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Brightening the Path: Riboflavin Illuminates Breast Cancer Resistance Protein Monitoring [Viewpoint]
Brightening the Path: Riboflavin Illuminates Breast Cancer Resistance Protein Monitoring [Viewpoint]
The membrane transporter breast cancer resistance protein [BCRP, also known as ATP-binding cassette superfamily G member 2...
A Pilot Study To Assess the Suitability of Riboflavin As a Surrogate Marker of Breast Cancer Resistance Protein in Healthy Participants [Metabolism, Transport, and Pharmacogenetics]
A Pilot Study To Assess the Suitability of Riboflavin As a Surrogate Marker of Breast Cancer Resistance Protein in Healthy Participants [Metabolism, Transport, and Pharmacogenetics]
AbstractWe recently showed that riboflavin is a selected substrate of breast cancer resistance protein (BCRP) over P-glyco...
Mechanistic Chronopharmacology: Preclinical Modeling of an SGLT2 Inhibitor in Preventing Painful Diabetic Neuropathy [Viewpoint]
Mechanistic Chronopharmacology: Preclinical Modeling of an SGLT2 Inhibitor in Preventing Painful Diabetic Neuropathy [Viewpoint]
Several forms of neuropathy caused by diffuse and focal damage to the peripheral and autonomic nervous systems occur in up...
Dosing Time-Dependent Difference in the Suppressive Effect of Empagliflozin on the Development of Mechanical Pain Hypersensitivity in Diabetic Mice [Endocrine and Diabetes]
Dosing Time-Dependent Difference in the Suppressive Effect of Empagliflozin on the Development of Mechanical Pain Hypersensitivity in Diabetic Mice [Endocrine and Diabetes]
AbstractA problem for patients with diabetes is the rise of complications, such as peripheral neuropathy, nephropathy, and...
Special Section on Therapeutic Approaches to Treat Disorders of the Urinary and Gastrointestinal Tracts--Editorial [Editorial]
Special Section on Therapeutic Approaches to Treat Disorders of the Urinary and Gastrointestinal Tracts--Editorial [Editorial]
This Special Section, published in the Journal of Pharmacology and Experimental Therapeutics, collected five manuscripts, ...
Rapid-Onset, Short-Duration Induction of Colorectal Contractions in Anesthetized, Adult, Male Rats [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Rapid-Onset, Short-Duration Induction of Colorectal Contractions in Anesthetized, Adult, Male Rats [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractSubstantial clinical and preclinical evidence indicates that transient receptor potential vanilloid 1 (TRPV1) rece...
Investigating the Mechanisms Underlying U46619-Induced Contraction on Porcine Lower Esophageal Sphincter [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Investigating the Mechanisms Underlying U46619-Induced Contraction on Porcine Lower Esophageal Sphincter [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractGastroesophageal reflux disease (GERD) is associated with an incompetent lower esophageal sphincter (LES), resulti...
Satellite Glial Cells Bridge Sensory Neuron Crosstalk in Visceral Pain and Cross-Organ Sensitization [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
Satellite Glial Cells Bridge Sensory Neuron Crosstalk in Visceral Pain and Cross-Organ Sensitization [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
AbstractFollowing colonic inflammation, the uninjured bladder afferent neurons are also activated. The mechanisms and path...
Nitric Oxide Resistance in Priapism Associated with Sickle Cell Disease: Mechanisms, Therapeutic Challenges, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
Nitric Oxide Resistance in Priapism Associated with Sickle Cell Disease: Mechanisms, Therapeutic Challenges, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
AbstractPatients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the absence of sexual aro...
Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases [Minireview]
Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases [Minireview]
AbstractMAP4K4 is a serine/threonine protein kinase belonging to the germinal center kinase subgroup of sterile 20 protein...
Therapeutic Approaches for Urologic Chronic Pelvic Pain Syndrome; Management: Research Advances, Experimental Targets, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
Therapeutic Approaches for Urologic Chronic Pelvic Pain Syndrome; Management: Research Advances, Experimental Targets, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
AbstractUrologic chronic pelvic pain syndrome (UCPPS) is a painful chronic condition with persistent pain originating from...
AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice [Chemotherapy, Antibiotics, and Gene Therapy]
AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice [Chemotherapy, Antibiotics, and Gene Therapy]
AbstractMutations in the GNAO1 gene, which encodes the abundant brain G-protein Gαo, result in neurologic disorders charac...
Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction [Cardiovascular]
Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction [Cardiovascular]
AbstractSympathetic hyperinnervation is the leading cause of fatal ventricular arrhythmia (VA) after myocardial infarction...
Correction to "NCP, a Dual Kappa and mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties" [Erratum]
Correction to "NCP, a Dual Kappa and mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties" [Erratum]
The above article [Huang P, Ho CK, Cao D, Inan SM, Rawls S, Li M, Huang B, Pagare PP, Townsend EA, Poklis JL, Halquist MS,...
Preclinical Systemic Pharmacokinetics, Dose Proportionality, and Central Nervous System Distribution of the ATM Inhibitor WSD0628, a Novel Radiosensitizer for the Treatment of Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
Preclinical Systemic Pharmacokinetics, Dose Proportionality, and Central Nervous System Distribution of the ATM Inhibitor WSD0628, a Novel Radiosensitizer for the Treatment of Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
AbstractRadiation therapy, a standard treatment option for many cancer patients, induces DNA double-strand breaks (DSBs), ...
