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CN1699 Our Business - Guide for Agents
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Acknowledgement to Reviewer
error_outline You have to enabl...
Brain Pathology
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72‐year‐old man with right homonymous hemianopia and gait instability
1 CASE DESCRIPTION A 72-year-old man with a 40 pack-year smoking history, chronic obstructive pulmonary...
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No evidence of aberrant amyloid β and phosphorylated tau expression in herpes simplex virus‐infected neurons of the trigeminal ganglia and brain
Abstract Increasing evidence supports the role of neurotropic herpes simplex virus 1 (HSV-1) in the pathogenesis of Alzhei...
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The influence of HLA‐DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter
Abstract Cortical tissue injury is common in multiple sclerosis (MS) and associates with disability progression. We have p...
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Inactivation of the CB2 receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis
Abstract The activation of the cannabinoid receptor type-2 (CB2) afforded neuroprotection in amyotrophic lateral sclerosis...
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Application of deep learning to understand resilience to Alzheimer's disease pathology
Abstract People who have Alzheimer's disease neuropathologic change (ADNC) typically associated with dementia but not the ...
Brain Pathology
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Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors
Pediatric bithalamic gliomas encompass several histomolecular tumoral types from benign to malignant and underlines the ce...
Brain Pathology
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Lumbar spine intrathecal transplantation of neural precursor cells promotes oligodendrocyte proliferation in hot spots of chronic demyelination
Abstract Experimental autoimmune encephalomyelitis (EAE) is a basic and reliable model used to study clinical and patholog...
Brain Pathology
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Intracranial mesenchymal tumors with FET‐CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas
Abstract ‘Intracranial mesenchymal tumor, FET-CREB fusion-positive’ occurs primarily in children and young a...
Brain Pathology
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Expression pattern of mitochondrial respiratory chain enzymes in skeletal muscle of patients with mitochondrial myopathy associated with the homoplasmic m.14674T>C variant
Abstract Two homoplasmic variants in tRNAGlu (m.14674T>C/G) are associated with reversible infantile respiratory chain ...
Brain Pathology
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Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology
Abstract Misfolded α-synuclein spreads along anatomically connected areas through the brain, prompting progressive n...
Brain Pathology
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An elderly man with bilateral cavitary lesions in the globus pallidus
1 CLINICAL HISTORY An elderly man was involved in a motor vehicle collision in which he susta...
Brain Pathology
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Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid
Abstract Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, se...
Brain Pathology
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An H3F3A K27M‐mutation in a sonic hedgehog medulloblastoma
Medulloblastomas are malignant embryonal brain tumours that may harbour mutations in histone-modifying genes, while mutati...
Brain Pathology
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Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse
Abstract Mild traumatic brain injury (mTBI) affects brain structure and function and can lead to persistent abnormalities....
Brain Pathology
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A 2‐year‐old girl with posterior fossa mass
We present a rare case of an ETMR with co-occurrence of DICER1 and H3 K27M mutations.
Brain Pathology
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Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis
Abstract Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, i...
Brain Pathology
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Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α‐syn co‐pathology
Abstract Several degenerative brain disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Dementia with...
Brain Pathology
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Antenatal low‐intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone‐induced intrauterine growth restriction
Abstract Intrauterine growth restriction (IUGR) is a leading cause of perinatal mortality and morbidity, and IUGR survivor...
Brain Pathology
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CNS inflammation after natalizumab therapy for multiple sclerosis: A retrospective histopathological and CSF cohort study
Abstract Natalizumab, a recombinant humanized monoclonal antibody directed against the α4 subunit of the integrins &...
Brain Pathology
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Severe histomorphological alterations in post‐mortem olfactory glomeruli in Alzheimer’s disease
Abstract Alzheimer's disease (AD) is the most prevalent form of dementia. Key AD symptoms include memory and cognitive dec...
Brain Pathology
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Histamine in murine narcolepsy: What do genetic and immune models tell us?
Abstract An increased number of histaminergic neurons, identified by labeling histidine-decarboxylase (HDC) its synthesis ...
Brain Pathology
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Distinct subcortical tau burden: The tau pallido‐claustral ratio separates progressive supranuclear palsy and corticobasal degeneration
Abstract Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires ...
Brain Pathology
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Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology
Abstract Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to cognitive impairment, psychol...
Brain Pathology
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A deep learning‐based model for prediction of hemorrhagic transformation after stroke
Abstract Hemorrhagic transformation (HT) is one of the most serious complications after endovascular thrombectomy (EVT) in...
Brain Pathology
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An 82‐year‐old man with a right frontal lobe rim‐enhancing lesion
1 CLINICAL PRESENTATION An 82-year-old man presented with a 2-week history of fatigue, lethargy, memory...
Brain Pathology
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Targeting autotaxin impacts disease advance in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis
Abstract A preclinical strategy to broaden the search of potentially effective treatments in amyotrophic lateral sclerosis...
Brain Pathology
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Microvessel stenosis, enlarged perivascular spaces, and fibrinogen deposition are associated with ischemic periventricular white matter hyperintensities
Abstract Periventricular white matter hyperintensities (pvWMH) are neuroimaging abnormalities surrounding the lateral vent...
Brain Pathology
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Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer’s disease
Abstract Genome-wide association studies have described several genes as genetic susceptibility loci for Alzheimer's disea...
Brain Pathology
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Hispano‐American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders
Abstract Neurodevelopmental disorders (NDDs) are conditions that present with brain dysfunction due to alterations in the ...
Brain Pathology
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