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Regulations of mitoNEET by the key redox homeostasis molecule glutathione
Regulations of mitoNEET by the key redox homeostasis molecule glutathione
Human mitoNEET (mNT) and CISD2 are two NEET proteins characterized by an atypical [2Fe-2S] cluster coordination involving ...
One-pot synthesis, structural investigation, antitumor activity and molecular docking approach of two decavanadate compounds
One-pot synthesis, structural investigation, antitumor activity and molecular docking approach of two decavanadate compounds
Vanadium, being a trace transition metal, possesses potential biological, pharmacological, and physicochemical properties....
Reduction of molecular oxygen in flavodiiron proteins - Catalytic mechanism and comparison to heme-copper oxidases
Reduction of molecular oxygen in flavodiiron proteins - Catalytic mechanism and comparison to heme-copper oxidases
When oxygen, produced by cyanobacteria as a by-product of photosynthesis, started appearing in the atmosphere some 2.5 bil...
Erbium(III) complexes with fluoroquinolones: Structure and biological properties
Erbium(III) complexes with fluoroquinolones: Structure and biological properties
Lanthanides are a group of elements that have atomic numbers between 57 (lanthanum) to 71 (lutetium) [1]. Lanthanides are ...
Tyrosine nitration of glucagon impairs its function: Extending the role of heme in T2D pathogenesis
Tyrosine nitration of glucagon impairs its function: Extending the role of heme in T2D pathogenesis
Diabetes is a metabolic disorder characterized by hyperglycemia resulting from an absolute deficiency of insulin secretion...
Systematic review on antibacterial photodynamic therapeutic effects of transition metals ruthenium and iridium complexes
Systematic review on antibacterial photodynamic therapeutic effects of transition metals ruthenium and iridium complexes
Antibiotic resistance is one of the most urgent and savior health problems in the whole world; along with health care, it ...
Novel Titanocene Y derivative with albumin affinity exhibits improved anticancer activity against platinum resistant cells
Novel Titanocene Y derivative with albumin affinity exhibits improved anticancer activity against platinum resistant cells
The antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment in the past, but their lac...
Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy
Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy
Cisplatin, a typical cytotoxic antitumor drug, has been widely used for the treatment of solid tumors, such as testicular,...
Fluorination of porphyrin β-periphery boosts nickel(II)-catalyzed hydrogen evolution reaction
Fluorination of porphyrin β-periphery boosts nickel(II)-catalyzed hydrogen evolution reaction
Hydrogen, a clean energy source, holds great promise as an alternative in our transition away from the present-day hydroca...
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects
Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects
Unique anti-cancer mechanisms and broad spectrum of platinum drugs make them one of the most widely used chemotherapy drug...
Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex
Cancer has a significant impact and burden on public health and the socioeconomic landscape [1]. Although interventions su...
Thermoresponsive carboplatin-releasing prodrugs
Thermoresponsive carboplatin-releasing prodrugs
Platinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy ...
The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I)
Copper (Cu) is an essential micronutrient but is also a cytotoxic element [[1], [2], [3]]. Living organisms need to tightl...
Stabilization of a Cu-binding site by a highly conserved tryptophan residue
Stabilization of a Cu-binding site by a highly conserved tryptophan residue
KeywordsX-ray crystallographyCopper-binding siteMonohistidine braceDomain of unknown functionMetalloproteinAbbreviationsDU...
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer
The mortality rate of ovarian cancer is the highest among all gynecological malignancies [1]. Therapeutic strategies consi...
Redox potentials elucidate the electron transfer pathway of NAD+-dependent formate dehydrogenases
Redox potentials elucidate the electron transfer pathway of NAD+-dependent formate dehydrogenases
bis-MGDbis-metal-binding pterin guanine dinucleotideCAPSN-cyclohexyl-3-aminopropanesulfonic acidcryo-EMcryogenic electron ...
Evaluation of heteroscorpionate ligands as scaffolds for the generation of Ruthenium(II) metallodrugs in breast cancer therapy
Evaluation of heteroscorpionate ligands as scaffolds for the generation of Ruthenium(II) metallodrugs in breast cancer therapy
KeywordsHeteroscorpionate ligandsTNBCRAPTA derivativesPreclinical evaluationUptake studiesFluorescence lifetime imaging mi...
In Memoriam – Ademir Neves *1951-†2022
In Memoriam – Ademir Neves *1951-†2022
Volume 252, March 2024, 112485Author links open overlay panelRosely A. Peralta 1Show morePrevious article in issueNext art...
Investigating Cu(I) binding to model peptides of N-terminal Aβ isoforms
Investigating Cu(I) binding to model peptides of N-terminal Aβ isoforms
Amyloid beta (Aβ) peptides became the subject of intense interest in the 1980s when the amyloid cascade hypothesis (ACH) w...