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Metal-ruthenium complex based on dipyridylamine group as membrane-active antibacterial agent effectively decrease the development of drug-resistance on Staphylococcus aureus
Metal-ruthenium complex based on dipyridylamine group as membrane-active antibacterial agent effectively decrease the development of drug-resistance on Staphylococcus aureus
Bacterial resistance is a major problem caused by the overuse of antibiotics. The main causes of antimicrobial resistance ...
Utilizing coordination chemistry through formation of a CuII-quinalizarin complex to manipulate cell biology: An in vitro, in silico approach
Utilizing coordination chemistry through formation of a CuII-quinalizarin complex to manipulate cell biology: An in vitro, in silico approach
Inorganic compounds (more specifically coordination compounds) in varied forms are a subject of discussion today for diver...
Heme-copper and Heme O2-derived synthetic (bioinorganic) chemistry toward an understanding of cytochrome c oxidase dioxygen chemistry
Heme-copper and Heme O2-derived synthetic (bioinorganic) chemistry toward an understanding of cytochrome c oxidase dioxygen chemistry
In aerobic organisms, the electron transport chain utilizes dioxygen reduction to water which leads to the production of a...
Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail
Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail
The water-soluble mitochondrial Ferredoxin 1 protein, also known as Adrenodoxin (Adx), is the universal redox partner for ...
Enhanced antibacterial activity of dimethyl gallium quinolinolates toward drug-resistant Klebsiella pneumoniae in low iron environments
Enhanced antibacterial activity of dimethyl gallium quinolinolates toward drug-resistant Klebsiella pneumoniae in low iron environments
A series of dimethylgallium quinolinolate [GaMe2L] (L = 5-chloroquinolinolate, 5, 7-dichloroquinolinolate, 5, 7-dibromoqui...
Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens
Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens
Heme is an important protein cofactor that has critical roles in a range of cellular processes, including electron transfe...
Aqueous chemistry of nalidixic acid and its complexes with biological relevant cations: A combination of potentiometric, UV spectrophotometric, MS and MS/MS study
Aqueous chemistry of nalidixic acid and its complexes with biological relevant cations: A combination of potentiometric, UV spectrophotometric, MS and MS/MS study
Nalidixic acid (NAL) is a broad-spectrum antimicrobial widely used for urinary tract infections. As demonstrated, complexa...
Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes
Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes
Transition metal complexes containing Schiff bases have attracted considerable attention because of their diverse uses, in...
The Cu(II) affinity constant and reactivity of Hepcidin-25, the main iron regulator in human blood
The Cu(II) affinity constant and reactivity of Hepcidin-25, the main iron regulator in human blood
Hepcidin is an iron regulatory hormone that does not bind iron directly. Instead, its mature 25-peptide form (H25) contain...
Targeted Metallo-Drugs: Design, Development, and Mode of Action, in: Vol. 24 of Metal Ions in Life Sciences (Guest Editors: Etelka Farkas, Celine J. Marmion. Series Editors: Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K. O. Sigel). CRC Press/Taylor & Francis Group, Boca Raton, London, New York (2023), E, -book)
Targeted Metallo-Drugs: Design, Development, and Mode of Action, in: Vol. 24 of Metal Ions in Life Sciences (Guest Editors: Etelka Farkas, Celine J. Marmion. Series Editors: Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K. O. Sigel). CRC Press/Taylor & Francis Group, Boca Raton, London, New York (2023), E, -book)
Clotilde Policar is a professor of Bioinorganic Chemistry at the Ecole Normale Supérieure - Université Paris Sciences et L...
8-Hydroxyquinoline ruthenium(II) complexes induce ferroptosis in HeLa cells by down-regulating GPX4 and ferritin
8-Hydroxyquinoline ruthenium(II) complexes induce ferroptosis in HeLa cells by down-regulating GPX4 and ferritin
Cancer is considered as a severe public health burden at home and abroad in recent years, and platinum drugs, as one of th...
Antitumor studies evaluation of triphenylphosphine ruthenium complexes with 5,7-dihalo-substituted-8-quinolinoline targeting mitophagy pathways
Antitumor studies evaluation of triphenylphosphine ruthenium complexes with 5,7-dihalo-substituted-8-quinolinoline targeting mitophagy pathways
Worldwide, cisplatin and it's lead compounds still are a major used successfully for several tumor types [[1], [2], [3]], ...
Resonance Raman spectra of blue copper proteins: Variable temperature spectra of Thermus thermophilus HB27 laccase
Resonance Raman spectra of blue copper proteins: Variable temperature spectra of Thermus thermophilus HB27 laccase
Ruthenium compounds are known to be potential drug candidates since they offer the potential for reduced toxicity. Further...
