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Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
Among mucus-producing lung cancers, invasive mucinous adenocarcinoma of the lung is a rare and unique subtype of pulmonary...
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction
Acute coronary artery blockage leads to acute myocardial infarction (AMI). Cardiomyocytes are terminally differentiated ce...
PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway in osteoporosis
PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway in osteoporosis
Osteoporosis (OP) is a highly prevalent disorder characterized by low bone mass that severely reduces patient quality of l...
Combined use of hydrogen-rich water and enzyme-digested edible bird’s nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents
Combined use of hydrogen-rich water and enzyme-digested edible bird’s nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents
Gingival wound healing plays a critical role in maintaining oral health. However, this process can be delayed by oxidative...
Cancer-associated fibroblasts-derived exosomal METTL3 promotes the proliferation, invasion, stemness and glutaminolysis in non-small cell lung cancer cells by eliciting SLC7A5 m6A modification
Cancer-associated fibroblasts-derived exosomal METTL3 promotes the proliferation, invasion, stemness and glutaminolysis in non-small cell lung cancer cells by eliciting SLC7A5 m6A modification
Cancer-associated fibroblasts (CAFs) can promote the crosstalk between cancer cells and tumor microenvironment by exosomes...
IL-32/NFκB/miR-205 loop sustains the high expression of IL-32 and enhances the motility of cervical cancer cells
IL-32/NFκB/miR-205 loop sustains the high expression of IL-32 and enhances the motility of cervical cancer cells
Human papillomavirus (HPV) infection is a major contributor to cervical cancer. Persistent HPV infection can trigger the e...
Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic effects on haematologica...
EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer
EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer
Lobaplatin shows antitumor activity against a wide range of tumors, including triple-negative breast cancer (TNBC), and ha...
Targeted inhibition of SUMOylation: treatment of tumors
Targeted inhibition of SUMOylation: treatment of tumors
SUMOylation is a dynamic and reversible post-translational modification (PTM) of proteins involved in the regulation of bi...
Delivery of neurotrophin-3 by RVG-Lamp2b-modified mesenchymal stem cell-derived exosomes alleviates facial nerve injury
Delivery of neurotrophin-3 by RVG-Lamp2b-modified mesenchymal stem cell-derived exosomes alleviates facial nerve injury
We aim to investigate the effect of RVG-Lamp2b-modified exosomes (exos) loaded with neurotrophin-3 (NT-3) on facial nerve ...
Transforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo
Transforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo
Approximately 3–5% of non-small cell lung cancers (NSCLC) harbor ALK fusion genes and may be responsive to ...
β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression
β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression
To explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasi...
Tyndallized bacteria prime bronchial epithelial cells to mount an effective innate immune response against infections
Tyndallized bacteria prime bronchial epithelial cells to mount an effective innate immune response against infections
Airway epithelium represents a physical barrier against toxic substances and pathogens but also presents pattern recogniti...
Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?
Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?
Immunosuppressive regulatory cells (IRCs) play important roles in negatively regulating immune response, and are mainly di...
Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells
Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells
Authors and AffiliationsDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Sait...
Aquaporins in colorectal cancer: exploring their role in tumorigenesis, metastasis, and drug response
Aquaporins in colorectal cancer: exploring their role in tumorigenesis, metastasis, and drug response
Aquaporins (AQPs) are small, integral proteins facilitating water transport across plasma cell membranes in response to os...
DNMT1 driven by mouse amniotic fluid mesenchymal stem cell exosomes improved corneal cryoinjury via inducing microRNA-33 promoter DNA hypermethylation modification in corneal epithelium cells
DNMT1 driven by mouse amniotic fluid mesenchymal stem cell exosomes improved corneal cryoinjury via inducing microRNA-33 promoter DNA hypermethylation modification in corneal epithelium cells
Severe corneal cryoinjury can cause permanent corneal swelling and bullous keratopathy, one of the main reason for loss of...
Generation of induced pluripotent stem cells from an individual with early onset and severe hypertrophic cardiomyopathy linked to MYBPC3: c.772G > A mutation
Generation of induced pluripotent stem cells from an individual with early onset and severe hypertrophic cardiomyopathy linked to MYBPC3: c.772G > A mutation
Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in the MYPBC3 gene, which encodes the cardiac myosin-b...
Single-cell sequencing advances in research on mesenchymal stem/stromal cells
Single-cell sequencing advances in research on mesenchymal stem/stromal cells
Mesenchymal stem/stromal cells (MSCs), originating from the mesoderm, represent a multifunctional stem cell population cap...
CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells
CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells
Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that co...
Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor
Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor
Human ATP-binding cassette transporter C11 (ABCC11) is a membrane protein exhibiting ATP-dependent transport activity for ...
Establishment and characterization of TK-ALCL1: a novel NPM-ALK-positive anaplastic large-cell lymphoma cell line
Establishment and characterization of TK-ALCL1: a novel NPM-ALK-positive anaplastic large-cell lymphoma cell line
TK-ALCL1, a novel anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell line, was esta...
Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis
Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis
The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining wide...
Interrogating the estrogen-mediated regulation of adrenocortical Klotho expression using ovariectomized albino rat model exposed to repeated restraint stress
Interrogating the estrogen-mediated regulation of adrenocortical Klotho expression using ovariectomized albino rat model exposed to repeated restraint stress
Reproductive aging is associated with altered stress response and many other menopausal symptoms. Little is known about th...
VBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma
VBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor in East Asia. Hypoxia, a hallmark of solid tumors, s...
Overexpressing Bcl-2 enhances murine chimeric antigen receptor T cell therapy against solid tumor
Overexpressing Bcl-2 enhances murine chimeric antigen receptor T cell therapy against solid tumor
Chimeric antigen receptor T (CART) cell therapy has demonstrated promising potential in the treatment of hematologic malig...
A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe
A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe
Conflict of interest The authors declare no conflicts of interest. ...
Pioglitazone ameliorates ischemia/reperfusion-induced acute kidney injury via oxidative stress attenuation and NLRP3 inflammasome
Pioglitazone ameliorates ischemia/reperfusion-induced acute kidney injury via oxidative stress attenuation and NLRP3 inflammasome
Acute kidney injury (AKI) induced by renal ischemia/reperfusion injury (IRI) is a severe clinical condition. ROS accumulat...
The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs
The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs
Physical activity on a regular basis has been shown to bolster the overall wellness of an individual; research is now reve...
Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line
Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line
Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer that can result in significant morbidity, althoug...
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