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Transcriptome Profiling of Guinea Pig Skin Exposed to a High‐Power Terahertz Source
Transcriptome Profiling of Guinea Pig Skin Exposed to a High‐Power Terahertz Source
Abstract Terahertz (THz) radiation has a wide range of applications including use in medicine. However, effects of high-po...
Proteomic analysis of serum in workers exposed to diesel engine exhaust
Proteomic analysis of serum in workers exposed to diesel engine exhaust
Abstract Diesel engine exhaust (DEE) is classified as a Group 1 human carcinogen. Using a targeted proteomics approach, we...
In vitro cytotoxicity and genotoxicity of single and combined pesticides used by Bolivian farmers
In vitro cytotoxicity and genotoxicity of single and combined pesticides used by Bolivian farmers
Abstract We previously showed that farmers in Bolivia are exposed to many pesticides, some at elevated levels, and that th...
Utility of a Next Generation Framework for Assessment of Genomic Damage: A Case Study Using the Pharmaceutical Drug Candidate Etoposide
Utility of a Next Generation Framework for Assessment of Genomic Damage: A Case Study Using the Pharmaceutical Drug Candidate Etoposide
Abstract We present a hypothetical case study to examine the use of a next generation framework developed by the Genetic T...
Polymorphism in cytochrome P4502A6 reduces the risk to head and neck cancer and modifies the treatment outcome
Polymorphism in cytochrome P4502A6 reduces the risk to head and neck cancer and modifies the treatment outcome
Abstract The present case–control study consisting of 1300 cases of head and neck squamous cell carcinoma (HNSCC) a...
Polymorphism in cytochrome P4502A6 reduces the risk to head & neck cancer and modifies the treatment outcome
Polymorphism in cytochrome P4502A6 reduces the risk to head & neck cancer and modifies the treatment outcome
Abstract The present case-control study consisting of 1300 cases of head and neck squamous cell carcinoma (HNSCC) and the ...
Effect of life stage and target tissue on dose‐response assessment of ethyl methane sulfonate‐induced genotoxicity
Effect of life stage and target tissue on dose‐response assessment of ethyl methane sulfonate‐induced genotoxicity
Abstract In order to investigate the possibility that treatment age affects the genotoxic response to ethyl methane sulfon...
In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air‐liquid interface in exposure concentrations relevant at workplaces
In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air‐liquid interface in exposure concentrations relevant at workplaces
Abstract The ubiquitous use of phthalates in various materials and the knowledge about their potential adverse effects is ...
Mutagenicity of a novel 2‐phenylbenzotriazole (non‐chlorinated 2‐phenylbenzotriazole‐9) in mice
Mutagenicity of a novel 2‐phenylbenzotriazole (non‐chlorinated 2‐phenylbenzotriazole‐9) in mice
Abstract Dinitrophenylazo dyes can form 2-phenylbenzotriazoles (PBTAs) in the textile dyeing process upon the addition of ...
Assessment of cellular and molecular metrics for dose selection in an in vivo comet assay: A case study with MDI
Assessment of cellular and molecular metrics for dose selection in an in vivo comet assay: A case study with MDI
Abstract The in vivo comet assay can evaluate the genotoxic potential of a chemical in theoretically any tissue that can b...
Mutagenicity of a novel 2‐phenylbenzotriazole (non‐chlorinated PBTA‐9) in mice
Mutagenicity of a novel 2‐phenylbenzotriazole (non‐chlorinated PBTA‐9) in mice
Abstract Dinitrophenylazo dyes can form 2-phenylbenzotriazoles (PBTAs) in the textile dyeing process upon the addition of ...
Abstracts from the Environmental Mutagenesis and Genomics Society 52nd Annual Meeting, September 22–25, 2021, Virtual Meeting ‐ Real Science Program Chair: Jeff Bemis, PhD New Investigator Co‐Chair: Isabelle R. Miousse, PhD
Abstracts from the Environmental Mutagenesis and Genomics Society 52nd Annual Meeting, September 22–25, 2021, Virtual Meeting ‐ Real Science Program Chair: Jeff Bemis, PhD New Investigator Co‐Chair: Isabelle R. Miousse, PhD
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PacBio sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
PacBio sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
Abstract Genetic toxicology uses several assays to identity mutagens and protect the public. Most of these assays, however...
