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The diseased kidney: aging and senescent immunology
The diseased kidney: aging and senescent immunology
Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily cha...
The oldest unvaccinated Covid-19 survivors in South America
The oldest unvaccinated Covid-19 survivors in South America
Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians...
Immunosenescence in Caenorhabditis elegans
Immunosenescence in Caenorhabditis elegans
Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from in...
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by the novel severe acute respiratory syndr...
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium
Regulation of endometrial (EM) CD8+ T cells, which provide protection through cell-mediated cytotoxicity, is essential for...
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats
Statins have been widely used to prevent cardiovascular disease in middle-aged and elderly populations; however, the effec...
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults
Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction i...
Inflammation and cell-to-cell communication, two related aspects in frailty
Inflammation and cell-to-cell communication, two related aspects in frailty
Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes ...
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis
Patients with systemic lupus erythematosus (SLE) are highly susceptible to infection and cardiovascular events, suggesting...
Ageing-resembling phenotype of long-term allogeneic hematopoietic cells recipients compared to their donors
Ageing-resembling phenotype of long-term allogeneic hematopoietic cells recipients compared to their donors
Ageing is a complex phenomenon that leads to decreased proliferative activity, loss of function of the cells, and cellular...
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging
Immune cells infiltrating the central nervous system (CNS) are involved in the defense against invading microbes as well a...
Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal
Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal
Monocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with...
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression
Aging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus makin...
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of b...
Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases
Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases
The world population is progressively ageing, assuming an enormous social and health challenge. As the world ages, neurode...
Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes
Traditionally, the immune system is understood to be divided into discrete cell types that are identified via surface mark...
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches
The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenc...
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study
Cellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related immune phenot...
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity
The aging process can have detrimental effects on the immune system rendering the elderly more susceptible to infectious d...
A subset of gut leukocytes has telomerase-dependent “hyper-long” telomeres and require telomerase for function in zebrafish
A subset of gut leukocytes has telomerase-dependent “hyper-long” telomeres and require telomerase for function in zebrafish
Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to...
Altered transcriptional responses in the lungs of aged mice after influenza infection
Altered transcriptional responses in the lungs of aged mice after influenza infection
Influenza causes a serious infection in older individuals who are at the highest risk for mortality from this virus. Chang...
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp
Grass carp are an important farmed fish in China that are infected by many pathogens, especially grass carp reovirus (GCRV...
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study
Systemic inflammation has been linked to diseases and frailty. However, little is known about the effect of systemic infla...