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Cancers, Vol. 15, Pages 172: Anti-Anaplastic Thyroid Cancer (ATC) Effects and Mechanisms of PLX3397 (Pexidartinib), a Multi-Targeted Tyrosine Kinase Inhibitor (TKI)
Cancers, Vol. 15, Pages 172: Anti-Anaplastic Thyroid Cancer (ATC) Effects and Mechanisms of PLX3397 (Pexidartinib), a Multi-Targeted Tyrosine Kinase Inhibitor (TKI)
Background Anaplastic thyroid cancer (ATC) is the greatest lethal thyroid neoplasm with a low incidence and lacks an effec...
Cancers, Vol. 15, Pages 188: Immunohistochemical Study of Bladder Cancer Molecular Subtypes and Their Association with PD-L1 Expression
Cancers, Vol. 15, Pages 188: Immunohistochemical Study of Bladder Cancer Molecular Subtypes and Their Association with PD-L1 Expression
The significant heterogeneity in clinical outcomes among patients with bladder cancer has highlighted the existence of dif...
Cancers, Vol. 15, Pages 179: Targeted Therapy for Anaplastic Thyroid Carcinoma: Advances and Management
Cancers, Vol. 15, Pages 179: Targeted Therapy for Anaplastic Thyroid Carcinoma: Advances and Management
Anaplastic thyroid carcinoma (ATC) is a rare and highly fatal cancer with the worst prognosis of all thyroid carcinoma (TC...
Cancers, Vol. 15, Pages 186: Clinical Significance of Glycolytic Metabolic Activity in Hepatocellular Carcinoma
Cancers, Vol. 15, Pages 186: Clinical Significance of Glycolytic Metabolic Activity in Hepatocellular Carcinoma
High metabolic activity is a hallmark of cancers, including hepatocellular carcinoma (HCC). However, the molecular feature...
Cancers, Vol. 15, Pages 176: Single-Cell Transcriptomic Profiles of Lung Pre-Metastatic Niche Reveal Neutrophil and Lymphatic Endothelial Cell Roles in Breast Cancer
Cancers, Vol. 15, Pages 176: Single-Cell Transcriptomic Profiles of Lung Pre-Metastatic Niche Reveal Neutrophil and Lymphatic Endothelial Cell Roles in Breast Cancer
The establishment of a pre-metastatic niche (PMN) is critical for cancer metastasis. However, it remains unclear as to whi...
Cancers, Vol. 15, Pages 187: Different Tyrosine Kinase Inhibitors Used in Treating EGFR-Mutant Pulmonary Adenocarcinoma with Brain Metastasis and Intracranial Intervention Have No Impact on Clinical Outcomes
Cancers, Vol. 15, Pages 187: Different Tyrosine Kinase Inhibitors Used in Treating EGFR-Mutant Pulmonary Adenocarcinoma with Brain Metastasis and Intracranial Intervention Have No Impact on Clinical Outcomes
Brain metastasis in patients with non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mut...
Cancers, Vol. 15, Pages 180: Atypical Response in Metastatic Non-Small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitors: Radiographic Patterns and Clinical Value of Local Therapy
Cancers, Vol. 15, Pages 180: Atypical Response in Metastatic Non-Small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitors: Radiographic Patterns and Clinical Value of Local Therapy
Purpose: To explore the clinical characteristics, management, and survival outcomes of advanced NSCLC patients treated wit...
Cancers, Vol. 15, Pages 183: Molecular Basis of HER2-Targeted Therapy for HER2-Positive Colorectal Cancer
Cancers, Vol. 15, Pages 183: Molecular Basis of HER2-Targeted Therapy for HER2-Positive Colorectal Cancer
Human epidermal growth factor receptor 2 (HER2) amplification has emerged as a biomarker in colorectal cancer (CRC), occur...
Cancers, Vol. 15, Pages 178: A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K+ Channel in Breast Cancer
Cancers, Vol. 15, Pages 178: A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K+ Channel in Breast Cancer
Since the multifunctionality of transglutaminase 2 (TG2) includes extra- and intracellular functions, we investigated the ...
Cancers, Vol. 15, Pages 175: The SAFFO Study: Sex-Related Prognostic Role and Cut-Off Definition of Monocyte-to-Lymphocyte Ratio (MLR) in Metastatic Colorectal Cancer
Cancers, Vol. 15, Pages 175: The SAFFO Study: Sex-Related Prognostic Role and Cut-Off Definition of Monocyte-to-Lymphocyte Ratio (MLR) in Metastatic Colorectal Cancer
Background: Emerging data suggest that gender-related immune system composition affects both immune response and efficacy ...
