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Biomarkers in melanoma and non‐melanoma skin cancer prevention and risk stratification
Biomarkers in melanoma and non‐melanoma skin cancer prevention and risk stratification
Abstract The rates of melanoma and non-melanoma skin cancer (NMSC) have been increasing over the last twenty years in the ...
BRN2 and MITF together impact AXL expression in melanoma
BRN2 and MITF together impact AXL expression in melanoma
Abstract The inverse relationship between transcription factor MITF and receptor tyrosine kinase AXL has received much att...
Long non‐coding RNA LINC00665 promotes melanoma cell growth and migration via regulating the miR‐224‐5p/VMA21 axis
Long non‐coding RNA LINC00665 promotes melanoma cell growth and migration via regulating the miR‐224‐5p/VMA21 axis
Abstract Melanoma is an aggressive malignant skin tumor endangering the health of patients. Long non-coding RNAs (lncRNAs)...
Ultra‐high‐frequency ultrasound and machine learning approaches for the differential diagnosis of melanocytic lesions
Ultra‐high‐frequency ultrasound and machine learning approaches for the differential diagnosis of melanocytic lesions
Abstract Malignant melanoma (MM) is one of the most dangerous skin cancers. The aim of this study was to present a potenti...
Melanoma brain metastases: Biological basis and novel therapeutic strategies
Melanoma brain metastases: Biological basis and novel therapeutic strategies
Abstract The development of brain metastases is the deadliest complication of advanced melanoma and has long been associat...
Sorafenib induces pigmentation via the regulation of β‐catenin signalling pathway in melanoma cells
Sorafenib induces pigmentation via the regulation of β‐catenin signalling pathway in melanoma cells
Abstract We conducted large-scale screening test on drugs that were already approved for other diseases to find pigmentati...
Genetic drivers of non‐cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape
Genetic drivers of non‐cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape
Abstract Non-cutaneous melanomas most frequently involve the uveal tract and mucosal membranes, including the conjunctiva....
Programmed gene expression change in mouse skin after ultraviolet radiation damage
Programmed gene expression change in mouse skin after ultraviolet radiation damage
Abstract Ultraviolet (UV) radiation is a major cause of skin damage and carcinogenesis. Here, we systematically analyse th...
Roles of cutaneous cell‐cell communication in wound healing outcome: An emphasis on keratinocyte‐fibroblast crosstalk
Roles of cutaneous cell‐cell communication in wound healing outcome: An emphasis on keratinocyte‐fibroblast crosstalk
Abstract Tissue repair is a very complex event and involves a continuously orchestrated sequence of signals and responses ...
Mutational landscape in squamous cell carcinoma of the nail unit
Mutational landscape in squamous cell carcinoma of the nail unit
Abstract Background Squamous cell carcinoma (SCC) is the most common malignancy of the nail unit. Pathogenetic mechanisms ...
The programmed gene expression change in mouse skin after ultraviolet radiation damage
The programmed gene expression change in mouse skin after ultraviolet radiation damage
ABSTRACT Ultraviolet (UV) radiation is a major cause of skin damage and carcinogenesis. Here we systematically analyze the...
Roles of Cutaneous Cell‐Cell Communication in Wound Healing Outcome: Emphasis on Keratinocyte‐Fibroblast Crosstalk
Roles of Cutaneous Cell‐Cell Communication in Wound Healing Outcome: Emphasis on Keratinocyte‐Fibroblast Crosstalk
Abstract Tissue repair is a very complex event and involves a continuously orchestrated sequence of signals and responses ...
miR‐24‐3p obstructs the proliferation and migration of HSFs after thermal injury by targeting PPAR‐β and positively regulated by NF‐κB
miR‐24‐3p obstructs the proliferation and migration of HSFs after thermal injury by targeting PPAR‐β and positively regulated by NF‐κB
Abstract Thermal injury repair is a complex process during which the maintenance of the proliferation and migration of hum...
Effects of amniotic fluid on human keratinocyte gene expression ‐ Implications for wound healing
Effects of amniotic fluid on human keratinocyte gene expression ‐ Implications for wound healing
Abstract Cutaneous wounds can lead to huge suffering for patients. Early fetal wounds have the capacity to regenerate with...
Concomitant Variants in NF1, LZTR1, and GNAZ Genes Probably Contribute to the Aggressiveness of Plexiform Neurofibroma and Warrant Treatment with MEK Inhibitor
Concomitant Variants in NF1, LZTR1, and GNAZ Genes Probably Contribute to the Aggressiveness of Plexiform Neurofibroma and Warrant Treatment with MEK Inhibitor
Abstract Neurofibromatosis 1 (NF1) is caused by germline mutations in the NF1 gene and manifests as proliferation of vario...
