SCI时时刷

search
+
Influence of BAKs on tear film lipid layer: In vitro and in silico models
Ocular rosacea is a chronic inflammatory disorder with periods of exacerbation and remission, often underdiagnosed in chil...
Sustainable 3D printing of oral films with tunable characteristics using CMC-based inks from durian rind wastes
Additive manufacturing (AM), also known as three-dimensional printing (3DP), is an intriguing method that has been researc...
Design of chondroitin sulphate coated proglycosomes for localized delivery of tofacitinib for the treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease under the category of musculoskeletal condition that af...
Fed Intestinal Solubility Limits and Distributions Applied to the Developability Classification System
For solid oral dosage forms drug solubility in intestinal fluid is an important parameter influencing product performance ...
Study on Sgc8 aptamer-mediated nucleic acid nanomaterial-doxorubicin complex for tumor targeted therapy
Nowadays, malignancies continue to be a major problem affecting human health worldwide. According to a study of cancer dat...
Exploring temozolomide encapsulated PEGylated Liposomes and Lyotropic liquid crystals for effective treatment of glioblastoma: in-vitro, cell line, and pharmacokinetic studies
Glioblastoma is associated with abnormal proliferation of the glial cells in the brain and has the highest mortality rate ...
Evaluation of binders in twin-screw wet granulation – Optimal combination of binder and disintegrant
Tablets are frequently used solid oral dosage forms. Besides the identity, purity and content of the active pharmaceutical...
Exposure to a rotating magnetic field as a method of increasing the skin permeability of active pharmaceutical ingredients
The paper presents a method of increasing the permeability of various active substances through the skin by means of a rot...
Therapeutic Deep Eutectic Solvents: A Comprehensive Review of Their Thermodynamics, Microstructure and Drug Delivery Applications
The term eutectic, or eutaxia, is not just a recent occurrence within the scientific community. Reports from Frederick Gut...
Improved drug transfer into brain tissue via the “nose-to-brain” approach using suspension or powder formulations based on the amorphous solid dispersion technique
The concept of “nose-to-brain” drug delivery has attracted considerable attention because intranasally administered drugs ...
Seborrheic dermatitis: topical therapeutics and formulation design
Seborrheic dermatitis (SD) affects approximately 1–3 % of the adult population, causing skin inflammation, pronounced flak...
Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine
It is generally recognized that water, acting as a plasticizer, increases molecular mobility, leading to a decrease of the...
Effect of Light Source and UVA Quotient on Monoclonal Antibody Stability during Ambient Light Exposure Studies
Biologics molecules need special handling during drug substance and drug product manufacturing, usage, and storage. Extra ...
Development of a multifunctional platform for near-infrared imaging and targeted radionuclide therapy for tumors
Nowadays, cancer remains the main death cause of people around the world. It is urgent to develop efficient strategies to ...
Co-delivering of oleuropein and lentisk oil in phospholipid vesicles as an effective approach to modulate oxidative stress, cytokine secretion and promote skin regeneration
Oleuropein is a phenolic compound naturally occurring in Oleaceae, Cornales, and Gentianales family [1], while from the ch...
Model-based Optimization of Drug Release Rate from a Size Distributed Population of Biodegradable Polymer Carriers
Controlled drug delivery is a rapidly advancing technology of high economic importance to the pharmaceutical and health in...
Regorafenib loaded self-assembled lipid-based nanocarrier for colorectal cancer treatment via lymphatic absorption
Oral chemotherapy can improve life quality of patients. Approximately 70 oral small-molecule protein kinase inhibitors, in...
Lipid-functionalized gold nanorods with plug-to-direct mitochondria targeting ligand for synergetic photothermal-chemotherapy of tumor therapy
Chemotherapy is still one of the main clinical methods for cancer treatment, although it has some serious shortcomings inv...
Solid-in-oil nanodispersion as a novel topical transdermal delivery to enhance stability and skin permeation and retention of hydrophilic drugs l-ascorbic acid
Vitamin C (l-ascorbic acid, VC), a water soluble antioxidant [1], is an essential nutrient with the maintenance of various...
Drilling down the bioequivalence assessment of topical antifungal products: Microstructure and release
In recent years, the regulatory mechanisms for topical generic product bioequivalence (BE) assessment have been subjected ...
A triple crosslinked micelle-hydrogel lacrimal implant for localized and prolonged therapy of glaucoma
Glaucoma is the main trigger of global irreversible vision loss. Because of the growingly aging population, it has been pr...
Patient engagement in pharmaceutical development: Where are we? – Report from a symposium
Pharmaceutical companies are tasked with developing life-changing products that meet the needs of patients while adhering ...
Application of biorelevant in vitro assays for the assessment and optimization of ASD-based formulations for pediatric patients
In recent years, innovative formulation strategies have been developed to enable the oral administration of complex and ch...
Tacrolimus and paclitaxel co-loaded O/O ointment without surfactant: Synergistic combinations for the treatment of psoriasis
Psoriasis is an immune-mediated inflammatory disease characterized by differentiation coupled with scaly, itchy, erythemat...
Solid-in-oil nanodispersion as a novel topical transdermal delivery to enhance stability and skin permeation and retention of hydrophilic drugs L-ascorbic acid
Vitamin C (L-ascorbic acid, VC), a water soluble antioxidant [1], is an essential nutrient with the maintenance of various...
Nanodelivery systems for cutaneous melanoma treatment
5-ALA5-Aminolevulinic Acid5hmC5-HydroxymethylcytosineAIDSAcquired Immune Deficiency SyndromeAJCCAmerican Joint Committee o...
Folic acid-modified biocompatible Pullulan/Poly(acrylic acid) nanogels for targeted delivery to MCF-7 cancer cells
Polymeric biomaterials are increasingly being explored as anticancer drug delivery systems (DDS). Delivery of a therapeuti...
Transdermal and lateral effective diffusivities for drug transport in stratum corneum from a microscopic anisotropic diffusion model
The skin is the largest and one of the most important organs of the body, possessing a multilayered structure. The outermo...
Transdermal delivery of Protocatechuic aldehyde using hyaluronic acid/gelatin-based microneedles for the prevention and treatment of hypertrophic scars
Hypertrophic scar (HS) is a fibroproliferative disease that frequently occurs after burns, trauma, surgery, etc. It has be...
A skin pharmacokinetics study of permeation enhancers: The root cause of dynamic enhancement effect on in vivo drug permeation
Permeation enhancers, as the generally used excipients in transdermal drug-delivery system (TDDS) formulations, can weaken...
阅读更多
format_indent_increase