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SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis...
Butterflies in the gut: the interplay between intestinal microbiota and stress
Butterflies in the gut: the interplay between intestinal microbiota and stress
Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk ...
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in dange...
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remain...
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological m...
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles exten...
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (S...
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (m...
Extracellular release in the quality control of the mammalian mitochondria
Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mit...
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The ...
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class...
Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing
Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing
The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matri...
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have ...
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer maligna...
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrat...
Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus eryth...
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheu...
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative t...
A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with m...
Harnessing cell reprogramming for cardiac biological pacing
Harnessing cell reprogramming for cardiac biological pacing
Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life...
5ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
5ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
Epithelial-to-mesenchymal transition (EMT) of malignant cells is a driving force of disease progression in human papilloma...
Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring blaNDM-1: a comparative genomic analysis of carbapenem resistant strains
Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring blaNDM-1: a comparative genomic analysis of carbapenem resistant strains
Certain clonal complexes (CCs) of Klebsiella pneumoniae such as CC147 (ST147 and ST392) are major drivers of blaNDM dissem...
ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against s...
Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients
Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients
Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the ...
Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. T...
The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase
The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase
KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in v...
Fierce poison to others: the phenomenon of bacterial dependence on antibiotics
Fierce poison to others: the phenomenon of bacterial dependence on antibiotics
Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far...
Neuroprotective effects of osmotin in Parkinson’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways
Neuroprotective effects of osmotin in Parkinson’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways
Parkinson’s disease (PD) is the second most frequent age-related neurodegenerative disorder and is characterized by ...
Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma
Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma
Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cas...
Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration
Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative diseases Parkinson's or Al...
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