Cancers, Vol. 15, Pages 177: Extracellular Vesicle Membrane Protein Profiling and Targeted Mass Spectrometry Unveil CD59 and Tetraspanin 9 as Novel Plasma Biomarkers for Detection of Colorectal Cancer
Cancers, Vol. 15, Pages 177: Extracellular Vesicle Membrane Protein Profiling and Targeted Mass Spectrometry Unveil CD59 and Tetraspanin 9 as Novel Plasma Biomarkers for Detection of Colorectal Cancer
Extracellular vesicles (EVs) are valuable sources for the discovery of useful cancer biomarkers. This study explores the p...
Cancers, Vol. 15, Pages 185: Tumor Response, Disease Control, and Progression-Free Survival as Surrogate Endpoints in Trials Evaluating Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: Study- and Patient-Level Analyses
Cancers, Vol. 15, Pages 185: Tumor Response, Disease Control, and Progression-Free Survival as Surrogate Endpoints in Trials Evaluating Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: Study- and Patient-Level Analyses
Background: To assess the usefulness of tumor response and progression-free survival (PFS) as surrogates for overall survi...
Cancers, Vol. 15, Pages 173: Immune Checkpoint Inhibitors and Pregnancy: Analysis of the VigiBase® Spontaneous Reporting System
Cancers, Vol. 15, Pages 173: Immune Checkpoint Inhibitors and Pregnancy: Analysis of the VigiBase® Spontaneous Reporting System
In pregnancy, immune checkpoint pathways are involved in the maintenance of fetomaternal immune tolerance. Preclinical stu...
Cancers, Vol. 15, Pages 181: Histopathological Growth Pattern in Colorectal Liver Metastasis and The Tumor Immune Microenvironment
Cancers, Vol. 15, Pages 181: Histopathological Growth Pattern in Colorectal Liver Metastasis and The Tumor Immune Microenvironment
Almost half of all patients with colorectal cancer present with or eventually develop metastasis, most frequently in the l...
Cancers, Vol. 15, Pages 182: Palmitoyl Carnitine-Anchored Nanoliposomes for Neovasculature-Specific Delivery of Gemcitabine Elaidate to Treat Pancreatic Cancer
Cancers, Vol. 15, Pages 182: Palmitoyl Carnitine-Anchored Nanoliposomes for Neovasculature-Specific Delivery of Gemcitabine Elaidate to Treat Pancreatic Cancer
Being the fourth most fatal malignancy worldwide, pancreatic cancer is on track to become the second leading cause of canc...
Cancers, Vol. 15, Pages 135: The FDA-Approved Drug Pyrvinium Selectively Targets ER+ Breast Cancer Cells with High INPP4B Expression
Cancers, Vol. 15, Pages 135: The FDA-Approved Drug Pyrvinium Selectively Targets ER+ Breast Cancer Cells with High INPP4B Expression
The majority of breast cancers are estrogen receptor-positive (ER+), and endocrine therapies that suppress ER signaling ar...
Cancers, Vol. 15, Pages 129: Differentiation of Perilesional Edema in Glioblastomas and Brain Metastases: Comparison of Diffusion Tensor Imaging, Neurite Orientation Dispersion and Density Imaging and Diffusion Microstructure Imaging
Cancers, Vol. 15, Pages 129: Differentiation of Perilesional Edema in Glioblastomas and Brain Metastases: Comparison of Diffusion Tensor Imaging, Neurite Orientation Dispersion and Density Imaging and Diffusion Microstructure Imaging
Although the free water content within the perilesional T2 hyperintense region should differ between glioblastomas (GBM) a...
Cancers, Vol. 15, Pages 140: Blood Plasma Metabolome Profiling at Different Stages of Renal Cell Carcinoma
Cancers, Vol. 15, Pages 140: Blood Plasma Metabolome Profiling at Different Stages of Renal Cell Carcinoma
Early diagnostics significantly improves the survival of patients with renal cell carcinoma (RCC), which is the prevailing...
Cancers, Vol. 15, Pages 134: Research Progress and Direction of Novel Organelle—Migrasomes
Cancers, Vol. 15, Pages 134: Research Progress and Direction of Novel Organelle—Migrasomes
Migrasomes are organelles that are similar in structure to pomegranates, up to 3 μm in diameter, and contain small ...
