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Cryo-EM technique and its application: Structure of steroid hormone receptors
For decades, mechanistic understandings of how macromolecular complexes involving transcription factor proteins fulfill th...
Structure and functions of the N-terminal domain of steroid hormone receptors
The steroid hormone receptors (SHRs), which include receptors for glucocorticoid-, estrogen, progesterone, and mineralocor...
Steroid-receptor coactivator complexes in thyroid hormone-regulation of Xenopus metamorphosis
Ever since the discovery that one or more compounds in the thyroid could accelerate anuran metamorphosis over a century ag...
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
Insulin and insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) are hormones with a similar primary sequence (Fig. 1), 3...
Chapter One - Stem cell development involves divergent thyroid hormone receptor subtype expression and epigenetic modifications in the amphibian intestine during metamorphosis
Allan–Herndon–Dudley syndrome (AHDS), an X linked condition, is characterized by severe intellectual disability, dysarthri...
Chapter Two - Epigenetic developmental programming and intergenerational effects of thyroid hormones
Thyroid hormone (TH) regulate the expression of a wide range of genes. The signaling pathway is complex and highly regulat...
Chapter Three - Epigenetic regulation during 1,25-dihydroxyvitamin D3-dependent gene transcription
Vitamin D metabolites play a critical role in calcium and phosphorus homeostasis in vertebrate organisms by acting at the ...
Chapter Four - Endocannabinoid system and epigenetics in spermatogenesis and testicular cancer
Volume 122, 2023, Pages 75-106Author links open overlay panel, , , , AbstractIn mammals, male germ cell development starts...
Chapter Five - The potential role of environmental factors in modulating mitochondrial DNA epigenetic marks
Many studies implicate mitochondrial dysfunction in the development and progression of numerous chronic diseases. Mitochon...
Chapter Six - DNA methylation in the pathogenesis of type 2 diabetes
Glucose is the primary source of energy for living organisms. Post absorption, it is utilized by insulin-dependent tissues...
Chapter Seven - Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis
Endometriosis is a benign gynecological disease affecting ∼10% of reproductive-age women and is defined as the presence of...
Chapter Eight - Aberrant epigenetic regulation of estrogen and progesterone signaling at the level of endometrial/endometriotic tissue in the pathomechanism of endometriosis
To investigate PPARGC1A promoter methylation and mitochondria DNA (mtDNA) content in the leukocytes of women with polycyst...
Chapter Nine - Early-life AFB1 exposure: DNA methylation and hormone alterations
Exposure to fungi is a primary cause of diseases including mycoses and mycotoxicosis. Usually triggered by fungi-producing...
Chapter Ten - Crosstalk between epigenetics and tumor promoting androgen signaling in prostate cancer
Currently, prostate cancer (PCa) is the primary site of cancer in men globally (Sung et al., 2021). Androgen receptor (AR)...
Chapter Eleven - Effects of stress and mindfulness on epigenetics
Volume 122, 2023, Pages 283-306Author links open overlay panelAbstractEpigenetics are heritable changes in the rate of gen...
Chapter Twelve - Early life stress, depression and epigenetics
The concept of stress has been the subject of debate since its inception in the mid-19th century as a fundamental concept ...
Chapter Thirteen - On the road to resilience: Epigenetic effects of meditation
Many environmental and lifestyle related factors may influence the physiology of the brain and body by acting on fundament...
Unraveling corticotropin-releasing factor family-orchestrated signaling and function in both sexes
Stress responses to physical, psychological, environmental, or cellular stressors, has two arms: initiation and recovery. ...
On the road to resilience: Epigenetic effects of meditation
Many environmental and lifestyle related factors may influence the physiology of the brain and body by acting on fundament...
Effects of stress and mindfulness on epigenetics
Available online 9 February 2023Author links open overlay panelAbstractEpigenetics are heritable changes in the rate of ge...
Early life stress, depression and epigenetics
The concept of stress has been the subject of debate since its inception in the mid-19th century as a fundamental concept ...
Essential and subtype-dependent function of thyroid hormone receptors during Xenopus metamorphosis
Thyroid hormone (T3) have broad and diverse effects in vertebrates. It affects metabolisms in different organs and regulat...
Epigenetic developmental programming and intergenerational effects of thyroid hormones
Thyroid hormone (TH) regulate the expression of a wide range of genes. The signaling pathway is complex and highly regulat...
Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis
Endometriosis is a benign gynecological disease affecting ∼10% of reproductive-age women and is defined as the presence of...
Endocannabinoid system and epigenetics in spermatogenesis and testicular cancer
Available online 6 February 2023Author links open overlay panel, , , , AbstractIn mammals, male germ cell development star...
A structural perspective of liver X receptors
Nuclear receptors are one of the major transcription factor families by controlling the transcription of DNA to RNA in nuc...
Steroid hormone signaling: What we can learn from insect models
Ecdysteroids are a group of steroid hormones in arthropods that were originally identified as molting hormones in insects ...
The potential role of environmental factors in modulating mitochondrial DNA epigenetic marks
Many studies implicate mitochondrial dysfunction in the development and progression of numerous chronic diseases. Mitochon...
Epigenetic regulation during 1,25-dihydroxyvitamin D3-dependent gene transcription
Vitamin D metabolites play a critical role in calcium and phosphorus homeostasis in vertebrate organisms by acting at the ...
Early-life AFB1 exposure: DNA methylation and hormone alterations
Exposure to fungi is a primary cause of diseases including mycoses and mycotoxicosis. Usually triggered by fungi-producing...
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