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Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus
Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with unde...
Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease
Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease
Neurodegenerative diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are common complic...
Exploring paraptosis as a therapeutic approach in cancer treatment
Exploring paraptosis as a therapeutic approach in cancer treatment
A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis,&nb...
The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins
The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly a...
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dent...
CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
Extracellular vesicles (EVs) are cell-secreted particles conceived as natural vehicles for intercellular communication. Th...
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency
Primary ovarian insufficiency (POI) is an early decline in ovarian function that leads to ovarian failure. Conventional tr...
Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens
Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens
Recent breakthroughs in cancer immunotherapies have emphasized the importance of harnessing the immune system for treating...
Hijacking host extracellular vesicle machinery by hepatotropic viruses: current understandings and future prospects
Hijacking host extracellular vesicle machinery by hepatotropic viruses: current understandings and future prospects
Recent advances in studies exploring the roles of extracellular vesicles (EVs) in viral transmission and replication have ...
Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
Triple-negative breast cancer (TNBC), characterized by high invasiveness, is associated with poor prognosis and elevated m...
Enhancing organoid culture: harnessing the potential of decellularized extracellular matrix hydrogels for mimicking microenvironments
Enhancing organoid culture: harnessing the potential of decellularized extracellular matrix hydrogels for mimicking microenvironments
Over the past decade, organoids have emerged as a prevalent and promising research tool, mirroring the physiological archi...
CCL5 is essential for axonogenesis and neuronal restoration after brain injury
CCL5 is essential for axonogenesis and neuronal restoration after brain injury
Traumatic brain injury (TBI) causes axon tearing and synapse degradation, resulting in multiple neurological dysfunctions ...
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliv...
Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma
Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma
Stromal fibrosis is highly associated with therapeutic resistance and poor survival in esophageal squamous cell carcinoma ...
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1
Dysregulation of vascular homeostasis can induce cardiovascular diseases and increase global mortality rates. Although lin...
Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson’s disease models
Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson’s disease models
The burgeoning field of regenerative medicine has significantly advanced with recent findings on biotherapies using human ...
Dengue NS1 interaction with lipids alters its pathogenic effects on monocyte derived macrophages
Dengue NS1 interaction with lipids alters its pathogenic effects on monocyte derived macrophages
While dengue NS1 antigen has been shown to be associated with disease pathogenesis in some studies, it has not been linked...
Extracellular vesicle therapy in neurological disorders
Extracellular vesicle therapy in neurological disorders
Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in...
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1
Human immunodeficiency virus type 1 (HIV-1) vaccine immunogens capable of inducing broadly neutralizing antibodies (bNAbs)...
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
Intracellular sensing of lipopolysaccharide (LPS) is essential for the immune response against gram-negative bacteria and ...
Machine learning enabled classification of lung cancer cell lines co-cultured with fibroblasts with lightweight convolutional neural network for initial diagnosis
Machine learning enabled classification of lung cancer cell lines co-cultured with fibroblasts with lightweight convolutional neural network for initial diagnosis
Identification of lung cancer subtypes is critical for successful treatment in patients, especially those in advanced stag...
Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era
Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era
Around 10% of people with HIV (PWH) exhibit a low-level viremia (LLV) under antiretroviral therapy (ART). However, its ori...
EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-indu...
Gene therapy for ultrarare diseases: a geneticist’s perspective
Gene therapy for ultrarare diseases: a geneticist’s perspective
Gene therapy has made considerable strides in recent years. More than 4000 protein-coding genes have been implicated in mo...
Targeted nanotherapeutics for the treatment of Helicobacter pylori infection
Targeted nanotherapeutics for the treatment of Helicobacter pylori infection
Helicobacter pylori infection is involved in gastric diseases such as peptic ulcer and adenocarcinoma. Approved antibiothe...
Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis
Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis
Dectin-1 is a transmembrane receptor that plays a pivotal role in recognising fungi and Mycobacterium tuberculosis (Mtb). ...
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections
Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as ...
A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation
A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation
Coronaviruses employ various strategies for survival, among which the activation of endogenous or exogenous apoptosis stan...
Enteroviruses: epidemic potential, challenges and opportunities with vaccines
Enteroviruses: epidemic potential, challenges and opportunities with vaccines
Enteroviruses (EVs) are the most prevalent viruses in humans. EVs can cause a range of acute symptoms, from mild common co...
Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression
Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression
Epithelial cell adhesion molecule (EpCAM) has been widely studied as a tumor antigen due to its expression in varieties of...
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