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Diabetes Causes NLRP3-Dependent Barrier Dysfunction in Mice with Detrusor Overactivity but not Underactivity
Diabetes Causes NLRP3-Dependent Barrier Dysfunction in Mice with Detrusor Overactivity but not Underactivity
Approximately half of diabetic patients develop diabetic bladder dysfunction (DBD). The initiation and progression of DBD ...
H2-gamendazole (H2-GMZ): a new therapeutic lead for treatment of polycystic kidney disease
H2-gamendazole (H2-GMZ): a new therapeutic lead for treatment of polycystic kidney disease
* Corresponding Author; email: [email protected]1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA...
Impact of Bedding on Dahl Salt-Sensitive Hypertension and Renal Damage
Impact of Bedding on Dahl Salt-Sensitive Hypertension and Renal Damage
Salt-sensitive hypertension, increases in blood pressure in response to increased salt intake, is associated with an incre...
H2-gamendazole (H2-GMZ): a new therapeutic lead for treatment of polycystic kidney4 disease
H2-gamendazole (H2-GMZ): a new therapeutic lead for treatment of polycystic kidney4 disease
* Corresponding Author; email: [email protected]1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA...
Potential of soluble (pro)renin receptor in kidney disease: Can it go beyond a biomarker?
Potential of soluble (pro)renin receptor in kidney disease: Can it go beyond a biomarker?
(Pro)renin receptor (PRR) also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2) belongs to type I transmembr...
SLC41A1 knockout mice display normal magnesium homeostasis
SLC41A1 knockout mice display normal magnesium homeostasis
Transcellular magnesium (Mg2+) reabsorption in the distal convoluted tubule (DCT) of the kidneys plays an important role i...
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury
Objective: Pericytes are considered as reparative mesenchymal stem cell (MSC)-like cells, but their ability to ameliorate ...
Podocytes are lost from glomeruli before completing apoptosis
Podocytes are lost from glomeruli before completing apoptosis
Although apoptosis of podocytes has been widely reported in in vitro studies, it is less frequently and less definitively ...
Mapping single nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging
Mapping single nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging
The kidney has an extraordinary ability to maintain glomerular filtration despite natural fluctuations in blood pressure o...
Role of coagulation in persistent renal ischemia following reperfusion in an animal model
Role of coagulation in persistent renal ischemia following reperfusion in an animal model
Ischemic acute kidney injury (AKI) is common, deadly, and accelerates progression of chronic kidney disease (CKD), yet has...
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice
End-stage kidney disease (ESKD), the most advanced stage of chronic kidney disease (CKD), requires renal replacement thera...
Cullin 3 mutant causing Familial Hyperkalemic Hypertension lacks normal activity in kidney
Cullin 3 mutant causing Familial Hyperkalemic Hypertension lacks normal activity in kidney
Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) cause the disease Familial Hyperkalemic Hypertension (F...
The Lonidamine Derivative H2-Gamendazole Reduces Cyst Formation in Polycystic Kidney Disease
The Lonidamine Derivative H2-Gamendazole Reduces Cyst Formation in Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating renal neoplastic disorder with limited treatment op...
The Michigan O'Brien Kidney Research Center - transforming translational kidney research through systems biology
The Michigan O'Brien Kidney Research Center - transforming translational kidney research through systems biology
Research on kidney diseases is being transformed by the rapid expansion and innovations in omics technologies. Analysis, i...
Kidney-targeted irradiation triggers renal ischemic preconditioning in mice
Kidney-targeted irradiation triggers renal ischemic preconditioning in mice
This study based on a mouse model of renal ischemia-reperfusion (I/R) aimed to 1) test whether and how irradiation strictl...
Aromatase Inhibition Increases Blood Pressure and Markers of Renal Injury in Female Rats
Aromatase Inhibition Increases Blood Pressure and Markers of Renal Injury in Female Rats
Aromatase is a monooxygenase that catalyzes the rate-limiting step of estrogen biosynthesis from androgens. Aromatase inhi...
Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier
Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier
Wilms tumor interacting protein (Wtip) has been implicated in cell junction assembly and cell differentiation and interact...