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Analysis of downstream targets of PAX6 and LHX2, fundamental regulators of the developing mammalian neocortex
Analysis of downstream targets of PAX6 and LHX2, fundamental regulators of the developing mammalian neocortex
The transcription factors PAX6 and LHX2 play fundamental roles in mammalian cerebral cortical development. Loss of either ...
Glutamate metabolism disruption in Johanson–Blizzard syndrome: Insights from C. elegans ubr-1 model
Glutamate metabolism disruption in Johanson–Blizzard syndrome: Insights from C. elegans ubr-1 model
The Johanson–Blizzard syndrome (JBS) is a complex autosomal recessive disorder that manifests through a spectrum of ...
Trypanosomatid DRBD9s are likely to be eIF4B orthologues
Trypanosomatid DRBD9s are likely to be eIF4B orthologues
Initiation of protein translation is one of the key steps in protein synthesis carried out by translation initiation facto...
Memory defects in post-dauer Caenorhabditis elegans are a result of altered insulin signalling
Memory defects in post-dauer Caenorhabditis elegans are a result of altered insulin signalling
In response to unfavourable conditions and environmental duress, Caenorhabditis elegans follows an alternative development...
From data to discovery: Neuroinformatics in understanding Alzheimer's disease
From data to discovery: Neuroinformatics in understanding Alzheimer's disease
Neuroinformatics, an interdisciplinary field integrating neuroscience and informatics, plays a crucial role in understandi...
Transitioning towards dynamic, nature-based crop defenses
Transitioning towards dynamic, nature-based crop defenses
The Anthropocene is posing extraordinary challenges for global agriculture. Agri-food production is increasingly impacted ...
Toxicity assessment of wastewater treatment plant sludge using Caenorhabditis elegans
Toxicity assessment of wastewater treatment plant sludge using Caenorhabditis elegans
Globally, sewage sludge is produced in large quantities as a by-product in wastewater treatment plants (WWTPs), which have...
Estimating protein–ligand interactions with geometric deep learning and mixture density models
Estimating protein–ligand interactions with geometric deep learning and mixture density models
Understanding the interactions between a ligand and its molecular target is crucial in guiding the optimization of molecul...
Induction of defence response in peanut elicited by Bacillus sp. CHEP5: A biological strategy for control of smut disease caused by Thecaphora frezzii in the field
Induction of defence response in peanut elicited by Bacillus sp. CHEP5: A biological strategy for control of smut disease caused by Thecaphora frezzii in the field
Peanut is susceptible to many diseases; among them, peanut smut disease caused by Thecaphora frezzii is the most damaging,...
MicroRNA dynamics in irisin-mediated signaling pathways within adipose tissue
MicroRNA dynamics in irisin-mediated signaling pathways within adipose tissue
The regulation of adipose tissue metabolism by irisin involves modulating gene expressions related to energy metabolism an...
Dendritic cells derived from induced pluripotent stem cells and stimulated by antigens of hepatitis C virus efficiently activate T-lymphocytes
Dendritic cells derived from induced pluripotent stem cells and stimulated by antigens of hepatitis C virus efficiently activate T-lymphocytes
During infection, the hepatitis C virus (HCV) can evade immune response and cause chronic disease. Formation of effective ...
Phosphorylation mapping of laminin γ1-chain: Kinases, functional interaction sequences, and phosphorylation-interfering cancer mutations
Phosphorylation mapping of laminin γ1-chain: Kinases, functional interaction sequences, and phosphorylation-interfering cancer mutations
We computationally predicted all phosphorylation sites in the sequence of the human laminin γ1-chain (LAMC1), and com...
CDCA: Community detection in RNA-seq data using centrality-based approach
CDCA: Community detection in RNA-seq data using centrality-based approach
One of the integral part of the network analysis is finding groups of nodes that exhibit similar properties. Community det...
scDiffCoAM: A complete framework to identify potential biomarkers for esophageal squamous cell carcinoma using scRNA-Seq data analysis
scDiffCoAM: A complete framework to identify potential biomarkers for esophageal squamous cell carcinoma using scRNA-Seq data analysis
Single-cell RNA sequencing (scRNA-Seq) technology provides the scope to gain insight into the interplay between intrinsic ...
An in vitro model of adipose tissue-associated macrophages
An in vitro model of adipose tissue-associated macrophages
Obesity-related chronic low-grade inflammation plays a central role in the development of insulin resistance. Macrophages ...
