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Determination of multicomponents from Zhuanggu Guanjie Capsule in rat plasma by UHPLC–MS/MS and pharmacokinetic study
Determination of multicomponents from Zhuanggu Guanjie Capsule in rat plasma by UHPLC–MS/MS and pharmacokinetic study
Aim: To develop a UHPLC–MS/MS method for the quantification of 12 constituents in rat plasma after oral administration of ...
Chronopharmacokinetics: a critical missing step in drug discovery and development
Chronopharmacokinetics: a critical missing step in drug discovery and development
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial intere...
Advancing the use of molecularly imprinted polymers in bioanalysis: the selective extraction of cotinine in human urine
Advancing the use of molecularly imprinted polymers in bioanalysis: the selective extraction of cotinine in human urine
Aim: To characterize a molecularly imprinted polymer via precipitation polymerization for the extraction of cotinine in ur...
Simultaneous estimation of raloxifene and cladrin by HPLC: application to metabolic stability studies in different species
Simultaneous estimation of raloxifene and cladrin by HPLC: application to metabolic stability studies in different species
Aim: A reliable, sensitive, HPLC method was developed and validated to simultaneously quantify raloxifene (RLX) and cladri...
Effect of chronopharmacology and food on in vivo pharmacokinetic profile of mavacamten
Effect of chronopharmacology and food on in vivo pharmacokinetic profile of mavacamten
Aim: This study investigated the impact of food intake and circadian rhythms on the pharmacokinetics of mavacamten. Materi...
Quantitative chromatographic method development for residual lidocaine in topical systems and biological samples
Quantitative chromatographic method development for residual lidocaine in topical systems and biological samples
Background: The aim of this work was to develop and validate sensitive and efficient analytical methods for estimating sys...
Insights and future trends in bioanalysis: an interview with Jing Tu
Insights and future trends in bioanalysis: an interview with Jing Tu
Jack Lodge, Commissioning Editor of Bioanalysis, and Neil Spooner, Editor in Chief, speak to Jing Tu.
Validated HPLC method for ceftriaxone from dried blood spots for pharmacokinetic studies and therapeutic drug monitoring in neonatal population
Validated HPLC method for ceftriaxone from dried blood spots for pharmacokinetic studies and therapeutic drug monitoring in neonatal population
Background: Pharmacokinetic evaluation is essential for the precise dosing of ceftriaxone in neonates. There is a need for...
Quantification of oxalate by novel LC–MS/MS: assay development, validation and application in lumasiran clinical trials
Quantification of oxalate by novel LC–MS/MS: assay development, validation and application in lumasiran clinical trials
Background: Measurement of plasma oxalate (POx) is challenging, but critical, for management of patients with primary hype...
Label-free immunosensing of telomerase using bio-conjugation of biotinylated antibody to poly(chitosan) gold nanoparticles
Label-free immunosensing of telomerase using bio-conjugation of biotinylated antibody to poly(chitosan) gold nanoparticles
Aim: This study aimed to establish a label-free electrochemical biosensor for telomerase detection in human biofluid. Meth...
Validation of LC–MS/MS methods for quantitative analysis of kynurenine pathway metabolites in human plasma and cerebrospinal fluid
Validation of LC–MS/MS methods for quantitative analysis of kynurenine pathway metabolites in human plasma and cerebrospinal fluid
Background: Dysregulation of the kynurenine metabolic pathway has been reported in several neurological conditions. Method...
Simultaneous assaying of NLG919, tryptophan and kynurenine by ultra-high performance LC–MS in pharmacokinetics and biodistribution studies
Simultaneous assaying of NLG919, tryptophan and kynurenine by ultra-high performance LC–MS in pharmacokinetics and biodistribution studies
Background: Indocyanine2,3-dioxygenase (IDO) is an enzyme that can catalyze the metabolism of tryptophan (Trp) into kynure...
Small extracellular vesicle biomarkers in breast cancer: a real-time snapshot for early diagnosis and prognosis?
Small extracellular vesicle biomarkers in breast cancer: a real-time snapshot for early diagnosis and prognosis?
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial intere...
Real-time in situ monitoring of CRM-197 and polysaccharide conjugation reaction by fluorescence spectroscopy
Real-time in situ monitoring of CRM-197 and polysaccharide conjugation reaction by fluorescence spectroscopy
Aims: Process analytical technology (PAT) is increasingly being adopted within the pharmaceutical industry to build qualit...
Green sample preparation in bioanalysis: where are we now?
Green sample preparation in bioanalysis: where are we now?
This work was supported by a National Institute of Pharmaceutical Education and Research fellowship from the Department of...
