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CN1699 Our Business - Guide for Agents
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Special Section on Cannabinoid Signaling in Human Health and Disease--Editorial [Special Section on Cannabinoid Signaling in Human Health and Disease-Editorial]
EditorialSpecial Section on Cannabinoid Signaling in Human Health and Disease—Editorial ...
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Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
AbstractCannabis and its products have been used for centuries for both medicinal and recreational purposes. The recent wi...
Journal Of Pharmacology And Experimental Therapeutics
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Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
AbstractTargeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only...
Journal Of Pharmacology And Experimental Therapeutics
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The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
AbstractThe National Center for Complementary and Integrative Health (NCCIH), which is part of the US National Institutes ...
Journal Of Pharmacology And Experimental Therapeutics
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Gabapentinoids Increase the Potency of Fentanyl and Heroin and Decrease the Potency of Naloxone to Antagonize Fentanyl and Heroin in Rats Discriminating Fentanyl [Behavioral Pharmacology]
AbstractDespite a significant decrease in the number of prescriptions for opioids, the opioid crisis continues, fueled in ...
Journal Of Pharmacology And Experimental Therapeutics
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Effects of Dual Inhibition at Dopamine Transporter and {sigma} Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats [Behavioral Pharmacology]
AbstractPrevious studies demonstrated that sigma receptor (σR) antagonists alone fail to alter cocaine self-administration...
Journal Of Pharmacology And Experimental Therapeutics
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The Potential of Cannabichromene (CBC) as a Therapeutic Agent [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
Cannabichromene Synthesis.Cannabinoids are a class of terpenophenolic compounds obtained by the alkylation of olivetolic a...
Journal Of Pharmacology And Experimental Therapeutics
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Proteomic Analysis of Signaling Pathways Modulated by Fatty Acid Binding Protein 5 (FABP5) in Macrophages [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractAlthough acute inflammation serves essential functions in maintaining tissue homeostasis, chronic inflammation is ...
Journal Of Pharmacology And Experimental Therapeutics
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The Intoxication Equivalency of 11-Hydroxy-{Delta}9-Tetrahydrocannabinol Relative to {Delta}9-Tetrahydrocannabinol [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractΔ9-Tetrahydrocannabinol (THC) is a psychoactive phytocannabinoid found in the Cannabis sativa plant. THC is primar...
Journal Of Pharmacology And Experimental Therapeutics
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Evaluating the Abuse Potential of Lenabasum, a Selective Cannabinoid Receptor 2 Agonist [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractEndocannabinoids, which are present throughout the central nervous system (CNS), can activate cannabinoid receptor...
Journal Of Pharmacology And Experimental Therapeutics
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Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractThe consumption of Δ9-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; ho...
Journal Of Pharmacology And Experimental Therapeutics
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Chronic Administration of Cannabinoid Agonists ACEA, AM1241, and CP55,940 Induce Sex-Specific Differences in Tolerance and Sex Hormone Changes in a Chemotherapy-Induced Peripheral Neuropathy [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractChemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely man...
Journal Of Pharmacology And Experimental Therapeutics
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Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology]
AbstractLow-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relati...
Journal Of Pharmacology And Experimental Therapeutics
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Regulation of Cannabinoid and Opioid Receptor Levels by Endogenous and Pharmacological Chaperones [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractCannabinoid and opioid receptor activities can be modulated by a variety of post-translational mechanisms includin...
Journal Of Pharmacology And Experimental Therapeutics
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{Delta}9-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractPeople with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pai...
Journal Of Pharmacology And Experimental Therapeutics
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Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines [Metabolism, Transport, and Pharmacogenetics]
Proinflammatory cytokines, elevated during inflammation caused by infection and/or autoimmune disorders, result in reduced...
