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Author Correction: Multi-ancestry polygenic mechanisms of type 2 diabetes
Timothy D. MajarianPresent address: Vertex Pharmaceuticals, Boston, MA, USAThese authors contributed equally: Kirk Smith, ...
A prognostic neural epigenetic signature in high-grade glioma
A prognostic neural epigenetic signature in high-grade glioma
Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited...
Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning
Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning
Precision in the diagnosis of diverse central nervous system (CNS) tumor types is crucial for optimal treatment. DNA methy...
Integrative multi-omics profiling in human decedents receiving pig heart xenografts
Integrative multi-omics profiling in human decedents receiving pig heart xenografts
In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence...
Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial
Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial
Clinical outcomes of catheter ablation for atrial fibrillation (AF) are suboptimal due, in part, to challenges in achievin...
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
p75 neurotrophin receptor (p75NTR) signaling pathways substantially overlap with degenerative networks active in Alzheimer...
Prevalence of comorbidities in individuals with neurodevelopmental disorders from the aggregated phenomics data of 51,227 pediatric individuals
Prevalence of comorbidities in individuals with neurodevelopmental disorders from the aggregated phenomics data of 51,227 pediatric individuals
The prevalence of comorbidities in individuals with neurodevelopmental disorders (NDDs) is not well understood, yet these ...
Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants
Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants
A leading explanation for translational failure in neurodegenerative disease is that new drugs are evaluated late in the d...
Effectiveness of Bariatric Metabolic Surgery versus Glucagon-Like Peptide-1 Receptor Agonists for prevention of Congestive Heart Failure
Comparative evidence for the effects of bariatric metabolic surgery (BMS) and glucagon-like peptide-1 receptor agonists (G...
The evolution of personalized nutrition
The evolution of personalized nutrition
Data from a large randomized trial show that a personalized diet can improve cardiometabolic health, providing support for...
Heat exposure induced risks of preterm birth mediated by maternal hypertension
Heat exposure induced risks of preterm birth mediated by maternal hypertension
Heat exposure is associated with an increased risk of preterm birth (PTB), with previous work suggesting that maternal blo...
Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial
Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial
Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors as maintenance therapy after first-line chemotherapy have ...
Studying paired patient tissue and blood enables insights into immunotherapy toxicity
Studying paired patient tissue and blood enables insights into immunotherapy toxicity
Using single-cell RNA and T cell receptor sequencing along with microscopy, we identified the cell types and genes associa...
Gene therapy trials deliver double win
Gene therapy trials deliver double win
Final results of two studies — whose preliminary data led to regulatory approval of the gene therapy exagamglogene autotem...
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis
Immune checkpoint inhibitor (ICI) therapy has revolutionized oncology, but treatments are limited by immune-related advers...
Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans
These authors jointly supervised this work: Rachel L. Kember, Henry R. Kranzler.Mental Illness Research, Education and Cli...
Using AI to improve medication safety
Using AI to improve medication safety
Large language models can translate the archaic language of pharmacy prescriptions into plain English, but reducing medica...
BiTE therapy for rheumatoid arthritis
BiTE therapy for rheumatoid arthritis
A pilot study suggests that the bispecific T cell engager blinatumomab may provide a new therapy for patients with refract...
Adequate information about clinical trial results must be given to participants
The lay summary of trial results to be provided to participants should be written in plain language, use infographics and ...
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution
The World Health Organization framework for tracking SARS-CoV-2 variants has been updated to reflect the continued evoluti...
Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial
Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial
Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for he...
APOE4 homozygosity is a new genetic form of Alzheimer’s disease
APOE4 homozygosity is a new genetic form of Alzheimer’s disease
New data confirm that APOE4 homozygosity is a major genetic cause of Alzheimer’s disease, warranting the development...
APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease
APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical,...
Pemigatinib in previously treated solid tumors with activating FGFR1–FGFR3 alterations: phase 2 FIGHT-207 basket trial
Pemigatinib in previously treated solid tumors with activating FGFR1–FGFR3 alterations: phase 2 FIGHT-207 basket trial
Fibroblast growth factor receptor (FGFR) alterations drive oncogenesis in multiple tumor types. Here we studied pemigatini...
A hierarchical kidney outcome using win statistics in patients with heart failure from the DAPA-HF and DELIVER trials
A hierarchical kidney outcome using win statistics in patients with heart failure from the DAPA-HF and DELIVER trials
Win statistics offer a new approach to the analysis of outcomes in clinical trials, allowing the combination of time-to-ev...
Exome sequencing in a Chinese cohort of children with cerebral palsy identifies likely pathogenic variants
Exome sequencing in a Chinese cohort of children with cerebral palsy identifies likely pathogenic variants
Exome-sequencing analysis in a Chinese cohort of 1,578 children with cerebral palsy established a genetic etiology in 387 ...
The future of brain–computer interfaces in medicine
The future of brain–computer interfaces in medicine
Growing interest in non-invasive brain–computer interfaces, rather than implants, might improve accessibility for patients...