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Immune cell phenotypes and mortality in the Framingham Heart Study
Immune cell phenotypes and mortality in the Framingham Heart Study
Global life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts th...
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau path...
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD)...
The role of blood related inflammatory factors on age-related macular degeneration (AMD)
The role of blood related inflammatory factors on age-related macular degeneration (AMD)
Age-related macular degeneration (AMD) is a significant retinal disease that leads to irreversible low vision, particularl...
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
Research has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, ...
Correction: The interplay between obesity, immunosenescence, and insulin resistance
Correction: The interplay between obesity, immunosenescence, and insulin resistance
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. ...
Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice
Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice
Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including anti...
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized ...
The effect of T cell aging on the change of human tissue structure
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Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities ...
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to...
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity of the immune syst...
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so cal...
Immune aging in annual killifish
Immune aging in annual killifish
Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hall...
Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients
Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients
Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including a...
The role of NLRP3 inflammasome in aging and age-related diseases
The role of NLRP3 inflammasome in aging and age-related diseases
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human heal...
The interplay between obesity, immunosenescence, and insulin resistance
The interplay between obesity, immunosenescence, and insulin resistance
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metaboli...
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Individual aged with various change in cell and cellular microenvironments and the skeletal system undergoes physiological...
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis
Age-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important ...
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence
Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be ...
Accelarated immune ageing is associated with COVID-19 disease severity
Accelarated immune ageing is associated with COVID-19 disease severity
The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related r...