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Association between body fat distribution and B-lymphocyte subsets in peripheral blood
Association between body fat distribution and B-lymphocyte subsets in peripheral blood
Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circ...
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study
Neutrophils and lymphocytes represent the larger percentage of all white blood cells, they vary with age, with a progressi...
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults
Women/females report more adverse events (AE) following immunization than men/males for many vaccines, including the influ...
Short-term intensive fasting enhances the immune function of red blood cells in humans
Short-term intensive fasting enhances the immune function of red blood cells in humans
Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribu...
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population
Fatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process. However, there is em...
Kinetics of COVID-19 mRNA primary and booster vaccine-associated neutralizing activity against SARS-CoV-2 variants of concern in long-term care facility residents: a prospective longitudinal study in Japan
Kinetics of COVID-19 mRNA primary and booster vaccine-associated neutralizing activity against SARS-CoV-2 variants of concern in long-term care facility residents: a prospective longitudinal study in Japan
Coronavirus disease 2019 (COVID-19) remains a threat to vulnerable populations such as long-term care facility (LTCF) resi...
Systemic immune response in young and elderly patients after traumatic brain injury
Systemic immune response in young and elderly patients after traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary brain ...
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease
More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (A...
Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older
Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older
Seasonal influenza causes significant morbidity and mortality with a disproportionately high disease burden in older adult...
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection
Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous ...
Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor
Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor
Older adults are more vulnerable to seasonal influenza than younger adults. The immune responses of older persons to the i...
Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study
Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study
Evidence has linked self-reported sedentary behavior (SB) and physical activity (PA) with cognitive impairment; however, t...
Obesity accelerates age defects in B cells, and weight loss improves B cell function
Obesity accelerates age defects in B cells, and weight loss improves B cell function
We have previously shown that obesity accelerates age-associated defects in B cell function and antibody production leadin...
Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa
Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa
Immune function in the genital mucosa balances reproduction with protection against pathogens. As women age, genital infec...
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals
Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification...
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2
Since the beginning of SARS-CoV2 pandemic, the mortality rate among elderly patients (60–90 years) has been...
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα
Human aging is characterized by a state of chronic inflammation, termed inflammaging, for which the causes are incompletel...
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial
Adjuvanted inactivated influenza vaccine (aIIV) and high-dose inactivated influenza vaccine (HD-IIV) are U.S.-licensed for...
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans
Progressive age-associated change in frequencies and functional capacities of immune cells is known as immunosenescence. D...
Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines
Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines
Age-associated impairments of immune response and inflammaging likely contribute to poor vaccine efficacy. An appropriate ...
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS
TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyo...
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3
Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4+ T c...
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psych...
Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults
Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults
Dementia and frailty are common age-related syndromes often linked to chronic inflammation. Identifying the biological fac...
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults
Age-related declines in immune response pose a challenge in combating diseases later in life. Influenza (flu) infection re...
12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial
12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial
Age-related accumulation of highly differentiated CD8+ effector memory re-expressing CD45RA (EMRA) T-cells and disruption ...
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging
Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis f...
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice
Current influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development...
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model
Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a cons...
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and dimini...
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