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Role of immune cell homeostasis in research and treatment response in hepatocellular carcinoma
Role of immune cell homeostasis in research and treatment response in hepatocellular carcinoma
Introduction Recently, immune cells within the tumor microenvironment (TME) have become crucial in regulating cancer progr...
The association between immunoinflammatory biomarkers NLR, PLR, LMR and nonalcoholic fatty liver disease: a systematic review and meta-analysis
The association between immunoinflammatory biomarkers NLR, PLR, LMR and nonalcoholic fatty liver disease: a systematic review and meta-analysis
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder closely linked to metabolic syndrome. Identifying no...
Enhancing staging in multiple myeloma using an m6A regulatory gene-pairing model
Enhancing staging in multiple myeloma using an m6A regulatory gene-pairing model
Multiple myeloma (MM) is characterized by clonal plasma cell proliferation in the bone marrow, challenging prognosis predi...
Adoptive NK cell therapy in AML: progress and challenges
Adoptive NK cell therapy in AML: progress and challenges
Adoptive cell therapy (ACT) using natural killer (NK) cells has emerged as a promising therapeutic strategy for acute myel...
Mast cell-mediated microRNA functioning in immune regulation and disease pathophysiology
Mast cell-mediated microRNA functioning in immune regulation and disease pathophysiology
Upon stimulation and activation, mast cells (MCs) release soluble mediators, including histamine, proteases, and cytokines...
Comparative application of MAFLD and MASLD diagnostic criteria on NAFLD patients: insights from a single-center cohort
Comparative application of MAFLD and MASLD diagnostic criteria on NAFLD patients: insights from a single-center cohort
The diagnostic criteria for Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) and Metabolic Associated Steatoti...
Decreased STING predicts adverse efficacy in bortezomib regimens and poor survival in multiple myeloma
Decreased STING predicts adverse efficacy in bortezomib regimens and poor survival in multiple myeloma
STING (stimulator of interferon genes) is involved in viral and bacterial defense through interferon pathway and innate im...
Recent developments and future directions in point-of-care next-generation CRISPR-based rapid diagnosis
Recent developments and future directions in point-of-care next-generation CRISPR-based rapid diagnosis
The demand for sensitive, rapid, and affordable diagnostic techniques has surged, particularly following the COVID-19 pand...
Harnessing IL-27: challenges and potential in cancer immunotherapy
Harnessing IL-27: challenges and potential in cancer immunotherapy
IL-27 is structurally an immune-enhancing and pleiotropic two-chain cytokine associated with IL-12 and IL-6 families. IL-2...
Diagnostic value of glypican-1; a new marker differentiating pulmonary squamous cell carcinoma from adenocarcinoma: immunohistochemical study on Egyptian series
Diagnostic value of glypican-1; a new marker differentiating pulmonary squamous cell carcinoma from adenocarcinoma: immunohistochemical study on Egyptian series
Lung cancer is one of the major causes of cancer morbidity and mortality. Subtyping of non-small cell lung cancer is neces...
The prognosis and immune repertoire characteristics of HBsAg and anti-HBs double positive chronic hepatitis B patients
The prognosis and immune repertoire characteristics of HBsAg and anti-HBs double positive chronic hepatitis B patients
Coexistence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) has been observed in some c...
Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis
Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis
Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4+subsets in AC...
Putative biomarkers of hepatic dysfunction in critically ill sepsis patients
Putative biomarkers of hepatic dysfunction in critically ill sepsis patients
Sepsis is a major cause of morbidity and mortality worldwide. Among the various types of end-organ damage associated with ...
The clinical features and outcomes of elderly patients with acute myeloid leukemia: a real word research
The clinical features and outcomes of elderly patients with acute myeloid leukemia: a real word research
The aim of this study was to investigate the clinical features and outcomes of elderly patients with acute myeloid leukemi...
Donafenib activates the p53 signaling pathway in hepatocellular carcinoma, induces ferroptosis, and enhances cell apoptosis
Donafenib activates the p53 signaling pathway in hepatocellular carcinoma, induces ferroptosis, and enhances cell apoptosis
Donafenib is an improved version of sorafenib in which deuterium is substituted into the drug’s chemical structure, ...
Viral infections in celiac disease: what should be considered for better management
Viral infections in celiac disease: what should be considered for better management
Following a gluten-free diet (GFD) is known as the main effective therapy available for celiac disease (CD) patients, whic...
