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Methocinnamox is a Potent and Long-Acting Antagonist that can Prevent and Reverse Opioid-Induced Respiratory Depression [Viewpoint]
Methocinnamox is a Potent and Long-Acting Antagonist that can Prevent and Reverse Opioid-Induced Respiratory Depression [Viewpoint]
The latest data from the US Centers for Disease Control and Prevention for opioid overdose deaths puts the number at 84,60...
Comparison of the {mu}-Opioid Receptor Antagonists Methocinnamox and Naloxone to Reverse and Prevent the Ventilatory Depressant Effects of Fentanyl, Carfentanil, 3-Methylfentanyl, and Heroin in Male Rats [Behavioral Pharmacology]
Comparison of the {mu}-Opioid Receptor Antagonists Methocinnamox and Naloxone to Reverse and Prevent the Ventilatory Depressant Effects of Fentanyl, Carfentanil, 3-Methylfentanyl, and Heroin in Male Rats [Behavioral Pharmacology]
Received November 22, 2023.Accepted February 9, 2024.This work was funded by National Institutes of Health National Instit...
A "Furious" Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics [Viewpoint]
A "Furious" Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics [Viewpoint]
Research with psychedelic drugs is at an all-time high. A recent (09 Feb 2024) PubMed query for “psychedelic OR hallucinog...
Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine [Behavioral Pharmacology]
Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine [Behavioral Pharmacology]
Abstract3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic st...
The Effects of Eating a Traditional High Fat/High Carbohydrate or a Ketogenic Diet on Sensitivity of Female Rats to Morphine [Behavioral Pharmacology]
The Effects of Eating a Traditional High Fat/High Carbohydrate or a Ketogenic Diet on Sensitivity of Female Rats to Morphine [Behavioral Pharmacology]
AbstractPatients diagnosed with obesity are prescribed opioid medications at a higher rate than the general population; ho...
Aloperine Attenuates Hepatic Ischemia/Reperfusion-Induced Liver Injury via STAT-3 Signaling in a Murine Model [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Aloperine Attenuates Hepatic Ischemia/Reperfusion-Induced Liver Injury via STAT-3 Signaling in a Murine Model [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractHepatic ischemia/reperfusion (I/R) damage is one of the most common side effects of liver surgery. This pathophysi...
Translational Pharmacokinetic-Toxicodynamic Model of Myelosuppression for Dose Optimization in Combination Chemotherapy of Capecitabine and Oxaliplatin from Rats to Humans [Drug Discovery and Translational Medicine]
Translational Pharmacokinetic-Toxicodynamic Model of Myelosuppression for Dose Optimization in Combination Chemotherapy of Capecitabine and Oxaliplatin from Rats to Humans [Drug Discovery and Translational Medicine]
AbstractXELOX therapy, which comprises capecitabine and oxaliplatin, is the standard first-line chemotherapeutic regimen f...
High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model [Gastrointestinal, Hepatic, Pulmonary, and Renal]
High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractCannabis sativa L. has a long history of medicinal use, particularly for gastrointestinal diseases. Patients with ...
Recent Developments in On-Demand Voiding Therapies [Minireview]
Recent Developments in On-Demand Voiding Therapies [Minireview]
AbstractOne cannot survive without regularly urinating and defecating. People with neurologic injury (spinal cord injury, ...
Developing Novel Therapies in Coronary Vasomotor Disorders: Translational Gaps from Basic Science to Clinical Impact [Viewpoint]
Developing Novel Therapies in Coronary Vasomotor Disorders: Translational Gaps from Basic Science to Clinical Impact [Viewpoint]
This issue of The Journal of Pharmacology and Experimental Therapeutics contains a comprehensive paper evaluating a novel ...
Efficacy of BAY 60-2770, a Soluble Guanylate Cyclase Activator, for Coronary Spasm in Animal Models [Cardiovascular]
Efficacy of BAY 60-2770, a Soluble Guanylate Cyclase Activator, for Coronary Spasm in Animal Models [Cardiovascular]
AbstractIschemia with non-obstructive coronary arteries (INOCA), caused by coronary artery spasm, has gained increasing at...
Seeing through the Haze: Monoacylglycerol Lipase Inhibitors As Analgesics [Viewpoint]
Seeing through the Haze: Monoacylglycerol Lipase Inhibitors As Analgesics [Viewpoint]
Chronic pain affects approximately 20% of adults in the United States, but effective analgesics with minimal side effects ...
Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice [Behavioral Pharmacology]
Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice [Behavioral Pharmacology]
AbstractMJN110 inhibits the enzyme monoacylglycerol lipase (MAGL) to increase levels of the endocannabinoid 2-arachidonoyl...
Brightening the Path: Riboflavin Illuminates Breast Cancer Resistance Protein Monitoring [Viewpoint]
Brightening the Path: Riboflavin Illuminates Breast Cancer Resistance Protein Monitoring [Viewpoint]
The membrane transporter breast cancer resistance protein [BCRP, also known as ATP-binding cassette superfamily G member 2...
A Pilot Study To Assess the Suitability of Riboflavin As a Surrogate Marker of Breast Cancer Resistance Protein in Healthy Participants [Metabolism, Transport, and Pharmacogenetics]
A Pilot Study To Assess the Suitability of Riboflavin As a Surrogate Marker of Breast Cancer Resistance Protein in Healthy Participants [Metabolism, Transport, and Pharmacogenetics]
AbstractWe recently showed that riboflavin is a selected substrate of breast cancer resistance protein (BCRP) over P-glyco...
