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Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
This research delves into Primary Hyperoxaluria Type 2 (PH2), an autosomal recessive disorder precipitated by a unique cas...
Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase
Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase
Only a few human ovarian endometrioid carcinoma cell lines are currently available, partly due to the difficulty of establ...
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke, and the neuroprotective effects of nimodipine following SAH...
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
Cancer, a complicated disease characterized by aberrant cellular metabolism, has emerged as a formidable global health cha...
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
Autophagy, a cellular degradation process involving the formation and clearance of autophagosomes, is mediated by autophag...
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
We previously examined the antitumor effects of short interfering RNA nanoparticles targeting mammalian target of rapamyci...
The dual role of PTPN22 in immune modulation and transplantation tolerance
The dual role of PTPN22 in immune modulation and transplantation tolerance
Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, et al. Identification of substrates of human protein-tyrosine p...
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
The study explores the development and characterization of lymph node stromal cell cultures (LNSCs) from patients with ora...
Title: Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
Title: Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
This research delves into Primary Hyperoxaluria Type 2 (PH2), an autosomal recessive disorder precipitated by a unique cas...
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its c...
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Imatinib resistance is a major obstacle to the successful treatment of gastrointestinal stromal tumors (GIST). Long non-co...
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a primary malignant neoplasm exhibiting a high mortality rate. Taxifolin is a naturally ...
Loss of hepatocyte growth factor activator inhibitor type 1 (HAI-1) upregulates MMP-9 expression and induces degradation of the epidermal basement membrane
Loss of hepatocyte growth factor activator inhibitor type 1 (HAI-1) upregulates MMP-9 expression and induces degradation of the epidermal basement membrane
Hepatocyte growth factor activator inhibitor type 1 (HAI-1), which is encoded by the SPINT1 gene, is a membrane-associated...
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
Acute injury and secondary injury caused by traumatic brain injury (TBI) seriously threaten the health of patients. The pu...
Curzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B
Curzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B
Curzerenone is a major component of the traditional herbal medicine Curcumae Rhizoma with potential cancer-suppressing eff...
Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers
Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers
Human pluripotent stem cells (hPSCs) have at least three distinct states: naïve pluripotency that represents the cell...
MiR-34a regulates renal circadian rhythms during cisplatin-induced nephrotoxicity
MiR-34a regulates renal circadian rhythms during cisplatin-induced nephrotoxicity
El-Arabey AA. Dihydrotestosterone as mediator for cisplatin induced nephrotoxicity: New insight down the road. Toxicology....
Exosomal miR-146a-5p derived from bone marrow mesenchymal stromal cells regulate Th1/Th2 balance and alleviates immune thrombocytopenia in pregnancy
Exosomal miR-146a-5p derived from bone marrow mesenchymal stromal cells regulate Th1/Th2 balance and alleviates immune thrombocytopenia in pregnancy
Immune thrombocytopenia (ITP) is a common hematological disorder. Our previous study has found that exosomal miR-146a-5p d...
N6-methyladenosine-modified SRD5A3, identified by IGF2BP3, sustains cisplatin resistance in bladder cancer
N6-methyladenosine-modified SRD5A3, identified by IGF2BP3, sustains cisplatin resistance in bladder cancer
Resistance to cisplatin-based chemotherapy limits the clinical benefit to some bladder cancer patients, and understanding ...
Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone
Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a rare osteolytic tumor composed of mononuclear stromal cells, macrophages, and osteocl...
Establishment of two novel organoid lines from patients with combined hepatocellular cholangiocarcinoma
Establishment of two novel organoid lines from patients with combined hepatocellular cholangiocarcinoma
Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a unique subtype of primary liver cancer displaying both hepatocy...
Establishment and characterization of a novel patient-derived cell line from conventional central grade 3 chondrosarcoma, NCC-CS1-C1
Establishment and characterization of a novel patient-derived cell line from conventional central grade 3 chondrosarcoma, NCC-CS1-C1
Chondrosarcoma (CS) is a malignant tumor that produces cartilaginous matrix and is the second most common primary bone sar...
Establishment and characterization of the novel myxofibrosarcoma cell line, SMU-MFS
Establishment and characterization of the novel myxofibrosarcoma cell line, SMU-MFS
Myxofibrosarcoma (MFS) is one of the most common soft-tissue sarcomas in elderly patients. Owing to the limited efficacy o...
Emerging role of exosomes during the pathogenesis of viral hepatitis, non-alcoholic steatohepatitis and alcoholic hepatitis
Emerging role of exosomes during the pathogenesis of viral hepatitis, non-alcoholic steatohepatitis and alcoholic hepatitis
Extracellular vesicles (EVs) refer to a diverse range of membranous vesicles that are secreted by various cell types, they...
ZC3H13 promotes autophagy in bladder cancer through m6A methylation modification of PJA2 and ubiquitination of KSR1
ZC3H13 promotes autophagy in bladder cancer through m6A methylation modification of PJA2 and ubiquitination of KSR1
The N6-methyladenine (m6A) modification is the most common modification of messenger RNAs in eukaryotes and has crucial ro...
Molecular leveraging of HOX-embedded non-coding RNAs in the progression of acute myeloid leukemia
Molecular leveraging of HOX-embedded non-coding RNAs in the progression of acute myeloid leukemia
Acute myeloid leukemia (AML) is characterized by impaired differentiation of myeloid cells leading to hematopoietic failur...
Mesenchymal stem/stromal cells: dedicator to maintain tumor homeostasis
Mesenchymal stem/stromal cells: dedicator to maintain tumor homeostasis
Mesenchymal stem/stromal cells （MSCs） act as a factor in tumor recurrence after drug treatment with their in...
Establishment of a novel benign meningioma cell line spontaneously immortalized under hypoxic conditions
Establishment of a novel benign meningioma cell line spontaneously immortalized under hypoxic conditions
Meningiomas are the most frequent brain tumors, typically benign and curable by surgery. However, some patients experience...
Establishment and characterization of NCC-GCTB14-C1 and NCC-GCTB15-C1: two novel patient-derived cell lines of giant cell tumor of bone
Establishment and characterization of NCC-GCTB14-C1 and NCC-GCTB15-C1: two novel patient-derived cell lines of giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a rare bone tumor that is genetically characterized by a unique mutation in the H3-3A g...
In Vitro differentiation of hair-follicle bulge stem cells into synaptophysin-expressing neurons: a potential new approach for neuro-regeneration
In Vitro differentiation of hair-follicle bulge stem cells into synaptophysin-expressing neurons: a potential new approach for neuro-regeneration
Stem cells, particularly bulge hair follicle stem cells (HFSCs), have recently attracted significant interest due to their...
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