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Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey
Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey
IntroductionStiff-person syndrome (SPS) is a rare autoimmune neurologic disorder characterized by progressive axial muscle...
Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin {beta}7+ Compartment
Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin {beta}7+ Compartment
AbstractBackground and Objectives Natalizumab, a monoclonal humanized antibody targeting integrin α4, inhibits the transmi...
mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis
mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis
AbstractBackground and Objective In people with multiple sclerosis (pwMS), concern for potential disease exacerbation or t...
A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings
A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings
AbstractA 28-year-old woman presented with subacute relapsing left-sided weakness. MRI demonstrated both enhancing C3-C6 a...
Kappa Free Light Chain Index Predicts Disease Course in Clinically and Radiologically Isolated Syndromes
Kappa Free Light Chain Index Predicts Disease Course in Clinically and Radiologically Isolated Syndromes
AbstractBackground and Objectives To evaluate whether the kappa free light chain index (K-index) can predict the occurrenc...
Peptides From the Variable Domain of Immunoglobulin G as Biomarkers in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Peptides From the Variable Domain of Immunoglobulin G as Biomarkers in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
IntroductionChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a neuroinflammatory disorder demonstrating...
Immunotherapy-Responsive Neuropathic Pain and Allodynia in a Patient With Glycine Receptor Autoantibodies: A Case Report
Immunotherapy-Responsive Neuropathic Pain and Allodynia in a Patient With Glycine Receptor Autoantibodies: A Case Report
AbstractObjectives Neuropathic pain is common and distressing. Improved mechanistic understanding and pharmacotherapies ar...
SARS-CoV-2-Specific Immune Responses in Patients With Postviral Syndrome After Suspected COVID-19
SARS-CoV-2-Specific Immune Responses in Patients With Postviral Syndrome After Suspected COVID-19
AbstractBackground and Objectives Millions of Americans were exposed to SARS-CoV-2 early in the pandemic but could not get...
Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies
Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies
AbstractBackground and Objectives Autoimmune-associated epilepsy (AAE) with antiglutamic acid decarboxylase 65 (GAD65) ant...
Trigeminal Nerve Involvement in Bulbar-Onset Anti-IgLON5 Disease
Trigeminal Nerve Involvement in Bulbar-Onset Anti-IgLON5 Disease
AbstractObjectives Anti-IgLON5 disease (IgLON5-D) may present with a bulbar-onset motor neuron disease-like phenotype, mim...
Efficacy of Rituximab Outlasts B-Cell Repopulation in Multiple Sclerosis: Time to Rethink Dosing?
Efficacy of Rituximab Outlasts B-Cell Repopulation in Multiple Sclerosis: Time to Rethink Dosing?
AbstractBackground and Objectives Patients with multiple sclerosis (PwMS) receiving extended dosing of rituximab (RTX) hav...
Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head
Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head
IntroductionAntileucine-rich glioma-inactivated-1 (LGI1) autoimmune encephalitis was first described in 20101,2 and is tod...
IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation
IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subu...
Dramatic Response to Anti-IL-6 Receptor Therapy in Children With Life-Threatening Myelin Oligodendrocyte Glycoprotein-Associated Disease
AbstractObjectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated neuroinfl...
LGI1 Encephalitis and IgG4-Related Disease: Rare Conditions Collide
AbstractObjectives Leucine-rich glioma-inactivated 1 (LGI1) encephalitis and IgG4-related disease (IgG4RD) have traditiona...
Mimics of Autoimmune Encephalitis: Validation of the 2016 Clinical Autoimmune Encephalitis Criteria
IntroductionThe discovery of anti-NMDAR encephalitis (anti-NMDARE) in 2007 is regarded as a major breakthrough by introduc...
Visual System Involvement in Glial Fibrillary Acidic Protein Astrocytopathy: Two Case Reports and a Systematic Literature Review
Visual System Involvement in Glial Fibrillary Acidic Protein Astrocytopathy: Two Case Reports and a Systematic Literature Review
IntroductionGlial fibrillary acidic protein (GFAP) antibody–associated astrocytopathy is an autoimmune, inflammatory CNS d...
