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Lactiplantibacillus plantarum surface-displayed VP6 (PoRV) protein can prevent PoRV infection in piglets
Lactiplantibacillus plantarum surface-displayed VP6 (PoRV) protein can prevent PoRV infection in piglets
Rotavirus (RV), a ds RNA virus, is one of the enteric pathogens that cause diarrhea in neonatal or young animals, while ad...
Duration of antibody response to the receptor binding domain of SARS-CoV-2 in infected or vaccinated individuals – A one year retrospective cohort study
Duration of antibody response to the receptor binding domain of SARS-CoV-2 in infected or vaccinated individuals – A one year retrospective cohort study
The 2019 coronavirus (COVID-19) pandemic raised many scientific and medical questions. Of interest are the duration and ef...
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis
Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by recurrent eczema-like lesions and intense it...
High mobility group box 1 mediates inflammatory responses in malignant peritoneal mesothelioma
High mobility group box 1 mediates inflammatory responses in malignant peritoneal mesothelioma
Malignant mesothelioma, an uncommon neoplasm predominantly originating from the pleura, encompasses various histopathologi...
Acevaltrate promotes apoptosis and inhibits proliferation by suppressing HIF-1α accumulation in cancer cells
Acevaltrate promotes apoptosis and inhibits proliferation by suppressing HIF-1α accumulation in cancer cells
As the rapid and uncontrolled proliferation of tumors limits the availability of oxygen, hypoxia is a typical microenviron...
Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns
Blocking OLFM4/galectin-3 axis in placental polymorphonuclear myeloid-derived suppressor cells triggers intestinal inflammation in newborns
Fetal growth restriction (FGR) is characterized by a failure to achieve genetically determined fetal growth, and it is one...
AMPA receptor inhibition alleviates inflammatory response and myocardial apoptosis after myocardial infarction by inhibiting TLR4/NF-κB signaling pathway
AMPA receptor inhibition alleviates inflammatory response and myocardial apoptosis after myocardial infarction by inhibiting TLR4/NF-κB signaling pathway
Myocardial infarction results from myocardial necrosis due to the interruption of blood flow in the coronary arteries, lea...
Anlotinib may enhance the efficacy of anti-PD1 therapy by inhibiting the AKT pathway and promoting the apoptosis of CAFs in lung adenocarcinoma
Anlotinib may enhance the efficacy of anti-PD1 therapy by inhibiting the AKT pathway and promoting the apoptosis of CAFs in lung adenocarcinoma
Non-small cell lung cancer (NSCLC) is the second most common cancer and the leading cause of cancer-related death worldwid...
Serum Dehydroepiandrosterone sulfate (DHEA-S) level and its potential impact on immune responses and symptom severity after Oxford-AstraZeneca COVID-19 vaccination
Serum Dehydroepiandrosterone sulfate (DHEA-S) level and its potential impact on immune responses and symptom severity after Oxford-AstraZeneca COVID-19 vaccination
The new coronavirus disease (COVID-19), caused by the severe acute respiratory distress syndrome-associated coronavirus-2 ...
Analysis of the sodium pump subunit ATP1A3 in glioma patients: Potential value in prognostic prediction and immunotherapy
Analysis of the sodium pump subunit ATP1A3 in glioma patients: Potential value in prognostic prediction and immunotherapy
Glioblastoma multiforme (GBM) is the most aggressive cancer in the central nervous system (CNS) [1]. Most patients with GB...
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma
Gliomas represent more than half of the primary brain tumors [1]. The World Health Organization (WHO) classified them into...
Combination of chidamide and PD-1 blockade in Refractory/Relapsed aggressive large B-cell lymphomas with high risk of failing CAR-T therapy
Combination of chidamide and PD-1 blockade in Refractory/Relapsed aggressive large B-cell lymphomas with high risk of failing CAR-T therapy
BackgroundRefractoriness and relapse after chimeric antigen receptor T-cell therapy have emerged as major challenges for i...
Roles of IRF4 in various immune cells in systemic lupus erythematosus
Roles of IRF4 in various immune cells in systemic lupus erythematosus
Interferon (IFN) regulatory factor 4 (IRF4) (also known as PIP, MUM1, LSIRF, NFEM5, and ICSAT) is a member of the IRF fami...
Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification
Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification
Celiac disease (CeD) and inflammatory bowel disease (IBD) and are chronic gastrointestinal disorders that exhibit overlapp...
