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Brown-Norway chromosome 1 mitigates the upregulation of proinflammatory pathways in mTAL cells and subsequent age-related CKD in Dahl SS/JrHsdMcwi rats
Brown-Norway chromosome 1 mitigates the upregulation of proinflammatory pathways in mTAL cells and subsequent age-related CKD in Dahl SS/JrHsdMcwi rats
This study shows that the robust age-related progression of kidney disease in Dahl SS/JrHsdMcw rats maintained on a normal...
Therapeutic effects of KCC2 chloride transporter activation on detrusor overactivity in mice with spinal cord injury
Therapeutic effects of KCC2 chloride transporter activation on detrusor overactivity in mice with spinal cord injury
This study aimed to clarify whether the down regulation of K+-Cl−co-transporter 2 (KCC2) in the sacral parasympathetic nuc...
Pendrin regulation is prioritized by anion in high potassium diets
Pendrin regulation is prioritized by anion in high potassium diets
The bicarbonate-chloride exchanger, pendrin, in the kidney maintains acid-base balance and intravascular volume. Pendrin i...
Magnesium reabsorption in the kidney
Magnesium reabsorption in the kidney
Magnesium is essential for many cellular and physiological processes, including muscle contraction, neuronal activity and ...
B2 cells contribute to hypertension and natural killer cell activation possibly via AT1-AA in response to placental ischemia
B2 cells contribute to hypertension and natural killer cell activation possibly via AT1-AA in response to placental ischemia
This study demonstrates that placental ischemia-stimulated B2 cells induce hypertension and circulating natural killer cel...
The Transcription Factor Foxi1 Promotes Expression of V-ATPase and Gpr116 in M-1 Cells
The Transcription Factor Foxi1 Promotes Expression of V-ATPase and Gpr116 in M-1 Cells
The diverse functions of each nephron segment rely on the coordinated action of specialized cell populations that are uniq...
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity
Mutations in the HNF1B gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD)-HNF1β, a rare and heterogen...
WT1 regulates expression of DNA-repair gene Neil3 during nephrogenesis
WT1 regulates expression of DNA-repair gene Neil3 during nephrogenesis
Mammalian nephrons arise from a population of nephron progenitor cells (NPCs) expressing the master transcription factor, ...
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney
Recent studies using murine models have shown that SRY box transcription factor 9 (SOX9) is activated during repair of ren...
Cardiac effects of renal ischemia
Cardiac effects of renal ischemia
Acute kidney injury is common, expensive, and deadly, yet morbidity and mortality are often secondary to remote organ dysf...
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort
The findings of our study are significant in several ways: 1) loss of an amino acid chaperone in the proximal tubule is su...
Lasmiditan promotes recovery from acute kidney injury through induction of mitochondrial biogenesis
Lasmiditan promotes recovery from acute kidney injury through induction of mitochondrial biogenesis
AKI pathology involves a rapid decline in kidney function and occurs in 8–16% of hospitalized patients. There is currently...
Data resource: vasopressin-regulated protein phosphorylation sites in the collecting duct
Data resource: vasopressin-regulated protein phosphorylation sites in the collecting duct
Vasopressin regulates renal water excretion through control of the aquaporin-2 water channel in collecting duct cells. Stu...
Brown-Norway chromosome 1 mitigates the upregulation of pro-inflammatory pathways in mTAL cells and subsequent age-related CKD in Dahl SS/JrHsdMcwi Rats
Brown-Norway chromosome 1 mitigates the upregulation of pro-inflammatory pathways in mTAL cells and subsequent age-related CKD in Dahl SS/JrHsdMcwi Rats
Chronic kidney disease (CKD) has a strong genetic component; however, the underlying pathways are not well understood. Dah...
Epoxyeicosatrienoic Acid administration or Soluble Epoxide Hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy
Epoxyeicosatrienoic Acid administration or Soluble Epoxide Hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites with biological effects, including anti-apoptotic, anti-...
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in human kidney
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in human kidney
Induction of SRY-box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where ...
Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis
Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis
* Corresponding Author; email: [email protected]1Department of Medicine, Indiana University School of Medicine and the Ind...
Nicorandil protects podocytes via modulation of antioxidative capacity in acute puromycin aminonucleoside-induced nephrosis in rats
Nicorandil protects podocytes via modulation of antioxidative capacity in acute puromycin aminonucleoside-induced nephrosis in rats
Nephrotic syndrome, characterized by proteinuria and hypoalbuminemia, results from the dysregulation of glomerular podocyt...
Intracellular sites of AQP2 S256 phosphorylation identified using inhibitors of the AQP2 recycling itinerary
Intracellular sites of AQP2 S256 phosphorylation identified using inhibitors of the AQP2 recycling itinerary
Vasopressin (VP) regulated aquaporin-2 (AQP2) trafficking between cytoplasmic vesicles and the plasma membrane of kidney p...
H2-gamendazole: a new therapeutic lead for the treatment of polycystic kidney disease
H2-gamendazole: a new therapeutic lead for the treatment of polycystic kidney disease
Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PennsylvaniaDepartment of Biochemistry and Molecula...
B2 cells Contribute to the Pathophysiology of Hypertension in Response to Placental Ischemia
B2 cells Contribute to the Pathophysiology of Hypertension in Response to Placental Ischemia
Preeclampsia (PE), new onset hypertension during pregnancy, is associated with activated T Helper cells (Th), and B cells ...
Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis
Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis
While mesangial cell-glomerular basement membrane (GBM) connections play a key role in maintaining the glomerular capillar...
Formation of the glomerular microvasculature is regulated by VEGFR-3
Formation of the glomerular microvasculature is regulated by VEGFR-3
Microvascular dysfunction is a key driver of kidney disease. Pathophysiological changes in the kidney vasculature are regu...
VEGFR2 insufficiency enhances phosphotoxicity and undermines Klotho's protection against peritubular capillary rarefaction and kidney fibrosis
VEGFR2 insufficiency enhances phosphotoxicity and undermines Klotho's protection against peritubular capillary rarefaction and kidney fibrosis
The vascular endothelial growth factor (VEGF) and its cognate receptor (VEGFR2) system is crucial for cell functions assoc...
Cardiac Effects of Renal Ischema
Cardiac Effects of Renal Ischema
Mortality in acute kidney injury (AKI) remains unacceptably high, yet the cause of death is commonly related to dysfunctio...
Lasmiditan Promotes Recovery of Renal Function Through Mitochondrial Biogenesis
Lasmiditan Promotes Recovery of Renal Function Through Mitochondrial Biogenesis
Background. Acute kidney injury (AKI) involves rapid loss of renal function and occurs in 8-16% of hospitalized patients. ...
Collectrin (Tmem27) Deficiency in Proximal Tubule Causes Hypertension in Mice and a TMEM27 Variant Associates with Blood Pressure in Males in a Latino Cohort
Collectrin (Tmem27) Deficiency in Proximal Tubule Causes Hypertension in Mice and a TMEM27 Variant Associates with Blood Pressure in Males in a Latino Cohort
Background: Collectrin (Tmem27), an ACE2 homologue, is a chaperone of amino acid transporters in the kidney and endotheliu...
Sex Differences in Circadian Regulation of Kidney Function of the Mouse
Sex Differences in Circadian Regulation of Kidney Function of the Mouse
Kidney function is regulated by the circadian clock. Not only do glomerular filtration rate (GFR) and urinary excretion os...
The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis
The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis
The renal response to acid-base disturbances involves phenotypic and remodeling changes in the collecting duct. This study...
Mutagenesis of the Cleavage Site of (Pro)Renin Receptor Abrogates Aldosterone-salt-Induced Hypertension and Renal injury in Mice
Mutagenesis of the Cleavage Site of (Pro)Renin Receptor Abrogates Aldosterone-salt-Induced Hypertension and Renal injury in Mice
Soluble (pro)renin receptor (sPRR), the extracellular domain of (pro)renin receptor (PRR), is primarily generated by site-...
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