Meet the Editorial Board: an introduction to and insights from Fumin Li
Meet the Editorial Board: an introduction to and insights from Fumin Li
Jack Lodge, Commissioning Editor of Bioanalysis, and Neil Spooner, Editor-in-Chief, speak to Fumin Li.
Development of Fe3O4/reduced graphene oxide nanocomposite-based dispersive solid-phase extraction for the quantification of five steroid hormones
Development of Fe3O4/reduced graphene oxide nanocomposite-based dispersive solid-phase extraction for the quantification of five steroid hormones
Aim: An accurate and sensitive analytical method was proposed to detect some steroid hormones in biological samples. Mater...
Characterization of murine lymphocyte activation and exhaustion markers by a 14-color flow cytometry panel
Characterization of murine lymphocyte activation and exhaustion markers by a 14-color flow cytometry panel
Previously designed flow cytometry panels have provided a framework to analyze T-cell activation; however, few provide an ...
Simultaneous assaying of NLG919, tryptophan and kynurenine by ultrahigh performance LC–MS in pharmacokinetics and biodistribution studies
Simultaneous assaying of NLG919, tryptophan and kynurenine by ultrahigh performance LC–MS in pharmacokinetics and biodistribution studies
Background: Indocyanine2,3-dioxygenase (IDO) is an enzyme that can catalyze the metabolism of tryptophan (Trp) into kynure...
Simultaneous determination of four antibiotics in human plasma by high-performance LC–MS/MS: application to therapeutic drug monitoring
Simultaneous determination of four antibiotics in human plasma by high-performance LC–MS/MS: application to therapeutic drug monitoring
Background: Aimed to simultaneously measure linezolid, voriconazole, cefoperazone and fluconazole in human plasma suitable...
Development of a sensitive HPLC method with fluorescence detection for the determination of motilin in human plasma
Development of a sensitive HPLC method with fluorescence detection for the determination of motilin in human plasma
Background: Motilin is a peptide-structured gastrointestinal system hormone. In this study, a sensitive HPLC-fluorescence ...
LC–MS/MS method for the quantitation of OCT1 biomarker isobutyrylcarnitine in human plasma with clinical sample analysis
LC–MS/MS method for the quantitation of OCT1 biomarker isobutyrylcarnitine in human plasma with clinical sample analysis
Aim: Isobutyrylcarnitine (IBC) is a possible biomarker for hepatic OCT1, as IBC plasma concentrations are reduced when OCT...
Novel sorptive microextraction approaches in bioanalysis: the paradigm of endocrine disruptors
Novel sorptive microextraction approaches in bioanalysis: the paradigm of endocrine disruptors
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial intere...
Development and validation of LC–MS/MS method for quantitation of sodium oligomannate in human plasma, urine and feces
Development and validation of LC–MS/MS method for quantitation of sodium oligomannate in human plasma, urine and feces
Background: Sodium oligomannate was approved for marketing by the National Medical Products Administration of China in 201...
Comparison of pharmacokinetic study profiles of insulin in rat plasma through conventional sampling and microsampling by micro-LC–MS/MS
Comparison of pharmacokinetic study profiles of insulin in rat plasma through conventional sampling and microsampling by micro-LC–MS/MS
Aim: With microsamples of blood, full pharmacokinetic profiles from individual animals can be obtained as an alternative t...
Determination of asundexian and its metabolite M-10 in human plasma by LC–MS/MS
Determination of asundexian and its metabolite M-10 in human plasma by LC–MS/MS
Background: The authors present a validated method for the simultaneous quantification of asundexian (BAY 2433334) and its...
Signature peptide selection workflow for biomarker quantification using LC–MS based targeted proteomics
Signature peptide selection workflow for biomarker quantification using LC–MS based targeted proteomics
In contrast to quantification of biotherapeutics, endogenous protein biomarker and target quantification using LC–MS based...
Single-day protein LC–MS bioanalysis: can next-generation trypsins cut it?
Single-day protein LC–MS bioanalysis: can next-generation trypsins cut it?
Aims: The drive toward more sensitive LC–MS assays has resulted in long, complex methods. We assessed next-generation tryp...
Single-analyte biomarker assays for pharmacodynamic or safety assessment during biotherapeutic development
Single-analyte biomarker assays for pharmacodynamic or safety assessment during biotherapeutic development
E Williams is an employee of Future Science Group and Digital Editor of Bioanalysis Zone. The author has no other relevant...
Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF
Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF
Background: An antibody specific to small-molecule inhibitor-bound TNF has enabled the development of target occupancy bio...
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