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Signal-to-noise ratio to assess magnitude, kinetics and impact on pharmacokinetics of the immune response to an adalimumab biosimilar
Signal-to-noise ratio to assess magnitude, kinetics and impact on pharmacokinetics of the immune response to an adalimumab biosimilar
Background: The antidrug antibody (ADA) signal-to-noise (S/N) ratio was explored as a novel immunogenicity measure to eval...
Quality control of psychoactive substances in human breastmilk samples from a human milk bank by disposable pipette extraction–gas chromatography–mass spectrometry
Quality control of psychoactive substances in human breastmilk samples from a human milk bank by disposable pipette extraction–gas chromatography–mass spectrometry
The lack of data regarding infant exposure to drugs of abuse consumed by lactating mothers has become a major health conce...
Development and validation of a UPLC–MS/MS method for determination of SYHA1807 in a first-in-human study
Development and validation of a UPLC–MS/MS method for determination of SYHA1807 in a first-in-human study
Background: SYHA1807 is a novel lysine specific demethylase 1 inhibitor being developed for the treatment of small-cell lu...
Bioanalysis of six antibiotics from volumetric microsamples: a new tool for precision dosing in critically ill children
Bioanalysis of six antibiotics from volumetric microsamples: a new tool for precision dosing in critically ill children
Background: Volumetric absorptive microsamples (VAMS) can support pharmacokinetic / pharmacodynamic studies. We present th...
Development, validation and application of a liquid chromatography–tandem mass spectrometry method for quantifying lurasidone in dried blood spot samples
Development, validation and application of a liquid chromatography–tandem mass spectrometry method for quantifying lurasidone in dried blood spot samples
Background: A liquid chromatography–tandem mass spectrometry method for quantifying lurasidone in rat dried blood spot (DB...
A singlicate immunogenicity method to detect anti-polyethylene glycol antibodies: pre- and post-dose of PEGylated therapies
A singlicate immunogenicity method to detect anti-polyethylene glycol antibodies: pre- and post-dose of PEGylated therapies
Aim: Preexisting anti-polyethylene glycol (PEG) antibodies (APAs) may affect the efficacy and safety of PEGylated compound...
Challenges and current advances in the methodology of thyroglobulin measurements
Challenges and current advances in the methodology of thyroglobulin measurements
Thyroglobulin (Tg) is a large protein secreted exclusively by the thyroid gland. In a clinical setting, it is measured for...
Meet the Editorial Board – an interview with Min Meng and transitions from small regional labs to global CRO
Meet the Editorial Board – an interview with Min Meng and transitions from small regional labs to global CRO
Min Meng received her PhD in biomedicinal chemistry from the School of Pharmacy, University of Maryland, in 1996. From 199...
Metabolite identification and quantitation of RBD1016 siRNA: a direct comparison of hybridization-based LC-FD and LC-HRAM assays
Metabolite identification and quantitation of RBD1016 siRNA: a direct comparison of hybridization-based LC-FD and LC-HRAM assays
Aim: RBD1016 is an N-acetylgalactosamine-conjugated siRNA drug currently in a phase II trial for treatment of chronic hepa...
Biomonitoring of arsenic, lead, manganese and mercury in hair from a presumably exposed Uruguayan child population
Biomonitoring of arsenic, lead, manganese and mercury in hair from a presumably exposed Uruguayan child population
Aim: To perform an exposure assessment of arsenic, manganese, mercury and lead levels in hair samples from children from p...
An eco-friendly ultra-performance liquid chromatography–mass spectrometry method for quantification of rivaroxaban and ticagrelor in rat plasma: grapefruit interactions
An eco-friendly ultra-performance liquid chromatography–mass spectrometry method for quantification of rivaroxaban and ticagrelor in rat plasma: grapefruit interactions
Aim: An eco-friendly ultra-performance liquid chromatography–tandem mass spectrometry method was developed to study the ph...
Conference report for the 10th China Bioanalysis Forum annual meeting
Conference report for the 10th China Bioanalysis Forum annual meeting
The 10th China Bioanalysis Forum annual conference was held in Suzhou between 9 and 11 June 2023. This year a full range o...
Running the assay of 2023 and introducing Bioanalysis volume 16
Running the assay of 2023 and introducing Bioanalysis volume 16
J Lodge is the Managing Editor of Bioanalysis and an employee of Newlands Press Ltd. The author has no other relevant affi...
Considerations in designing and implementing a bioanalytical contract research organization key performance indicator system
Considerations in designing and implementing a bioanalytical contract research organization key performance indicator system
The author has no financial involvement with any organization or entity with a financial interest in or financial conflict...
