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A broadly immunogenic polyvalent Shigella multiepitope fusion antigen protein protects against Shigella sonnei and Shigella flexneri lethal pulmonary challenges in mice
A broadly immunogenic polyvalent Shigella multiepitope fusion antigen protein protects against Shigella sonnei and Shigella flexneri lethal pulmonary challenges in mice
ABSTRACT There are no licensed vaccines for Shigella, a leading cause of children’s diarrhea and a common etiology of trav...
Turicibacterales protect mice from severe Citrobacter rodentium infection
Turicibacterales protect mice from severe Citrobacter rodentium infection
ABSTRACTOne of the major contributors to child mortality in the world is diarrheal diseases, with an estimated 800,000 dea...
IL-9 promotes methicillin-resistant Staphylococcus aureus pneumonia by regulating the polarization and phagocytosis of macrophages
IL-9 promotes methicillin-resistant Staphylococcus aureus pneumonia by regulating the polarization and phagocytosis of macrophages
ABSTRACTIn this study, we examined the effect of Il9 deletion on macrophages in methicillin-resistant Staphylococcus aureu...
Oh my gut! Is the microbial origin of neurodegenerative diseases real?
Oh my gut! Is the microbial origin of neurodegenerative diseases real?
ABSTRACTThere is no cure or effective treatment for neurodegenerative protein conformational diseases (PCDs), such as Alzh...
Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence
Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence
ABSTRACT Listeria monocytogenes is a remarkably well-adapted facultative intracellular pathogen that can thrive in a wide ...
Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin
Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin
ABSTRACT Clostridioides difficile is a leading cause of antibiotic-associated diarrheal disease. C. difficile colonization...
Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso
Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso
ABSTRACT In this study, we investigated how different categories of prenatal malaria exposure (PME) influence levels of ma...
Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells
Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells
ABSTRACT Hematopoietic stem and progenitor cells (HSPCs) play a vital role in the host response to infection through the r...
Protective efficacy and correlates of immunity of immunodominant recombinant Babesia microti antigens
Protective efficacy and correlates of immunity of immunodominant recombinant Babesia microti antigens
ABSTRACT Babesia microti, an intraerythrocytic apicomplexan parasite, is the primary causative agent of human babesiosis a...
Delayed host mortality and immune response upon infection with P. aeruginosa persister cells
Delayed host mortality and immune response upon infection with P. aeruginosa persister cells
ABSTRACT Chronic infections are a heavy burden on healthcare systems worldwide. Persister cells are thought to be largely ...
Roles of host SUMOylation in bacterial pathogenesis
Roles of host SUMOylation in bacterial pathogenesis
ABSTRACT Bacteria frequently interfere with the post-translational modifications of host cells to facilitate their surviva...
Early transcriptional responses to human enteric fever challenge
Early transcriptional responses to human enteric fever challenge
ABSTRACT Enteric fever, caused by oral infection with typhoidal Salmonella serovars, presents as a non-specific febrile il...
Identification of the glycopeptide epitope recognized by a protective Cryptosporidium monoclonal antibody
Identification of the glycopeptide epitope recognized by a protective Cryptosporidium monoclonal antibody
ABSTRACT Cryptosporidium species are a leading cause of pediatric diarrheal disease and death in low- and middle-income co...
Therapeutic potential of rWnt5A in curbing Leishmania donovani infection
Therapeutic potential of rWnt5A in curbing Leishmania donovani infection
ABSTRACT In view of the antagonism of Wnt5A signaling toward microbial pathogens, we were interested in evaluating the the...
Inactivation of the Sts enzymes promotes resistance to lethal Staphylococcus aureus infection
Inactivation of the Sts enzymes promotes resistance to lethal Staphylococcus aureus infection
ABSTRACT Staphylococcus aureus is a highly infective Gram-positive bacterial pathogen that causes a wide range of diseases...
Protection against lethal sepsis following immunization with Candida species varies by isolate and inversely correlates with bone marrow tissue damage
Protection against lethal sepsis following immunization with Candida species varies by isolate and inversely correlates with bone marrow tissue damage
ABSTRACT Protection against lethal Candida albicans (Ca)/Staphylococcus aureus (Sa) intra-abdominal infection (IAI)-mediat...