Modern avenues in metal-nucleic acid chemistry, in: Metal Ions in Life Sciences (Guest Editors: Jens Müller, Bernhard Lippert. Series Editors: Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K. O. Sigel), Vol. 25. CRC Press/Taylor & Francis Group, Boca Raton, London, New York (2023), 445 + xviii pp; ISSN: 1559-0836; 1868-0402 (electronic). ISBN: 978-1-032-21817-5 (hardback); 978-1-032-21827-4 (paperback); 978-1-003-27020-1 (E-book)
Modern avenues in metal-nucleic acid chemistry, in: Metal Ions in Life Sciences (Guest Editors: Jens Müller, Bernhard Lippert. Series Editors: Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K. O. Sigel), Vol. 25. CRC Press/Taylor & Francis Group, Boca Raton, London, New York (2023), 445 + xviii pp; ISSN: 1559-0836; 1868-0402 (electronic). ISBN: 978-1-032-21817-5 (hardback); 978-1-032-21827-4 (paperback); 978-1-003-27020-1 (E-book)
Christian Hartinger was born in 1974 in Gmünd, Austria. He received a MSc degree in Chemistry in 1999 from the University ...
Functional characterization of CYP1 enzymes: Complex formation, membrane localization and function
Functional characterization of CYP1 enzymes: Complex formation, membrane localization and function
Cytochrome P450s are known to catalyze the oxygenation of a wide variety of chemically diverse substrates [1,2]. The broad...
Tsuneo Omura – In memory of a Pioneer in cytochrome P450 research
Tsuneo Omura – In memory of a Pioneer in cytochrome P450 research
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22nd International Conference on Cytochrome P450 (ICCP450)
22nd International Conference on Cytochrome P450 (ICCP450)
The 21-hydroxylase (CYP21A2) is a steroidogenic enzyme crucial for the synthesis of mineralo- and glucocorticoids. It is d...
Anticandidal Cu(I) complexes with neocuproine and 1-(4-methoxyphenyl)piperazine based diphenylaminomethylphosphine: Is Cu-diimine moiety a pharmacophore?
Anticandidal Cu(I) complexes with neocuproine and 1-(4-methoxyphenyl)piperazine based diphenylaminomethylphosphine: Is Cu-diimine moiety a pharmacophore?
The studies on metal complexes as potential antifungals are of growing interest because they may be the answer to increasi...
Nitric oxide binding to ferrous nitrobindins: A computer simulation investigation
Nitric oxide binding to ferrous nitrobindins: A computer simulation investigation
Nitrobindins (Nbs) represent an evolutionary conserved all-β-barrel heme-proteins displaying a highly solvent-exposed heme...
Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands
Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands
KeywordsCobalt(III) complexesβ-KetoesterProdrugsHypoxia-activated drug deliveryAnticancer drugsDNA bindingAbbreviationsbza...
Influence of cholesterol on kinetic parameters for human aromatase (P450 19A1) in phospholipid nanodiscs
Cholesterol, which comprises 5–30% [[1], [2], [3], [4]] of the endoplasmic reticulum membrane, exerts significant effects ...
The case for an oxidopyrylium intermediate in the mechanism of quercetin dioxygenases
The family of quercetin dioxygenases (QDOs) catalyze the oxidative cleavage of the flavonol central ring, forming a depsid...
Ferrous nitrosylated cytochrome c: The unusual strength of the proximal His18-Fe bond
Retinal changes are poorly described in early treated phenylketonuria (ETPKU). We aimed to investigate possible visual fun...
Understanding the effect of the membrane-mimetic micelles on the interplay between α-synuclein and Cu(II)/Cu(I) cations
α-Synuclein (αS) is a presynaptic protein whose aggregates are considered as a hallmark of Parkinson's disease (PD). Altho...
Organogold(III)-dithiocarbamate compounds and their coordination analogues as anti-tumor and anti-leishmanial metallodrugs
The first use of gold in medicine can be dated back to the ancient imperial Chinese culture, around early 2500 BCE, when g...
IRMPD spectroscopy and quantum-chemical simulations of the reaction products of cisplatin with the dipeptide CysGly
The inorganic antineoplastic drug cisplatin was made to react in solution with the dipeptide cysteinylglycine (CysGly), ch...
Interactions of arylhydroxylamines and alkylaldoximes with a rhodium porphyrin
Organic compounds containing the N-hydroxyl “NOH” functional group are important intermediates in the global nitrogen cycl...
Neutral and cationic nickel(II) complexes with substituted salicylaldehydes: Characterization, antibacterial activity, and interaction with biomacromolecules
Nickel was involved during the early stages of life evolution before the ‘Great Oxidation Event’ and the accumulation of o...
The terminal oxidase cytochrome bd-I confers carbon monoxide resistance to Escherichia coli cells
Volume 247, October 2023, 112341Author links open overlay panel, , AbstractCarbon monoxide (CO) plays a multifaceted role ...
Michael R. Waterman and Cytochrome P450
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