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Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial
Patients with obesity-related heart failure with preserved ejection fraction (HFpEF) display circulatory volume expansion ...
Lipid signatures of cardiometabolic risk in children and adolescents with obesity
Lipid signatures of cardiometabolic risk in children and adolescents with obesity
Blood lipid profiling in a pediatric cohort identified lipid species associated with cardiometabolic risk factors. Circula...
Are GLP-1 drugs really for everybody?
As GLP-1 receptor agonists emerge as treatment options for conditions beyond diabetes and obesity, it becomes critical to ...
Author Correction: Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial
These authors contributed equally: Jahan Rahman, Ran Xu.Lymphoma Service, Department of Medicine, Memorial Sloan Kettering...
Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections
Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections
Metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) is an agnostic method for broad-based diagnosis...
Moving toward response-adapted trials in oncology
Moving toward response-adapted trials in oncology
The I-SPY clinical trial platform was designed to accelerate clinical development of neoadjuvant treatments for early-stag...
H5N1 from an infected dairy worker sheds light on viral transmission
H5N1 from an infected dairy worker sheds light on viral transmission
Two studies reveal high transmissibility and lethality of the viral isolate in animal models, and hint at potential drug s...
TRBC1-CAR T cell therapy in peripheral T cell lymphoma: a phase 1/2 trial
TRBC1-CAR T cell therapy in peripheral T cell lymphoma: a phase 1/2 trial
Relapsed/refractory peripheral T cell lymphomas (PTCLs) are aggressive tumors with a poor prognosis. Unlike B cell lymphom...
Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial
Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial
There is a critical unmet need for safe and efficacious neoadjuvant treatment for cisplatin-ineligible patients with muscl...
Collaboration between clinicians and vision–language models in radiology report generation
Collaboration between clinicians and vision–language models in radiology report generation
Automated radiology report generation has the potential to improve patient care and reduce the workload of radiologists. H...
HIV-1 remission following stem cell transplant without CCR5Δ32 mutation
HIV-1 remission following stem cell transplant without CCR5Δ32 mutation
We report the first case of a person achieving sustained HIV-1 remission after transplantation with allogeneic hematopoiet...
Clinical validation of an AI-based pathology tool for scoring of metabolic dysfunction-associated steatohepatitis
Clinical validation of an AI-based pathology tool for scoring of metabolic dysfunction-associated steatohepatitis
Metabolic dysfunction-associated steatohepatitis (MASH) is a major cause of liver-related morbidity and mortality, yet tre...
A systematic review and meta-analysis of heat exposure impacts on maternal, fetal and neonatal health
Climate Change has severe and wide-ranging health impacts, especially for vulnerable groups. Despite growing evidence of h...
Author Correction: Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Using AVATAR therapy to conquer auditory hallucinations
Using AVATAR therapy to conquer auditory hallucinations
AVATAR therapy, in which patient and therapist interact with a digital embodiment of patients’ auditory hallucinatio...
Regulatory reforms will boost African vaccine production and access
Regulatory reforms will boost African vaccine production and access
Growing momentum to transform the African regulatory landscape should enable 60% of the vaccines needed in Africa to be lo...
Recommendations to promote equity, diversity and inclusion in decentralized clinical trials
Recommendations to promote equity, diversity and inclusion in decentralized clinical trials
Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. Rapid...
Mapping metastatic breast cancer complexity through single-cell and spatial profiling
Mapping metastatic breast cancer complexity through single-cell and spatial profiling
Techniques for single-cell and spatial expression profiling hold great promise for defining the complexity of metastatic m...
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Although metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly chara...
Exploring the limits of life extension
Exploring the limits of life extension
The twentieth century saw unprecedented rises in life expectancy in high-income countries, but data suggest that this tren...
Culturally adapted CBT for postnatal depression
Culturally adapted CBT for postnatal depression
In British South Asian women, a culturally adapted and community-informed cognitive behavioral therapy intervention led to...
Safety principles for medical summarization using generative AI
Google’s development of MedLM found that risk management processes were an essential tool to protect patient safety.
The Cannabis and Health Research Initiative will help integrate medicinal cannabis in healthcare
Competing interests R.V. has received consulting fees and honoraria for service ...
An explainable foundation model for drug repurposing
An explainable foundation model for drug repurposing
A foundation model leverages large-scale medical knowledge to repurpose drugs for diseases that currently lack approved tr...
How health technology can ease the terrible toll of war
How health technology can ease the terrible toll of war
Trauma and infections increase during war, while routine cancer care is disrupted, but telemedicine, AI chatbots and elect...
Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial
Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial
Transcranial direct current stimulation (tDCS) has been proposed as a new treatment in major depressive disorder (MDD). Th...
An ethics assessment tool for artificial intelligence implementation in healthcare: CARE-AI
Competing interests X.L. has previously received consulting fees from Hardian He...
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial
These authors contributed equally: Jing Pan, Yue Tan, Lingling Shan.State Key Laboratory of Experimental Hematology, Boren...
Health AI needs meaningful human involvement: lessons from war
Artificial intelligence (AI) continues to show its potential for innovation in healthcare. As this transformation occurs, ...
Perioperative immunotherapy for bladder cancer
Perioperative immunotherapy for bladder cancer
In the NIAGARA trial, the addition of perioperative durvalumab to standard treatment for muscle-invasive bladder cancer im...
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