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A gene-by-sex interaction contributes to liver disease susceptibility in women
A gene-by-sex interaction contributes to liver disease susceptibility in women
Clinical and population-based cohorts revealed an interaction between the inherited PNPLA3 p.I148M variant and female sex ...
Genomic epidemiology of Clostridioides difficile in individuals admitted to an intensive care unit
Genomic epidemiology of Clostridioides difficile in individuals admitted to an intensive care unit
Whole-genome sequencing of Clostridioides difficile from a densely sampled intensive care unit (ICU) population showed tha...
Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial
Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial
Multiple myeloma (MM) is a plasma cell malignancy expressing B cell maturation antigen (BCMA). Elranatamab, a bispecific a...
Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial
Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial
Cystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-altering. We initiated a phas...
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques
The main barrier to HIV cure is a persistent reservoir of latently infected CD4+ T cells harboring replication-competent p...
Early detection of autism using digital behavioral phenotyping
Early detection of autism using digital behavioral phenotyping
Early detection of autism, a neurodevelopmental condition associated with challenges in social communication, ensures time...
Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcus aureus bacteremia: a randomized trial
Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcus aureus bacteremia: a randomized trial
Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacterem...
Discontinued CRISPR gene therapy for sickle-cell disease improves symptoms
Discontinued CRISPR gene therapy for sickle-cell disease improves symptoms
Nature Medicine explores the latest translation and clinical research news, with results from a clinical trial of Novartis...
Balancing healthcare systems’ performance and environmental footprints
Balancing healthcare systems’ performance and environmental footprints
As healthcare systems perform better, their resource footprints have an increasingly negative impact on the environment an...
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial
Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by heterotopic ossification (HO) in connective...
Senolytic therapy for Alzheimer’s disease
Senolytic therapy for Alzheimer’s disease
As the search for new and better treatments for Alzheimer’s disease continues, a phase 1 proof-of-concept study eval...
Developing the West African Digital Mental Health Alliance (WADMA)
Competing interests D.B.-Z. has financial interests in Merlin LLC, FOCUS Technol...
A revolution in obesity treatment
A revolution in obesity treatment
Mounting evidence, including the recent (and unprecedented) phase 2 data on retatrutide, supports a role for incretin horm...
Prescription for a healthy diet
Prescription for a healthy diet
Produce prescriptions improved fruit and vegetable intake, reduced food insecurity and improved biomarkers of cardiometabo...
Modeling policy interventions for slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda
Modeling policy interventions for slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda
Artemisinin combination therapies (ACTs) are highly effective at treating uncomplicated Plasmodium falciparum malaria, but...
A H3K27M-targeted vaccine in adults with diffuse midline glioma
A H3K27M-targeted vaccine in adults with diffuse midline glioma
Substitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous s...
Human embryo models offer glimpse into early development
Human embryo models offer glimpse into early development
Grown from stem cells, the models recapitulate the hallmarks of post-implantation human embryos up to day 14, opening new ...
Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women
Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women
Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver disease and the prevalence is risi...
Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease
Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease
Aberrant CD4+ T cell reactivity against intestinal microorganisms is considered to drive mucosal inflammation in inflammat...
Five discoveries about COVID-19 made since the public health emergency ended
Five discoveries about COVID-19 made since the public health emergency ended
We asked leading researchers to share new discoveries about SARS-CoV-2 and COVID-19, from how the virus spreads and the ri...
The Sustainable Development Goals should be reset to prioritize poverty, health and climate
The Sustainable Development Goals should be reset to prioritize poverty, health and climate
The UN SDGs will only improve human health if they are accompanied by systemic change that addresses global power imbalances.
Progress at last against RSV
The approval of two vaccines and a monoclonal antibody that target respiratory syncytial virus could shift the tide on the...
Managing maintenance therapy for bipolar 1 depression
Managing maintenance therapy for bipolar 1 depression
A trial comparing long-term versus short-term antidepressant maintenance therapy fails to show a significant benefit of co...
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy and safety of 3,4-methylenedi...
Axicabtagene ciloleucel in large B cell lymphoma ineligible for autologous stem cell transplantation: the phase 2 ALYCANTE trial
Axicabtagene ciloleucel in large B cell lymphoma ineligible for autologous stem cell transplantation: the phase 2 ALYCANTE trial
Axicabtagene ciloleucel (axi-cel) demonstrated superior efficacy compared to standard of care as second-line therapy in pa...
Optimized glycemic control of type 2 diabetes with reinforcement learning: a proof-of-concept trial
Optimized glycemic control of type 2 diabetes with reinforcement learning: a proof-of-concept trial
The personalized titration and optimization of insulin regimens for treatment of type 2 diabetes (T2D) are resource-demand...
Amivantamab plus lazertinib in osimertinib-relapsed EGFR-mutant advanced non-small cell lung cancer: a phase 1 trial
Amivantamab plus lazertinib in osimertinib-relapsed EGFR-mutant advanced non-small cell lung cancer: a phase 1 trial
Patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) often develop resistance ...
Distinct monkeypox virus lineages co-circulating in humans before 2022
Distinct monkeypox virus lineages co-circulating in humans before 2022
The 2022 global mpox outbreak raises questions about how this zoonotic disease established effective human-to-human transm...
Hobbies for mental health
Hobbies for mental health
At a time when global mental health is in crisis, new data support the promotion of hobby engagement at the policy level i...
Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer
Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer
Anthracycline-based chemotherapy is associated with increased subsequent breast cancer (SBC) risk in female childhood canc...
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