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New Insights on DR and DQ Human Leukocyte Antigens in Anti-LGI1 Encephalitis
New Insights on DR and DQ Human Leukocyte Antigens in Anti-LGI1 Encephalitis
The leucine-rich glioma-inactivated 1 (LGI1) protein is a synaptic protein secreted by neurons in the CNS. Anti–LGI1-assoc...
TNF-Blockade for Primary Stroke Prevention in Adenosine Deaminase 2 Deficiency: A Case Series
TNF-Blockade for Primary Stroke Prevention in Adenosine Deaminase 2 Deficiency: A Case Series
AbstractObjectives Adenosine deaminase 2 deficiency (DADA2) is a genetic, neurologic, and systemic vasculitis syndrome, wh...
Immune Profiling Reveals the T-Cell Effect of Ocrelizumab in Early Relapsing-Remitting Multiple Sclerosis
Immune Profiling Reveals the T-Cell Effect of Ocrelizumab in Early Relapsing-Remitting Multiple Sclerosis
AbstractBackground and Objectives Ocrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in pat...
Risk HLA Variants Affect the T-Cell Repertoire in Multiple Sclerosis
Risk HLA Variants Affect the T-Cell Repertoire in Multiple Sclerosis
AbstractBackground and Objectives The major histocompatibility complex (MHC) locus has a predominant role in the genetic p...
Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosis
Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosis
AbstractBackground and Objectives Ocrelizumab improved clinical and MRI measures of disease activity and progression in th...
Neurologic Manifestations of Common Variable Immunodeficiency: Impact on Quality of Life
Neurologic Manifestations of Common Variable Immunodeficiency: Impact on Quality of Life
AbstractBackground and Objectives Common variable immunodeficiency is a systemic disease and not solely a disease of humor...
Reduced Number of Thymoma CTLA4-Positive Cells Is Associated With a Higher Probability of Developing Myasthenia Gravis
Reduced Number of Thymoma CTLA4-Positive Cells Is Associated With a Higher Probability of Developing Myasthenia Gravis
AbstractBackground and Objectives Myasthenia gravis (MG) is an autoimmune disease associated with comorbid thymoma in 10%–...
Ocrelizumab Treatment Modulates B-Cell Regulating Factors in Multiple Sclerosis
Ocrelizumab Treatment Modulates B-Cell Regulating Factors in Multiple Sclerosis
AbstractBackground and Objectives Antibodies to CD20 efficiently reduce new relapses in multiple sclerosis (MS), and ocrel...
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity
AbstractBackground and Objectives Anti-CD20 monoclonal antibody (mAb) B-cell depletion is a remarkably successful multiple...
Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy
Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy
AbstractBackground and Objectives The objective of this study was to discover novel nodal autoantibodies in chronic inflam...
N2 Year in Review
N2 Year in Review
Two thousand twenty-two has been the year in which the COVID-19 pandemic has receded leaving us with a substantial number ...
Remote Observational Research for Multiple Sclerosis: A Natural Experiment
Remote Observational Research for Multiple Sclerosis: A Natural Experiment
AbstractBackground and Objectives Prospective, deeply phenotyped research cohorts monitoring individuals with chronic neur...
Elsberg Syndrome Secondary to Cytomegalovirus Infection in an Immunocompetent Patient: A Case Report
Elsberg Syndrome Secondary to Cytomegalovirus Infection in an Immunocompetent Patient: A Case Report
AbstractObjectives Infectious lumbosacral radiculitis and myelitis, a clinical entity called Elsberg syndrome, is classica...
Neuroaxonal and Glial Markers in Patients of the Same Age With Multiple Sclerosis
Neuroaxonal and Glial Markers in Patients of the Same Age With Multiple Sclerosis
AbstractBackground and Objectives The specificity of novel blood biomarkers for multiple sclerosis (MS)–related neurodegen...
Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated With Onchocerca volvulus
Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated With Onchocerca volvulus
AbstractBackground and Objective Nodding syndrome (NS) is a unique childhood-onset epileptic disorder that occurs predomin...
Increased Percentage of CD8+CD28- Regulatory T Cells With Fingolimod Therapy in Multiple Sclerosis
Increased Percentage of CD8+CD28- Regulatory T Cells With Fingolimod Therapy in Multiple Sclerosis
AbstractBackground and Objectives Fingolimod, an oral therapy for MS, decreases expression of membrane S1P1 receptors on C...
Immune-Mediated Rippling Muscle Disease Associated With Thymoma and Anti-MURC/Cavin-4 Autoantibodies
Immune-Mediated Rippling Muscle Disease Associated With Thymoma and Anti-MURC/Cavin-4 Autoantibodies
AbstractObjectives Rippling muscle disease (RMD) is characterized by muscle stiffness, muscle hypertrophy, and rippling mu...