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Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy
People living with HIV (PLHIV) demonstrate accelerated aging and immunosenescence in spite of immune-restoration following...
The role of autoantibodies in bridging obesity, aging, and immunosenescence
The role of autoantibodies in bridging obesity, aging, and immunosenescence
Antibodies are essential to immune homeostasis due to their roles in neutralizing pathogenic agents. However, failures in ...
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults
Memory responses to the antigens that an individual encounters throughout life may vary with the intensity and duration of...
Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling
Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling
Decline in immune function with age has been studied extensively, but approaches to immune restoration have been hampered ...
Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy
Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy
Immunotherapy with checkpoint inhibition (ICI) is increasingly prescribed to older patients with cancer. High age, especia...
Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation
Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation
MicroRNAs (miRNAs) play crucial roles in regulating inflammation and cellular senescence. Among them, miR-146a has emerged...
Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats
Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats
Cognitive decline is a critical hallmark of brain aging. Although aging is a natural process, there is significant heterog...
Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection
Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection
Ageing is a major risk factor that contributes to increased mortality and morbidity rates during influenza A virus (IAV) i...
p16Ink4a-induced senescence in cultured mast cells as a model for ageing reveals significant morphological and functional changes
p16Ink4a-induced senescence in cultured mast cells as a model for ageing reveals significant morphological and functional changes
Mast cells (MCs) are tissue resident cells of the immune system, mainly known for their role in allergy. However, mounting...
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging
In the last forty years, the number of people over 60 years of age has increased significantly owing to better nutrition a...
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis
The circulatory peripheral immune system is the most convenient approach for determining an individual’s immune stat...
Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process
Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process
The immune system undergoes progressive functional remodeling from neonatal stages to old age. Therefore, understanding ho...
Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages
Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages
Previous research has indicated that extracellular vesicles (EVs) potentially play significant roles in multiple ageing ph...
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)
Historical survey confirms that, over the latter part of the 20th century, autoimmune-based diseases, including multiple s...
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway
Systemic lupus erythematosus (SLE) is an autoimmune disorder that commonly affects the skin, kidneys, joints, and various ...
Association between serum IgM and all-cause mortality risk in Chinese centenarians: a prospective cohort study
Association between serum IgM and all-cause mortality risk in Chinese centenarians: a prospective cohort study
We investigated the associations between IgM, IgG, IgA, and IgE levels and all-cause mortality risk in Chinese centenarian...
Health characteristics associated with persistence of SARS-CoV-2 antibody responses after repeated vaccinations in older persons over time: the Doetinchem cohort study
Health characteristics associated with persistence of SARS-CoV-2 antibody responses after repeated vaccinations in older persons over time: the Doetinchem cohort study
Older persons elicit heterogeneous antibody responses to vaccinations that generally are lower than those in younger, heal...
Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
Systemic inflammation significantly increases the risk of short- and long-term mortality in geriatric hospitalized patient...
Monocyte-driven inflamm-aging reduces intestinal barrier function in females
Monocyte-driven inflamm-aging reduces intestinal barrier function in females
The intestinal barrier encompasses physical and immunological components that act to compartmentalize luminal contents, su...
Association of adipose tissue inflammation and physical fitness in older adults
Association of adipose tissue inflammation and physical fitness in older adults
An active lifestyle is of key importance for reduction of obesity and inflammation, as well as circulating levels of adipo...
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults
Previous research has shown that repeated COVID-19 mRNA vaccination leads to a marked increase of SARS-CoV-2 spike-specifi...
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes
Most insects are poikilotherms and ectotherms, so their body temperature is predicated by environmental temperature. With ...
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells
Ageing is associated with an increased risk of lung infection and chronic inflammatory lung disease. Innate immune respons...
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses
Aging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of infl...
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway
Natural killer (NK) cells are crucial innate immune cells that provide defense against viruses and tumors. However, aging ...
Correction: Heat‑killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans
Correction: Heat‑killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna
Mouse brains can contain specific polyglucosan aggregates known as Periodic Acid-Schiff (PAS)-granules. Generated in astro...
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice
Aging is a complex biological process characterized by obesity and immunosenescence throughout the organism. Immunosenesce...
Harnessing immunomodulation to combat sarcopenia: current insights and possible approaches
Harnessing immunomodulation to combat sarcopenia: current insights and possible approaches
Sarcopenia is a complex age-associated syndrome of progressive loss of muscle mass and strength. Although this condition i...
The immunology of B-1 cells: from development to aging
The immunology of B-1 cells: from development to aging
B-1 cells have intricate biology, with distinct function, phenotype and developmental origin from conventional B cells. Th...
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