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Effect of air pollution on the human immune system
Effect of air pollution on the human immune system
Inhaled particulates from environmental pollutants accumulate in macrophages in lung-associated lymph nodes over years, co...
Targeted therapy for osteoarthritis: progress and pitfalls
Targeted therapy for osteoarthritis: progress and pitfalls
Osteoarthritis is highly heterogeneous, so effective therapies will need to target clearly defined molecular endotypes, re...
Efficacy of supermarket and web-based interventions for improving dietary quality: a randomized, controlled trial
Efficacy of supermarket and web-based interventions for improving dietary quality: a randomized, controlled trial
Dietary interventions may best be delivered at supermarkets, which offer convenience, accessibility, full food inventories...
Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial
Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial
Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying drug approved to date. We discove...
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes
The post-acute sequelae of SARS-CoV-2 infection (PASC) refers to a broad spectrum of symptoms and signs that are persisten...
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring
Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic st...
A universal flu vaccine on the horizon
A universal flu vaccine on the horizon
An mRNA-based vaccine encoding antigens from all known influenza virus A and B subtypes worked well in animal models — whi...
A new class of antibiotics delivers promising trial results against tuberculosis
A new class of antibiotics delivers promising trial results against tuberculosis
Nature Medicine explores the latest translational and clinical research news, with a clinical trial of a tRNA synthetase i...
Mapping the hideouts and habits of bacteria in tumors
Mapping the hideouts and habits of bacteria in tumors
High-resolution spatial profiling reveals the preferred niches for bacteria in tumors, and shows how their presence enhanc...
Prenatal treatment for Pompe’s disease
Prenatal treatment for Pompe’s disease
To prevent irreversible organ damage, an infant with early-onset Pompe’s disease was treated in utero; early data suggest ...
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or im...
Merck bets on sotatercept in pulmonary arterial hypertension
Merck bets on sotatercept in pulmonary arterial hypertension
Nature Medicine explores the latest translational and clinical research news, with news that sotatercept met its primary e...
Global and regional estimates of orphans attributed to maternal cancer mortality in 2020
Global and regional estimates of orphans attributed to maternal cancer mortality in 2020
Despite women being disproportionally affected by cancer deaths at young ages, there are no global estimates of the result...
Holding back progression of kidney disease
Holding back progression of kidney disease
In the EMPA-KIDNEY trial, the SGLT2 inhibitor empagliflozin reduced the risk of kidney disease progression in a broad pati...
Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes
Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes
Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong...
Medical education in the metaverse
Medical education in the metaverse
In his 1992 book Snow Crash, science fiction writer Neal Stephenson coined the term “metaverse”, a portmanteau between “me...
AI detection of cardiac dysfunction from consumer watch ECG recordings
AI detection of cardiac dysfunction from consumer watch ECG recordings
To enable large-scale screening for left ventricular dysfunction — a serious and under-detected cardiac disease R...
Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction
Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction
Although artificial intelligence (AI) algorithms have been shown to be capable of identifying cardiac dysfunction, defined...
Broad-capture proteomics and machine learning for early detection of type 2 diabetes risk
Broad-capture proteomics and machine learning for early detection of type 2 diabetes risk
Impaired glucose tolerance (IGT) is a common condition that affects glucose control after sugar consumption. Isolated IGT ...
Circulating tumor DNA as a novel prognostic indicator
Circulating tumor DNA as a novel prognostic indicator
Circulating tumor DNA (ctDNA) informs predictive biomarkers in non–small-cell lung cancer, but the presence of ctDNA...
Reducing surgical site infections in low-resource settings
Reducing surgical site infections in low-resource settings
Changing gloves and instruments before wound closure significantly reduces the infection rate, offering a low-cost and imp...
The long road to a cure for Alzheimer’s disease is paved with failures
The long road to a cure for Alzheimer’s disease is paved with failures
99% of clinical trials for Alzheimer’s disease fail to show positive results, but researchers remain optimistic that...
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer&...
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acu...
The landscape of mRNA nanomedicine
The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and treatment of a wide range of disease...
Cancer immunotherapy gets personal
Cancer immunotherapy gets personal
In a first in-human study, researchers used an array of technologies to generate highly personalized cell therapy products...
Bittersweet: artificial sweeteners and the gut microbiome
Bittersweet: artificial sweeteners and the gut microbiome
In a clinical trial, non-nutritive sweeteners — which are supposedly inert — were shown to disrupt the gut mic...
Author Correction: Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus
These authors contributed equally: Andreas Mackensen, Fabian Müller, Dimitrios Mougiakakos, Gerhard Krönke, Georg Schett.D...