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Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma
KeywordsHepatocellular carcinomaEnhancer of zeste homolog 2Tumor microenvironmentUNC1999Myeloid-derived suppressor cellsCh...
Farnesoid X receptor protects against lipopolysaccharide-induced endometritis by inhibiting ferroptosis and inflammatory response
Endometritis is an inflammatory condition that affects the endometrium; it is induced by bacterial infection and often lea...
CCL17 acts as an antitumor chemokine in micromilieu‐driven immune skewing
BackgroundChemokines are critical players in the local immune responses to tumors. CCL17 (thymus and activation-regulated ...
d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice
Psoriasis is an autoimmune chronic inflammatory skin disease with an unclear pathogenesis that is difficult to cure, causi...
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy
Plastic surgery frequently employs random skin flaps. However, its clinical applicability is constrained by flap necrosis ...
Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation
KeywordsDiabetic encephalopathyLipin2NLRP3 inflammasomeJNK/ERK signaling pathwayAbbreviationsBDNFbrain derived neurotrophi...
Supramolecular salicylic acid ameliorates rosacea-like eruptions by suppressing NLRP3-mediated inflammasome activation in mice
BackgroundRosacea is a chronic inflammatory skin disease with immunological dysfunction. Supramolecular salicylic acid (SS...
Ablation of CD226 on CD4+ T cells modulates asthma progress associated with altered IL-10 response and gut microbiota
To investigate the role of the costimulatory molecule CD226 in asthma pathogenesis, we produced a CD4+ T-cell-specific CD2...
Study on immune status alterations in patients with sepsis
Sepsis, characterized by cytokine-mediated hyper-inflammation and a consistent decline in immune responsiveness, is associ...
IKBIP might be a potential prognostic biomarker for glioblastoma multiforme
Volume 118, May 2023, 110030Author links open overlay panel, , , , , , , , Highlights•IKBIP was identified as an independe...
The superiority of immune-inflammation summary index for diagnosing periprosthetic joint infection
KeywordsPeriprosthetic joint infectionDiagnostic biomarkerImmune-inflammatory statusImmune-inflammation summary indexAbbre...
Cardioprotective role of A-cycloglycosylated derivative of Rubiadin in diabetic cardiomyopathy in rats
Diabetic cardiomyopathy (DCM) is a kind of idiopathic heart disease, which is one of the main complications of diabetes an...
Ubiquitin-specific proteases: Vital regulatory molecules in bone and bone-related diseases
Stabilization of bone structure and function involves multiple cell-to-cell and molecular interactions, in which the regul...
Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation
Sepsis-associated acute lung injury remains to be a major cause of morbidity and mortality worldwide, and there is a lack ...
The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics
The complement system is one of the oldest known tightly regulated host defense systems evolved for efficiently functionin...
Effect of gamma-irradiated honey bee venom on gene expression of inflammatory and anti-inflammatory cytokines in mice
In this study, the effect of gamma-irradiated honey bee venom (doses of 0, 2, 4, 6, and 8 kGy, volume of 0.1 ml and concen...
Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway
BackgroundOur previous studies have shown that berberine can improve the nerve function deficits in ischemic stroke by inh...
Deubiquitinase USP47 attenuates virus-induced type I interferon signaling
The innate immune responses are tightly regulated to ensure effective clearance of invading pathogens and avoid excessive ...
Eriocitrin attenuates sepsis-induced acute lung injury in mice by regulating MKP1/MAPK pathway mediated-glycolysis
Metabolic reprogramming has been shown to aggravate sepsis-induced acute lung injury. In particular, enhanced glycolysis i...
Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly
Aberrant activation of the NLRP3 inflammasome has been implicated in the occurrence and development of many inflammatory d...