infection in adults: a retrospective study
Clinical characteristics and prognosis analysis of pseudomonas aeruginosa bloodstream infection in adults: a retrospective study
Pseudomonas aeruginosa bloodstream infections (PA BSIs) in adults, especially those complicated by sepsis, are associated ...
Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes
Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes
This study aims to analyze the differential expression of METTL14 in pancreatic cancer (PC) tissues and adjacent normal ti...
Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4
Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4
Understanding the metastatic cascade is critical for the treatment and prevention of cancer-related death. Within a tumor,...
Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response
Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response
Minimal residual disease (MRD) is of growing interest in light chain (AL) amyloidosis and is associated with higher rates ...
Development and validation of a model for predicting who can benefit from multiple TACE in HCC patients
Development and validation of a model for predicting who can benefit from multiple TACE in HCC patients
This study was to develop and validate a model for predicting who can benefit from multiple transcatheter arterial chemoem...
GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer
GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer
Colorectal cancer is a leading cause of global mortality and presents a significant barrier to improving life expectancy. ...
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
Colorectal cancer (CRC) ranks among the most prevalent malignant tumors worldwide, with a multifactorial etiology encompas...
Identifying the prognostic significance of mitophagy-associated genes in multiple myeloma: a novel risk model construction
Identifying the prognostic significance of mitophagy-associated genes in multiple myeloma: a novel risk model construction
Multiple myeloma (MM) is a highly heterogeneous hematological malignancy that is currently incurable. Individualized thera...
Influence of recipient KRAS gene rs712 polymorphisms on the overall survival rate of hepatocellular carcinoma after hepatic transplantation
Influence of recipient KRAS gene rs712 polymorphisms on the overall survival rate of hepatocellular carcinoma after hepatic transplantation
Hepatocellular carcinoma (HCC) recurrence appears commonly after liver transplantation (LT), and it severely affected the ...
Risk of subsequent primary cancers in bladder cancer survivors
Risk of subsequent primary cancers in bladder cancer survivors
We aimed to investigate the risk of bladder cancer (BCa) survivors developing or dying from 15 specific-subsequent primary...
The role of trimethoprim/sulfamethoxazole in preventing opportunistic infections in systemic lupus erythematosus patients receiving low-level immunosuppressive treatment: an open-label, randomized, controlled trial
The role of trimethoprim/sulfamethoxazole in preventing opportunistic infections in systemic lupus erythematosus patients receiving low-level immunosuppressive treatment: an open-label, randomized, controlled trial
Objective: Systemic lupus erythematosus (SLE) patients receiving immunosuppressive therapy are at risk for opportunistic i...
Assessing the practice of total neoadjuvant therapy for rectal cancer: an online survey among radiation oncology departments in Germany and German-speaking regions of Austria and Switzerland
Assessing the practice of total neoadjuvant therapy for rectal cancer: an online survey among radiation oncology departments in Germany and German-speaking regions of Austria and Switzerland
Total neoadjuvant therapy (TNT) of rectal cancer improves rates of pathological complete remission and progression-free su...
SASS6 promotes tumor proliferation and is associated with TP53 and immune infiltration in lung adenocarcinoma
SASS6 promotes tumor proliferation and is associated with TP53 and immune infiltration in lung adenocarcinoma
The most common type of non-small cell lung cancer is lung adenocarcinoma (LUAD), which is characterized by high morbidity...
CXCL13: a common target for immune-mediated inflammatory diseases
CXCL13: a common target for immune-mediated inflammatory diseases
CXCL13 is a chemokine that plays an important role in the regulation and development of secondary lymphoid organs. CXCL13 ...
Liver at crossroads: unraveling the links between obesity, chronic liver diseases, and the mysterious obesity paradox
Liver at crossroads: unraveling the links between obesity, chronic liver diseases, and the mysterious obesity paradox
Obesity is a global health issue that is intricately linked to the development and progression of chronic liver disease (C...
Aberrant DNA polymerase beta expression is associated with dysregulated tumor immune microenvironment and its prognostic value in gastric cancer
Aberrant DNA polymerase beta expression is associated with dysregulated tumor immune microenvironment and its prognostic value in gastric cancer
Gastric cancer is caused by different exogenous risk factors. Polymerase beta (POLB) is critical to repair oxidative and a...
Evaluating the impact of treatment sequencing on outcomes in hepatocellular carcinoma: a comparative analysis of TACE and systemic therapies
Evaluating the impact of treatment sequencing on outcomes in hepatocellular carcinoma: a comparative analysis of TACE and systemic therapies
This study aimed to evaluate how the timing of transarterial chemoembolization (TACE) relative to systemic therapy (tyrosi...
Immunotherapy response and resistance in patients with advanced uveal melanoma: a retrospective cohort study
Immunotherapy response and resistance in patients with advanced uveal melanoma: a retrospective cohort study
Metastatic uveal melanoma (mUM) is associated with poor prognosis. Ipilimumab/nivolumab has shown antitumor efficacy in ph...
The renal histopathology of nonproteinuric kidney impairment: a three center experience
The renal histopathology of nonproteinuric kidney impairment: a three center experience
Proteinuria is a biomarker of kidney injury that typically results from glomerular and/or tubulointerstitial disease. Wher...
Tumor hypoxia unveiled: insights into microenvironment, detection tools and emerging therapies
Tumor hypoxia unveiled: insights into microenvironment, detection tools and emerging therapies
Hypoxia is one of the defining characteristics of the tumor microenvironment (TME) in solid cancers. It has a major impact...
Evaluating the predictive effect of vitamin D on clinical outcomes of infliximab-treated Crohn’s disease patients in western China
Evaluating the predictive effect of vitamin D on clinical outcomes of infliximab-treated Crohn’s disease patients in western China
The aim was to evaluate predictors of clinical outcomes in infliximab (IFX)-treated Crohn’s disease (CD) patients in...
lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer
lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progress...
Personalized neoantigen cancer vaccines: current progression, challenges and a bright future
Personalized neoantigen cancer vaccines: current progression, challenges and a bright future
Tumor neoantigens possess specific immunogenicity and personalized therapeutic vaccines based on neoantigens which have sh...
Intestinal permeability disturbances: causes, diseases and therapy
Intestinal permeability disturbances: causes, diseases and therapy
Nowadays, a pathological increase in the permeability of the intestinal barrier (the so-called leaky gut) is increasingly ...
Effectiveness and safety of upadacitinib in acute severe ulcerative colitis patients from single Chinese IBD Center: a monocentric study
Effectiveness and safety of upadacitinib in acute severe ulcerative colitis patients from single Chinese IBD Center: a monocentric study
Upadacitinib is an oral new selective JAK1 inhibitor that has been approved for treating adult patients with moderately to...
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