Severe Neuroinvasive West Nile Virus in Association With Anti-CD20 Monotherapy for Multiple Sclerosis
Severe Neuroinvasive West Nile Virus in Association With Anti-CD20 Monotherapy for Multiple Sclerosis
AbstractObjectives The objective of this study was to report on the development of neuroinvasive West Nile virus (WNV) inf...
EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls
EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls
IntroductionMultiple sclerosis (MS) is a chronic, heterogenous, and incurable demyelinating disease that significantly det...
Disease Evolution in Women With Highly Active MS Who Suspended Natalizumab During Pregnancy vs Rituximab/Ocrelizumab Before Conception
Disease Evolution in Women With Highly Active MS Who Suspended Natalizumab During Pregnancy vs Rituximab/Ocrelizumab Before Conception
AbstractBackground and Objectives In women with highly active multiple sclerosis (MS), suspending rituximab (RTX) for plan...
Utility of Protein Microarrays for Detection of Classified and Novel Antibodies in Autoimmune Neurologic Disease
Utility of Protein Microarrays for Detection of Classified and Novel Antibodies in Autoimmune Neurologic Disease
AbstractBackground and Objectives Neural antibodies are detected by tissue-based indirect immunofluorescence assay (IFA) i...
Structural Changes of Cutaneous Immune Cells in Patients With Type 1 Diabetes and Their Relationship With Diabetic Polyneuropathy
Structural Changes of Cutaneous Immune Cells in Patients With Type 1 Diabetes and Their Relationship With Diabetic Polyneuropathy
IntroductionApproximately half of people with diabetes eventually develop diabetic polyneuropathy (DPN), which usually pre...
Unilateral Relapsing Primary CNS Vasculitis: Description of 3 Cases From a Single-Institutional Cohort of 216 Cases
Unilateral Relapsing Primary CNS Vasculitis: Description of 3 Cases From a Single-Institutional Cohort of 216 Cases
AbstractObjectives To define the frequency and characteristics of patients with unilateral relapsing involvement in a coho...
Upregulation of the CD155-CD226 Axis Is Associated With Muscle Inflammation and Disease Severity in Idiopathic Inflammatory Myopathies
Upregulation of the CD155-CD226 Axis Is Associated With Muscle Inflammation and Disease Severity in Idiopathic Inflammatory Myopathies
AbstractBackground and Objectives The CD155-CD226/T-cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) doma...
Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Disorder in Animal Models: Visual System Manifestations
Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Disorder in Animal Models: Visual System Manifestations
AbstractBackground and Objectives Mechanisms of visual impairment in aquaporin 4 antibody (AQP4-IgG) seropositive neuromye...
Immune Repertoire Profiling Reveals Its Clinical Application Potential and Triggers for Neuromyelitis Optica Spectrum Disorders
Immune Repertoire Profiling Reveals Its Clinical Application Potential and Triggers for Neuromyelitis Optica Spectrum Disorders
IntroductionNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the CNS with acute ...
Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report
Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report
AbstractObjectives JC virus granule cell neuronopathy is a potentially fatal otherwise highly disabling disease without an...
Synthetic Cell-Based Immunotherapies for Neurologic Diseases
Synthetic Cell-Based Immunotherapies for Neurologic Diseases
AbstractThe therapeutic success and widespread approval of genetically engineered T cells for a variety of hematologic mal...
Intrathecal CD8+CD20+ T Cells in Primary Progressive Multiple Sclerosis
Intrathecal CD8+CD20+ T Cells in Primary Progressive Multiple Sclerosis
AbstractBackground and Objective Despite accumulating evidence of intrathecal inflammation in patients with primary progre...
TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis
TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis
In most cases, multiple sclerosis (MS) begins as a relapsing-remitting disease (RRMS), but many patients proceed to second...
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