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Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis
Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis
Enolase 1 (ENO1) is a conserved glycolytic enzyme that regulates glycolysis metabolism. However, its role beyond glycolysi...
Advances in nucleic acid-based cancer vaccines
Advances in nucleic acid-based cancer vaccines
Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global r...
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis
Recent studies indicate that N6-methyladenosine (m6A) RNA modification may regulate ferroptosis in cancer cells, while its...
Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects
Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects
Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the p...
A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA
A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA
Obesity is becoming one of the major non-communicable diseases with increasing incidence and risks that cannot be ignored....
Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis
Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis
ROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of...
Increasing the biomolecular relevance of cell culture practice
Increasing the biomolecular relevance of cell culture practice
The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular comp...
Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management
Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management
The increasing prevalence of chronic diseases and their associated morbidities demands a deeper understanding of underlyin...
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus
Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with unde...
Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease
Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease
Neurodegenerative diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are common complic...
Exploring paraptosis as a therapeutic approach in cancer treatment
Exploring paraptosis as a therapeutic approach in cancer treatment
A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis,&nb...
CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
Extracellular vesicles (EVs) are cell-secreted particles conceived as natural vehicles for intercellular communication. Th...
Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens
Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens
Recent breakthroughs in cancer immunotherapies have emphasized the importance of harnessing the immune system for treating...
Hijacking host extracellular vesicle machinery by hepatotropic viruses: current understandings and future prospects
Hijacking host extracellular vesicle machinery by hepatotropic viruses: current understandings and future prospects
Recent advances in studies exploring the roles of extracellular vesicles (EVs) in viral transmission and replication have ...
Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
Triple-negative breast cancer (TNBC), characterized by high invasiveness, is associated with poor prognosis and elevated m...
CCL5 is essential for axonogenesis and neuronal restoration after brain injury
CCL5 is essential for axonogenesis and neuronal restoration after brain injury
Traumatic brain injury (TBI) causes axon tearing and synapse degradation, resulting in multiple neurological dysfunctions ...
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliv...
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1
Dysregulation of vascular homeostasis can induce cardiovascular diseases and increase global mortality rates. Although lin...
Dengue NS1 interaction with lipids alters its pathogenic effects on monocyte derived macrophages
Dengue NS1 interaction with lipids alters its pathogenic effects on monocyte derived macrophages
While dengue NS1 antigen has been shown to be associated with disease pathogenesis in some studies, it has not been linked...
Extracellular vesicle therapy in neurological disorders
Extracellular vesicle therapy in neurological disorders
Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in...
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1
Human immunodeficiency virus type 1 (HIV-1) vaccine immunogens capable of inducing broadly neutralizing antibodies (bNAbs)...
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
Intracellular sensing of lipopolysaccharide (LPS) is essential for the immune response against gram-negative bacteria and ...