Transposon sequencing identifies genes impacting Staphylococcus aureus invasion in a human macrophage model
Transposon sequencing identifies genes impacting Staphylococcus aureus invasion in a human macrophage model
ABSTRACT Staphylococcus aureus is a facultative intracellular pathogen in many host cell types, facilitating its persisten...
Class-Driven Synergy and Antagonism between a Pseudomonas Phage and Antibiotics
Class-Driven Synergy and Antagonism between a Pseudomonas Phage and Antibiotics
The ubiquitous bacterial pathogen Pseudomonas aeruginosa is responsible for severe infections in patients with burns, cyst...
Fusobacterium nucleatum Promotes Megakaryocyte Maturation in Patients with Gastric Cancer via Inducing the Production of Extracellular Vesicles Containing 14-3-3ε
Fusobacterium nucleatum Promotes Megakaryocyte Maturation in Patients with Gastric Cancer via Inducing the Production of Extracellular Vesicles Containing 14-3-3ε
Fusobacterium nucleatum colonization contributes to the occurrence of portal vein thrombosis in patients with gastric canc...
Susceptibility to Cryptococcus neoformans Infection with Bruton’s Tyrosine Kinase Inhibition
Susceptibility to Cryptococcus neoformans Infection with Bruton’s Tyrosine Kinase Inhibition
Patients receiving the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib have an increased likelihood of fungal infection...
Legionella pneumophila Rhizoferrin Promotes Bacterial Biofilm Formation and Growth within Amoebae and Macrophages
Legionella pneumophila Rhizoferrin Promotes Bacterial Biofilm Formation and Growth within Amoebae and Macrophages
Previously, we showed that Legionella pneumophila secretes rhizoferrin, a polycarboxylate siderophore that promotes bacter...
Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens?
Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens?
ABSTRACT Fungal infections represent a major, albeit neglected, public health threat with serious medical and economic bur...
Ehrlichia Wnt SLiM ligand mimic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis
Ehrlichia Wnt SLiM ligand mimic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis
ABSTRACT Ehrlichia chaffeensis TRP120 effector has evolved short linear motif (SLiM) ligand mimicry to repurpose multiple ...
The choline-binding proteins PspA, PspC, and LytA of Streptococcus pneumoniae and their interaction with human endothelial and red blood cells
The choline-binding proteins PspA, PspC, and LytA of Streptococcus pneumoniae and their interaction with human endothelial and red blood cells
ABSTRACT Streptococcus pneumoniae is a Gram-positive opportunistic pathogen that can colonize the upper respiratory tract....
Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis
Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis
ABSTRACT Ehrlichia chaffeensis has evolved multiple strategies to evade innate defenses of the mononuclear phagocyte. Rece...
Social networking at the microbiome-host interface
Social networking at the microbiome-host interface
ABSTRACT Microbial species colonizing host ecosystems in health or disease rarely do so alone. Organisms conglomerate into...
Vibrio cholerae phage ICP3 requires O1 antigen for infection
Vibrio cholerae phage ICP3 requires O1 antigen for infection
ABSTRACT In its natural aquatic environment, the bacterial pathogen Vibrio cholerae, the causative agent of the enteric di...
Species- and strain-specific differences in the phagocytosis of Prototheca: insights from live-cell imaging
Species- and strain-specific differences in the phagocytosis of Prototheca: insights from live-cell imaging
ABSTRACT The genus Prototheca is an extremely unusual group of achlorophyllic, obligately heterotrophic algae. Six species...
Formate production is dispensable for Haemophilus ducreyi virulence in human volunteers
Formate production is dispensable for Haemophilus ducreyi virulence in human volunteers
ABSTRACT Haemophilus ducreyi is a causative agent of cutaneous ulcers in children who live in the tropics and of the genit...
Apolipoprotein E genotype affects innate susceptibility to Listeria monocytogenes infection in aged male mice
Apolipoprotein E genotype affects innate susceptibility to Listeria monocytogenes infection in aged male mice
ABSTRACT Apolipoprotein E (ApoE) is a lipid transport protein that is hypothesized to suppress proinflammatory cytokine pr...
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