SCI时时刷

search
+
Effects of wet granulation process variables on the quantitative assay model of transmission Raman spectroscopy for pharmaceutical tablets
Effects of wet granulation process variables on the quantitative assay model of transmission Raman spectroscopy for pharmaceutical tablets
Tablets are among the most widely manufactured and prescribed oral dosage forms, offering numerous advantages over other d...
Navigating the complexities of medicating paediatric patients: Insights from an enteral feeding tube workshop
Navigating the complexities of medicating paediatric patients: Insights from an enteral feeding tube workshop
Enteral feeding tubes (EFT) are used to administer nutrition into the gastrointestinal tract of patients who are unable to...
Microstructural insight into inhalation powder blends through correlative multi-scale X-ray computed tomography
Microstructural insight into inhalation powder blends through correlative multi-scale X-ray computed tomography
Dry powder inhalers (DPI) are important for topical drug delivery to the lungs, but characterising the pre-aerosolised pow...
Design, development and in vitro quantification of novel electrosprayed everolimus-loaded Soluplus®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy
Design, development and in vitro quantification of novel electrosprayed everolimus-loaded Soluplus®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy
KeywordsRAD001High-Performance Liquid ChromatographyCross-linkingFreeze-thawingForced DegradationSustained ReleaseBioavail...
Prediction of the penetration depth of multi-lamellar liposomes in artificial skin. Application to the vectorization of corticosteroid in human skin
Prediction of the penetration depth of multi-lamellar liposomes in artificial skin. Application to the vectorization of corticosteroid in human skin
Topical drug delivery can be considered to deliver drugs either into the bloodstream (transdermal delivery) or into a spec...
Quality by design engineered, enhanced anticancer activity of temozolomide and resveratrol coloaded NLC and brain targeting via lactoferrin conjugation in treatment of glioblastoma
Quality by design engineered, enhanced anticancer activity of temozolomide and resveratrol coloaded NLC and brain targeting via lactoferrin conjugation in treatment of glioblastoma
Glioblastoma multiforme (GBM) is most dangerous type of high-grade astrocytoma. It is due to complex differentiated malign...
Survey-based investigation into the current use of paediatric medicines and administration devices in China
Survey-based investigation into the current use of paediatric medicines and administration devices in China
Accurate, fast and convenient administration of medicines with the appropriate aid of various administration devices has b...
Stepping into Small Shoes: Gaining User Perspective on Appropriate Administration Devices for Paediatric Medication in India
Stepping into Small Shoes: Gaining User Perspective on Appropriate Administration Devices for Paediatric Medication in India
Administering medications to children can be a challenging task, especially when measuring and delivering the correct dosa...
Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms
The development of biofilms on different surfaces continues to be a major public health problem. The antimicrobial resista...
Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of Exenatide in T2DM rats
Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of Exenatide in T2DM rats
Peptides have achieved large-scale production and are widely used in the treatment of various fields due to the developmen...
Co-delivery of beta-caryophyllene and indomethacin in the oily core of nanoemulsions potentiates the anti-inflammatory effect in LPS-stimulated macrophage model
Co-delivery of beta-caryophyllene and indomethacin in the oily core of nanoemulsions potentiates the anti-inflammatory effect in LPS-stimulated macrophage model
To enhance the therapeutic effect of substances and drugs, it is common to employ technological strategies and the associa...
PLGA and PEG based porous microparticles as vehicles for pulmonary somatropin delivery
PLGA and PEG based porous microparticles as vehicles for pulmonary somatropin delivery
Growth hormone deficiency is a rare disorder affecting 1 in 4000 children in the United States, characterized by short sta...
Transdermal delivery of mitochondrial-targeted hydrogen sulphide donor, AP39 protects against 6-hydroxydopamine-induced mitochondrial dysfunction
Transdermal delivery of mitochondrial-targeted hydrogen sulphide donor, AP39 protects against 6-hydroxydopamine-induced mitochondrial dysfunction
Parkinson’s disease (PD) is a neurodegenerative disorder, associated with the loss of function of dopaminergic neurones in...
pH-Triggered polymeric Nanoparticles-in-Gel for Preventing Vaginal Transmission of HIV and Unintended Pregnancy
pH-Triggered polymeric Nanoparticles-in-Gel for Preventing Vaginal Transmission of HIV and Unintended Pregnancy
Sexually transmitted infections (STIs) such as chlamydia, gonorrhoea, syphilis and trichomoniasis are on the rise with aro...
Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications
Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications
While novel and more powerful drugs continue to be designed and synthesized, growing focus is being given to the technique...
