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Genomic and transmission dynamics of the 2024 Marburg Virus Outbreak in Rwanda
The ongoing outbreak of Marburg virus disease (MVD) in Rwanda marks the third largest historically, though it has exhibite...
Long-acting PrEP prevents HIV in women
Long-acting PrEP prevents HIV in women
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The harms of ultra-processed foods
The harms of ultra-processed foods
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First tumor-agnostic approval for an ADC
In April, the HER2-targeting antibody–drug conjugate (ADC) trastuzumab deruxtecan was granted accelerated approval by the ...
Multi-organ benefits of incretin agonists
Following successful clinical trials and approvals for weight loss, accumulating evidence reported this year supports posi...
From clinical to biological definitions of neurological diseases
February saw the release of revised criteria for the diagnosis and staging of Alzheimer’s disease (AD) by the Alzheimer’s ...
AlphaFold gets an upgrade (and a Nobel)
AlphaFold, the artificial intelligence tool developed by Google DeepMind to predict protein structure, marked a watershed ...
Stem cells reverse type 1 diabetes
For decades, researchers have tried to harness autologous, pluripotent stem cells to replace lost or damaged tissues in th...
Health impacts of microplastic exposure
Microplastics and nanoplastics (MNPs) are everywhere — the oceans, air, soil and food supply — but evidence of their effec...
Publisher Correction: Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial
Breast Center, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Munich, LMU University Hospital, Munic...
Identification of distinct types of steatotic liver disease with specific clinical trajectories
Identification of distinct types of steatotic liver disease with specific clinical trajectories
In a cluster analysis study, we identified two types of metabolic dysfunction-associated steatotic liver disease (MASLD) c...
Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease
Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) exhibits considerable variability in clinical outcomes. I...
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an excess of lipids, mainly triglycer...
Vascular cells of blood vessels and organs across the human body
Vascular cells of blood vessels and organs across the human body
The vascular system has many different functions across the human body beyond its role in oxygen and nutrient transport. W...
How big data can improve women’s health
How big data can improve women’s health
Health data should measure the complexity of women’s lives.
Seven unanswered questions about blockbuster weight-loss drugs
Seven unanswered questions about blockbuster weight-loss drugs
Nature Medicine asks experts to explain the research priorities for the field of GLP-1 receptor agonists such as semagluti...
Declaration of Helsinki embraces health equity
The updated Declaration of Helsinki empowers ethics committees to require community engagement and equitable partnerships
Hypothalamic deep brain stimulation augments walking after spinal cord injury
Hypothalamic deep brain stimulation augments walking after spinal cord injury
A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces...
Internet use linked to better mental health in older adults
Internet use linked to better mental health in older adults
According to a large international study, Internet use among adults 50 or more years of age correlates with reduced depres...
Genetic basis of early onset and progression of type 2 diabetes in South Asians
Genetic basis of early onset and progression of type 2 diabetes in South Asians
South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for...
Early readout shows promise of genomic newborn screening
Early readout shows promise of genomic newborn screening
Interim results from a large, ongoing study shows that genomic newborn screening identifies treatable conditions that woul...
Lifestyle interventions for cardiometabolic health
Lifestyle interventions for cardiometabolic health
Unhealthy lifestyle behaviors such as poor diets and physical inactivity account for most of the cardiometabolic disease (...
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
A prospective, multicenter study of patients hospitalized with COVID-19 demonstrates objective global cognitive impairment...
Editorial Expression of Concern: Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
The editors would like to alert the readers that concerns have been raised regarding some of the data presented in the fig...
High-resolution spatial multiomic census of the human placenta
High-resolution spatial multiomic census of the human placenta
The placenta has an essential role in maintaining a successful pregnancy, yet its molecular composition and functions rema...
An organotypic atlas of human vascular cells
The human vascular system, comprising endothelial (EC) and mural cells, covers a vast surface area in the body, providing ...
Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases
These authors contributed equally: Daniel E. Coral, Femke Smit, Ali Farzaneh.Genetic and Molecular Epidemiology Unit, Lund...
Using tumor DNA methylomes to predict cancer metastasis to the brain
Using tumor DNA methylomes to predict cancer metastasis to the brain
Metastatic spread of cancer to the brain has a devastating effect on patient outcomes, yet identifying patients who will d...
Obesity predisposes to specific cancer driver mutations
Obesity predisposes to specific cancer driver mutations
A large-scale genomic analysis reveals associations between body mass index and certain driver mutations in various cancer...
Citizen science as an instrument for women’s health research
Citizen science as an instrument for women’s health research
Women’s health research is receiving increasing attention globally, but considerable knowledge gaps remain. Across m...