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72‐year‐old man with right homonymous hemianopia and gait instability
72‐year‐old man with right homonymous hemianopia and gait instability
1 CASE DESCRIPTION A 72-year-old man with a 40 pack-year smoking history, chronic obstructive pulmonary...
No evidence of aberrant amyloid β and phosphorylated tau expression in herpes simplex virus‐infected neurons of the trigeminal ganglia and brain
No evidence of aberrant amyloid β and phosphorylated tau expression in herpes simplex virus‐infected neurons of the trigeminal ganglia and brain
Abstract Increasing evidence supports the role of neurotropic herpes simplex virus 1 (HSV-1) in the pathogenesis of Alzhei...
The influence of HLA‐DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter
The influence of HLA‐DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter
Abstract Cortical tissue injury is common in multiple sclerosis (MS) and associates with disability progression. We have p...
Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis
Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis
Abstract The activation of the cannabinoid receptor type-2 (CB2) afforded neuroprotection in amyotrophic lateral sclerosis...
Application of deep learning to understand resilience to Alzheimer's disease pathology
Application of deep learning to understand resilience to Alzheimer's disease pathology
Abstract People who have Alzheimer's disease neuropathologic change (ADNC) typically associated with dementia but not the ...
Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors
Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors
Pediatric bithalamic gliomas encompass several histomolecular tumoral types from benign to malignant and underlines the ce...
Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination
Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination
Abstract Experimental autoimmune encephalomyelitis (EAE) is a basic and reliable model used to study clinical and patholog...
Intracranial mesenchymal tumors with FET‐CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas
Intracranial mesenchymal tumors with FET‐CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas
Abstract ‘Intracranial mesenchymal tumor, FET-CREB fusion-positive’ occurs primarily in children and young a...
Expression pattern of mitochondrial respiratory chain enzymes in skeletal muscle of patients with mitochondrial myopathy associated with the homoplasmic m.14674T>C variant
Expression pattern of mitochondrial respiratory chain enzymes in skeletal muscle of patients with mitochondrial myopathy associated with the homoplasmic m.14674T>C variant
Abstract Two homoplasmic variants in tRNAGlu (m.14674T>C/G) are associated with reversible infantile respiratory chain ...
Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology
Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology
Abstract Misfolded α-synuclein spreads along anatomically connected areas through the brain, prompting progressive n...
An elderly man with bilateral cavitary lesions in the globus pallidus
An elderly man with bilateral cavitary lesions in the globus pallidus
1 CLINICAL HISTORY An elderly man was involved in a motor vehicle collision in which he susta...
Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid
Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid
Abstract Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, se...
An H3F3A K27M‐mutation in a sonic hedgehog medulloblastoma
An H3F3A K27M‐mutation in a sonic hedgehog medulloblastoma
Medulloblastomas are malignant embryonal brain tumours that may harbour mutations in histone-modifying genes, while mutati...
Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse
Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse
Abstract Mild traumatic brain injury (mTBI) affects brain structure and function and can lead to persistent abnormalities....
A 2‐year‐old girl with posterior fossa mass
A 2‐year‐old girl with posterior fossa mass
We present a rare case of an ETMR with co-occurrence of DICER1 and H3 K27M mutations.
Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis
Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis
Abstract Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, i...
Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α‐syn co‐pathology
Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α‐syn co‐pathology
Abstract Several degenerative brain disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Dementia with...
Antenatal low‐intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone‐induced intrauterine growth restriction
Antenatal low‐intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone‐induced intrauterine growth restriction
Abstract Intrauterine growth restriction (IUGR) is a leading cause of perinatal mortality and morbidity, and IUGR survivor...
CNS inflammation after natalizumab therapy for multiple sclerosis: A retrospective histopathological and CSF cohort study
CNS inflammation after natalizumab therapy for multiple sclerosis: A retrospective histopathological and CSF cohort study
Abstract Natalizumab, a recombinant humanized monoclonal antibody directed against the α4 subunit of the integrins &...
Severe histomorphological alterations in post‐mortem olfactory glomeruli in Alzheimer’s disease
Severe histomorphological alterations in post‐mortem olfactory glomeruli in Alzheimer’s disease
Abstract Alzheimer's disease (AD) is the most prevalent form of dementia. Key AD symptoms include memory and cognitive dec...
Histamine in murine narcolepsy: What do genetic and immune models tell us?
Histamine in murine narcolepsy: What do genetic and immune models tell us?
Abstract An increased number of histaminergic neurons, identified by labeling histidine-decarboxylase (HDC) its synthesis ...
Distinct subcortical tau burden: The tau pallido‐claustral ratio separates progressive supranuclear palsy and corticobasal degeneration
Distinct subcortical tau burden: The tau pallido‐claustral ratio separates progressive supranuclear palsy and corticobasal degeneration
Abstract Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires ...
Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology
Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology
Abstract Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to cognitive impairment, psychol...
A deep learning‐based model for prediction of hemorrhagic transformation after stroke
A deep learning‐based model for prediction of hemorrhagic transformation after stroke
Abstract Hemorrhagic transformation (HT) is one of the most serious complications after endovascular thrombectomy (EVT) in...
An 82‐year‐old man with a right frontal lobe rim‐enhancing lesion
An 82‐year‐old man with a right frontal lobe rim‐enhancing lesion
1 CLINICAL PRESENTATION An 82-year-old man presented with a 2-week history of fatigue, lethargy, memory...
Targeting autotaxin impacts disease advance in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis
Targeting autotaxin impacts disease advance in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis
Abstract A preclinical strategy to broaden the search of potentially effective treatments in amyotrophic lateral sclerosis...
Microvessel stenosis, enlarged perivascular spaces, and fibrinogen deposition are associated with ischemic periventricular white matter hyperintensities
Microvessel stenosis, enlarged perivascular spaces, and fibrinogen deposition are associated with ischemic periventricular white matter hyperintensities
Abstract Periventricular white matter hyperintensities (pvWMH) are neuroimaging abnormalities surrounding the lateral vent...
Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer’s disease
Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer’s disease
Abstract Genome-wide association studies have described several genes as genetic susceptibility loci for Alzheimer's disea...
Hispano‐American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders
Hispano‐American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders
Abstract Neurodevelopmental disorders (NDDs) are conditions that present with brain dysfunction due to alterations in the ...
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