Blood Pressure Lowering in Patients with Left Ventricular Hypertrophy - Navigating between Scylla and Charybdis [Viewpoint]
Blood Pressure Lowering in Patients with Left Ventricular Hypertrophy - Navigating between Scylla and Charybdis [Viewpoint]
Ever since the randomized controlled Systolic Blood Pressure Intervention Trial (SPRINT), we have known that targeting a s...
Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy [Cardiovascular]
Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy [Cardiovascular]
AbstractBackground: Recent reports have evidenced an increased mortality rate in hypertensive patients with electrocardiog...
The Evolving Challenge of New Psychoactive Substances: Understanding the Risks and Behavioral Effects of Novel Analogs of Dissociative Anesthetics [Viewpoint]
The Evolving Challenge of New Psychoactive Substances: Understanding the Risks and Behavioral Effects of Novel Analogs of Dissociative Anesthetics [Viewpoint]
New psychoactive substances (NPSs), also known as “designer drugs,” present a rapidly evolving challenge in the global dru...
Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents [Behavioral Pharmacology]
Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents [Behavioral Pharmacology]
AbstractAbuse of novel arylcyclohexylamines (ACX) poses risks for toxicities, including adverse neurocognitive effects. In...
Special Section on Nanotherapeutics in Cancer Research--Editorial [Editorial]
Special Section on Nanotherapeutics in Cancer Research--Editorial [Editorial]
Nanobiomaterials such as peptide-based nanoparticles (NPs), poly(lactic-co-glycolic acid) (PLGA)-based NPs, aluminum salt–...
Neurotoxicity Profiling of Aluminum Salt-Based Nanoparticles as Adjuvants for Therapeutic Cancer Vaccine [Toxicology]
Neurotoxicity Profiling of Aluminum Salt-Based Nanoparticles as Adjuvants for Therapeutic Cancer Vaccine [Toxicology]
AbstractTherapeutic vaccines containing aluminum adjuvants have been widely used in the treatment of tumors due to their p...
Small Peptide-Based Nanodelivery Systems for Cancer Therapy and Diagnosis [Minireview]
Small Peptide-Based Nanodelivery Systems for Cancer Therapy and Diagnosis [Minireview]
AbstractDeveloping nano-biomaterials with tunable topology, size, and surface characteristics has shown tremendously favor...
Immunogenic Treatment of Metastatic Breast Cancer Using Targeted Carbon Nanotube Mediated Photothermal Therapy in Combination with Anti-Programmed Cell Death Protein-1 [Special Section on Nanotherapeutics in Cancer Research]
Immunogenic Treatment of Metastatic Breast Cancer Using Targeted Carbon Nanotube Mediated Photothermal Therapy in Combination with Anti-Programmed Cell Death Protein-1 [Special Section on Nanotherapeutics in Cancer Research]
AbstractThe high prevalence of breast cancer is a global health concern, compounded by the lack of safe or effective treat...
Clinical Advances in Triple Negative Breast Cancer Treatment: Focus on Poly (L-lactide-coglycolide) Nanoparticles [Minireview]
Clinical Advances in Triple Negative Breast Cancer Treatment: Focus on Poly (L-lactide-coglycolide) Nanoparticles [Minireview]
AbstractTriple negative breast cancer (TNBC) is the most aggressive type of breast cancer and is associated with high prob...
Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor {alpha} Do Not Perform Liquid-Liquid Phase Separation in Cells [Cellular and Molecular]
Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor {alpha} Do Not Perform Liquid-Liquid Phase Separation in Cells [Cellular and Molecular]
AbstractConstitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor α (PPARα) are members of the...
Chemotherapeutics-Loaded Poly(Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment [Chemotherapy, Antibiotics, and Gene Therapy]
Chemotherapeutics-Loaded Poly(Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment [Chemotherapy, Antibiotics, and Gene Therapy]
AbstractChemophotothermal therapy is an emerging treatment of metastatic and drug-resistant cancer anomalies. Among variou...
Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractNonsteroidal anti-inflammatory drugs (NSAIDs) possess anti-inflammatory, antipyretic, and analgesic properties and...
Unique Binding Sites of Uricosuric Agent Dotinurad for Selective Inhibition of Renal Uric Acid Reabsorptive Transporter URAT1 [Drug Discovery and Translational Medicine]
Unique Binding Sites of Uricosuric Agent Dotinurad for Selective Inhibition of Renal Uric Acid Reabsorptive Transporter URAT1 [Drug Discovery and Translational Medicine]
AbstractDotinurad was developed as a uricosuric agent, inhibiting urate (UA) reabsorption through the UA transporter URAT1...
High-dose Agomelatine Combined with Haloperidol Decanoate Improves Cognition, Downregulates MT2, Upregulates D5, and Maintains Krüppel-like Factor 9 But Alters Cardiac Electrophysiology [Neuropharmacology]
High-dose Agomelatine Combined with Haloperidol Decanoate Improves Cognition, Downregulates MT2, Upregulates D5, and Maintains Krüppel-like Factor 9 But Alters Cardiac Electrophysiology [Neuropharmacology]
IntroductionOver time, the cholinergic deficiency hypothesis culminating in cognitive and memory disruptions has proven re...
Tauroursodeoxycholic Acid Reverses Dextran Sulfate Sodium-Induced Colitis in Mice via Modulation of Intestinal Barrier Dysfunction and Microbiome Dysregulation [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Tauroursodeoxycholic Acid Reverses Dextran Sulfate Sodium-Induced Colitis in Mice via Modulation of Intestinal Barrier Dysfunction and Microbiome Dysregulation [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractUlcerative colitis (UC) is an immune-mediated inflammatory disease that can lead to persistent damage and even can...
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