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PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma
PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma
Although immune checkpoint blockade (ICB) therapy has brought survival benefits to patients with specific cancer types, mo...
Attenuation of IFN signaling due to m6A modification of the host epitranscriptome promotes EBV lytic reactivation
Attenuation of IFN signaling due to m6A modification of the host epitranscriptome promotes EBV lytic reactivation
Reactivation of Epstein Barr virus (EBV) leads to modulation of the viral and cellular epitranscriptome. N6-methyladenosin...
Upregulation of galectin-3 in influenza A virus infection promotes viral RNA synthesis through its association with viral PA protein
Upregulation of galectin-3 in influenza A virus infection promotes viral RNA synthesis through its association with viral PA protein
Influenza is one of the most important viral infections globally. Viral RNA-dependent RNA polymerase (RdRp) consists of th...
Current status of hand-foot-and-mouth disease
Current status of hand-foot-and-mouth disease
Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children under 5 years of age, chara...
CLEC5A mediates Zika virus-induced testicular damage
CLEC5A mediates Zika virus-induced testicular damage
Zika virus (ZIKV) infection is clinically known to induce testicular swelling, termed orchitis, and potentially impact mal...
ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking
ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking
Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atheroscleroti...
Correction: Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
Correction: Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Marine prebiotics mediate decolonization of Pseudomonas aeruginosa from gut by inhibiting secreted virulence factor interactions with mucins and enriching Bacteroides population
Marine prebiotics mediate decolonization of Pseudomonas aeruginosa from gut by inhibiting secreted virulence factor interactions with mucins and enriching Bacteroides population
Pseudomonas aeruginosa intestinal carriage rates are significantly higher in immunosuppressed individuals and hospitalized...
Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites
Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites
The association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study...
Chronic stress in solid tumor development: from mechanisms to interventions
Chronic stress in solid tumor development: from mechanisms to interventions
Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experienc...
Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
This work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated bl...
Correction: Akt: a key transducer in cancer
Correction: Akt: a key transducer in cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
The role of autophagy in viral infections
The role of autophagy in viral infections
Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral functions during a viral invasio...
Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction
Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction
The leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are still u...
Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities
Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities
The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with...
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis
Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulatio...
Intimate communications within the tumor microenvironment: stromal factors function as an orchestra
Intimate communications within the tumor microenvironment: stromal factors function as an orchestra
Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the view of cancer as a tumor cell-...
Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy
Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA...
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling
Ovarian cancer has the highest mortality among gynecological cancers due to late diagnosis and lack of effective targeted ...
Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants
Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants
The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, w...
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to mo...
Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis
Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis
In endothelial cells, phospholipase C (PLC) β1-activated Ca2+ is a crucial second messenger for the signaling pathway...
Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer
Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer
Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting ...
Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium
Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium
yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S. Typhimurium) in human cells; however, how ...
Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1
Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1
Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1), an inflammatory cytokine, under serum-deplet...
Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis
Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis
Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and ant...
Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis
Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis
Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms rem...
Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling
Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling
Sorafenib (SOR) is the first line treatment for advanced hepatocellular carcinoma (HCC), but resistance develops frequentl...
Interference in melanoma CD248 function reduces vascular mimicry and metastasis
Interference in melanoma CD248 function reduces vascular mimicry and metastasis
Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment....
Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis
Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis
The complement system functions primarily as a first-line host defense against invading microbes, including viruses. Howev...
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