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Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction
Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction
The function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory comp...
Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics
Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics
The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and ...
Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer’s disease
Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer’s disease
Neutrophils play an essential role in Alzheimer’s disease (AD) pathology. However, the extent of their heterogeneity...
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice
Age > 65 years is a key risk factor for poor outcomes after human influenza infection. Specifically, in...
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan
The magnitude and durability of cell-mediated immunity in older and severely frail individuals following coronavirus disea...
Single-cell landscape of immunological responses in elderly patients with sepsis
Single-cell landscape of immunological responses in elderly patients with sepsis
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenes...
Immune cell phenotypes and mortality in the Framingham Heart Study
Immune cell phenotypes and mortality in the Framingham Heart Study
Global life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts th...
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau path...
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort
The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD)...
The role of blood related inflammatory factors on age-related macular degeneration (AMD)
The role of blood related inflammatory factors on age-related macular degeneration (AMD)
Age-related macular degeneration (AMD) is a significant retinal disease that leads to irreversible low vision, particularl...
Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection
Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection
Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci...
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
An elevated neutrophil–lymphocyte ratio (NLR) in blood has been associated with Alzheimer’s disease (AD). Howe...
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
Research has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, ...
Correction: The interplay between obesity, immunosenescence, and insulin resistance
Correction: The interplay between obesity, immunosenescence, and insulin resistance
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. ...
Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice
Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice
Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including anti...
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly...
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized ...
Correction: The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT
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The effect of T cell aging on the change of human tissue structure
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Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution
The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities ...
B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice
B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice
Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signa...
Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer’s disease and vascular dementia in a prospective study
Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer’s disease and vascular dementia in a prospective study
It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiova...
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to...
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity of the immune syst...
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so cal...
Immune aging in annual killifish
Immune aging in annual killifish
Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hall...
Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients
Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients
Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including a...
The role of NLRP3 inflammasome in aging and age-related diseases
The role of NLRP3 inflammasome in aging and age-related diseases
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human heal...
The interplay between obesity, immunosenescence, and insulin resistance
The interplay between obesity, immunosenescence, and insulin resistance
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metaboli...
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