Mechanistic Chronopharmacology: Preclinical Modeling of an SGLT2 Inhibitor in Preventing Painful Diabetic Neuropathy [Viewpoint]
Mechanistic Chronopharmacology: Preclinical Modeling of an SGLT2 Inhibitor in Preventing Painful Diabetic Neuropathy [Viewpoint]
Several forms of neuropathy caused by diffuse and focal damage to the peripheral and autonomic nervous systems occur in up...
Dosing Time-Dependent Difference in the Suppressive Effect of Empagliflozin on the Development of Mechanical Pain Hypersensitivity in Diabetic Mice [Endocrine and Diabetes]
Dosing Time-Dependent Difference in the Suppressive Effect of Empagliflozin on the Development of Mechanical Pain Hypersensitivity in Diabetic Mice [Endocrine and Diabetes]
AbstractA problem for patients with diabetes is the rise of complications, such as peripheral neuropathy, nephropathy, and...
Special Section on Therapeutic Approaches to Treat Disorders of the Urinary and Gastrointestinal Tracts--Editorial [Editorial]
Special Section on Therapeutic Approaches to Treat Disorders of the Urinary and Gastrointestinal Tracts--Editorial [Editorial]
This Special Section, published in the Journal of Pharmacology and Experimental Therapeutics, collected five manuscripts, ...
Rapid-Onset, Short-Duration Induction of Colorectal Contractions in Anesthetized, Adult, Male Rats [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Rapid-Onset, Short-Duration Induction of Colorectal Contractions in Anesthetized, Adult, Male Rats [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractSubstantial clinical and preclinical evidence indicates that transient receptor potential vanilloid 1 (TRPV1) rece...
Investigating the Mechanisms Underlying U46619-Induced Contraction on Porcine Lower Esophageal Sphincter [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Investigating the Mechanisms Underlying U46619-Induced Contraction on Porcine Lower Esophageal Sphincter [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractGastroesophageal reflux disease (GERD) is associated with an incompetent lower esophageal sphincter (LES), resulti...
Satellite Glial Cells Bridge Sensory Neuron Crosstalk in Visceral Pain and Cross-Organ Sensitization [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
Satellite Glial Cells Bridge Sensory Neuron Crosstalk in Visceral Pain and Cross-Organ Sensitization [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
AbstractFollowing colonic inflammation, the uninjured bladder afferent neurons are also activated. The mechanisms and path...
Nitric Oxide Resistance in Priapism Associated with Sickle Cell Disease: Mechanisms, Therapeutic Challenges, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
Nitric Oxide Resistance in Priapism Associated with Sickle Cell Disease: Mechanisms, Therapeutic Challenges, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
AbstractPatients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the absence of sexual aro...
Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases [Minireview]
Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases [Minireview]
AbstractMAP4K4 is a serine/threonine protein kinase belonging to the germinal center kinase subgroup of sterile 20 protein...
Therapeutic Approaches for Urologic Chronic Pelvic Pain Syndrome; Management: Research Advances, Experimental Targets, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
Therapeutic Approaches for Urologic Chronic Pelvic Pain Syndrome; Management: Research Advances, Experimental Targets, and Future Directions [Therapeutic Approaches to Treat Disorders of the Genitourinary and Gastrointestinal Tracts]
AbstractUrologic chronic pelvic pain syndrome (UCPPS) is a painful chronic condition with persistent pain originating from...
AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice [Chemotherapy, Antibiotics, and Gene Therapy]
AAV9-Mediated Intrastriatal Delivery of GNAO1 Reduces Hyperlocomotion in Gnao1 Heterozygous R209H Mutant Mice [Chemotherapy, Antibiotics, and Gene Therapy]
AbstractMutations in the GNAO1 gene, which encodes the abundant brain G-protein Gαo, result in neurologic disorders charac...
Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction [Cardiovascular]
Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction [Cardiovascular]
AbstractSympathetic hyperinnervation is the leading cause of fatal ventricular arrhythmia (VA) after myocardial infarction...
Correction to "NCP, a Dual Kappa and mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties" [Erratum]
Correction to "NCP, a Dual Kappa and mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties" [Erratum]
The above article [Huang P, Ho CK, Cao D, Inan SM, Rawls S, Li M, Huang B, Pagare PP, Townsend EA, Poklis JL, Halquist MS,...
Preclinical Systemic Pharmacokinetics, Dose Proportionality, and Central Nervous System Distribution of the ATM Inhibitor WSD0628, a Novel Radiosensitizer for the Treatment of Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
Preclinical Systemic Pharmacokinetics, Dose Proportionality, and Central Nervous System Distribution of the ATM Inhibitor WSD0628, a Novel Radiosensitizer for the Treatment of Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
AbstractRadiation therapy, a standard treatment option for many cancer patients, induces DNA double-strand breaks (DSBs), ...
Blood Pressure Lowering in Patients with Left Ventricular Hypertrophy - Navigating between Scylla and Charybdis [Viewpoint]
Blood Pressure Lowering in Patients with Left Ventricular Hypertrophy - Navigating between Scylla and Charybdis [Viewpoint]
Ever since the randomized controlled Systolic Blood Pressure Intervention Trial (SPRINT), we have known that targeting a s...
Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy [Cardiovascular]
Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy [Cardiovascular]
AbstractBackground: Recent reports have evidenced an increased mortality rate in hypertensive patients with electrocardiog...
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