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Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
Early-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ ...
Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study
Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study
Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cogniti...
Alteration of medial temporal lobe metabolism related to Alzheimer’s disease and dementia with lewy bodies
Alteration of medial temporal lobe metabolism related to Alzheimer’s disease and dementia with lewy bodies
Association of medial temporal lobe (MTL) metabolism with Alzheimer’s disease (AD) and dementia with Lewy bodies (DL...
Longitudinal validation of cognitive reserve proxy measures: a cohort study in a rural Chinese community
Longitudinal validation of cognitive reserve proxy measures: a cohort study in a rural Chinese community
While evidence supports cognitive reserve (CR) in preserving cognitive function, longitudinal validation of CR proxies, in...
Exploring morphological similarity and randomness in Alzheimer’s disease using adjacent grey matter voxel-based structural analysis
Exploring morphological similarity and randomness in Alzheimer’s disease using adjacent grey matter voxel-based structural analysis
Alzheimer’s disease is characterized by large-scale structural changes in a specific pattern. Recent studies develop...
Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy
Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy
Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) for react...
Who am I with my Lewy bodies? The insula as a core region of the self-concept networks
Who am I with my Lewy bodies? The insula as a core region of the self-concept networks
Dementia with Lewy bodies (DLB) is characterized by insular atrophy, which occurs at the early stage of the disease. Damag...
Pathophysiology characterization of Alzheimer’s disease in South China’s aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS)
Pathophysiology characterization of Alzheimer’s disease in South China’s aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS)
The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significan...
Prefrontal intra-individual ERP variability and its asymmetry: exploring its biomarker potential in mild cognitive impairment
Prefrontal intra-individual ERP variability and its asymmetry: exploring its biomarker potential in mild cognitive impairment
The worldwide trend of demographic aging highlights the progress made in healthcare, albeit with health challenges like Al...
Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis
Risk of conversion to mild cognitive impairment or dementia among subjects with amyloid and tau pathology: a systematic review and meta-analysis
Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of ne...
Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow
Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow
In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Pat...
Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer’s disease
Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer’s disease
Previous studies have demonstrated that early intervention was the best plan to inhibit the progression of Alzheimer’...
Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer’...
Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals
Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals
Individuals on the preclinical Alzheimer's continuum, particularly those with both amyloid and tau positivity (A ...
Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition
Biophysical models applied to dementia patients reveal links between geographical origin, gender, disease duration, and loss of neural inhibition
The hypothesis of decreased neural inhibition in dementia has been sparsely studied in functional magnetic resonance imagi...
Equine-assisted services for people living with dementia: a systematic review
Equine-assisted services for people living with dementia: a systematic review
Dementia has a significant impact on the social, physical, and psychological wellbeing of people living with dementia, the...
Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy
Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy
Neuropsychiatric symptoms (NPS) may affect cognition, but their burden in cerebral amyloid angiopathy (CAA), one of the ma...
Utility of visual rating scales in primary progressive aphasia
Utility of visual rating scales in primary progressive aphasia
Differential diagnosis among subjects with Primary Progressive Aphasia (PPA) can be challenging. Structural MRI can suppor...
Use of a digital tool to support the diagnostic process in memory clinics–a usability study
Use of a digital tool to support the diagnostic process in memory clinics–a usability study
Both memory clinic professionals and patients see value in digital tools, yet these hardly find their way to clinical prac...
Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers
Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers
Vascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases,...
Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model
Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model
The aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathologica...
White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition
White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition
White matter hyperintensities (WMHs) are often measured globally, but spatial patterns of WMHs could underlie different ri...
Human in vivo evidence of associations between herpes simplex virus and cerebral amyloid-beta load in normal aging
Human in vivo evidence of associations between herpes simplex virus and cerebral amyloid-beta load in normal aging
Mounting data suggests that herpes simplex virus type 1 (HSV-1) is involved in the pathogenesis of AD, possibly instigatin...
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-ass...
A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors
A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors
Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading ...
ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study
ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study
It has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National Univers...
Potential ocular indicators to distinguish posterior cortical atrophy and typical Alzheimer’s disease: a cross-section study using optical coherence tomography angiography
Potential ocular indicators to distinguish posterior cortical atrophy and typical Alzheimer’s disease: a cross-section study using optical coherence tomography angiography
Posterior cortical atrophy (PCA) is a form of dementia that frequently displays significant visual dysfunction and relativ...
Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer’s astrocytes
Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer’s astrocytes
Alzheimer’s disease (AD) is the most common cause of dementia, and its underlying mechanisms have been a subject of ...
Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease
Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia, progressively impairing cognitive abilities. While neu...
Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms
Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms
Predicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive dec...
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