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Colchicine in acute coronary syndromes: the present and the possible future
Colchicine in acute coronary syndromes: the present and the possible future
Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap opt...
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue
A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regu...
The molecular structure of LDL has finally been elucidated
The molecular structure of LDL has finally been elucidated
Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intel...
Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment
Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment
Anthracyclines are the cornerstone of treatment for many malignancies. However, anthracycline cardiotoxicity is a consider...
The relationship between cannabis and cardiovascular disease: clearing the haze
The relationship between cannabis and cardiovascular disease: clearing the haze
Cannabis has been consumed for centuries, but global regulatory changes over the past three decades have increased the ava...
Interventions for adult congenital heart disease
Interventions for adult congenital heart disease
Advances in imaging diagnostics, surgical techniques and transcatheter interventions for paediatric patients with severe c...
Traction force microscopy of cardiomyocytes
Traction force microscopy of cardiomyocytes
In this Tools of the Trade article, Lyall discusses the use of traction force microscopy to assess the contractile functio...
AI-driven evolution of precision population cardiovascular health in cities
New research shows how the social determinants of cardiovascular health vary locally within cities. Artificial intelligenc...
Effective CRISPR modulation of complex non-coding RNA loci
Effective CRISPR modulation of complex non-coding RNA loci
In this Tools of the Trade article, Francesca Vacante and Andrew Baker describe a CRISPR-based approach to target the regu...
Engineering extracellular vesicles for therapeutic delivery in ischaemic stroke
Engineering extracellular vesicles for therapeutic delivery in ischaemic stroke
In this Tools of the Trade article, Birch describes how extracellular vesicles can be engineered to deliver therapeutic mi...
Mind the gap: sex-related differences in cardiovascular disease
Anju Loveridge discusses the Framingham Heart Study report that described the link between diabetes mellitus and cardiovas...
Cardiac optogenetics: controlling the heart with light
Sasha Forbes discusses the study that demonstrated that the electrical activity of the heart could be regulated with light...
Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches
Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches
Atherosclerosis is a disease of large and medium arteries that can lead to life-threatening cardiovascular and cerebrovasc...
The rapid delayed-rectifier potassium current: a biophysical basis for cardiac repolarization and arrhythmia
Joseph Carr highlights the study that described the rapid component of the delayed-rectifier potassium current and laid th...
The spleen in ischaemic heart disease
The spleen in ischaemic heart disease
Ischaemic heart disease is a consequence of coronary atherosclerosis, and atherosclerosis is a systemic inflammatory disea...
Extracellular matrix in vascular homeostasis and disease
Extracellular matrix in vascular homeostasis and disease
The extracellular matrix is an essential component and constitutes a dynamic microenvironment of the vessel wall with an i...
Haematometabolism rewiring in atherosclerotic cardiovascular disease
Haematometabolism rewiring in atherosclerotic cardiovascular disease
Atherosclerotic cardiovascular diseases are the most frequent cause of death worldwide. The clinical complications of athe...
Apolipoprotein B-containing lipoproteins in atherogenesis
Apolipoprotein B-containing lipoproteins in atherogenesis
Apolipoprotein B (apoB) is the main structural protein of LDLs, triglyceride-rich lipoproteins and lipoprotein(a), and is ...
Functional diversity of cardiac macrophages in health and disease
Functional diversity of cardiac macrophages in health and disease
Macrophages make up a substantial portion of the stromal compartment of the heart in health and disease. In the past decad...
Renal denervation for hypertension
Renal denervation for hypertension
Innovative therapies for hypertension are desperately needed given the rising prevalence and falling rates of control of h...
Targeting macrophage–fibroblast interactions in the failing heart
Targeting macrophage–fibroblast interactions in the failing heart
Macrophage–fibroblast interactions have a central role in cardiac fibrosis. In response to left ventricular pressure...
Left atrial appendage closure after ablation: the best OPTION for patients with AF?
Left atrial appendage closure after ablation: the best OPTION for patients with AF?
Two studies presented at AHA 2024 Scientific Sessions describe the efficacy and safety of left atrial appendage closure af...
Pro-arrhythmic potential of proton-pump inhibitors
Population studies have reported that proton-pump inhibitors (PPIs) increase cardiovascular mortality, at least in part ow...
Cholesterol crystals in the pathogenesis of atherosclerosis
Cholesterol crystals in the pathogenesis of atherosclerosis
The presence of cholesterol crystals (CCs) in tissues was first described more than 100 years ago. CCs have a pathogenic r...
Charting the future of cardiology with large language model artificial intelligence
Charting the future of cardiology with large language model artificial intelligence
Large language models represent a transformative leap in artificial intelligence and natural language processing, offering...
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine
This call to action aims to increase awareness of inclusive language in medicine to enhance the experiences of patients an...
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials
Heart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for pa...
Cardiodermatology: the heart of the connection between the skin and cardiovascular disease
Cardiodermatology: the heart of the connection between the skin and cardiovascular disease
The skin and cardiovascular systems are connected in unique and meaningful ways, and many diseases conventionally consider...
Improving English proficiency for scientific communication by non-fluent speakers
English has long been the dominant language in scientific communication. Although having a universal language for scientif...