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Bath Salts to Therapies: Can Separation of Adverse and Therapeutic Effects of Substituted Cathinones Lead to a Medication for Psychostimulant Use Disorder? [Viewpoint]
Bath Salts to Therapies: Can Separation of Adverse and Therapeutic Effects of Substituted Cathinones Lead to a Medication for Psychostimulant Use Disorder? [Viewpoint]
Cathinone is the main psychoactive compound derived from the leaves of the shrub Khat (Catha edulis). The Khat plant is na...
Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats [Viewpoint]
Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats [Viewpoint]
AbstractSynthetic cathinones are a class of new psychoactive substances that display psychomotor stimulant properties, and...
Assessment of Abuse-Related Discriminative Stimulus Effects of Nicotine Aerosol in Rodents [Behavioral Pharmacology]
Assessment of Abuse-Related Discriminative Stimulus Effects of Nicotine Aerosol in Rodents [Behavioral Pharmacology]
AbstractThe rapid increase in e-cigarette use highlights the importance of developing relevant, predictive animal models e...
Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats [Behavioral Pharmacology]
Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats [Behavioral Pharmacology]
Departments of Pharmaceutics (S.H.K., T.I.K., E.C.B., S.R.R.K., C.R.M., A.S.), Translational Drug Development Core (S.H.K....
TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy [Drug Discovery and Translational Medicine]
TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy [Drug Discovery and Translational Medicine]
AbstractLoss of orexin neurons is associated with narcolepsy type 1 (NT1), which is characterized by multiple symptoms inc...
BI-Y, an Neuropilin-1 Antagonist, Enhances Revascularization and Prevents Vascular Endothelial Growth Factor-A Induced Retinal Hyperpermeability in Rodent Models of Retinopathies [Endocrine and Diabetes]
BI-Y, an Neuropilin-1 Antagonist, Enhances Revascularization and Prevents Vascular Endothelial Growth Factor-A Induced Retinal Hyperpermeability in Rodent Models of Retinopathies [Endocrine and Diabetes]
AbstractDiabetic retinopathy (DR) is a leading cause of vision loss in working-age adults. Despite an established standard...
In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent-Verticilide [Drug Discovery and Translational Medicine]
In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent-Verticilide [Drug Discovery and Translational Medicine]
AbstractThe unnatural verticilide enantiomer (ent-verticilide) is a selective and potent inhibitor of cardiac ryanodine re...
Correction to "Cannabinoid Tolerance in S426A/S430A x {beta}-Arrestin 2 Knockout Double-Mutant Mice" [Erratum]
Correction to "Cannabinoid Tolerance in S426A/S430A x {beta}-Arrestin 2 Knockout Double-Mutant Mice" [Erratum]
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.NOTE: We request your email add...
Identification of 5-hydroxycotinine in the Plasma of Nicotine-treated Mice-Implications for Cotinine Metabolism and Disposition in vivo [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Identification of 5-hydroxycotinine in the Plasma of Nicotine-treated Mice-Implications for Cotinine Metabolism and Disposition in vivo [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Abstract ID 16490Poster Board 590Introduction: Nicotine, the addictive ingredient of tobacco, is metabolized in the liver ...
Evaluation of Influx and Efflux Transporters of Metformin in an In Vitro Blood-Brain Barrier Model During Normoxic and Ischemic Conditions [ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development]
Evaluation of Influx and Efflux Transporters of Metformin in an In Vitro Blood-Brain Barrier Model During Normoxic and Ischemic Conditions [ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development]
Abstract ID 15609Poster Board 563Purpose: Studies from our lab have shown that metformin attenuates post-ischemic brain in...
Identifying the mechanism underlying iatrogenic intravenous paracetamol-induced hypotension [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Identifying the mechanism underlying iatrogenic intravenous paracetamol-induced hypotension [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Abstract ID 25830Poster Board 591Background: Intravenous acetaminophen (APAP; paracetamol) is used commonly in the intensi...
N-cadherin Signaling via PI3K{beta}-Akt3 Stabilizes Occludin Tight Junctions in the Blood-Brain Barrier [ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology]
N-cadherin Signaling via PI3K{beta}-Akt3 Stabilizes Occludin Tight Junctions in the Blood-Brain Barrier [ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology]
Abstract ID 19653Poster Board 567Tight junctions (TJs) seal brain endothelial cells (BECs) to form a restrictive blood-bra...
Redox Partner Adrenodoxin Allosterically Alters the Function of the Human Steroidogenic Cytochrome P450 11B Enzymes [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Redox Partner Adrenodoxin Allosterically Alters the Function of the Human Steroidogenic Cytochrome P450 11B Enzymes [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Abstract ID 28439Poster Board 592Cytochrome P450 (CYP) enzymes are a class of heme monooxygenases with diverse functions, ...
Butyrate Prevents Opioid Induced Peripheral Hypersensitivity via a Gut Dependent Mechanism [ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology]
Butyrate Prevents Opioid Induced Peripheral Hypersensitivity via a Gut Dependent Mechanism [ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology]
Abstract ID 16983Poster Board 569Background: Recent evidence has shown that changes in the gut microbiome occur with chron...
Evaluation of Diversity and Bias Topics in a Medical School Pain & Opioid Analgesic Curriculum [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Evaluation of Diversity and Bias Topics in a Medical School Pain & Opioid Analgesic Curriculum [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Abstract ID 20961Poster Board 599Introduction: Despite national directives to improve pain, opioid, and analgesic pharmaco...
