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Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment: data from the NORFACE cohort
Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment: data from the NORFACE cohort
Optical coherence tomography (OCT) enables high-resolution imaging of ocular structures in health and disease. Choroid thi...
Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease
Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease
The role of Vascular risk factors (VRFs) in the progression of Alzheimer’s Disease (AD) and cognitive decline remain...
Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer’s disease
Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer’s disease
Females have a higher age-adjusted incidence of Alzheimer’s Disease (AD) than males, even when accounting for longer...
Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer’s disease progression: a systematic review
Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer’s disease progression: a systematic review
Alzheimer disease (AD) remains a significant global health concern. The progression from preclinical stages to overt demen...
Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort
Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort
White matter hyperintensities (WMH) on brain MRI images are the most common feature of cerebral small vessel disease (CSVD...
Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and the drivers of such a structural cha...
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults
For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked...
Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer’s disease or frontotemporal dementia
Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer’s disease or frontotemporal dementia
The loss of olfactory function is known to occur in patients suffering from (behavioral variant) frontotemporal dementia (...
EEG biomarkers in Alzheimer’s and prodromal Alzheimer’s: a comprehensive analysis of spectral and connectivity features
EEG biomarkers in Alzheimer’s and prodromal Alzheimer’s: a comprehensive analysis of spectral and connectivity features
Biomarkers of Alzheimer’s disease (AD) and mild cognitive impairment (MCI, or prodromal AD) are highly significant f...
Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology
Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology
Dementia preventive interventions targeting multiple modifiable risk factors are a promising approach. However, the impact...
Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia
Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia
Behavioral variant frontotemporal dementia (bvFTD) is characterized by profound and early deficits in social cognition (SC...
Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases
Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases
Alzheimer’s disease (AD) is a multifactorial disease with both genetic and environmental factors contributing to its...
The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study
The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study
Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer’s disease (AD) demen...
Blockade of brain alkaline phosphatase efficiently reduces amyloid-β plaque burden and associated cognitive impairment
Blockade of brain alkaline phosphatase efficiently reduces amyloid-β plaque burden and associated cognitive impairment
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. Three new drugs for AD based on monoclonal...
Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease
Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease
Variants of the gene triggering receptor expressed on myeloid cells-2 (TREM2) increase the risk of Alzheimer’s disea...
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites
Blood-derived mitochondrial DNA copy number (mtDNA-CN) is a proxy measurement of mitochondrial function in the peripheral ...
Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies
Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies
Diagnosis of dementia with Lewy bodies (DLB) is challenging, especially in the earlier stages of the disease, owing to the...
Plasma lipidomic signatures of dementia with Lewy bodies revealed by machine learning, and compared to alzheimer's disease
Plasma lipidomic signatures of dementia with Lewy bodies revealed by machine learning, and compared to alzheimer's disease
Dementia with Lewy Bodies (DLB) is a complex neurodegenerative disorder that often overlaps clinically with Alzheimer̵...
Association of psychosocial state with subsequent risk of dementia: a prospective cohort study based on the UK Biobank
Association of psychosocial state with subsequent risk of dementia: a prospective cohort study based on the UK Biobank
Multiple psychosocial factors have been associated with dementia, while the individual or joint effects of various psychos...
Network dynamics-based subtyping of Alzheimer’s disease with microglial genetic risk factors
Network dynamics-based subtyping of Alzheimer’s disease with microglial genetic risk factors
The potential of microglia as a target for Alzheimer’s disease (AD) treatment is promising, yet the clinical and pat...
Intestinal endogenous metabolites affect neuroinflammation in 5×FAD mice by mediating “gut-brain” axis and the intervention with Chinese Medicine
Intestinal endogenous metabolites affect neuroinflammation in 5×FAD mice by mediating “gut-brain” axis and the intervention with Chinese Medicine
Emerging evidence suggested the association between gut dysbiosis and Alzheimer’s disease (AD) progression. However,...
Biological mechanisms of resilience to tau pathology in Alzheimer’s disease
Biological mechanisms of resilience to tau pathology in Alzheimer’s disease
In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well...
Safety, tolerability, pharmacokinetics and pharmacodynamics of a single intravenous dose of SHR-1707 in healthy adult subjects: two randomized, double-blind, single-ascending-dose, phase 1 studies
Safety, tolerability, pharmacokinetics and pharmacodynamics of a single intravenous dose of SHR-1707 in healthy adult subjects: two randomized, double-blind, single-ascending-dose, phase 1 studies
SHR-1707 is a novel humanized anti-Aβ IgG1 monoclonal antibody that binds to Aβ fibrils and monomers to block th...
Associations of metabolic heterogeneity of obesity with the risk of dementia in middle-aged adults: three prospective studies
Associations of metabolic heterogeneity of obesity with the risk of dementia in middle-aged adults: three prospective studies
The associations of different obesity and metabolic phenotypes during midlife with the risk of incident dementia ...
Development and assessment of algorithms for predicting brain amyloid positivity in a population without dementia
Development and assessment of algorithms for predicting brain amyloid positivity in a population without dementia
The accumulation of amyloid-β (Aβ) peptide in the brain is a hallmark of Alzheimer’s disease (AD), occurri...
Prognostic model for predicting Alzheimer’s disease conversion using functional connectome manifolds
Prognostic model for predicting Alzheimer’s disease conversion using functional connectome manifolds
Early detection of Alzheimer’s disease (AD) is essential for timely management and consideration of therapeutic opti...
Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study
Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study
There is a substantial body of observational research indicating an association between hearing impairment and dementia, y...
Inflammatory proteins associated with Alzheimer’s disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial
Inflammatory proteins associated with Alzheimer’s disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial
Glucagon-like peptide-1 receptor agonists are a viable option for the prevention of Alzheimer’s disease (AD) but the...
Brain Iron in signature regions relating to cognitive aging in older adults: the Taizhou Imaging Study
Brain Iron in signature regions relating to cognitive aging in older adults: the Taizhou Imaging Study
Recent magnetic resonance imaging (MRI) studies have established that brain iron accumulation might accelerate cognitive d...
High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
Recent advances in blood-based biomarker discovery are paving the way for simpler, more accessible diagnostic tools that c...
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