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Association between body fat distribution and B-lymphocyte subsets in peripheral blood
Association between body fat distribution and B-lymphocyte subsets in peripheral blood
Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circ...
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults
Women/females report more adverse events (AE) following immunization than men/males for many vaccines, including the influ...
Short-term intensive fasting enhances the immune function of red blood cells in humans
Short-term intensive fasting enhances the immune function of red blood cells in humans
Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribu...
Systemic immune response in young and elderly patients after traumatic brain injury
Systemic immune response in young and elderly patients after traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary brain ...
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease
More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (A...
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection
Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous ...
Obesity accelerates age defects in B cells, and weight loss improves B cell function
Obesity accelerates age defects in B cells, and weight loss improves B cell function
We have previously shown that obesity accelerates age-associated defects in B cell function and antibody production leadin...
Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa
Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa
Immune function in the genital mucosa balances reproduction with protection against pathogens. As women age, genital infec...
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals
Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification...
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2
Since the beginning of SARS-CoV2 pandemic, the mortality rate among elderly patients (60–90 years) has been...
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα
Human aging is characterized by a state of chronic inflammation, termed inflammaging, for which the causes are incompletel...
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial
Adjuvanted inactivated influenza vaccine (aIIV) and high-dose inactivated influenza vaccine (HD-IIV) are U.S.-licensed for...
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans
Progressive age-associated change in frequencies and functional capacities of immune cells is known as immunosenescence. D...
Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines
Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines
Age-associated impairments of immune response and inflammaging likely contribute to poor vaccine efficacy. An appropriate ...
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS
TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyo...
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psych...
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults
Age-related declines in immune response pose a challenge in combating diseases later in life. Influenza (flu) infection re...
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging
Morphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis f...
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model
Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a cons...
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and dimini...