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What will it take to make precision health a global reality
As healthcare becomes more data-driven and precise, promising greater accuracy, targeted use of resources and healthier po...
Disrupted neural rhythms predict response in deep brain stimulation for OCD
Disrupted neural rhythms predict response in deep brain stimulation for OCD
Ventral striatal activity in individuals with OCD has strong circadian periodicity and high predictability in the severely...
Sleep patterns and risk of chronic disease as measured by long-term monitoring with commercial wearable devices in the All of Us Research Program
Sleep patterns and risk of chronic disease as measured by long-term monitoring with commercial wearable devices in the All of Us Research Program
Poor sleep health is associated with increased all-cause mortality and incidence of many chronic conditions. Previous stud...
Integrated image-based deep learning and language models for primary diabetes care
Integrated image-based deep learning and language models for primary diabetes care
Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage ...
Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist
Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist
Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison ...
Author Correction: A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma
Author Correction: A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma
These authors contributed equally: Lisa Kinget, Stefan Naulaerts.Laboratory of Experimental Oncology, KU Leuven, Leuven, B...
A life-course multisectoral approach to precision health in LMICs
A life-course multisectoral approach to precision health in LMICs
Precision health in low- and middle-income countries should focus on disease prevention and implementation in order to be ...
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus
Global emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b viruses, and their transmission to dairy ...
Challenges to identifying risk versus protective factors in Alzheimer’s disease
Authors and AffiliationsDepartment of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, ItalyChiara Pap...
Reply to: Challenges to identifying risk versus protective factors in Alzheimer’s disease
Competing interests S.C.J. has served at scientific advisory boards for ALZPath,...
The capacity of brain circuits to enhance psychiatry
The capacity of brain circuits to enhance psychiatry
Circuitry-based neuroimaging analyses can enhance our understanding of abnormal brain functioning in patients with major d...
Walking alleviates lower back pain
Walking alleviates lower back pain
A randomized trial shows that a low-cost, accessible, walking-based intervention reduced low-back-pain recurrence, and cou...
Revised criteria for the diagnosis and staging of Alzheimer’s disease
Revised criteria for the diagnosis and staging of Alzheimer’s disease
Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, promptin...
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-paramet...
Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial
Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial
Immunotherapy combined with chemotherapy regimen has been shown to be effective in recurrent or metastatic (R/M) head and ...
AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient
AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient
There are more than 10,000 individual rare diseases and most are without therapy. Personalized genetic therapy represents ...
Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Supplementation with CBM588, a bifidogenic live bacterial product, has been associated with improved clinical outcomes in ...
The limits of fair medical imaging AI in real-world generalization
The limits of fair medical imaging AI in real-world generalization
As artificial intelligence (AI) rapidly approaches human-level performance in medical imaging, it is crucial that it does ...
A malaria drug could help treat polycystic ovary syndrome
A malaria drug could help treat polycystic ovary syndrome
Artemisinin treatment alleviated the symptoms of PCOS in animal models and in 19 patients recruited to a pilot clinical tr...
Navigating the health frontiers of Africa’s climate challenge
Navigating the health frontiers of Africa’s climate challenge
Fortunate Machingura heads CeSHHAR Zimbabwe’s Climate, Environment, and Health Department and is also a lecturer at ...
Effects of semaglutide with and without concomitant SGLT2 inhibitor use in participants with type 2 diabetes and chronic kidney disease in the FLOW trial
People with type-2-diabetes (T2D) and chronic kidney disease (CKD), have a high risk for kidney failure and cardiovascular...
Author Correction: Inhibition of lysine acetyltransferase KAT6 in ER+HER2− metastatic breast cancer: a phase 1 trial
National Cancer Center Hospital East, Kashiwa, JapanToru MukoharaSamsung Medical Center, Sungkyunkwan University School of...
Long COVID research in minority ethnic populations may be lost in translation
Competing interests K.K. was chair of the ethnicity subgroup of the UK Scientifi...
Making diabetes technology accessible to all
Making diabetes technology accessible to all
As diabetes technology evolves, implementation of equitable, sustainable, remote patient monitoring will ensure that this ...
A portable thermal ablation device for cervical cancer prevention in a screen-and-treat setting: a randomized, noninferiority trial
A portable thermal ablation device for cervical cancer prevention in a screen-and-treat setting: a randomized, noninferiority trial
Implementing standard-of-care cryotherapy or electrosurgical excision to treat cervical precancers is challenging in resou...
Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes
Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes
The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent due in part to the complexity o...
Adaptive selection at G6PD and disparities in diabetes complications
Adaptive selection at G6PD and disparities in diabetes complications
Diabetes complications occur at higher rates in individuals of African ancestry. Glucose-6-phosphate dehydrogenase deficie...
Meet the PrEP ambassadors who use social media to combat HIV
Meet the PrEP ambassadors who use social media to combat HIV
African nations now lead the world in the rollout of pre-exposure prophylaxis against HIV — in part thanks to social...
Estimating the total effect of anthropogenic climate change on human health and wellbeing
In a recent World View in Nature Medicine, Carlson1 reinforces the value of estimating the global human health burden of a...
Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment
Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment
In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through accurate assessment of minimal ...
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