Assessment of Cellular and Molecular Metrics for Dose Selection in an in vivo Comet Assay: A Case Study with 1,1′‐Methylenebis(4‐isocyanatobenzene) (MDI)
Assessment of Cellular and Molecular Metrics for Dose Selection in an in vivo Comet Assay: A Case Study with 1,1′‐Methylenebis(4‐isocyanatobenzene) (MDI)
Abstract The in vivo Comet assay can evaluate the genotoxic potential of a chemical in theoretically any tissue that can b...
Polycyclic Aromatic Hydrocarbons Induce Endothelial Injury Through miR‐155 to Promote Atherosclerosis
Polycyclic Aromatic Hydrocarbons Induce Endothelial Injury Through miR‐155 to Promote Atherosclerosis
Abstract Polycyclic aromatic hydrocarbons (PAHs) are considered as an external factor that induces atherosclerotic cardiov...
Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust
Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust
ABSTRACT Urinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/carcinogenic agents and is linke...
Impact of XRCC1 genetic variants on its Tissue Expression and Breast Cancer Risk: A Case Control Study
Impact of XRCC1 genetic variants on its Tissue Expression and Breast Cancer Risk: A Case Control Study
Abstract Background X-ray repair cross-complementing group 1 (XRCC1), a coordinator protein of the DNA repair complex, is ...
Effect of dose and dose rate of gamma irradiation on the formation of micronuclei in bone marrow cells isolated from whole body irradiated mice
Effect of dose and dose rate of gamma irradiation on the formation of micronuclei in bone marrow cells isolated from whole body irradiated mice
Abstract It is well-known that the cytotoxicity and mutagenic effects of high dose rate (HDR) IR are increased by increasi...
Dietary fat intake during early pregnancy is associated with cord blood DNA methylation at IGF2 and H19 genes in newborns
Dietary fat intake during early pregnancy is associated with cord blood DNA methylation at IGF2 and H19 genes in newborns
Abstract Maternal fat intake during pregnancy affects fetal growth, but mechanisms underlying these relations are unclear....
Global and gene‐specific promoter methylation, and micronuclei induction in lead‐exposed workers: A cross‐sectional study
Global and gene‐specific promoter methylation, and micronuclei induction in lead‐exposed workers: A cross‐sectional study
Abstract Perturbation of epigenetic regulation is a well-established mechanism for cancer but its role for lead (Pb)-assoc...
Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro
Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro
Abstract Cadmium (Cd), anenvironmental toxic heavy metal, has been reported to cause testicular toxicity, which contribute...
The Regulatory Function of Tandem Repeat VNTR2‐1 in hTERT Gene Involves Basic Helix‐loop‐helix Family Transcription Factors
The Regulatory Function of Tandem Repeat VNTR2‐1 in hTERT Gene Involves Basic Helix‐loop‐helix Family Transcription Factors
Abstract Telomerase is a ribonucleoprotein enzyme that synthesizes telomere end sequence. The expression of hTERT gene, en...
Mutational signatures in T‐lymphocytes of rats treated with N‐propyl‐N‐nitrosourea and procarbazine
Mutational signatures in T‐lymphocytes of rats treated with N‐propyl‐N‐nitrosourea and procarbazine
Abstract We have used whole genome sequencing (WGS) to determine mutational signatures induced in the T-cells of rats trea...
Investigating aneuploidy‐inducing effect of Nemacur, Rogor, and Dursban in human peripheral blood lymphocyte cultures
Investigating aneuploidy‐inducing effect of Nemacur, Rogor, and Dursban in human peripheral blood lymphocyte cultures
Abstract For many years, organophosphate (OP) pesticides have been considered an attractive choice for pest control around...
Permitted daily exposure limits for noteworthy N‐nitrosamines
Permitted daily exposure limits for noteworthy N‐nitrosamines
Abstract A genotoxic carcinogen, N-nitrosodimethylamine (NDMA), was detected as a synthesis impurity in some valsartan dru...
Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
Abstract The organotypic human air-liquid-interface (ALI) airway tissue model has been used as an in vitro cell culture sy...
Concentration‐ and time‐dependent induction of Cyp1a and DNA damage response by benzo(a)pyrene in LMH three‐dimensional spheroids
Concentration‐ and time‐dependent induction of Cyp1a and DNA damage response by benzo(a)pyrene in LMH three‐dimensional spheroids
Abstract In vitro liver toxicity tests performed using cell lines cultured as two-dimensional (2D) monolayer have limited ...
Design of a digital‐PCR assay to quantify fragmented human mitochondrial DNA
Design of a digital‐PCR assay to quantify fragmented human mitochondrial DNA
Abstract Digital PCR (dPCR) has been adapted to quantify the proportion of mitochondrial DNA (mtDNA) molecules without and...
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