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Purpose in life promotes resilience to age-related brain burden in middle-aged adults
Purpose in life promotes resilience to age-related brain burden in middle-aged adults
Disease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable fac...
Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
Alzheimer’s disease (AD) and osteoporosis are two distinct diseases but often occur in the same patient. Their relat...
Cerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
Cerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
Neurofilament light (NfL) and neurogranin (Ng) are promising candidate AD biomarkers, reflecting axonal and synaptic damag...
Comparison of ultrasensitive and mass spectrometry quantification of blood-based amyloid biomarkers for Alzheimer’s disease diagnosis in a memory clinic cohort
Comparison of ultrasensitive and mass spectrometry quantification of blood-based amyloid biomarkers for Alzheimer’s disease diagnosis in a memory clinic cohort
Alzheimer’s disease (AD) is a complex neurodegenerative disorder with β-amyloid pathology as a key underlying p...
Letter to the Editor Authors’ Response: Choroid and choriocapillaris changes in early-stage Parkinson’s disease: a swept-source optical coherence tomography angiography-based cross-sectional study
Letter to the Editor Authors’ Response: Choroid and choriocapillaris changes in early-stage Parkinson’s disease: a swept-source optical coherence tomography angiography-based cross-sectional study
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity
Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity
Subtypes and patterns are defined using tau-PET (tau pathology) and structural MRI (atrophy) in Alzheimer’s disease ...
The dynamics of plasma biomarkers across the Alzheimer’s continuum
The dynamics of plasma biomarkers across the Alzheimer’s continuum
Failures in drug trials strengthen the necessity to further determine the neuropathological events during the development ...
Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology
Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology
Electroencephalogram (EEG) has emerged as a non-invasive tool to detect the aberrant neuronal activity related to differen...
Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse
Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse
Toll-like receptor 3 (TLR3) plays an important role in the immune/inflammatory response in the nervous system and is a mai...
Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease
Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease
To better assist with the design of future clinical trials for Alzheimer’s disease (AD) and aid in our understanding...
Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy
Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy
To evaluate the potential of cerebrospinal fluid (CSF) levels of matrix metalloproteinases and tissue-type inhibitors (MMP...
Correction: Cortical microstructure in primary progressive aphasia: a multicenter study
Correction: Cortical microstructure in primary progressive aphasia: a multicenter study
Ignacio Illán-Gala and Victor Montal contributed equally to this work.Memory Unit, Department of Neurology, Hospital de la...
Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials
Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials
Timely accrual of a representative sample is a key factor in whether Alzheimer’s disease (AD) clinical trials succes...
Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment
Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment
Mild cognitive impairment (MCI) has been thought of as the transitional stage between normal ageing and Alzheimer’s ...
How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model
How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model
Wide evidence suggests that physical activity (PA) confers protection against Alzheimer’s disease (AD). On the other...
Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation
Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation
Semantic variant primary progressive aphasia (svPPA) is generally sporadic, with very few reports of tau pathology caused ...
Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit
Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit
Alzheimer’s disease (AD) is a complex and heterogeneous disease, which requires reliable biomarkers for diagnosis an...
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder characterised by the progressive buildup of toxi...
Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial
Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial
This phase II proof-of-concept study assessed the efficacy and safety of BI 425809, a novel selective glycine transporter-...
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
The earliest pathological features of Alzheimer’s disease (AD) appear decades before the clinical symptoms. The path...
The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials
The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials
Dementia [i.e., Alzheimer disease (AD)], the most common neurodegenerative disease, causes profound negative impacts on ex...
Correction: Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy
Correction: Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease
Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease
Neuroinflammatory factors, especially chemokines, have been widely reported to be involved in the pathogenesis of Alzheime...
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallm...
Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Atrial fibrillation (AF) is a strong risk factor for Alzheimer’s disease (AD) independent of ischemic stroke. Howeve...
The effects of a moderate physical activity intervention on physical fitness and cognition in healthy elderly with low levels of physical activity: a randomized controlled trial
The effects of a moderate physical activity intervention on physical fitness and cognition in healthy elderly with low levels of physical activity: a randomized controlled trial
Increasing physical activity is one of the most promising and challenging interventions to delay or prevent cognitive decl...
The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic
The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic
We investigated the relevance of various imaging markers for the clinical trajectory of cerebral amyloid angiopathy (CAA) ...
Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study
Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study
Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if p...
More extensive hypometabolism and higher mortality risk in patients with right- than left-predominant neurodegeneration of the anterior temporal lobe
More extensive hypometabolism and higher mortality risk in patients with right- than left-predominant neurodegeneration of the anterior temporal lobe
Left-predominant neurodegeneration of the anterior temporal lobe (ATL) and the associated syndrome termed semantic variant...
Continuity of care (COC) and amyloid-β PET scan: the CARE-IDEAS study
Continuity of care (COC) and amyloid-β PET scan: the CARE-IDEAS study
High continuity of care (COC) is associated with better clinical outcomes among older adults. The impact of amyloid-β...
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