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Impact of cumulative exposure to anticholinergic and sedative drugs on cognition in older adults: a memory clinic cohort study
Impact of cumulative exposure to anticholinergic and sedative drugs on cognition in older adults: a memory clinic cohort study
Long-term exposure to anticholinergic and sedative drugs could be a modifiable risk factor for cognitive decline. The obje...
The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
The cognitive effect of non-invasive brain stimulation combined with cognitive training in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis
Non-invasive brain stimulation (NIBS) combined with cognitive training (CT) may have shown some prospects on improving cog...
The criteria used to rule out mild cognitive impairment impact dementia incidence rates in subjective cognitive decline
The criteria used to rule out mild cognitive impairment impact dementia incidence rates in subjective cognitive decline
The research criteria for subjective cognitive decline (SCD) exclude mild cognitive impairment (MCI), but do not stipulate...
Diagnostic performance of plasma pTau217, pTau181, Aβ1-42 and Aβ1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease
Diagnostic performance of plasma pTau217, pTau181, Aβ1-42 and Aβ1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease
Recently developed blood markers for Alzheimer's disease (AD) detection have high accuracy but usually require ultra-s...
Association between depression and young-onset dementia in middle-aged women
Association between depression and young-onset dementia in middle-aged women
Dementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (...
The longitudinal trajectory of CSF sTREM2: the alzheimer’s disease neuroimaging initiative
The longitudinal trajectory of CSF sTREM2: the alzheimer’s disease neuroimaging initiative
The soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) is considered a biomark...
Association of MAFLD and MASLD with all-cause and cause-specific dementia: a prospective cohort study
Association of MAFLD and MASLD with all-cause and cause-specific dementia: a prospective cohort study
Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the...
Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals
Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals
Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, ...
Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Aging and sex are major risk factors for developing late-onset Alzheimer’s disease. Compared to men, women experienc...
Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis
Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis
Computer gaming has recently been suggested to be associated with benefits for cognition, but its impact on incident demen...
Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers
Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers
Studies suggest that cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)42 and Aβ40 present a circadian rhyt...
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations
Our study aims to evaluate the genetic and phenotypic spectrum of Frontotemporal dementia (FTD) gene variant carriers in C...
Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study
Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study
This study aimed to evaluate the potential clinical value of a new brain age prediction model as a single interpretable va...
Amyloid-PET imaging predicts functional decline in clinically normal individuals
Amyloid-PET imaging predicts functional decline in clinically normal individuals
There is good evidence that elevated amyloid-β (Aβ) positron emission tomography (PET) signal is associ...
Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer’s pathology: a cohort study
Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer’s pathology: a cohort study
Autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (LC) is among the earliest regions...
Distinct effects of blood pressure parameters on Alzheimer’s and vascular markers in 1,952 Asian individuals without dementia
Distinct effects of blood pressure parameters on Alzheimer’s and vascular markers in 1,952 Asian individuals without dementia
Risk factors for cardiovascular disease, including elevated blood pressure, are known to increase risk of Alzheimer’...
A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults—study design and baseline characteristics of the FINGER-NL randomized controlled trial
A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults—study design and baseline characteristics of the FINGER-NL randomized controlled trial
Evidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without ...
Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults
Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults
Higher order regulation of autonomic function is maintained by the coordinated activity of specific cortical and subcortic...
Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion
Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion
Recent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of ...
Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical ...
Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer’s disease
Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer’s disease
Beta-amyloid (Aβ) deposition in the brain parenchyma is a crucial initiating step in the amyloid cascade hypothesis o...
Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia
Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia
Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases ...
Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease
Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease
Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline ...
Cholinesterase inhibitors and memantine are associated with a reduced mortality in nursing home residents with dementia: a longitudinal observational study
Cholinesterase inhibitors and memantine are associated with a reduced mortality in nursing home residents with dementia: a longitudinal observational study
A large proportion of nursing home (NH) residents suffer from dementia and effects of conventional anti-dementia drugs on ...
Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer’s disease: the MIND-ADmini randomized controlled trial
Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer’s disease: the MIND-ADmini randomized controlled trial
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits...
Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly
Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly
Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using bl...
Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia
Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia
The gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, and deoxycarnit...
Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer’s-like clinical phenotype
Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer’s-like clinical phenotype
Systemic inflammation and neuroinflammation affect the natural course of the sporadic form of Alzheimer’s disease (A...
Photobiomodulation in experimental models of Alzheimer’s disease: state-of-the-art and translational perspectives
Photobiomodulation in experimental models of Alzheimer’s disease: state-of-the-art and translational perspectives
Alzheimer’s disease (AD) poses a significant public health problem, affecting millions of people across the world. D...
Comparison of plasma and neuroimaging biomarkers to predict cognitive decline in non-demented memory clinic patients
Comparison of plasma and neuroimaging biomarkers to predict cognitive decline in non-demented memory clinic patients
Plasma biomarkers of Alzheimer’s disease (AD) pathology, neurodegeneration, and neuroinflammation are ideally suited...
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