Comparative safety profile of bivalent and original COVID-19 mRNA vaccines regarding myocarditis/pericarditis: A pharmacovigilance study
Comparative safety profile of bivalent and original COVID-19 mRNA vaccines regarding myocarditis/pericarditis: A pharmacovigilance study
KeywordsBivalent COVID-19 mRNA vaccineoriginal COVID-19 mRNA vaccineMyocarditisPericarditisVAERSDisproportionality analysi...
Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs
Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs
Background and purposeOsteoporosis (OP) is a frequent clinical problem for the elderly. Traditional Chinese Medicine (TCM)...
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia–reperfusion-induced renal fibrosis
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia–reperfusion-induced renal fibrosis
Renal ischemia–reperfusion injury (IRI) is one of the main causes of acute kidney injury [1]. It is prevalent in clinical,...
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model
Osteoarthritis (OA) is a prevalent bone and joint disease, typically characterized by the loss and degeneration of underly...
The role of the CXCR6/CXCL16 axis in the pathogenesis of fibrotic disease
The role of the CXCR6/CXCL16 axis in the pathogenesis of fibrotic disease
Four families of chemokines are recognized on the basis of N-terminal cysteines: C, CC, CXC and CX3C, where C represents t...
Genetically predicted hypotaurine levels mediate the relationship between immune cells and intracerebral hemorrhage
Genetically predicted hypotaurine levels mediate the relationship between immune cells and intracerebral hemorrhage
The evidence supports a strong link between immune cells and intracerebral hemorrhage (ICH). Nonetheless, the specific cau...
Differences in nature killer cell response and interference with mitochondrial DNA induced apoptosis in moxifloxacin environment
Differences in nature killer cell response and interference with mitochondrial DNA induced apoptosis in moxifloxacin environment
KeywordsMoxifloxacinSingle-cell RNA sequencingNature killer cellMitochondrial DNAOxidative phosphorylationSafetyData avail...
Establishment and validation of a tumor-infiltrating γδT cell related prognostic gene signature in head and neck squamous cell carcinoma
Establishment and validation of a tumor-infiltrating γδT cell related prognostic gene signature in head and neck squamous cell carcinoma
KeywordsHead and neck squamous cell carcinomaγδT cellsPrognosisTumor immune microenvironmentSingle-cell RNA sequencingData...
Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota
Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota
Ulcerative colitis (UC) is a widespread recurrent inflammatory bowel disease (IBD) with an increasing incidence in countri...
Corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis
Corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis
Pancreatic cancer (PC) is a severe disease with a poor prognosis. The 5-year survival rate of PC is 9 %, and the incidence...
Impact of COVID-19 on arthritis with generative AI
Impact of COVID-19 on arthritis with generative AI
This research utilizes a specialized AI tool capable of generating Python code to examine the impact of the COVID-19 pande...
Potential therapeutic options for celiac Disease: An update on Current evidence from Gluten-Free diet to cell therapy
Potential therapeutic options for celiac Disease: An update on Current evidence from Gluten-Free diet to cell therapy
Celiac disease (CD) is a chronic immune-mediated disorder in genetically susceptible individuals, triggered by ingesting g...
Mitochondrial dysfunction of peripheral blood mononuclear cells is associated with lung carcinogenesis
Mitochondrial dysfunction of peripheral blood mononuclear cells is associated with lung carcinogenesis
Globally, lung cancer is the fastest-growing cancer in terms of incidence and malignancy, making it one of the most danger...
Identification of shared potential diagnostic markers in asthma and depression through bioinformatics analysis and machine learning
Identification of shared potential diagnostic markers in asthma and depression through bioinformatics analysis and machine learning
Asthma is a condition characterized by chronically inflamed airways caused by many factors. The main characteristics of as...
Inhibition of Drp1-mediated mitochondrial fission improves contrast-induced acute kidney injury by targeting the mROS-TXNIP-NLRP3 inflammasome axis
Inhibition of Drp1-mediated mitochondrial fission improves contrast-induced acute kidney injury by targeting the mROS-TXNIP-NLRP3 inflammasome axis
Contrast-induced acute kidney injury (CI-AKI), also known as contrast-induced nephropathy (CIN), is characterized by a swi...
STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1β-induced IL-8 production
STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1β-induced IL-8 production
The activation of immune system is critical for the prevention of the invasion of pathogens, and for the elimination of th...
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