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Intracerebral hemorrhage following mild ARIA-H in an APOE ε2 carrier receiving lecanemab
Intracerebral hemorrhage following mild ARIA-H in an APOE ε2 carrier receiving lecanemab
Report a case of an apolipoprotein E (APOE)ε2 carrier receiving lecanemab who developed late onset intracerebral hemo...
Cognitive decline profiles associated with lewy pathology in the context of Alzheimer’s disease neuropathologic change
Cognitive decline profiles associated with lewy pathology in the context of Alzheimer’s disease neuropathologic change
Alzheimer’s disease neuropathologic change (ADNC) and Lewy pathology (LP) often coexist in cognitively impaired indi...
Association of critically short telomeres with brain and blood markers of ageing and Alzheimer’s disease in older adults
Association of critically short telomeres with brain and blood markers of ageing and Alzheimer’s disease in older adults
Accumulation of critically short telomeres (CST) is implicated in decreased tissular regenerative capacity and increased s...
Longitudinal trajectory of plasma p-tau217 in cognitively unimpaired subjects
Longitudinal trajectory of plasma p-tau217 in cognitively unimpaired subjects
The advent of Alzheimer’s disease-modifying drugs requires accurate biological diagnosis to identify candidates for ...
Brain derived β-interferon is a potential player in Alzheimer’s disease pathogenesis and cognitive impairment
Brain derived β-interferon is a potential player in Alzheimer’s disease pathogenesis and cognitive impairment
Recent research has postulated that the activation of cGAS-STING-interferon signalling pathways could be implicated in the...
Frequency, sociodemographic, and neuropsychological features of patients with subjective cognitive decline diagnosed using different neuropsychological criteria
Frequency, sociodemographic, and neuropsychological features of patients with subjective cognitive decline diagnosed using different neuropsychological criteria
Subjective Cognitive Decline (SCD) is recognized as a risk stage for future cognitive impairment and dementia. The criteri...
Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway
Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway
Neurodegenerative disorders, including Alzheimer’s disease (AD), have been linked to alterations in tryptophan (TRP)...
Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort
Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort
Second-generation tau tracers for positron emission tomography (PET) show high affinity for paired helical filaments tau d...
Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia
Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia
The increasing prevalence of dementia and the introduction of disease-modifying therapies (DMTs) highlight the need for ef...
Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly
Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly
Cognitive decline with age has heterogeneous, which might be related to the accumulation of protective factors called cogn...
Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217
Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217
The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer’s disease ...
A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first results
A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first results
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multimodal lifestyle inte...
Can the clinical sign “head-turning sign” and simple questions in “Neucop-Q” predict amyloid β pathology?
Can the clinical sign “head-turning sign” and simple questions in “Neucop-Q” predict amyloid β pathology?
To establish simple screening tests to suspect Alzheimer’s disease (AD) pathology, the clinical sign “head-tur...
Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans
Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans
Phosphorylated tau (p-tau) and amyloid beta (Aβ) in human plasma may provide an affordable and minimally invasive met...
Unveiling the molecular mechanisms of Danggui-Shaoyao-San against Alzheimer’s disease in APP/PS1 mice via integrating proteomic and metabolomic approaches
Unveiling the molecular mechanisms of Danggui-Shaoyao-San against Alzheimer’s disease in APP/PS1 mice via integrating proteomic and metabolomic approaches
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder for which no effective therapy is currentl...
Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment: data from the NORFACE cohort
Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment: data from the NORFACE cohort
Optical coherence tomography (OCT) enables high-resolution imaging of ocular structures in health and disease. Choroid thi...
Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease
Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease
The role of Vascular risk factors (VRFs) in the progression of Alzheimer’s Disease (AD) and cognitive decline remain...
Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer’s disease
Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer’s disease
Females have a higher age-adjusted incidence of Alzheimer’s Disease (AD) than males, even when accounting for longer...
Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer’s disease progression: a systematic review
Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer’s disease progression: a systematic review
Alzheimer disease (AD) remains a significant global health concern. The progression from preclinical stages to overt demen...
Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort
Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort
White matter hyperintensities (WMH) on brain MRI images are the most common feature of cerebral small vessel disease (CSVD...
Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and the drivers of such a structural cha...
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked...
Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer’s disease or frontotemporal dementia
Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer’s disease or frontotemporal dementia
The loss of olfactory function is known to occur in patients suffering from (behavioral variant) frontotemporal dementia (...
EEG biomarkers in Alzheimer’s and prodromal Alzheimer’s: a comprehensive analysis of spectral and connectivity features
EEG biomarkers in Alzheimer’s and prodromal Alzheimer’s: a comprehensive analysis of spectral and connectivity features
Biomarkers of Alzheimer’s disease (AD) and mild cognitive impairment (MCI, or prodromal AD) are highly significant f...
Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology
Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology
Dementia preventive interventions targeting multiple modifiable risk factors are a promising approach. However, the impact...
Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia
Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia
Behavioral variant frontotemporal dementia (bvFTD) is characterized by profound and early deficits in social cognition (SC...
Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases
Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases
Alzheimer’s disease (AD) is a multifactorial disease with both genetic and environmental factors contributing to its...
The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study
The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study
Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer’s disease (AD) demen...
Blockade of brain alkaline phosphatase efficiently reduces amyloid-β plaque burden and associated cognitive impairment
Blockade of brain alkaline phosphatase efficiently reduces amyloid-β plaque burden and associated cognitive impairment
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. Three new drugs for AD based on monoclonal...
Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease
Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease
Variants of the gene triggering receptor expressed on myeloid cells-2 (TREM2) increase the risk of Alzheimer’s disea...
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