Defining genomic landscape for identification of potential candidate resistance genes associated with major rice diseases through MetaQTL analysis
Defining genomic landscape for identification of potential candidate resistance genes associated with major rice diseases through MetaQTL analysis
Rice production is severely affected by various diseases such as bacterial leaf blight (BLB), brown spot (BS), false smut ...
Paradoxical sleep deprivation and restriction promote castration-like effects and local inflammatory responses in male gerbil prostate
Paradoxical sleep deprivation and restriction promote castration-like effects and local inflammatory responses in male gerbil prostate
Paradoxical sleep deprivation (PSD) presents different effects on metabolism and neurological functions. In addition, over...
Goat weed (Ageratum conyzoides L.): A biological threat to plant diversity in Eastern Ghats of India
Goat weed (Ageratum conyzoides L.): A biological threat to plant diversity in Eastern Ghats of India
The Kunming–Montreal Global Biodiversity Framework (GBF) is a recently signed protocol by the conference of the part...
Nitric oxide brings innate immune resistance to M. tuberculosis infection among high-risk household contacts of pulmonary tuberculosis patients
Nitric oxide brings innate immune resistance to M. tuberculosis infection among high-risk household contacts of pulmonary tuberculosis patients
Nitric oxide (NO) and iNOS are crucial host factors in innate immunity against intracellular pathogens. However, the role ...
Cell membrane proteome analysis in HEK293T cells challenged with α-synuclein amyloids
Cell membrane proteome analysis in HEK293T cells challenged with α-synuclein amyloids
Amyloids interact with plasma membranes. Extracellular amyloids cross the plasma membrane barrier. Internalized extracellu...
Neural pathways that compel us to scratch an itch
Neural pathways that compel us to scratch an itch
Itch is a unique sensory experience that is responded to by scratching. How pruritogens, which are mechanical and chemical...
Comparative assessment of two in-house-built isothermal assays for visual detection of African swine fever virus
Comparative assessment of two in-house-built isothermal assays for visual detection of African swine fever virus
Owing to the lack of effective vaccines, current control measures and eradication strategies for the African swine fever v...
Collaborative action between noradrenergic and serotoninergic systems in peripheral antinociception in mice
Collaborative action between noradrenergic and serotoninergic systems in peripheral antinociception in mice
Noradrenaline (NA) and serotonin (5-HT) induce nociception and antinociception. This antagonistic effect can be explained ...
Quantitative analysis of fibrillar collagen organization in the immediate proximity of embedded fibroblasts in 3D collagen hydrogels
Quantitative analysis of fibrillar collagen organization in the immediate proximity of embedded fibroblasts in 3D collagen hydrogels
Fibroblasts embedded in a 3D matrix microenvironment can remodel the matrix to regulate cell adhesion and function. Collag...
Diagnosis and treatment of cystic fibrosis in India: What is at stake for developing countries?
Diagnosis and treatment of cystic fibrosis in India: What is at stake for developing countries?
Cystic fibrosis (CF) is a life-threatening monogenic disease affecting thousands of people worldwide. Cystic fibrosis tran...
The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation
The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation
We have extensively described that the neoplastic process (NP) has deep evolutionary roots and we have made specific predi...
Harnessing the innate immune system by revolutionizing macrophage-mediated cancer immunotherapy
Harnessing the innate immune system by revolutionizing macrophage-mediated cancer immunotherapy
Immunotherapy is a promising and safer alternative to conventional cancer therapies. It involves adaptive T-cell therapy, ...
Roles of mitochondrial alternative oxidase in photosynthetic electron transport in illuminated leaves of Arabidopsis thaliana at low temperature
Roles of mitochondrial alternative oxidase in photosynthetic electron transport in illuminated leaves of Arabidopsis thaliana at low temperature
ATP-uncoupling alternative oxidase (AOX) in the plant respiratory chain is often induced under stress conditions such as l...
Milk supply chain as a reservoir of antimicrobial-resistant Staphylococcus species
Milk supply chain as a reservoir of antimicrobial-resistant Staphylococcus species
Milk is a source of essential nutrients, but food safety across the milk supply chain has emerged as an integral part of f...
NMR-based comparative metabolomics of quiescent muscle cells
NMR-based comparative metabolomics of quiescent muscle cells
Adult muscle tissue largely comprised of differentiated myofibers also harbors quiescent muscle-resident stem cells (MuSCs...
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