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Valproate Administration to Adult 5xFAD Mice Upregulates Expression of Neprilysin and Improves Olfaction and Memory
Valproate Administration to Adult 5xFAD Mice Upregulates Expression of Neprilysin and Improves Olfaction and Memory
It is well known that the development of neurodegeneration, and especially Alzheimer’s disease (AD), is often accomp...
Investigation of Association Between Expression of DYX1C1, KIAA0319, and ROBO1 Genes and Specific Learning Disorder in Children and Adolescents
Investigation of Association Between Expression of DYX1C1, KIAA0319, and ROBO1 Genes and Specific Learning Disorder in Children and Adolescents
Specific learning disorder (SLD) is prevalent worldwide and is a complex disorder with variable symptoms and significant d...
Role and Interplay of Different Signaling Pathways Involved in Sciatic Nerve Regeneration
Role and Interplay of Different Signaling Pathways Involved in Sciatic Nerve Regeneration
Regeneration of the sciatic nerve is a sophisticated process that involves the interplay of several signaling pathways tha...
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy
Mitochondria play a pivotal role in cellular metabolism, energy production, and apoptotic signaling, making mitophagy, the...
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury—An In Vitro Model Approach
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury—An In Vitro Model Approach
Traumatic brain injury (TBI) is caused by an external mechanical force to the head, resulting in abnormal brain functionin...
Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise
Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise
Physical activity has been demonstrated to improve cognitive function, thereby preventing/slowing neurodegenerative diseas...
Molecular and Clinical Characterization of a Cohort of Autosomal Recessive Sensorineural Hearing Loss in Egyptian Patients
Molecular and Clinical Characterization of a Cohort of Autosomal Recessive Sensorineural Hearing Loss in Egyptian Patients
Hearing loss (HL) is one of the most common health problems worldwide. Autosomal recessive non-syndromic sensorineural hea...
A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures
A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures
With the persistent challenge that epilepsy presents to therapeutic avenues, the study seeks to decipher the effe...
The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
Although brain amyloid-β (Aβ) peptide buildup is the main cause of Alzheimer’s disease (AD), mitochondrial...
The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice
The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice
Chromodomain helicase DNA-binding 8 (CHD8) is a gene that poses a high risk for autism spectrum disorder (ASD) and neurolo...
Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets
Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets
Mitochondrion is an important organelle present in our cells responsible for meeting energy requirements. All higher organ...
A Novel Pathogenic Mutation in WNK1 Gene Causing HSAN Type II in Three Siblings
A Novel Pathogenic Mutation in WNK1 Gene Causing HSAN Type II in Three Siblings
Hereditary sensory and autonomic neuropathy (HSAN) is a rare genetic disorder that primarily affects the peripheral nervou...
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
The Inhibition of Reactive Oxygen Species Modulator 1 Attenuates Sevoflurane-Induced Neural Injury via Reducing Apoptosis and Oxidative Stress
Sevoflurane causes neural injury by promoting apoptosis and oxidative stress. Reactive oxygen species modulator 1 (ROMO1) ...
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice
Addressing the intricate challenge of chronic neuropathic pain has significant implications for the physical and psycholog...
Identification of Pathogenic Missense Mutations of NF1 Using Computational Approaches
Identification of Pathogenic Missense Mutations of NF1 Using Computational Approaches
Neurofibromatosis type 1 (NF1) is a prevalent autosomal dominant disorder caused by mutations in the NF1 gene, leading to ...
Exploring the hub Genes and Potential Mechanisms of Complement system-related Genes in Parkinson Disease: Based on Transcriptome Sequencing and Mendelian Randomization
Exploring the hub Genes and Potential Mechanisms of Complement system-related Genes in Parkinson Disease: Based on Transcriptome Sequencing and Mendelian Randomization
An accurate diagnosis of Parkinson’s disease (PD) remains challenging and the exact cause of the disease is unclean....
Investigating the Genetic Association of 40 Biochemical Indicators with Parkinson’s Disease
Investigating the Genetic Association of 40 Biochemical Indicators with Parkinson’s Disease
The mechanisms of Parkinson’s disease (PD) are not fully understood, which hinders the development of effective ther...
Clinical and Molecular Profiles of a Cohort of Egyptian Patients with Collagen VI-Related Dystrophy
Clinical and Molecular Profiles of a Cohort of Egyptian Patients with Collagen VI-Related Dystrophy
Collagen VI-related dystrophies (COL6-RD) display a wide spectrum of disease severity and genetic variability ranging from...
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia
Trigeminal neuralgia (TN) is a severe facial pain disease of uncertain pathophysiology and unclear genetic background. Alt...
The Role of Thioredoxin System in Shank3 Mouse Model of Autism
The Role of Thioredoxin System in Shank3 Mouse Model of Autism
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social interactio...
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
Spinal muscular atrophy (SMA) is a rare degenerative disorder with loss of motor neurons caused by mutations in the SMN1 g...
Lactoferrin Protects Against Rotenone-Induced Toxicity in Dopaminergic SH-SY5Y Cells through the Modulation of Apoptotic-Associated Pathways
Lactoferrin Protects Against Rotenone-Induced Toxicity in Dopaminergic SH-SY5Y Cells through the Modulation of Apoptotic-Associated Pathways
Parkinson’s disease (PD) is a common motor neurodegenerative disease that still lacks effective therapeutic options....
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Chemokine ligands and their receptors have acquired less attention than pro- and anti-inflammatory cytokines in schizophre...
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Endoplasmic reticulum stress (ERS) plays an essential role in the development of traumatic brain injury (TBI). We aimed to...
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
Parkinson’s disease (PD) is characterized by astrocyte activation and disruptions in circadian rhythm. Within the as...
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Cocaine use disorder (CUD) is a chronic neuropsychiatric disorder estimated to effect 1–3% of the population. Activi...
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
The soy isoflavone daidzin (DZN) has been considered a hopeful bioactive compound having diverse biological activities, in...
Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Hippocamposeptal (HS) neurons send GABAergic projections from the hippocampus to the medial septum/diagonal band of Broca ...
Associations Between Gut Microbiota and Alcohol Abuse: A Mendelian Randomisation and Bioinformatics Study
Associations Between Gut Microbiota and Alcohol Abuse: A Mendelian Randomisation and Bioinformatics Study
Alcohol abuse, also known as Alcohol Use Disorder (AUD), is a substance dependency psychiatric disorder. We aimed to estab...
Assessment of Expression of lncRNAs in Autistic Patients
Assessment of Expression of lncRNAs in Autistic Patients
Autism is a severe neurodevelopmental condition with unknown pathobiology. Nevertheless, multiple pieces of evidence sugge...
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