Validation of low-volume sampling devices for pharmacokinetic analysis: technical and logistical challenges and solutions
Validation of low-volume sampling devices for pharmacokinetic analysis: technical and logistical challenges and solutions
While low-volume sampling technologies offer numerous advantages over venipuncture, implementation in clinical trials pose...
Highlights of the 14th Japan Bioanalysis Forum Symposium
Highlights of the 14th Japan Bioanalysis Forum Symposium
The 14th Japan Bioanalysis Forum Symposium was held at Tower Hall Funabori, Japan from 1–3 March 2023. The conference them...
Decentralized clinical trial design using blood microsampling technology for serum bioanalysis
Decentralized clinical trial design using blood microsampling technology for serum bioanalysis
Background: Alternatives to phlebotomy in clinical trials increase options for patients and clinicians by simplifying and ...
Fabry disease biomarkers in patients switched from enzyme replacement therapy to migalastat oral chaperone therapy
Fabry disease biomarkers in patients switched from enzyme replacement therapy to migalastat oral chaperone therapy
Background: A biomarker profile was evaluated longitudinally in patients with Fabry disease switched from enzyme replaceme...
A new method for the therapeutic drug monitoring of chlorpromazine in plasma by gas chromatography–mass spectrometry using dispersive liquid–liquid microextraction
A new method for the therapeutic drug monitoring of chlorpromazine in plasma by gas chromatography–mass spectrometry using dispersive liquid–liquid microextraction
Background: Chlorpromazine is the first antipsychotic drug developed and is included in the list of ‘essential drugs’ prep...
Measurement of free fraction, total concentration and protein binding for testosterone, triiodothyronine and thyroxine
Measurement of free fraction, total concentration and protein binding for testosterone, triiodothyronine and thyroxine
Aims: Measuring the total and free concentrations of hormones is useful, but the technology to do this simultaneously is l...
Development and validation of reversed-phase-HPLC method for simultaneous quantification of fulvestrant and disulfiram in liposomes
Development and validation of reversed-phase-HPLC method for simultaneous quantification of fulvestrant and disulfiram in liposomes
This study aims to develop and validate an HPLC technique for the determination of fulvestrant and disulfiram in liposomes...
Aptasensors: employing molecular probes for precise medical diagnostics and drug monitoring
Aptasensors: employing molecular probes for precise medical diagnostics and drug monitoring
Accurate detection and monitoring of therapeutic drug levels are vital for effective patient care and treatment management...
SPE of gallic acid and ascorbic acid in fruits using polymerized deep eutectic solvent-modified substrate
SPE of gallic acid and ascorbic acid in fruits using polymerized deep eutectic solvent-modified substrate
Aim: Novel substrates were synthesized by porous and nonporous polymerization of deep eutectic solvents on magnetic silica...
Factors contributing to the nonlinear pharmacokinetics of astegolimab: a close examination of potential causes
Factors contributing to the nonlinear pharmacokinetics of astegolimab: a close examination of potential causes
Aim: This paper describes a case study of an antibody therapeutic targeting a membrane-bound receptor, also present in sys...
Empowering peptidomics: utilizing computational tools and approaches
Empowering peptidomics: utilizing computational tools and approaches
Bioinformatics plays a critical role in the advancement of peptidomics by providing powerful tools for data analysis, inte...
The application of capability indices in the validation of ELISA methodology
The application of capability indices in the validation of ELISA methodology
Aim: To investigate the impact of sample replication number (duplicate vs triplicate) on the validation of ELISA methodolo...
Good clinical practices in the bioanalytical laboratory
Good clinical practices in the bioanalytical laboratory
Despite the existence of good clinical practice guidelines, the way in which they are applied to the bioanalytical laborat...
Solid-phase extraction of gallic acid and ascorbic acid in fruits using polymerized deep eutectic solvent-modified substrate
Solid-phase extraction of gallic acid and ascorbic acid in fruits using polymerized deep eutectic solvent-modified substrate
Aim: Novel substrates were synthesized by porous and nonporous polymerization of deep eutectic solvents on magnetic silica...
Quantitative bioanalysis of proteins by digestion and LC–MS/MS: the use of multiple signature peptides
Quantitative bioanalysis of proteins by digestion and LC–MS/MS: the use of multiple signature peptides
The use of multiple signature peptides for the quantification of proteins by digestion and LC–MS/MS is reviewed and evalua...
Pharmacokinetics and toxicity considerations for antibody–drug conjugates: an overview
Pharmacokinetics and toxicity considerations for antibody–drug conjugates: an overview
Antibody–drug conjugates (ADCs) is one of the fastest-growing drug delivery systems. It involves a monoclonal antibody con...
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