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Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens
Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens
Heme is an important protein cofactor that has critical roles in a range of cellular processes, including electron transfe...
The Cu(II) affinity constant and reactivity of Hepcidin-25, the main iron regulator in human blood
The Cu(II) affinity constant and reactivity of Hepcidin-25, the main iron regulator in human blood
Hepcidin is an iron regulatory hormone that does not bind iron directly. Instead, its mature 25-peptide form (H25) contain...
8-Hydroxyquinoline ruthenium(II) complexes induce ferroptosis in HeLa cells by down-regulating GPX4 and ferritin
8-Hydroxyquinoline ruthenium(II) complexes induce ferroptosis in HeLa cells by down-regulating GPX4 and ferritin
Cancer is considered as a severe public health burden at home and abroad in recent years, and platinum drugs, as one of th...
Resonance Raman spectra of blue copper proteins: Variable temperature spectra of Thermus thermophilus HB27 laccase
Resonance Raman spectra of blue copper proteins: Variable temperature spectra of Thermus thermophilus HB27 laccase
Ruthenium compounds are known to be potential drug candidates since they offer the potential for reduced toxicity. Further...
Functional characterization of CYP1 enzymes: Complex formation, membrane localization and function
Functional characterization of CYP1 enzymes: Complex formation, membrane localization and function
Cytochrome P450s are known to catalyze the oxygenation of a wide variety of chemically diverse substrates [1,2]. The broad...
Tsuneo Omura – In memory of a Pioneer in cytochrome P450 research
Tsuneo Omura – In memory of a Pioneer in cytochrome P450 research
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22nd International Conference on Cytochrome P450 (ICCP450)
22nd International Conference on Cytochrome P450 (ICCP450)
The 21-hydroxylase (CYP21A2) is a steroidogenic enzyme crucial for the synthesis of mineralo- and glucocorticoids. It is d...
Nitric oxide binding to ferrous nitrobindins: A computer simulation investigation
Nitric oxide binding to ferrous nitrobindins: A computer simulation investigation
Nitrobindins (Nbs) represent an evolutionary conserved all-β-barrel heme-proteins displaying a highly solvent-exposed heme...
Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands
Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands
KeywordsCobalt(III) complexesβ-KetoesterProdrugsHypoxia-activated drug deliveryAnticancer drugsDNA bindingAbbreviationsbza...
Influence of cholesterol on kinetic parameters for human aromatase (P450 19A1) in phospholipid nanodiscs
Cholesterol, which comprises 5–30% [[1], [2], [3], [4]] of the endoplasmic reticulum membrane, exerts significant effects ...
The case for an oxidopyrylium intermediate in the mechanism of quercetin dioxygenases
The family of quercetin dioxygenases (QDOs) catalyze the oxidative cleavage of the flavonol central ring, forming a depsid...
Ferrous nitrosylated cytochrome c: The unusual strength of the proximal His18-Fe bond
Retinal changes are poorly described in early treated phenylketonuria (ETPKU). We aimed to investigate possible visual fun...
Understanding the effect of the membrane-mimetic micelles on the interplay between α-synuclein and Cu(II)/Cu(I) cations
α-Synuclein (αS) is a presynaptic protein whose aggregates are considered as a hallmark of Parkinson's disease (PD). Altho...
Organogold(III)-dithiocarbamate compounds and their coordination analogues as anti-tumor and anti-leishmanial metallodrugs
The first use of gold in medicine can be dated back to the ancient imperial Chinese culture, around early 2500 BCE, when g...
IRMPD spectroscopy and quantum-chemical simulations of the reaction products of cisplatin with the dipeptide CysGly
The inorganic antineoplastic drug cisplatin was made to react in solution with the dipeptide cysteinylglycine (CysGly), ch...
Interactions of arylhydroxylamines and alkylaldoximes with a rhodium porphyrin
Organic compounds containing the N-hydroxyl “NOH” functional group are important intermediates in the global nitrogen cycl...
The terminal oxidase cytochrome bd-I confers carbon monoxide resistance to Escherichia coli cells
Volume 247, October 2023, 112341Author links open overlay panel, , AbstractCarbon monoxide (CO) plays a multifaceted role ...
Michael R. Waterman and Cytochrome P450
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