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Lupus mice derived mesenchymal stromal cells: Beneficial or detrimental on SLE disease outcome
Lupus mice derived mesenchymal stromal cells: Beneficial or detrimental on SLE disease outcome
Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease representing multi-organ manifestations s...
Role and mechanism of miR-871-3p/Megf8 in regulating formaldehyde-induced cardiomyocyte inflammation and congenital heart disease
Role and mechanism of miR-871-3p/Megf8 in regulating formaldehyde-induced cardiomyocyte inflammation and congenital heart disease
Increasing evidence indicates that the cardiovascular system and stages of cardiac development are impressionable to the h...
Transcriptomic and genomic profiling of multiple primary colorectal cancers reveals intratumor heterogeneity and a distinct immune microenvironment
Transcriptomic and genomic profiling of multiple primary colorectal cancers reveals intratumor heterogeneity and a distinct immune microenvironment
Colorectal cancer (CRC) is the third most common malignancy worldwide, with approximately 151,030 new cases and 52,580 dea...
Quinacrine, a PLA2 inhibitor, alleviates LPS-induced acute kidney injury in rats: Involvement of TLR4/NF-κB/TNF α-mediated signaling
Quinacrine, a PLA2 inhibitor, alleviates LPS-induced acute kidney injury in rats: Involvement of TLR4/NF-κB/TNF α-mediated signaling
Acute Kidney Injury (AKI) is a clinical condition characterized by an abrupt decrease in glomerular filtration rate, resul...
Mirabegron, dependent on β3-adrenergic receptor, alleviates mercuric chloride-induced kidney injury by reversing the impact on the inflammatory network, M1/M2 macrophages, and claudin-2
Mirabegron, dependent on β3-adrenergic receptor, alleviates mercuric chloride-induced kidney injury by reversing the impact on the inflammatory network, M1/M2 macrophages, and claudin-2
Mercury is one of the main environmental pollutants that despite being ubiquitously used in medicine, industry, and agricu...
Treponema pallidum recombinant protein Tp47 activates NOD-like receptor family protein 3 inflammasomes in macrophages via glycolysis
Treponema pallidum recombinant protein Tp47 activates NOD-like receptor family protein 3 inflammasomes in macrophages via glycolysis
Syphilis, a chronic systemic sexually transmitted disease, is caused by Treponema pallidum (T. pallidum). With 22.3 millio...
Upregulation of CX3CR1 expression in circulating T cells of systemic lupus erythematosus patients as a reflection of autoimmune status through characterization of cytotoxic capacity
Upregulation of CX3CR1 expression in circulating T cells of systemic lupus erythematosus patients as a reflection of autoimmune status through characterization of cytotoxic capacity
Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects multiple systems, characterized by systemic chro...
Melatonin inhibits the formation of chemically induced experimental encapsulating peritoneal sclerosis through modulation of T cell differentiation by suppressing of NF-κB activation in dendritic cells
Melatonin inhibits the formation of chemically induced experimental encapsulating peritoneal sclerosis through modulation of T cell differentiation by suppressing of NF-κB activation in dendritic cells
Peritoneal dialysis (PD) is a safe therapeutic strategy for patients with end-stage renal disease (ESRD). In addition, it ...
Esketamine mitigates cognitive impairment following exposure to LPS by modulating the intestinal flora/subdiaphragmatic vagus nerve/spleen axis
Esketamine mitigates cognitive impairment following exposure to LPS by modulating the intestinal flora/subdiaphragmatic vagus nerve/spleen axis
In mice, systemic injection of bacterial lipopolysaccharides (LPS) triggers the innate immune inflammatory response, causi...
Inhibition of circulating exosomes release with GW4869 mitigates severe acute pancreatitis-stimulated intestinal barrier damage through suppressing NLRP3 inflammasome-mediated pyroptosis
Inhibition of circulating exosomes release with GW4869 mitigates severe acute pancreatitis-stimulated intestinal barrier damage through suppressing NLRP3 inflammasome-mediated pyroptosis
Acute pancreatitis (AP) is a prevalent and consequential gastrointestinal disorder, may lead to a considerable mortality r...
Prediction of biomarkers associated with membranous nephropathy: Bioinformatic analysis and experimental validation
Prediction of biomarkers associated with membranous nephropathy: Bioinformatic analysis and experimental validation
Membranous nephropathy (MN), the most prevalent form of nephrotic syndrome in non-diabetic adults globally, is currently t...
Diosgenin alters LPS-induced macrophage polarization by activating PPARγ/NF-κB signaling pathway
Diosgenin alters LPS-induced macrophage polarization by activating PPARγ/NF-κB signaling pathway
Diosgenin (DG) is a steroidal saponin derived from plants, and it exhibits anti-inflammatory properties. In this study, we...
Comprehensive study of clinicopathological and immune cell infiltration and lactate dehydrogenase expression in patients with thymic epithelial tumours
Comprehensive study of clinicopathological and immune cell infiltration and lactate dehydrogenase expression in patients with thymic epithelial tumours
Thymoma (TM) and thymic carcinoma (TC) are common tumours of the mediastinal region originating from thymic epithelial cel...
Polystyrene microplastics exposure aggravates acute liver injury by promoting Kupffer cell pyroptosis
Polystyrene microplastics exposure aggravates acute liver injury by promoting Kupffer cell pyroptosis
Volume 126, 5 January 2024, 111307Author links open overlay panel, , , , , , , AbstractObjectiveTo investigate the long-te...
