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Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)
The progressive deregulation of the immune system with age, termed immunosenescence, has been well studied in mammalian sy...
UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis
UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis
The aging lungs are vulnerable to chronic pulmonary diseases; however, the underlying mechanisms are not well understood. ...
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease
Natural antibodies (nAbs) against aggregation-prone proteins have been found in healthy normal subjects. These proteins li...
Glycyrrhizic acid inhibits myeloid differentiation of hematopoietic stem cells by binding S100 calcium binding protein A8 to improve cognition in aged mice
Glycyrrhizic acid inhibits myeloid differentiation of hematopoietic stem cells by binding S100 calcium binding protein A8 to improve cognition in aged mice
Glycyrrhizic acid (GA), a saponin compound often used as a flavoring agent, can elicit anti-inflammatory and anti-tumor ef...
“Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation
“Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation
The loss in age-related immunological markers, known as immunosenescence, is caused by a combination of factors, one of wh...
Higher plasma levels of thymosin-α1 are associated with a lower waning of humoral response after COVID-19 vaccination: an eight months follow-up study in a nursing home
Higher plasma levels of thymosin-α1 are associated with a lower waning of humoral response after COVID-19 vaccination: an eight months follow-up study in a nursing home
Older people achieve lower levels of antibody titers than younger populations after Covid-19 vaccination and show a marked...
Decreased thymic output predicts progression of chronic kidney disease
Decreased thymic output predicts progression of chronic kidney disease
Chronic kidney disease (CKD) is age-related disease, and decreased renal function is associated with the premature aging o...
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging
Chronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-...
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals
Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and mortality. Little is known about the facto...
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We sho...
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults
Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frai...
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease
The diffuse distribution of nicotinic cholinergic receptors (nAChRs) in both brain and peripheral immune cells points out ...
Immunosenescence and inflammaging in the aged horse
Immunosenescence and inflammaging in the aged horse
The equine population in the United States and worldwide now includes a higher percentage of geriatric horses than ever pr...
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study
Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition,...
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging
CD8+ T cells play an important role in host defense against infections and malignancies as well as contribute to the devel...
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice
Obesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the dev...
Phenotypic and functional alterations of monocyte subsets with aging
Phenotypic and functional alterations of monocyte subsets with aging
It has been widely accepted that monocytes are one of the central mediators contributing to inflammaging. However, it rema...
MicroRNAs: a crossroad that connects obesity to immunity and aging
MicroRNAs: a crossroad that connects obesity to immunity and aging
Obesity is characterized by an elevated amount of fat and energy storage in the adipose tissue (AT) and is believed to be ...
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients
The risk for symptomatic COVID-19 requiring hospitalization is higher in the older population. The course of the disease i...
Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study
Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study
Systemic chronic inflammation occurs with age. The association of the leukocyte mitochondrial DNA copy number, a measure o...
Correction: The oldest unvaccinated Covid-19 survivors in South America
Correction: The oldest unvaccinated Covid-19 survivors in South America
Mateus V. de Castro, Monize V. R. Silva, Erick C. Castelli and Keity S. Santos contributed equally to this work.Human Geno...
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis
Traumatic injury elicits a hyperinflammatory response and remodelling of the immune system leading to immuneparesis. This ...
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis
The sequestering of oxidation-modified low-density lipoprotein by macrophages results in the accumulation of fatty deposit...
The diseased kidney: aging and senescent immunology
The diseased kidney: aging and senescent immunology
Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily cha...
The oldest unvaccinated Covid-19 survivors in South America
The oldest unvaccinated Covid-19 survivors in South America
Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians...
Immunosenescence in Caenorhabditis elegans
Immunosenescence in Caenorhabditis elegans
Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from in...
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by the novel severe acute respiratory syndr...
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium
Regulation of endometrial (EM) CD8+ T cells, which provide protection through cell-mediated cytotoxicity, is essential for...
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats
Statins have been widely used to prevent cardiovascular disease in middle-aged and elderly populations; however, the effec...
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults
Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction i...
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