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In Vitro differentiation of hair-follicle bulge stem cells into synaptophysin-expressing neurons: a potential new approach for neuro-regeneration
In Vitro differentiation of hair-follicle bulge stem cells into synaptophysin-expressing neurons: a potential new approach for neuro-regeneration
Stem cells, particularly bulge hair follicle stem cells (HFSCs), have recently attracted significant interest due to their...
Generation of human induced pluripotent stem cell lines derived from patients of cystic biliary atresia
Generation of human induced pluripotent stem cell lines derived from patients of cystic biliary atresia
Biliary atresia (BA), resulting from abnormal development of the liver’s internal or external bile ducts, can lead t...
Strong genetic effect on gout revealed by genetic risk score from meta-analysis of two genome-wide association studies
Strong genetic effect on gout revealed by genetic risk score from meta-analysis of two genome-wide association studies
The authors express our sincere thanks to all the participants in this study. Our heartfelt gratitude goes to the members ...
Pancreatic cancer-derived exosomal miR-510 promotes macrophage M2 polarization and facilitates cancer cell aggressive phenotypes
Pancreatic cancer-derived exosomal miR-510 promotes macrophage M2 polarization and facilitates cancer cell aggressive phenotypes
Extensive tumor microenvironment (TME) and tumor-associated macrophages (TAMs) contribute to the initiation and progressio...
Identification of novel gout loci from trans-ethnic meta-analysis of serum urate level
Identification of novel gout loci from trans-ethnic meta-analysis of serum urate level
Gout is a well-known inflammatory arthritis characterized by sudden, severe pain attacks. It is caused by persistent hyper...
Pathophysiology, molecular mechanisms, and genetics of atrial fibrillation
Pathophysiology, molecular mechanisms, and genetics of atrial fibrillation
The development of atrial fibrillation (AF) is a highly complex, multifactorial process involving pathophysiologic mechani...
Establishment and drug resistance characterization of paired organoids using human primary colorectal cancer and matched tumor deposit specimens
Establishment and drug resistance characterization of paired organoids using human primary colorectal cancer and matched tumor deposit specimens
Tumor deposits (TDs) represent a specific form tumor metastasis observed in colorectal cancer (CRC). The lack of successfu...
Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation in exon 6 of the CaSR gene
Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation in exon 6 of the CaSR gene
The calcium-sensing receptor (CaSR) gene encodes a cell membrane G protein-coupled receptor (GPCR) which has a key role in...
Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy
Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy
RAG2 deficiency is characterized by a lack of B and T lymphocytes, causing severe lethal infections. Currently, RAG2 defic...
MiR-124-3p inhibits cell stemness in glioblastoma via targeting EPHA2 through ALKBH5-mediated m6A modification
MiR-124-3p inhibits cell stemness in glioblastoma via targeting EPHA2 through ALKBH5-mediated m6A modification
Glioblastoma (GBM) is the most aggressive form of glioma, characterized by high mortality and poor prognosis. Dysregulatio...
Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells
Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells
Adiponectin (APN), a vasoactive cytokine produced by adipocytes, has emerged as a critical player in retinal diseases. Ren...
Brain inflammaging in the pathogenesis of late-life depression
Brain inflammaging in the pathogenesis of late-life depression
Late-life depression (LLD) is a prevalent mental disorder among older adults. Previous studies revealed that many patholog...
Emodin regulated lactate metabolism by inhibiting MCT1 to delay non-small cell lung cancer progression
Emodin regulated lactate metabolism by inhibiting MCT1 to delay non-small cell lung cancer progression
Lung cancer is one of the most common malignant tumors in the world, with high incidence rate and mortality. Monocarboxyla...
Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1
Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1
The methods available for treating metastatic Ewing sarcoma (ES) are inadequate; thus, innovative therapeutic approaches n...
Application of hydrogel-loaded dental stem cells in the field of tissue regeneration
Application of hydrogel-loaded dental stem cells in the field of tissue regeneration
Mesenchymal stem cells (MSCs) are highly favored in clinical trials due to their unique characteristics, which have isolat...
