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Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington’s disease
Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington’s disease
Huntington’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunctio...
Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice
Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice
Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead t...
Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model
Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model
This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as A...
Correction: A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Correction: A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Significance of hepatitis B virus capsid dephosphorylation via polymerase
Significance of hepatitis B virus capsid dephosphorylation via polymerase
It is generally believed that hepatitis B virus (HBV) core protein (HBc) dephosphorylation (de-P) is important for viral D...
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance an...
Improving CRISPR–Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration
Improving CRISPR–Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration
The field of genome editing has been revolutionized by the development of an easily programmable editing tool, the CRISPR&...
Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue d...
A matter of new life and cell death: programmed cell death in the mammalian ovary
A matter of new life and cell death: programmed cell death in the mammalian ovary
The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproduc...
The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design
The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design
Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely emulating the functions of natur...
Tick-borne encephalitis virus transmitted singly and in duo with Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum bacteria by ticks as pathogens modifying lipid metabolism in human blood
Tick-borne encephalitis virus transmitted singly and in duo with Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum bacteria by ticks as pathogens modifying lipid metabolism in human blood
Ticks are vectors of various pathogens, including tick-borne encephalitis virus causing TBE and bacteria such as Borrelia ...
Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes
Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes
Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections ...
Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6’s role in hematopoietic differentiation and leukemia
Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6’s role in hematopoietic differentiation and leukemia
Long non-coding RNAs (lncRNAs) are pivotal players in cellular processes, and their unique cell-type specific expression p...
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of en...
Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson’s disease phenotypes in vivo and in cell models
Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson’s disease phenotypes in vivo and in cell models
Mutations in CHCHD2 have been linked to Parkinson’s disease, however, their exact pathophysiologic roles are unclear...
The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits
The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits
Pregnancy associated plasma protein-A (PAPP-A) plays an integral role in breast cancer (BC), especially triple negative br...
Translational research on drug development and biomarker discovery for hepatocellular carcinoma
Translational research on drug development and biomarker discovery for hepatocellular carcinoma
Translational research plays a key role in drug development and biomarker discovery for hepatocellular carcinoma (HCC). Ho...
Germline mutations of homologous recombination genes and clinical outcomes in pancreatic cancer: a multicenter study in Taiwan
Germline mutations of homologous recombination genes and clinical outcomes in pancreatic cancer: a multicenter study in Taiwan
Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the heredit...
Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer
Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed on the surface of T cells. High expressi...
FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors
FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors
Previous research in FMS-like tyrosine kinase 3 ligands (FLT3L) has primarily focused on their potential to generate dendr...
Targeting MDM2 in malignancies is a promising strategy for overcoming resistance to anticancer immunotherapy
Targeting MDM2 in malignancies is a promising strategy for overcoming resistance to anticancer immunotherapy
MDM2 has been established as a biomarker indicating poor prognosis for individuals undergoing immune checkpoint inhibitor ...
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus
Mycobacterium abscessus, a fast-growing non-tuberculous mycobacterium, is an emerging opportunistic pathogen responsible f...
Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells
Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells
SUMOylation, which is a type of post-translational modification that involves covalent conjugation of small ubiquitin-like...
Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma
Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma
The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), y...
Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice
Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice
CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down...
Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics ...
TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts
TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts
Pathologic scars, including keloids and hypertrophic scars, represent a common form of exaggerated cutaneous scarring that...
Physiology and pharmacological targeting of phase separation
Physiology and pharmacological targeting of phase separation
Liquid–liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates...
Inactivation of pentraxin 3 suppresses M2-like macrophage activity and immunosuppression in colon cancer
Inactivation of pentraxin 3 suppresses M2-like macrophage activity and immunosuppression in colon cancer
The tumor microenvironment is characterized by inflammation-like and immunosuppression situations. Although cancer-associa...
Engineered EVs with pathogen proteins: promising vaccine alternatives to LNP-mRNA vaccines
Engineered EVs with pathogen proteins: promising vaccine alternatives to LNP-mRNA vaccines
Extracellular vesicles (EVs) are tiny, lipid membrane-bound structures that are released by most cells. They play a vital ...
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