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Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans
Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to...
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study
People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity of the immune syst...
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling
Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so cal...
Immune aging in annual killifish
Immune aging in annual killifish
Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hall...
Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients
Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients
Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including a...
The role of NLRP3 inflammasome in aging and age-related diseases
The role of NLRP3 inflammasome in aging and age-related diseases
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human heal...
The interplay between obesity, immunosenescence, and insulin resistance
The interplay between obesity, immunosenescence, and insulin resistance
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metaboli...
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Individual aged with various change in cell and cellular microenvironments and the skeletal system undergoes physiological...
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis
Age-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important ...
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence
Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be ...
Accelarated immune ageing is associated with COVID-19 disease severity
Accelarated immune ageing is associated with COVID-19 disease severity
The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related r...
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor
The Disposable Soma Theory of aging suggests a trade-off between energy allocation for growth, reproduction and somatic ma...
Neuroimmunology and ageing – the state of the art
Neuroimmunology and ageing – the state of the art
This Topical Collection of papers on Neuroimmunology and Ageing showcases a growing body of work characterizing the comple...
Inflammatory markers and physical frailty: towards clinical application
Inflammatory markers and physical frailty: towards clinical application
Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decrease...
An aging-related immune landscape in the hematopoietic immune system
An aging-related immune landscape in the hematopoietic immune system
Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall p...
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability
Parkinson’s disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the d...
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions
Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downreg...
Blood circulating bacterial DNA in hospitalized old COVID-19 patients
Blood circulating bacterial DNA in hospitalized old COVID-19 patients
Coronavirus disease COVID-19 is a heterogeneous condition caused by SARS-CoV-2 infection. Generally, it is characterized b...
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
Although the concept of declined immune function associated with cancer has been accepted extensively, real-world clinical...
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice
Alzheimer’s disease (AD), which is the most common cause of dementia in elderly individuals, is a progressive neurod...
The effect of metformin on senescence of T lymphocytes
The effect of metformin on senescence of T lymphocytes
Immunosenescence occurs as people age, leading to an increased incidence of age-related diseases. The number of senescent ...
Impact of NAD+ metabolism on ovarian aging
Impact of NAD+ metabolism on ovarian aging
Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-r...
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remai...
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T...
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adver...
Toll-like receptor 4 (TLR4): new insight immune and aging
Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous l...