Journal Of Pharmacology And Experimental Therapeutics
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Comparison of the Genomic Activity of an EP4-Receptor and {beta}2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression [Inflammation, Immunopharmacology, and Asthma]
AbstractIt has been proposed that inhaled E-prostanoid 4 (EP4)-receptor agonists could represent a new class of bronchodil...
Journal Of Pharmacology And Experimental Therapeutics
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Levetiracetam Prevents Neurophysiological Changes and Preserves Cognitive Function in the Human Immunodeficiency Virus (HIV)-1 Transactivator of Transcription Transgenic Mouse Model of HIV-Associated Neurocognitive Disorder [Neuropharmacology]
AbstractHuman immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) affects nearly half of the 39 million...
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Lenacapavir Exhibits Atropisomerism--Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway [Metabolism, Transport, and Pharmacogenetics]
AbstractLenacapavir (LEN), a long-acting injectable, is the first approved human immunodeficiency virus type 1 capsid inhi...
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Correction to "Comments on: Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice" [Erratum]
The above article [Brudvig JJ, Tuske S, Castelli J, Weimer JM (2024) J Pharmacol Exp Ther, 389:310–312; DOI: https://doi.o...
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Primaquine-5,6-Orthoquinone Is Directly Hemolytic to Older G6PD Deficient RBCs in a Humanized Mouse Model [Toxicology]
Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia (K.H.D.-C., A.M.H., J.C.Z.);...
Journal Of Pharmacology And Experimental Therapeutics
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Effect of Vascular Senescence on the Efficacy and Safety of Warfarin: Insights from Rat Models and a Prospective Cohort Study [Cardiovascular]
AbstractWarfarin, with its narrow therapeutic range, requires the understanding of various influencing factors for persona...
Journal Of Pharmacology And Experimental Therapeutics
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Methocinnamox is a Potent and Long-Acting Antagonist that can Prevent and Reverse Opioid-Induced Respiratory Depression [Viewpoint]
The latest data from the US Centers for Disease Control and Prevention for opioid overdose deaths puts the number at 84,60...
Journal Of Pharmacology And Experimental Therapeutics
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Comparison of the {mu}-Opioid Receptor Antagonists Methocinnamox and Naloxone to Reverse and Prevent the Ventilatory Depressant Effects of Fentanyl, Carfentanil, 3-Methylfentanyl, and Heroin in Male Rats [Behavioral Pharmacology]
Received November 22, 2023.Accepted February 9, 2024.This work was funded by National Institutes of Health National Instit...
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A "Furious" Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics [Viewpoint]
Research with psychedelic drugs is at an all-time high. A recent (09 Feb 2024) PubMed query for “psychedelic OR hallucinog...
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Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine [Behavioral Pharmacology]
Abstract3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic st...
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The Effects of Eating a Traditional High Fat/High Carbohydrate or a Ketogenic Diet on Sensitivity of Female Rats to Morphine [Behavioral Pharmacology]
AbstractPatients diagnosed with obesity are prescribed opioid medications at a higher rate than the general population; ho...
Journal Of Pharmacology And Experimental Therapeutics
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Aloperine Attenuates Hepatic Ischemia/Reperfusion-Induced Liver Injury via STAT-3 Signaling in a Murine Model [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractHepatic ischemia/reperfusion (I/R) damage is one of the most common side effects of liver surgery. This pathophysi...
Journal Of Pharmacology And Experimental Therapeutics
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Translational Pharmacokinetic-Toxicodynamic Model of Myelosuppression for Dose Optimization in Combination Chemotherapy of Capecitabine and Oxaliplatin from Rats to Humans [Drug Discovery and Translational Medicine]
AbstractXELOX therapy, which comprises capecitabine and oxaliplatin, is the standard first-line chemotherapeutic regimen f...
Journal Of Pharmacology And Experimental Therapeutics
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High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractCannabis sativa L. has a long history of medicinal use, particularly for gastrointestinal diseases. Patients with ...
Journal Of Pharmacology And Experimental Therapeutics
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