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CH6824025, Potent and Selective Discoidin Domain Receptor 1 Inhibitor, Reduces Kidney Fibrosis in Unilateral Ureteral Obstruction Mice [Drug Discovery and Translational Medicine]
CH6824025, Potent and Selective Discoidin Domain Receptor 1 Inhibitor, Reduces Kidney Fibrosis in Unilateral Ureteral Obstruction Mice [Drug Discovery and Translational Medicine]
AbstractDiscoidin domain receptor 1 (DDR1) is a collagen receptor with tyrosine kinase activity, and its expression is enh...
Understanding Cisplatin Pharmacokinetics and Toxicodynamics to Predict and Prevent Kidney Injury [Minireview]
Understanding Cisplatin Pharmacokinetics and Toxicodynamics to Predict and Prevent Kidney Injury [Minireview]
AbstractCisplatin is a common platinum-based chemotherapeutic that induces acute kidney injury (AKI) in about 30% of patie...
Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease [Cellular and Molecular]
Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease [Cellular and Molecular]
AbstractAmyloid β(Aβ) deposition and neurofibrillary tangles are widely considered the primary pathological hallmarks of f...
Dopamine D1-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats [Behavioral Pharmacology]
Dopamine D1-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats [Behavioral Pharmacology]
AbstractPrevious studies indicated differing effects of dopamine D1-like and D2-like receptor (D1R and D2R, respectively) ...
Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers [Drug Discovery and Translational Medicine]
Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers [Drug Discovery and Translational Medicine]
AbstractSingle nucleotide polymorphisms (SNPs) in cytochrome P450 (CYP450) enzymes alter the metabolism of a variety of dr...
The Influence of the Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors [Neuropharmacology]
The Influence of the Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors [Neuropharmacology]
AbstractThe neuropeptide S receptor (NPSR) has been identified as a potential therapeutic target for anxiety and post-trau...
Humans and Rodents: The Case of hOAT4 and mOat5 [Viewpoint]
Humans and Rodents: The Case of hOAT4 and mOat5 [Viewpoint]
The human organic anion transporter 4, hOAT4 (SLC22A11, solute carrier family 22 member 11) is expressed at the apical mem...
Characterization of Human Organic Anion Transporter 4 (hOAT4) and Mouse Oat5 (mOat5) As Functional Orthologs for Renal Anion Uptake and Efflux Transport [Metabolism, Transport, and Pharmacogenetics]
Characterization of Human Organic Anion Transporter 4 (hOAT4) and Mouse Oat5 (mOat5) As Functional Orthologs for Renal Anion Uptake and Efflux Transport [Metabolism, Transport, and Pharmacogenetics]
AbstractOrganic anions (OAs) are compounds including drugs or toxicants that are negatively charged at physiologic pH and ...
Precisely Providing Analgesia through Selectively Targeting the GABAA {alpha}2/{alpha}3 Subtypes [Viewpoint]
Precisely Providing Analgesia through Selectively Targeting the GABAA {alpha}2/{alpha}3 Subtypes [Viewpoint]
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter within the brain regulating neuronal excitability th...
Antinociceptive Effects of {alpha}2/{alpha}3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity [Behavioral Pharmacology]
Antinociceptive Effects of {alpha}2/{alpha}3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity [Behavioral Pharmacology]
AbstractRecent studies suggest that among the gamma-aminobutyric acid type A (GABAA)receptor subtype heterogeneity, α2/α3 ...
Alternative Reinforcers Enhance the Effects of Opioid Antagonists, but Not Agonists, on Oxycodone Choice Self-Administration in Nonhuman Primates [Behavioral Pharmacology]
Alternative Reinforcers Enhance the Effects of Opioid Antagonists, but Not Agonists, on Oxycodone Choice Self-Administration in Nonhuman Primates [Behavioral Pharmacology]
AbstractClinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehens...
The Dawning of a New Age of Preclinical Analgesic Drug Screening [Viewpoint]
The Dawning of a New Age of Preclinical Analgesic Drug Screening [Viewpoint]
The search for novel compounds that produce analgesia in the absence of tolerance, dependence, addiction, and unpleasant o...
Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors [Metabolism, Transport, and Pharmacogenetics]
Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors [Metabolism, Transport, and Pharmacogenetics]
AbstractGlioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-bra...
Cannabinoid 2 Receptor Activation Protects against Diabetic Cardiomyopathy through Inhibition of AGE/RAGE-Induced Oxidative Stress, Fibrosis, and Inflammasome Activation [Special Section: Cannabinoid Signaling in Human Health and Disease]
Cannabinoid 2 Receptor Activation Protects against Diabetic Cardiomyopathy through Inhibition of AGE/RAGE-Induced Oxidative Stress, Fibrosis, and Inflammasome Activation [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractOxidative stress, fibrosis, and inflammasome activation from advanced glycation end product (AGE)–receptor of adva...
