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Purpose in life promotes resilience to age-related brain burden in middle-aged adults
Purpose in life promotes resilience to age-related brain burden in middle-aged adults
Disease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable fac...
Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
Alzheimer’s disease (AD) and osteoporosis are two distinct diseases but often occur in the same patient. Their relat...
Cerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
Cerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
Neurofilament light (NfL) and neurogranin (Ng) are promising candidate AD biomarkers, reflecting axonal and synaptic damag...
The dynamics of plasma biomarkers across the Alzheimer’s continuum
The dynamics of plasma biomarkers across the Alzheimer’s continuum
Failures in drug trials strengthen the necessity to further determine the neuropathological events during the development ...
Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology
Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology
Electroencephalogram (EEG) has emerged as a non-invasive tool to detect the aberrant neuronal activity related to differen...
Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse
Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse
Toll-like receptor 3 (TLR3) plays an important role in the immune/inflammatory response in the nervous system and is a mai...
Correction: Cortical microstructure in primary progressive aphasia: a multicenter study
Correction: Cortical microstructure in primary progressive aphasia: a multicenter study
Ignacio Illán-Gala and Victor Montal contributed equally to this work.Memory Unit, Department of Neurology, Hospital de la...
Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials
Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials
Timely accrual of a representative sample is a key factor in whether Alzheimer’s disease (AD) clinical trials succes...
Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment
Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment
Mild cognitive impairment (MCI) has been thought of as the transitional stage between normal ageing and Alzheimer’s ...
Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation
Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation
Semantic variant primary progressive aphasia (svPPA) is generally sporadic, with very few reports of tau pathology caused ...
Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit
Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit
Alzheimer’s disease (AD) is a complex and heterogeneous disease, which requires reliable biomarkers for diagnosis an...
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder characterised by the progressive buildup of toxi...
Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial
Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial
This phase II proof-of-concept study assessed the efficacy and safety of BI 425809, a novel selective glycine transporter-...
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
Early visual alterations in individuals at-risk of Alzheimer’s disease: a multidisciplinary approach
The earliest pathological features of Alzheimer’s disease (AD) appear decades before the clinical symptoms. The path...
Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease
Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease
Neuroinflammatory factors, especially chemokines, have been widely reported to be involved in the pathogenesis of Alzheime...
Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Atrial fibrillation (AF) is a strong risk factor for Alzheimer’s disease (AD) independent of ischemic stroke. Howeve...
The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic
The effects of imaging markers on clinical trajectory in cerebral amyloid angiopathy: a longitudinal study in a memory clinic
We investigated the relevance of various imaging markers for the clinical trajectory of cerebral amyloid angiopathy (CAA) ...
Continuity of care (COC) and amyloid-β PET scan: the CARE-IDEAS study
Continuity of care (COC) and amyloid-β PET scan: the CARE-IDEAS study
High continuity of care (COC) is associated with better clinical outcomes among older adults. The impact of amyloid-β...