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Distribution of papG alleles among uropathogenic Escherichia coli from reproductive age women
Distribution of papG alleles among uropathogenic Escherichia coli from reproductive age women
Extraintestinal Escherichia coli (E. coli) causing urinary tract infections (UTIs), and often referred to as uropathogenic...
A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies
A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of chall...
TRIM proteins in hepatocellular carcinoma
TRIM proteins in hepatocellular carcinoma
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, m...
Protein O-GlcNAcylation and the regulation of energy homeostasis: lessons from knock-out mouse models
Protein O-GlcNAcylation and the regulation of energy homeostasis: lessons from knock-out mouse models
O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or threonine residues of cytosolic, ...
The A’-helix of CYP11A1 remodels mitochondrial cristae
The A’-helix of CYP11A1 remodels mitochondrial cristae
CYP11A1 is a protein located in the inner membrane of mitochondria catalyzing the first step of steroid synthesis. As a ma...
Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism
Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism
Parkinson’s disease (PD) is one of the most important neurodegenerative disorders in elderly people. Mutations in th...
Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity
Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity
For centuries, microbial-based agents have been investigated as a therapeutic modality for the treatment of cancer. In the...
Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment
Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment
All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosi...
TRIM18 is a critical regulator of viral myocarditis and organ inflammation
TRIM18 is a critical regulator of viral myocarditis and organ inflammation
Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as my...
Gut microenvironmental changes as a potential trigger in Parkinson’s disease through the gut–brain axis
Gut microenvironmental changes as a potential trigger in Parkinson’s disease through the gut–brain axis
Parkinson’s disease (PD) is the second most common neurodegenerative disease attributed to the synergistic effects o...
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during n...
CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation
CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation
Coronavirus-induced disease 19 (COVID-19) infects more than three hundred and sixty million patients worldwide, and people...
Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
Disruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, in...
A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory
A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory
Social recognition memory (SRM) is the ability to distinguish familiar from novel conspecifics and is crucial for survival...
Dengue and COVID-19: two sides of the same coin
Dengue and COVID-19: two sides of the same coin
Many countries in Asia and Latin America are currently facing a double burden of outbreaks due to dengue and COVID-19. Her...
HrpA anchors meningococci to the dynein motor and affects the balance between apoptosis and pyroptosis
HrpA anchors meningococci to the dynein motor and affects the balance between apoptosis and pyroptosis
In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including m...
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction
Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional ba...
Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics
Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics
Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understa...
Hepatitis B virus virion secretion is a CRM1-spike-mediated late event
Hepatitis B virus virion secretion is a CRM1-spike-mediated late event
Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis...
The power of heteronemin in cancers
The power of heteronemin in cancers
Heteronemin (Haimian jing) is a sesterterpenoid-type natural marine product that is isolated from sponges and has anticanc...
Post-translational modifications on the retinoblastoma protein
Post-translational modifications on the retinoblastoma protein
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critic...