Transglutaminase 2 mediates UVB‐induced matrix metalloproteinase‐1 expression by inhibiting nuclear p65 degradation in dermal fibroblasts
Transglutaminase 2 mediates UVB‐induced matrix metalloproteinase‐1 expression by inhibiting nuclear p65 degradation in dermal fibroblasts
Abstract Matrix metalloproteinases (MMPs) play a key role in tissue remodeling by cleaving extracellular matrix (ECM) comp...
Small plaque psoriasis re‐visited: A type of psoriasis mediated by a type‐I interferon pathway
Small plaque psoriasis re‐visited: A type of psoriasis mediated by a type‐I interferon pathway
Abstract TNFα-inhibitor-induced psoriasis is mediated by the type-I interferon pathway, of which IFNα, LL37 an...
Tranexamic acid inhibits melanogenesis partially via stimulation of TGF‐β1 expression in human epidermal keratinocytes
Tranexamic acid inhibits melanogenesis partially via stimulation of TGF‐β1 expression in human epidermal keratinocytes
Abstract Background Oral tranexamic acid (TA) has been an effective treatment for melasma with unclear mechanism. Objectiv...
Novel PTCH1 and concurrent TP53 mutations in four patients with numerous non‐syndromic basal cell carcinomas: The paradigm of oncogenic synergy
Novel PTCH1 and concurrent TP53 mutations in four patients with numerous non‐syndromic basal cell carcinomas: The paradigm of oncogenic synergy
ABSTRACT There has been a significant increase in basal cell carcinoma (BCC) incidence, the most common cancer in humans, ...
Evaluation of human acellular amniotic membrane for promoting anterior auricle reconstruction
Evaluation of human acellular amniotic membrane for promoting anterior auricle reconstruction
Corresponding Author Department of Dermatology, Sichuan University West China H...
Topical κ‐Opioid Receptor Agonist Asimadoline Improves Dermatitis in a Canine Model of Atopic Dermatitis
Topical κ‐Opioid Receptor Agonist Asimadoline Improves Dermatitis in a Canine Model of Atopic Dermatitis
Abstract This prospective, 4-week, placebo-controlled, cross-over study aimed to investigate the efficacy of 1% topical &#...
Impact of the chronic wound microenvironment and marine omega‐3 fatty acids on skin cell regeneration processes
Impact of the chronic wound microenvironment and marine omega‐3 fatty acids on skin cell regeneration processes
ABSTRACT Marine long chain omega-3 polyunsaturated fatty acids (ω3 FA) are involved in numerous cell responses and t...
Studying the in vivo application of a liquid dermal scaffold in promoting wound healing in a mouse model
Studying the in vivo application of a liquid dermal scaffold in promoting wound healing in a mouse model
Abstract Lack of matrix deposition is one of the main factors that complicates the healing process of wounds. The aim of t...
Ketoconazole beyond antifungal activity: bioinformatics‐based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis
Ketoconazole beyond antifungal activity: bioinformatics‐based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis
Corresponding Author Center for Natural Sciences and Humanities, Federal Univer...
An integrative multi‐omic analysis reveals a major metabolic rewiring between baby foreskin keratinocytes and adult female abdominal keratinocytes.
An integrative multi‐omic analysis reveals a major metabolic rewiring between baby foreskin keratinocytes and adult female abdominal keratinocytes.
Abstract Even though its development starts early in utero, neonatal skin is still immature at birth relative to adult and...
Gene expression profiling of laminin α3 blocked keratinocytes reveals an immune‐independent mechanism of blistering
Gene expression profiling of laminin α3 blocked keratinocytes reveals an immune‐independent mechanism of blistering
Abstract Laminin-332 pemphigoid is a rare and chronic autoimmune blistering disease which results in subepidermal blisters...
Vorinostat, a histone deacetylase inhibitor, as a potential novel treatment for psoriasis
Vorinostat, a histone deacetylase inhibitor, as a potential novel treatment for psoriasis
Abstract Background Psoriasis is characterized by aberrant activation of several pro-inflammatory circuits as well as abno...
Evidence for a role of extracellular heat shock protein 70 in epidermolysis bullosa acquisita
Evidence for a role of extracellular heat shock protein 70 in epidermolysis bullosa acquisita
Abstract Heat shock protein 90 (Hsp90) and Hsp70 are chaperones implicated in different inflammatory disorders, given thei...
Two novel mutations of the γ‐secretase genes in Chinese acne inversa (hidradenitis suppurativa)
Two novel mutations of the γ‐secretase genes in Chinese acne inversa (hidradenitis suppurativa)
Corresponding Author McKusick-Zhang Center for Genetic Medicine, State Key Labo...
MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity
MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity
Abstract MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and power...
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