Cancers, Vol. 15, Pages 131: Sulfatase 2 Affects Polarization of M2 Macrophages through the IL-8/JAK2/STAT3 Pathway in Bladder Cancer
Cancers, Vol. 15, Pages 131: Sulfatase 2 Affects Polarization of M2 Macrophages through the IL-8/JAK2/STAT3 Pathway in Bladder Cancer
Sulfatase 2 (SULF2) affects the occurrence and development of cancer by regulating HSPG-binding factors. However, the mech...
Cancers, Vol. 15, Pages 130: Transcriptomic Changes Associated with ERBB2 Overexpression in Colorectal Cancer Implicate a Potential Role of the Wnt Signaling Pathway in Tumorigenesis
Cancers, Vol. 15, Pages 130: Transcriptomic Changes Associated with ERBB2 Overexpression in Colorectal Cancer Implicate a Potential Role of the Wnt Signaling Pathway in Tumorigenesis
Colorectal cancer (CRC) remains the third most common cause of cancer mortality worldwide. Precision medicine using OMICs ...
Cancers, Vol. 15, Pages 138: Post-Translational Modifications in Tumor-Associated Antigens as a Platform for Novel Immuno-Oncology Therapies
Cancers, Vol. 15, Pages 138: Post-Translational Modifications in Tumor-Associated Antigens as a Platform for Novel Immuno-Oncology Therapies
Post-translational modifications (PTMs) are generated by adding small chemical groups to amino acid residues after the tra...
Cancers, Vol. 15, Pages 136: Time for Dynamic Assessment of Fitness in Acute Myeloid Leukemia
Cancers, Vol. 15, Pages 136: Time for Dynamic Assessment of Fitness in Acute Myeloid Leukemia
Informed treatment decision-making in acute myeloid leukemia (AML) requires a comprehensive evaluation of all clinical and...
Cancers, Vol. 15, Pages 148: Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer
Cancers, Vol. 15, Pages 148: Controversies and Opportunities in the Clinical Daily Use of the 21-Gene Assay for Prognostication and Prediction of Chemotherapy Benefit in HR+/HER2- Early Breast Cancer
Several multigene assays have been developed to help clinicians in defining adjuvant treatment for patients with hormone-r...
Cancers, Vol. 15, Pages 147: Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth
Cancers, Vol. 15, Pages 147: Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth
Current prognostic and diagnostic tests for prostate cancer are not able to accurately distinguish between aggressive and ...
Cancers, Vol. 15, Pages 113: The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis
Cancers, Vol. 15, Pages 113: The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis
Hyperthermia is clinically applied cancer treatment in conjunction with radio- and/or chemotherapy, in which the tumor vol...
Cancers, Vol. 15, Pages 112: Differences in Tumor Growth and Differentiation in NSG and Humanized-BLT Mice; Analysis of Human vs. Humanized-BLT-Derived NK Expansion and Functions
Cancers, Vol. 15, Pages 112: Differences in Tumor Growth and Differentiation in NSG and Humanized-BLT Mice; Analysis of Human vs. Humanized-BLT-Derived NK Expansion and Functions
There is significant interest and debate regarding the best mouse model of human disease, since studies in wild-type mice ...
Cancers, Vol. 15, Pages 128: MicroRNAs miR-584-5p and miR-425-3p Are Up-Regulated in Plasma of Colorectal Cancer (CRC) Patients: Targeting with Inhibitor Peptide Nucleic Acids Is Associated with Induction of Apoptosis in Colon Cancer Cell Lines
Cancers, Vol. 15, Pages 128: MicroRNAs miR-584-5p and miR-425-3p Are Up-Regulated in Plasma of Colorectal Cancer (CRC) Patients: Targeting with Inhibitor Peptide Nucleic Acids Is Associated with Induction of Apoptosis in Colon Cancer Cell Lines
Liquid biopsy has dramatically changed cancer management in the last decade; however, despite the huge number of miRNA sig...
Cancers, Vol. 15, Pages 118: 5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia
Cancers, Vol. 15, Pages 118: 5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia
Cancer cells accumulate epigenetic modifications that allow escape from intrinsic and extrinsic surveillance mechanisms. I...
Cancers, Vol. 15, Pages 126: Current Biological, Pathological and Clinical Landscape of HER2-Low Breast Cancer
Cancers, Vol. 15, Pages 126: Current Biological, Pathological and Clinical Landscape of HER2-Low Breast Cancer
HER2-low breast cancer (BC) is a newly defined subset of HER2-negative BC that has HER2 immunohistochemical (IHC) score of...
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