KLS-13019, a Novel Structural Analogue of Cannabidiol and GPR55 Receptor Antagonist, Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]
KLS-13019, a Novel Structural Analogue of Cannabidiol and GPR55 Receptor Antagonist, Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractNeuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neu...
Special Section on Cannabinoid Signaling in Human Health and Disease--Editorial [Special Section on Cannabinoid Signaling in Human Health and Disease-Editorial]
Special Section on Cannabinoid Signaling in Human Health and Disease--Editorial [Special Section on Cannabinoid Signaling in Human Health and Disease-Editorial]
EditorialSpecial Section on Cannabinoid Signaling in Human Health and Disease—Editorial ...
Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
AbstractCannabis and its products have been used for centuries for both medicinal and recreational purposes. The recent wi...
Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
AbstractTargeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only...
The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
AbstractThe National Center for Complementary and Integrative Health (NCCIH), which is part of the US National Institutes ...
Gabapentinoids Increase the Potency of Fentanyl and Heroin and Decrease the Potency of Naloxone to Antagonize Fentanyl and Heroin in Rats Discriminating Fentanyl [Behavioral Pharmacology]
Gabapentinoids Increase the Potency of Fentanyl and Heroin and Decrease the Potency of Naloxone to Antagonize Fentanyl and Heroin in Rats Discriminating Fentanyl [Behavioral Pharmacology]
AbstractDespite a significant decrease in the number of prescriptions for opioids, the opioid crisis continues, fueled in ...
Effects of Dual Inhibition at Dopamine Transporter and {sigma} Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats [Behavioral Pharmacology]
Effects of Dual Inhibition at Dopamine Transporter and {sigma} Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats [Behavioral Pharmacology]
AbstractPrevious studies demonstrated that sigma receptor (σR) antagonists alone fail to alter cocaine self-administration...
The Potential of Cannabichromene (CBC) as a Therapeutic Agent [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
The Potential of Cannabichromene (CBC) as a Therapeutic Agent [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
Cannabichromene Synthesis.Cannabinoids are a class of terpenophenolic compounds obtained by the alkylation of olivetolic a...
Proteomic Analysis of Signaling Pathways Modulated by Fatty Acid Binding Protein 5 (FABP5) in Macrophages [Special Section: Cannabinoid Signaling in Human Health and Disease]
Proteomic Analysis of Signaling Pathways Modulated by Fatty Acid Binding Protein 5 (FABP5) in Macrophages [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractAlthough acute inflammation serves essential functions in maintaining tissue homeostasis, chronic inflammation is ...
The Intoxication Equivalency of 11-Hydroxy-{Delta}9-Tetrahydrocannabinol Relative to {Delta}9-Tetrahydrocannabinol [Special Section: Cannabinoid Signaling in Human Health and Disease]
The Intoxication Equivalency of 11-Hydroxy-{Delta}9-Tetrahydrocannabinol Relative to {Delta}9-Tetrahydrocannabinol [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractΔ9-Tetrahydrocannabinol (THC) is a psychoactive phytocannabinoid found in the Cannabis sativa plant. THC is primar...
Evaluating the Abuse Potential of Lenabasum, a Selective Cannabinoid Receptor 2 Agonist [Special Section: Cannabinoid Signaling in Human Health and Disease]
Evaluating the Abuse Potential of Lenabasum, a Selective Cannabinoid Receptor 2 Agonist [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractEndocannabinoids, which are present throughout the central nervous system (CNS), can activate cannabinoid receptor...
Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]
Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractThe consumption of Δ9-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; ho...
Chronic Administration of Cannabinoid Agonists ACEA, AM1241, and CP55,940 Induce Sex-Specific Differences in Tolerance and Sex Hormone Changes in a Chemotherapy-Induced Peripheral Neuropathy [Special Section: Cannabinoid Signaling in Human Health and Disease]
Chronic Administration of Cannabinoid Agonists ACEA, AM1241, and CP55,940 Induce Sex-Specific Differences in Tolerance and Sex Hormone Changes in a Chemotherapy-Induced Peripheral Neuropathy [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractChemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely man...
Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology]
Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology]
AbstractLow-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relati...
Regulation of Cannabinoid and Opioid Receptor Levels by Endogenous and Pharmacological Chaperones [Special Section: Cannabinoid Signaling in Human Health and Disease]
Regulation of Cannabinoid and Opioid Receptor Levels by Endogenous and Pharmacological Chaperones [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractCannabinoid and opioid receptor activities can be modulated by a variety of post-translational mechanisms includin...
{Delta}9-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease [Special Section: Cannabinoid Signaling in Human Health and Disease]
{Delta}9-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractPeople with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pai...
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