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Potential link between the nerve injury-induced protein (Ninjurin) and the pathogenesis of endometriosis
Endometriosis remains a widespread but severe gynecological disease in women of reproductive age, with an unknown etiology...
IgD enhances the release of neutrophil extracellular traps (NETs) via FcδR in rheumatoid arthritis patients
Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disorder affecting primarily the joints. Neutrophils and t...
Overexpression of IFIT1 protects against LPS-induced acute lung injury via regulating CCL5-p65NF-κB signaling
Acute lung injury (ALI) is featured by intensive inflammatory responses causing significant morbidity and mortality. Inter...
The relationships of CD8+ T cell subsets in RA patients with disease activity and clinical parameters
BackgroundCD8+ T cells are plentiful in rheumatoid arthritis (RA) and have a important role in it’s pathogenesis. Many sub...
Blocking Cx43 alleviates neuropathic pain in rats with chronic constriction injury via the P2X4 and P38/ERK-P65 pathways
Neuropathic pain is a growing concern in the medical community, and studies on new analgesic targets for neuropathic pain ...
Manganese enhances macrophage defense against Mycobacterium tuberculosis via the STING-TNF signaling pathway
The host cell antiviral response pathway depends heavily on manganese (Mn), but its role in defense against Mycobacterium ...
Reprograming immune microenvironment modulates CD47 cancer stem cells in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. There are different therapeutic approaches to canc...
Metabolomics window into the diagnosis and treatment of inflammatory bowel disease in recent 5 years
Inflammatory bowel disease (IBD) is a kind of chronic inflammation that occurs in gastrointestinal tract, including Ulcera...
The role of NOD2 in intestinal immune response and microbiota modulation: A therapeutic target in inflammatory bowel disease
As an intracellular pattern recognition receptor (PPR), the nucleotide-binding oligomerization domain-containing protein 2...
Research progress on Mincle as a multifunctional receptor
Macrophage-induced C-type lectin (Mincle), a lipopolysaccharide-induced protein, is widely expressed on antigen-presenting...
Protein kinase C isoforms mediate the formation of neutrophil extracellular traps
Neutrophils release extracellular traps (NETs) in response to numerous pathogenic microbes as the last suicidal resource (...
Binimetinib ameliorates the severity of septic cardiomyopathy by downregulating inflammatory factors
BackgroundSeptic cardiomyopathy (SCM) has a worse prognosis with mortality rates of up to 70%. Most existing treatment is ...
Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance
Dysregulated immune responses have now been recognized as an essential stimulator of ulcerative colitis (UC). Neutrophil e...
Immunotherapy combination with regorafenib for refractory hepatocellular carcinoma: A real-world study
PurposeTo compare the efficacy and safety of immunotherapy plus regorafenib versus regorafenib only in patients with pretr...
Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating result...