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Effect of exogenous IL-37 on immune cells from a patient carrying a potential IL37 loss-of-function variant: A case study
IntroductionChronic inflammatory or autoimmune diseases are commonly treated with immunosuppressive medication such as NSA...
IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline
RationaleType 2 (T2) asthma is characterized by airflow limitations and elevated levels of blood and sputum eosinophils, f...
Single nucleotide polymorphisms rs7799039 and rs2167270 in leptin gene and elevated serum levels of adiponectin predispose Iranians to Behçet's disease
Volume 162, February 2023, 156100Author links open overlay panelAbstractBackgroundBehçet's Disease (BD) is a chronic autoi...
The role of Chemerin in human diseases
Volume 162, February 2023, 156089Author links open overlay panelAbstractChemerin is a protein encoded by the Rarres2 gene ...
Prevalence of common sensitizing aeroallergens in patients with atopic dermatitis
Atopic dermatitis (AD) is a chronic skin disorder characterized by relapsing and remitting pruritic eczematous lesions wit...
Cytokine profiling in patients with hepatic glycogen storage disease: Are there clues for unsolved aspects?
Hepatic Glycogen Storage Diseases (GSD) are a set of rare genetic disorders in which glycogen breakdown is impaired. The g...
Serum biomarkers in patients with unilateral or bilateral active pulmonary tuberculosis: Immunological networks and promising diagnostic applications
Tuberculosis is a chronic granulomatous disease transmitted via inhalation of aerosolized droplets carrying Mycobacterium ...
Circulating sTREM-1 as a predictive biomarker of pediatric multisystemic inflammatory syndrome (MIS-C)
The exacerbation of the inflammatory response caused by SARS-CoV-2 in adults promotes the production of soluble mediators ...
Inhibition of ferroptosis protects sepsis-associated encephalopathy
SAE is a widespread brain dysfunction without a clear central nervous system (CNS) infection and the primary symptom is a ...
Identification of two theranostic biomarker panels for epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is the most common form of ovarian cancer (OC), which is the second leading cause of death...
Association between IL-38 and inflammatory indicators in patients with bacterial pneumonia
BackgroundIL-38, a recently discovered cytokine of IL-1 family, exerts immunoregulatory activities in multi-type inflammat...
IL-6 evoked biochemical changes in prostate cancer cells
The pro-inflammatory cytokine IL-6 has been associated with the progression of PCa to a castration-resistant phenotype. In...
Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes
ObjectiveInterleukin-33 (IL-33) is associated with obesity-related inflammation. We aim to investigate IL-33 expression in...
Responses of complement C1q/tumor necrosis factor-related proteins to acute aerobic exercise
Aerobic exercise is an effective therapeutic strategy to manage metabolic disorders. However, the mechanisms of aerobic ex...
The impact of the PCSK-9/VLDL-Receptor axis on inflammatory cell polarization
BackgroundStudies have shown that lipoproteins, such as LDL and VLDL, as well as its major protein component ApoE2 impact ...
Type I and II interferon signaling in colorectal cancer liver metastasis
Metastatic colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Traditional chemotherapy ext...
The duality of STAT2 mediated type I interferon signaling in the tumor microenvironment and chemoresistance
The tumor microenvironment consists of tumor cells, extracellular matrix, blood vessels, and non-tumor cells such as fibro...
Bone marrow microenvironment- induced regulation of Bcl-2 family members in multiple myeloma (MM): Therapeutic implications
In Multiple Myeloma (MM) the finely tuned homeostasis of the bone marrow (BM) microenvironment is disrupted. Evasion of pr...
Correlation between oxidative stress markers and cytokines in different stages of breast cancer
This study aims to estimate the level of malondialdehyde (MDA) as oxidative stress marker and reduced glutathione (GSH) as...
Nuclear receptor coactivator 3 transactivates proinflammatory cytokines in collagen-induced arthritis
Rheumatoid arthritis (RA) is an autoimmune disorder in which the immune system mistakenly attacks joints. The molecular me...
Meta-analyses reveal serum or plasma Interleukin-6 as a biomarker for malignant ovarian neoplasia
Workflow and raw data available in supplementary material.Andrei Pașca is a Ph.D. candidate at the Department of Oncologic...
Unraveling the peripheral and local role of inflammatory cytokines in glioblastoma survival
Glioblastoma (GBM) is a life-threatening disease that presents high morbidity and mortality. The standardized treatment pr...
Evolvability and emergence of tumor heterogeneity as a space–time function
The loss of control of cell proliferation, apoptosis regulation and contact inhibition leads to tumor development. While b...
Alterations in levels of cytokine following treatment to predict outcome of sepsis: A meta-analysis
BackgroundThe mortality rate of patients with sepsis has been increasing in recent years. Alterations of biomarkers levels...
COX-2/PGE2/VEGF signaling promotes ERK-mediated BMSCs osteogenic differentiation under hypoxia by the paracrine action of ECs
Understanding the crosstalk between endothelial cells (ECs) and bone-marrow mesenchymal stem cells (BMSCs) in response to ...