Development and Implementation of Equitable and Inclusive Teaching Practices in Pharmacology [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Development and Implementation of Equitable and Inclusive Teaching Practices in Pharmacology [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Abstract ID 16603Poster Board 598In biomedical research, there exists a demographic gap in success from individuals from d...
Longitudinal Impact of Mnemonics Use on Pharmacy Students Exam Performance and Perceptions of Knowledge Retention and Clinical Application [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Longitudinal Impact of Mnemonics Use on Pharmacy Students Exam Performance and Perceptions of Knowledge Retention and Clinical Application [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Abstract ID 21983Poster Board 597Background: Health professions students attending pharmacology courses often feel overwhe...
Successful Integration of Pharmacology Instruction From Day One of Medical School [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Successful Integration of Pharmacology Instruction From Day One of Medical School [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Abstract ID 23564Poster Board 595Aim: Pharmacology instruction has traditionally been presented during the second year of ...
Student perceptions of scholarly scientific writing in pharmacology: student generation of collaborative rubrics to score literature reviews in social pharmacology [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Student perceptions of scholarly scientific writing in pharmacology: student generation of collaborative rubrics to score literature reviews in social pharmacology [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Abstract ID 15695Poster Board 596Scientific scholarly writing is an important skill in pharmacology and other fields in sc...
Identifying Students Causal Mechanistic Reasoning (CMR) in Medical Pharmacology [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Identifying Students Causal Mechanistic Reasoning (CMR) in Medical Pharmacology [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Abstract ID 18675Poster Board 593Background: Many medical students struggle with the overload of information in pharmacolo...
Addressing Healthcare Inequities Through The Medical Pharmacology Curriculum [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Addressing Healthcare Inequities Through The Medical Pharmacology Curriculum [ASPET 2023 Annual Meeting Abstract - Pharmacology Education]
Abstract ID 27490Poster Board 594Healthcare inequities have become more of a focus in medical education in the last few ye...
Clopidogrel Induces More Bleeding in P2Y12-deficient Mice: Optimization of Murine Tail Bleeding Assay [ASPET 2023 Annual Meeting Abstract - Cardiovascular Pharmacology]
Clopidogrel Induces More Bleeding in P2Y12-deficient Mice: Optimization of Murine Tail Bleeding Assay [ASPET 2023 Annual Meeting Abstract - Cardiovascular Pharmacology]
Abstract ID 17622Poster Board 561Arterial thrombosis remains the most common cause of death in the developed world. Clopid...
Structure-activity Exploration of Positive Allosteric Modulators of the Mu-opioid Receptor [ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development]
Structure-activity Exploration of Positive Allosteric Modulators of the Mu-opioid Receptor [ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development]
Abstract ID 23842Poster Board 565Mu-opioid receptor agonists are the gold standard for pain treatment. While efficacious f...
Identification of endogenous biomarkers of renal organic cation transporters in rats by global metabolomics analysis [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Identification of endogenous biomarkers of renal organic cation transporters in rats by global metabolomics analysis [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Abstract ID 18183Poster Board 577Kidney is one of the major drug-elimination organs. The total renal excretion of a compou...
Single-dose Brilaroxazine Pharmacokinetics, Metabolism, and Excretion Profile in Animals and Humans [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Single-dose Brilaroxazine Pharmacokinetics, Metabolism, and Excretion Profile in Animals and Humans [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Abstract ID 53587Poster Board 579Background: Brilaroxazine, a serotonin/dopamine modulator developed for treating schizoph...
Ligand and G Protein Selectivity in Kappa Opioid Receptor Revealed by Structural Pharmacology [ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology]
Ligand and G Protein Selectivity in Kappa Opioid Receptor Revealed by Structural Pharmacology [ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology]
Abstract ID 18996Poster Board 573The kappa opioid receptor (KOR) represents a highly desirable therapeutic target for trea...
Development and Characterization of Chemical Tools to Study Ester Drug Metabolic Enzymes in Live Cells [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Development and Characterization of Chemical Tools to Study Ester Drug Metabolic Enzymes in Live Cells [ASPET 2023 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD)]
Abstract ID 18248Poster Board 575Carboxylesterase-mediated metabolism of ester containing drugs can result in their activa...
Development of a Mouse Model to Study Alcohol Withdrawal-Induced Allodynia [ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology]
Development of a Mouse Model to Study Alcohol Withdrawal-Induced Allodynia [ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology]
Abstract ID 16458Poster Board 571Alcohol use disorder is a prevalent psychiatric disorder affecting nearly 15 million peop...
Correction to "Protein Kinase A-Mediated Effects of Protein Kinase C Partial Agonist 5-(Hydroxymethyl)Isophthalate 1a3 in Colorectal Cancer Cells" [Erratum]
Correction to "Protein Kinase A-Mediated Effects of Protein Kinase C Partial Agonist 5-(Hydroxymethyl)Isophthalate 1a3 in Colorectal Cancer Cells" [Erratum]
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.NOTE: We request your email add...
Alterations in Brain Neural Network and Stress System in Atopic Dermatitis: Novel Therapeutic Interventions [Minireview]
Alterations in Brain Neural Network and Stress System in Atopic Dermatitis: Novel Therapeutic Interventions [Minireview]
AbstractAtopic dermatitis is a common chronic inflammatory skin disease, with most cases experiencing skin barrier dysfunc...
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