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Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma
KeywordsHepatocellular carcinomaEnhancer of zeste homolog 2Tumor microenvironmentUNC1999Myeloid-derived suppressor cellsCh...
Farnesoid X receptor protects against lipopolysaccharide-induced endometritis by inhibiting ferroptosis and inflammatory response
Endometritis is an inflammatory condition that affects the endometrium; it is induced by bacterial infection and often lea...
CCL17 acts as an antitumor chemokine in micromilieu‐driven immune skewing
BackgroundChemokines are critical players in the local immune responses to tumors. CCL17 (thymus and activation-regulated ...
d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice
Psoriasis is an autoimmune chronic inflammatory skin disease with an unclear pathogenesis that is difficult to cure, causi...
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy
Plastic surgery frequently employs random skin flaps. However, its clinical applicability is constrained by flap necrosis ...
Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation
KeywordsDiabetic encephalopathyLipin2NLRP3 inflammasomeJNK/ERK signaling pathwayAbbreviationsBDNFbrain derived neurotrophi...
Supramolecular salicylic acid ameliorates rosacea-like eruptions by suppressing NLRP3-mediated inflammasome activation in mice
BackgroundRosacea is a chronic inflammatory skin disease with immunological dysfunction. Supramolecular salicylic acid (SS...
Ablation of CD226 on CD4+ T cells modulates asthma progress associated with altered IL-10 response and gut microbiota
To investigate the role of the costimulatory molecule CD226 in asthma pathogenesis, we produced a CD4+ T-cell-specific CD2...
The immunomodulatory effects of ethosuximide and sodium butyrate on experimentally induced fibromyalgia: The interaction between IL-4, synaptophysin, and TGF-β1/NF-κB signaling
Background and aimsFibromyalgia is a widespread chronic pain syndrome associated with several comorbid conditions that aff...
Neuroprotective mechanism of Ajugarin-I against Vincristine-Induced neuropathic pain via regulation of Nrf2/NF-κB and Bcl2 signalling
Vincristine (VCR) is a well-known chemotherapeutic agent that frequently triggers neuropathic pain. Ajugarin-I (Aju-I) iso...
Study on immune status alterations in patients with sepsis
Sepsis, characterized by cytokine-mediated hyper-inflammation and a consistent decline in immune responsiveness, is associ...
IKBIP might be a potential prognostic biomarker for glioblastoma multiforme
Volume 118, May 2023, 110030Author links open overlay panel, , , , , , , , Highlights•IKBIP was identified as an independe...
The superiority of immune-inflammation summary index for diagnosing periprosthetic joint infection
KeywordsPeriprosthetic joint infectionDiagnostic biomarkerImmune-inflammatory statusImmune-inflammation summary indexAbbre...
Cardioprotective role of A-cycloglycosylated derivative of Rubiadin in diabetic cardiomyopathy in rats
Diabetic cardiomyopathy (DCM) is a kind of idiopathic heart disease, which is one of the main complications of diabetes an...
Ubiquitin-specific proteases: Vital regulatory molecules in bone and bone-related diseases
Stabilization of bone structure and function involves multiple cell-to-cell and molecular interactions, in which the regul...
Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation
Sepsis-associated acute lung injury remains to be a major cause of morbidity and mortality worldwide, and there is a lack ...
Methionine enkephalin suppresses lung cancer metastasis by regulating the polarization of tumor-associated macrophages and the distribution of myeloid-derived suppressor cells in the tumor microenvironment and inhibiting epithelial-mesenchymal transition
Metastasis is one of the most difficult challenges for clinical lung cancer treatment. Epithelial-mesenchymal transition (...
The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics
The complement system is one of the oldest known tightly regulated host defense systems evolved for efficiently functionin...
Sinapic acid and 3,3′-diindolylmethane potentiate cyclophosphamide antitumor activity through induction of apoptosis and inhibition of metastasis
AimNew therapeutic strategies are required to enhance the anticancer efficacy of chemotherapeutic drugs and to reduce thei...
Effect of gamma-irradiated honey bee venom on gene expression of inflammatory and anti-inflammatory cytokines in mice
In this study, the effect of gamma-irradiated honey bee venom (doses of 0, 2, 4, 6, and 8 kGy, volume of 0.1 ml and concen...
Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway
BackgroundOur previous studies have shown that berberine can improve the nerve function deficits in ischemic stroke by inh...
C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3β-Nrf2 cascade via AdipoR1
C1q/tumor necrosis factor-related protein-9 (CTRP9) is linked to diverse pathological conditions via the effects on cell a...
Metformin plays an antitumor role by downregulating inhibitory cells and immune checkpoint molecules while activating protective immune responses in breast cancer
This study seeks to test the effect of metformin treatment on the outcomes of breast cancer in BALB/c mice bearing 4 T1 br...
Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways
KeywordsAtopic dermatitisUrsolic acid2, 4-dinitrochlorobenzeneInflammationOxidative stressAbbreviationsDNCB2, 4-dinitrochl...
Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
KeywordsHesperetinNeuroinflammationOxidative stressNrf2 signaling pathwayNLRP3-mediated pyroptosisAbbreviationsAOPPsAdvanc...
Deubiquitinase USP47 attenuates virus-induced type I interferon signaling
The innate immune responses are tightly regulated to ensure effective clearance of invading pathogens and avoid excessive ...
Eriocitrin attenuates sepsis-induced acute lung injury in mice by regulating MKP1/MAPK pathway mediated-glycolysis
Metabolic reprogramming has been shown to aggravate sepsis-induced acute lung injury. In particular, enhanced glycolysis i...
Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly
Aberrant activation of the NLRP3 inflammasome has been implicated in the occurrence and development of many inflammatory d...
Dihydromyricetin suppresses inflammatory injury in microglial cells to improve neurological behaviors of Alzheimer’s disease mice via the TLR4/MD2 signal
AimWe analyzed the role and mechanism of dihydromyricetin (DHM) in suppressing inflammatory injury in microglial cells via...
Highly pathogenic porcine reproductive and respiratory syndrome virus-induced inflammatory response in porcine pulmonary microvascular endothelial cells and effects of herbal ingredients on main inflammatory molecules
The role of microvascular endothelial cells (MVECs) in viral infection has received increasing attention. Our previous stu...
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