Discovery of β-sitosterol's effects on molecular changes in rat diabetic wounds and its impact on angiogenesis and macrophages
Discovery of β-sitosterol's effects on molecular changes in rat diabetic wounds and its impact on angiogenesis and macrophages
Diabetic foot ulcers (DFUs) lead to preventable clinical conditions in patients with diabetes, causing various negative co...
Comparative transcriptome analysis of E. coli & Staphylococcus aureus infected goat mammary epithelial cells reveals genes associated with infection
Comparative transcriptome analysis of E. coli & Staphylococcus aureus infected goat mammary epithelial cells reveals genes associated with infection
One of the most prevalent harmful conditions affecting dairy ruminants globally is mastitis. It causes inflammation of the...
The role of BATF2 deficiency in immune microenvironment rearrangement in cervical cancer – New biomarker benefiting from combination of radiotherapy and immunotherapy
The role of BATF2 deficiency in immune microenvironment rearrangement in cervical cancer – New biomarker benefiting from combination of radiotherapy and immunotherapy
With an estimated 500,000 cases per year worldwide, cervical cancer is the most prevalent gynaecological cancer type, caus...
Protective effect of arctiin against Toxoplasma gondii HSP70-induced allergic acute liver injury by disrupting the TLR4-mediated activation of cytosolic phospholipase A2 and platelet-activating factor
Protective effect of arctiin against Toxoplasma gondii HSP70-induced allergic acute liver injury by disrupting the TLR4-mediated activation of cytosolic phospholipase A2 and platelet-activating factor
Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that can infect almost all warm-blooded anim...
Comparative evaluation of antitumor effects of TNF superfamily costimulatory ligands delivered by mesenchymal stem cells
Comparative evaluation of antitumor effects of TNF superfamily costimulatory ligands delivered by mesenchymal stem cells
Immune checkpoint inhibition has become a milestone in cancer immunotherapy because of its initial success. However, only ...
Lysosomal membrane stabilization by imipramine attenuates gentamicin-induced renal injury: Enhanced LAMP2 expression, down-regulation of cytoplasmic cathepsin D and tBid/cytochrome c/cleaved caspase-3 apoptotic signaling
Lysosomal membrane stabilization by imipramine attenuates gentamicin-induced renal injury: Enhanced LAMP2 expression, down-regulation of cytoplasmic cathepsin D and tBid/cytochrome c/cleaved caspase-3 apoptotic signaling
Aminoglycosides are important class of today's antibacterial arsenal. They are a therapeutically valuable class because of...
Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier
Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, result in a significant health burden...
Construction and validation of a mitochondria-associated genes prognostic signature and immune microenvironment characteristic of sepsis
Construction and validation of a mitochondria-associated genes prognostic signature and immune microenvironment characteristic of sepsis
According to the 2016 consensus, sepsis is defined as a life-threatening organ dysfunction caused by the host's maladjuste...
Identifying the critical oncogenic mechanism of LDHA based on a prognostic model of T-cell synthetic drivers
Identifying the critical oncogenic mechanism of LDHA based on a prognostic model of T-cell synthetic drivers
Immune-checkpoint inhibitors (ICIs) and adoptive cell transfer therapy (ACT)-based anticancer immunotherapies have revolut...
MMP-9 inhibition alleviates postoperative cognitive dysfunction by improving glymphatic function via regulating AQP4 polarity
MMP-9 inhibition alleviates postoperative cognitive dysfunction by improving glymphatic function via regulating AQP4 polarity
Postoperative cognitive dysfunction (POCD) is characterized by impairments in multiple cognitive domains, including memory...
Intranasal immunotherapy with M2 macrophage soluble factors in post-COVID hyposmia: A pilot study
Intranasal immunotherapy with M2 macrophage soluble factors in post-COVID hyposmia: A pilot study
Smell and taste disorders are a common neurological complication of the novel SARS-CoV-2 infection (COVID-19), which has a...
Cytokine, chemokine alterations and immune cell infiltration in Radiation-induced lung injury: Implications for prevention and management
Cytokine, chemokine alterations and immune cell infiltration in Radiation-induced lung injury: Implications for prevention and management
Radiation therapy stands as a cornerstone in tumor treatment, playing a pivotal role in the management of solid malignant ...
IFITM3 overexpression reverses insufficient healing benefits of small extracellular vesicles from high-fat-diet BMSCs in sepsis via the HMGB1 pathway
IFITM3 overexpression reverses insufficient healing benefits of small extracellular vesicles from high-fat-diet BMSCs in sepsis via the HMGB1 pathway
Bone marrow mesenchymal stem cells (BMSCs) are a promising new therapy for sepsis, a common cause of death in hospitals. H...
Predictions based on inflammatory cytokine profiling of Egyptian COVID-19 with 2 potential therapeutic effects of certain marine-derived compounds
Predictions based on inflammatory cytokine profiling of Egyptian COVID-19 with 2 potential therapeutic effects of certain marine-derived compounds
According to the Wuhan Municipal Health Commission, the World Health Organization has designated SARS-CoV-2 as the officia...
PVB exerts anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB signaling pathways and ROS generation in neutrophils
PVB exerts anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB signaling pathways and ROS generation in neutrophils
Sepsis is a life-threatening multiple organ dysfunction caused by dysregulation of host response to infection, which is on...
The presumable effects of hydroxychloroquine and its metabolites in the treatment of systemic lupus erythematosus
The presumable effects of hydroxychloroquine and its metabolites in the treatment of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic, diffuse autoimmune connective tissue disease that can affect multiple org...
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