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Tumour cell heterogeneity in triple-negative breast cancer cells affects response to cisplatin, but not doxorubicin
Tumour cell heterogeneity affects cisplatin but not doxorubicin cytotoxicity in two phenotypes of the triple-negative brea...
A Vanadium(V) complexes derived from pyridoxal/salicylaldehyde. Interaction with CT-DNA/HSA, and molecular docking assessments
With the increasing development of metallopharmaceuticals, coordination compounds become viable alternatives for therapeut...
A hypoxia responsive silicon phthalocyanine containing naphthquinone axial ligands for photodynamic therapy activity
CAMCoulomb attenuated methodDCF2′,7′-dichlorodihydrofluoresceinDCFH2′,7′-dichlorodihydrofluorescein diacetateDFTdensity fu...
Mitochondrial targeting half-sandwich iridium(III) and ruthenium(II) dppf complexes and in vitro anticancer assay
A549 cellshuman non-small cell lung cancer cellsHela cellshuman cervical cancer cellsBEAS-2Bnormal human lung epithelial c...
Oxidation of bisphenol A (BPA) and related compounds by the multifunctional catalytic globin dehaloperoxidase
Dehaloperoxidase (DHP) from the marine polychaete Amphitrite ornata is a multifunctional enzyme that possesses peroxidase,...
How Cu(II) binding affects structure and dynamics of α-synuclein revealed by molecular dynamics simulations
We report accelerated molecular dynamics simulations of α-Synuclein and its complex with two Cu(II) ions bound to experime...
Unlocking the potential of iridium and ruthenium arene complexes as anti-tumor and anti-metastasis chemotherapeutic agents
It is a major challenge to design novel multifunctional metal-based chemotherapeutic agents for anti-tumor and anti-metast...
Biomimetics for purple acid phosphatases: A historical perspective
Biomimetics hold potential for varied applications in biotechnology and medicine but have also attracted particular intere...
The divergent pH dependence of substrate turnover in dehaloperoxidases A and B
The pH-dependent peroxidase activity in both dehaloperoxidases A and B was studied by a kinetic assay, stopped flow spectr...
Reactivity of a nitrosyl ruthenium complex and its potential impact on the fate of DNA – An in vitro investigation
The role of metal complexes on facing DNA has been a topic of major interest. However, metallonitrosyl compounds have been...
Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases
Boron-containing compounds (BCC) exert effects on neurons. After the expanding of both the identification and synthesis of...
Photo-chemical aspects of iron complexes exhibiting photo-activated chemotherapy (PACT)
KeywordsIron complexesPhotochemistryReactive oxygen speciesCancerPhoto-activated chemotherapy (PACT)AbbreviationsA549Human...
Rational design of photoactivatable metal complexes to target and modulate amyloid-β peptides
The accumulation of amyloid-β (Aβ) aggregates is found in the brains of Alzheimer's disease patients. Thus, numerous effor...
Anticancer effect evaluation of iridium(III) complexes targeting mitochondria and endoplasmic reticulum
KeywordsIridium(III) complexesEndoplasmic reticulum stressMitochondrial pathwayApoptosisWestern blot analysisAbbreviations...
Electrochemical characterization of a family AA10 LPMO and the impact of residues shaping the copper site on reactivity
Research on enzymes for lignocellulose biomass degradation has progressively increased in recent years due to the interest...
Chelating decorporation agents for internal contamination by actinides: Designs, mechanisms, and advances
During the wide utilization of the actinides in medicine, energy, military, and other fields, internal contaminations can ...