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A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe
A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe
Conflict of interest The authors declare no conflicts of interest. ...
Pioglitazone ameliorates ischemia/reperfusion-induced acute kidney injury via oxidative stress attenuation and NLRP3 inflammasome
Pioglitazone ameliorates ischemia/reperfusion-induced acute kidney injury via oxidative stress attenuation and NLRP3 inflammasome
Acute kidney injury (AKI) induced by renal ischemia/reperfusion injury (IRI) is a severe clinical condition. ROS accumulat...
The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs
The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs
Physical activity on a regular basis has been shown to bolster the overall wellness of an individual; research is now reve...
Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line
Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line
Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer that can result in significant morbidity, althoug...
Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA
Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA
A human ovarian clear cell carcinoma cell line was established from a 46-year-old Japanese woman. That line, designated MT...
The significance of m6A RNA methylation regulators in diagnosis and subtype classification of HBV-related hepatocellular carcinoma
The significance of m6A RNA methylation regulators in diagnosis and subtype classification of HBV-related hepatocellular carcinoma
In recent years, abnormal m6A alteration in hepatocellular carcinoma (HCC) has been a focus on investigating the biologica...
Pathological mechanisms of cold and mechanical stress in modulating cancer progression
Pathological mechanisms of cold and mechanical stress in modulating cancer progression
Environmental temperature and cellular mechanical force are the inherent factors that participate in various biological pr...
Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer
Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer
Patient-derived organoids (PDOs) retain the original tumor’s characteristics to a large degree and allow direct eval...
Compensatory upregulation of MT2A alleviates neurogenic intermittent claudication through inhibiting activated p38 MAPK-mediated neuronal apoptosis
Compensatory upregulation of MT2A alleviates neurogenic intermittent claudication through inhibiting activated p38 MAPK-mediated neuronal apoptosis
Neurogenic intermittent claudication (NIC), a classic symptom of lumbar spinal stenosis (LSS), is associated with neuronal...
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a complex gynaecological endocrine disease that occurs in women of childbearing age. T...
The mechanism of the contribution of ICAM-1 to epithelial–mesenchymal transition (EMT) in bladder cancer
The mechanism of the contribution of ICAM-1 to epithelial–mesenchymal transition (EMT) in bladder cancer
Bladder cancer is one of the most prevalent cancers worldwide. Moreover, if not optimally treated, bladder cancer is a sig...
Prognostic value of inflammation and immune-related gene NOD2 in clear cell renal cell carcinoma
Prognostic value of inflammation and immune-related gene NOD2 in clear cell renal cell carcinoma
Inflammation and immune responses play important roles in cancer development and prognosis. We identified 59 upregulated i...
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro
Merkel cell carcinoma (MCC) is an aggressive skin cancer, with a propensity for early metastasis. Therefore, early diagnos...
CLLU1 as an emerging biomarker in chronic lymphoid leukemia
CLLU1 as an emerging biomarker in chronic lymphoid leukemia
CLLU1, a disease-specific gene associated with chronic lymphoid leukemia (CLL), is located on chromosome 12q22. Previous s...
The role of cardiac microenvironment in cardiovascular diseases: implications for therapy
The role of cardiac microenvironment in cardiovascular diseases: implications for therapy
Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and ath...
Establishment and characterization of NCC-ASPS2-C1: a novel patient-derived cell line of alveolar soft part sarcoma
Establishment and characterization of NCC-ASPS2-C1: a novel patient-derived cell line of alveolar soft part sarcoma
Alveolar soft part sarcoma (ASPS) is a rare mesenchymal tumor characterized by rearrangement of the ASPSCR1 and TFE3 genes...
Lactate in breast cancer cells is associated with evasion of hypoxia-induced cell cycle arrest and adverse patient outcome
Lactate in breast cancer cells is associated with evasion of hypoxia-induced cell cycle arrest and adverse patient outcome
Tumor hypoxia is a common microenvironmental factor in breast cancers, resulting in stabilization of Hypoxia-Inducible Fac...
Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB8-C1 and NCC-GCTB9-C1
Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB8-C1 and NCC-GCTB9-C1
Giant cell tumor of bone (GCTB) is a rare osteolytic bone tumor consisting of mononuclear stromal cells, macrophages, and ...
Anexelekto (AXL) no more: microRNA-155 (miR-155) controls the “Uncontrolled” in SARS-CoV-2
Anexelekto (AXL) no more: microRNA-155 (miR-155) controls the “Uncontrolled” in SARS-CoV-2
AXL is the gene that encodes the Anexelekto (AXL) receptor tyrosine kinase that demonstrates significant roles in various ...
Liraglutide prevents cellular senescence in human retinal endothelial cells (HRECs) mediated by SIRT1: an implication in diabetes retinopathy
Liraglutide prevents cellular senescence in human retinal endothelial cells (HRECs) mediated by SIRT1: an implication in diabetes retinopathy
Diabetes mellitus (DM) is a chronic metabolic disorder affecting millions of people worldwide, characterized by dysregulat...
Transcription factors in chimeric antigen receptor T-cell development
Transcription factors in chimeric antigen receptor T-cell development
Chimeric antigen receptor (CAR) T-cell therapy is a new and innovative approach to treating cancers that has shown promisi...
Protein regulator of cytokinesis 1 accentuates cholangiocarcinoma progression via mTORC1-mediated glycolysis
Protein regulator of cytokinesis 1 accentuates cholangiocarcinoma progression via mTORC1-mediated glycolysis
This study aimed to investigate the expression of protein regulator of cytokinesis 1 (PRC1) in cholangiocarcinoma (CHOL) a...
Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation
Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation
Lethal graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic stem-cell transplantation (A...
MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas
MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas
MYCN (master regulator of cell cycle entry and proliferative metabolism) gene amplification defines a molecular subgroup o...
Saracatinib prompts hemin-induced K562 erythroid differentiation but suppresses erythropoiesis of hematopoietic stem cells
Saracatinib prompts hemin-induced K562 erythroid differentiation but suppresses erythropoiesis of hematopoietic stem cells
Human myeloid leukemia cells (such as K562) could be used for the study of erythropoiesis, and mature erythroid markers an...
Wnt, notch signaling and exercise: what are their functions?
Wnt, notch signaling and exercise: what are their functions?
In the last decade, the study of Wnt and Notch signaling in cell biology has led to significant progress in understanding ...
Identification of a family with van der Hoeve’s syndrome harboring a novel COL1A1 mutation and generation of patient-derived iPSC lines and CRISPR/Cas9-corrected isogenic iPSCs
Identification of a family with van der Hoeve’s syndrome harboring a novel COL1A1 mutation and generation of patient-derived iPSC lines and CRISPR/Cas9-corrected isogenic iPSCs
Van der Hoeve’s syndrome, also known as osteogenesis imperfecta (OI), is a genetic connective tissue disorder charac...
Establishment and characterization of ZJUCHi003: an induced pluripotent stem cell line from a patient with Temple–Baraitser/Zimmermann–Laband syndrome carrying KCNH1 c.1070G > A (p.R357Q) variant
Establishment and characterization of ZJUCHi003: an induced pluripotent stem cell line from a patient with Temple–Baraitser/Zimmermann–Laband syndrome carrying KCNH1 c.1070G > A (p.R357Q) variant
Pathogenic variants of the KCNH1 gene can cause dominant-inherited Temple–Baraitser/Zimmermann–Laband syndrome...
Establishment and characterization of NCC-DFSP5-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line
Establishment and characterization of NCC-DFSP5-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line
Dermatofibrosarcoma protuberans (DFSP) is the most prevalent dermal sarcoma, characterized by the presence of the fusion o...
Prognostic significance and immune escape implication of tumor-infiltrating neutrophil plasticity in human head and neck squamous cell carcinoma
Prognostic significance and immune escape implication of tumor-infiltrating neutrophil plasticity in human head and neck squamous cell carcinoma
Tumor-infiltrating neutrophils play a crucial role in the progression of head and neck squamous cell carcinoma (HNSCC). He...
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