Autophagy activation ameliorates the fibrosis of trabecular meshwork cells induced by TGFβ2 through the promotion of fibrotic proteins degradation
Autophagy activation ameliorates the fibrosis of trabecular meshwork cells induced by TGFβ2 through the promotion of fibrotic proteins degradation
The level of transforming growth factor-beta2 (TGFβ2) is elevated in aqueous humor of partial glaucoma patients, and ...
Interaction of SARS-CoV-2 Spike protein with ACE2 induces cortical actin modulation, including dephosphorylation of ERM proteins and reduction of cortical stiffness
Interaction of SARS-CoV-2 Spike protein with ACE2 induces cortical actin modulation, including dephosphorylation of ERM proteins and reduction of cortical stiffness
Cell surface cortical actin is a regulatory target for viral infection. We aimed to investigate the effect of severe acute...
ST3GAL4 promotes tumorigenesis in breast cancer by enhancing aerobic glycolysis
ST3GAL4 promotes tumorigenesis in breast cancer by enhancing aerobic glycolysis
Sialyltransferases are enzymes that play a crucial role in regulating cancer progression by modifying glycoproteins throug...
Cyclic tensile stress promotes osteogenic differentiation via upregulation of Piezo1 in human dental follicle stem cells
Cyclic tensile stress promotes osteogenic differentiation via upregulation of Piezo1 in human dental follicle stem cells
As periodontal progenitor cells, human dental follicle stem cells (hDFCs) play an important role in regenerative medicine ...
Sequencing-based study of neural induction of human dental pulp stem cells
Sequencing-based study of neural induction of human dental pulp stem cells
Techniques for triggering neural differentiation of embryonic and induced pluripotent stem cells into neural stem cells an...
Establishment and characterization of two novel patient-derived cell lines from myxofibrosarcoma: NCC-MFS7-C1 and NCC-MFS8-C1
Establishment and characterization of two novel patient-derived cell lines from myxofibrosarcoma: NCC-MFS7-C1 and NCC-MFS8-C1
Myxofibrosarcoma (MFS), an aggressive soft tissue sarcoma, presents a significant challenge because of its high recurrence...
Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma
Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma
Synovial sarcoma (SS) is identified as a sarcoma with monomorphic blue spindle cells that display variable epithelial diff...
GABAA receptor modulation by the endocannabinoid system: insights into the regulatory mechanisms involving glutamine synthetase and MAPK mediators
GABAA receptor modulation by the endocannabinoid system: insights into the regulatory mechanisms involving glutamine synthetase and MAPK mediators
Baur R, Gertsch J, Sigel E. Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action ...
Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer
Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer
Chronic systemic inflammation caused by diseases such as ulcerative colitis (UC) and Crohn’s disease (CD) increases ...
The role of monoglyceride lipase gene in promoting proliferation, metastasis, and free fatty acid accumulation in uveal melanoma cells
The role of monoglyceride lipase gene in promoting proliferation, metastasis, and free fatty acid accumulation in uveal melanoma cells
Uveal melanoma is a malignant tumor originating from melanocytes in the eye's uvea, often detected during routine opht...
Inhibition of the AP-1/TFPI2 axis contributes to alleviating cerebral ischemia/reperfusion injury by improving blood–brain barrier integrity
Inhibition of the AP-1/TFPI2 axis contributes to alleviating cerebral ischemia/reperfusion injury by improving blood–brain barrier integrity
Reperfusion after cerebral ischemia leads to secondary damage to the nervous system, called cerebral ischemia/reperfusion ...
Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome
Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome
Polycystic ovarian syndrome (PCOS) is a prevalent endocrinological disorder affected by ghrelin. This study aimed to inves...
The role of neutrophils in chronic cough
The role of neutrophils in chronic cough
Chronic cough is a common disorder lasting more than 8 weeks and affecting all age groups. The evidence supportin...
A call for standardization for secretome and extracellular vesicles in osteoarthritis: results show disease-modifying potential, but protocols are too heterogeneous—a systematic review
A call for standardization for secretome and extracellular vesicles in osteoarthritis: results show disease-modifying potential, but protocols are too heterogeneous—a systematic review
The currently available osteoarthritis (OA) treatments offer symptoms’ relief without disease-modifying effects. Inc...
KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma
KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma
The limited response of hepatocellular carcinoma (HCC) to chemotherapy drugs has always been a bottleneck in therapy. DNA ...
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