Cellular uptake and trafficking of peptide-based drug delivery systems for miRNA
Cellular uptake and trafficking of peptide-based drug delivery systems for miRNA
Today, macromolecular compounds such as microRNAs (miRNAs) are becoming more and more widespread as leading therapeutics. ...
Particulate antigens administrated by intranasal and intravaginal routes in a prime-boost strategy improve HIV-specific TFH generation, high-quality antibodies and long-lasting mucosal immunity
Particulate antigens administrated by intranasal and intravaginal routes in a prime-boost strategy improve HIV-specific TFH generation, high-quality antibodies and long-lasting mucosal immunity
Mucosal surfaces serve as the primary entry points for pathogens such as SARS- CoV-2 coronavirus or HIV in the human body....
Deep eutectic solvents based on sugars for oral applications
Deep eutectic solvents based on sugars for oral applications
Deep eutectic solvents (DESs) are mixtures composed of two or more solid or liquid components that form a eutectic mixture...
Co-delivery of beta-caryophyllne and indomethacin in the oily core of nanoemulsions potentiates the anti-inflammatory effect in LPS-stimulated macrophage model
Co-delivery of beta-caryophyllne and indomethacin in the oily core of nanoemulsions potentiates the anti-inflammatory effect in LPS-stimulated macrophage model
To enhance the therapeutic effect of substances and drugs, it is common to employ technological strategies and the associa...
Development of lipophilic ester prodrugs of dolutegravir for intestinal lymphatic transport
Development of lipophilic ester prodrugs of dolutegravir for intestinal lymphatic transport
KeywordsDolutegravirHIV reservoirsIntestinal lymphatic transportMesenteric lymph nodesLipophilic ester prodrugsLipolysisAb...
Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique
Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique
The small intestinal physiology changes with age [1], [2], and as such, pharmacokinetic (PK) profiles observed in adult po...
Preparation and in vitro/in vivo characterization of sustained-release ciprofloxacin-carrageenan complex
Preparation and in vitro/in vivo characterization of sustained-release ciprofloxacin-carrageenan complex
Ciprofloxacin (Cipro), a broad-spectrum quinolone antibiotic, is widely and successfully used to treat bacterial infection...
Compliance and regulatory considerations for the implementation of the multi-attribute-method by mass spectrometry in a quality control laboratory
Compliance and regulatory considerations for the implementation of the multi-attribute-method by mass spectrometry in a quality control laboratory
KeywordsLiquid chromatography mass spectrometryMulti-attribute methodQuality controlAnalytical target profileCritical qual...
Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer
Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer
As a derivative of artemisinin, artesunate (ART) has been universally used in the clinical treatment of malaria [1], [2]. ...
Inhalation powder development without carrier: How to engineer ultra-flying microparticles?
Inhalation powder development without carrier: How to engineer ultra-flying microparticles?
Spray drying (SD) for the production of pharmaceuticals is a well-established method [1], possessing many advantages over ...
A critical review of the novelties in the development of intravenous nanoemulsions
A critical review of the novelties in the development of intravenous nanoemulsions
Nanoemulsions have gained increasing attention in recent years as a drug delivery system due to their ability to improve t...
A drug-incorporated-microparticle-eggshell-membrane-scaffold (DIMES) dressing: A novel biomaterial for localised wound regeneration
A drug-incorporated-microparticle-eggshell-membrane-scaffold (DIMES) dressing: A novel biomaterial for localised wound regeneration
Chronic wounds affect millions of people annually and have emotional and financial implications in addition to health issu...
Direct drug milling in organic PLGA solution facilitates the encapsulation of nanosized drug into PLGA microparticles
Direct drug milling in organic PLGA solution facilitates the encapsulation of nanosized drug into PLGA microparticles
PLGA microparticles have been used to deliver drugs with durations of weeks to months [1]. Improved safety, convenience, c...
Predicting bioequivalence and developing dissolution bioequivalence safe space in vitro for warfarin using a Physiologically-Based pharmacokinetic absorption model
Predicting bioequivalence and developing dissolution bioequivalence safe space in vitro for warfarin using a Physiologically-Based pharmacokinetic absorption model
The generic drug is a product with the same efficacy, dose, indication, safety, and quality as the original drug. Generic ...
Screening techniques for monitoring the sub-visible particle formation of free fatty acids in biopharmaceuticals
Screening techniques for monitoring the sub-visible particle formation of free fatty acids in biopharmaceuticals
Protein therapeutics gained its popularity after the breakthrough of recombinant DNA technology in the 1970s, comprising t...
阅读更多
format_indent_increase