Cancer vaccines: an update on recent achievements and prospects for cancer therapy
Cancer vaccines: an update on recent achievements and prospects for cancer therapy
Decades of basic and translational research have led to a momentum shift in dissecting the relationship between immune cel...
CRISPR screening and cell line IC50 data reveal novel key genes for trametinib resistance
CRISPR screening and cell line IC50 data reveal novel key genes for trametinib resistance
In addition to advancing the development of clinical gene-editing therapeutics, CRISP...
The long-term survival outcome of sporadic bilateral renal cell carcinoma and optimization of surgical treatment: a large-scale population-based cohort study
The long-term survival outcome of sporadic bilateral renal cell carcinoma and optimization of surgical treatment: a large-scale population-based cohort study
Sporadic bilateral renal cell carcinoma (BRCC) is a rare situation of RCC. The treatment for BRCC is controversial and the...
Construction and validation of immunogenic cell death-related molecular clusters, signature, and immune landscape in pancreatic cancer
Construction and validation of immunogenic cell death-related molecular clusters, signature, and immune landscape in pancreatic cancer
Pancreatic cancer (PC) is a malignancy of the gastrointestinal tract that is characterized by a poor prognosis. This study...
Prediction and analysis of the tumor invasiveness of pulmonary ground-glass nodules based on metabolomics
Prediction and analysis of the tumor invasiveness of pulmonary ground-glass nodules based on metabolomics
In recent years, the incidence of ground-glass nodular lung adenocarcinoma has gradually increased. Preoperative evaluatio...
Impact of hyperkalaemia on renin–angiotensin–aldosterone (RAAS) inhibitor reduction or withdrawal following hospitalisation
Impact of hyperkalaemia on renin–angiotensin–aldosterone (RAAS) inhibitor reduction or withdrawal following hospitalisation
Inhibitors of the renin–angiotensin–aldosterone system (RAAS), such as ACE inhibitors (ACEi), angiotensin-II r...
CYB561 a potential prognostic biomarker for liver hepatocellular carcinoma
CYB561 a potential prognostic biomarker for liver hepatocellular carcinoma
Liver hepatocellular carcinoma (LIHC) is a malignancy characterized by a high rate of recurrence, metastasis, and poor pro...
Impact of pan-cancer analysis of the exportins family on prognosis, the tumor microenvironment and its potential therapeutic efficacy
Impact of pan-cancer analysis of the exportins family on prognosis, the tumor microenvironment and its potential therapeutic efficacy
This study aims to comprehensively analyze the role of the exportin (XPO) family in the development and progression of can...
FUS and METTL3 collaborate to regulate RNA maturation, preventing unfolded protein response and promoting gastric cancer progression
FUS and METTL3 collaborate to regulate RNA maturation, preventing unfolded protein response and promoting gastric cancer progression
FUS-mediated alternative splicing and METTL3-regulated RNA methylation play crucial roles in RNA processing. The purpose o...
Non-invasive early-stage cancer detection: current methods and future perspectives
Non-invasive early-stage cancer detection: current methods and future perspectives
This review paper explores the realm of non-invasive methods for early cancer detection. Early identification is crucial f...
Ex vivo evaluation of the effect of plasma-derived factor VIII/von Willebrand factor in patients with severe hemophilia A on emicizumab prophylaxis
Ex vivo evaluation of the effect of plasma-derived factor VIII/von Willebrand factor in patients with severe hemophilia A on emicizumab prophylaxis
Hemophilia A (HA) patients under emicizumab prophylaxis may require the concomitant use of procoagulant factors for breakt...
Autophagy-based therapy for hepatocellular carcinoma: from standard treatments to combination therapy, oncolytic virotherapy, and targeted nanomedicines
Autophagy-based therapy for hepatocellular carcinoma: from standard treatments to combination therapy, oncolytic virotherapy, and targeted nanomedicines
Human hepatocellular carcinoma (HCC) has been identified as a significant cause of mortality worldwide. In recent years, e...
The bacterial microbiome and cancer: development, diagnosis, treatment, and future directions
The bacterial microbiome and cancer: development, diagnosis, treatment, and future directions
The term "microbiome" refers to the collection of bacterial species that reside in the human body's tissues....
Bispecific antibodies in clinical practice: Understanding recent advances and current place in cancer treatment landscape
Bispecific antibodies in clinical practice: Understanding recent advances and current place in cancer treatment landscape
Immunotherapy has changed the treatment landscape of cancer in the past decade. Amongst various forms of immunotherapy, ma...
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