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Simvastatin protects against endothelial dysfunction via epigenetic mechanisms
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms
Simvastatin improves endothelial cell function by inhibiting endothelial-to-mesenchymal transition through an epigenetic r...
Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges
Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges
Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a continuous supply of ATP in larg...
Flow-induced reprogramming of endothelial cells in atherosclerosis
Flow-induced reprogramming of endothelial cells in atherosclerosis
Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral artery disease continue to be lead...
Global epidemiology of acute coronary syndromes
Global epidemiology of acute coronary syndromes
This Review provides an epidemiological overview of global mortality from acute coronary syndromes (ACS). Across the regio...
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk
Contemporary tools to predict cardiovascular risk lack accuracy on an individual-patient level. The use of single-cell RNA...
Hallmarks of cardiovascular ageing
Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan). Indeed, pathologies affecti...
Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention
Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality in individuals with type 2 diabetes melli...
Young women with AMI have worse outcomes than men up to 1 year after discharge
Young women with AMI have worse outcomes than men up to 1 year after discharge
Findings from the VIRGO study reveal that young women with acute myocardial infarction are more likely to be rehospitalize...
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction
Hyperphosphorylation of tau in the heart reduces the tyrosination of microtubules, leading to myocardial stiffness and hea...
Clonal haematopoiesis and atherosclerotic cardiovascular disease
Clonal haematopoiesis and atherosclerotic cardiovascular disease
Clonal haematopoiesis of indeterminate potential (CHIP) is defined as an expansion of mutant blood stem cells in individua...
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease
IgM antibodies have gained much attention as risk markers of atherosclerotic cardiovascular disease, but the exact antigen...
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course
Obesity, hypertension, type 2 diabetes mellitus and dyslipidaemia are highly prevalent among women of reproductive age and...
Interventional therapies for pulmonary embolism
Interventional therapies for pulmonary embolism
Pulmonary embolism (PE) is the leading cause of in-hospital death and the third most frequent cause of cardiovascular deat...
The contribution of the exposome to the burden of cardiovascular disease
The contribution of the exposome to the burden of cardiovascular disease
Large epidemiological and health impact assessment studies at the global scale, such as the Global Burden of Disease proje...
A role for lipophagy in atherosclerosis
A role for lipophagy in atherosclerosis
Lipophagy is a type of selective autophagy that targets lipid droplets for degradation. Since the discovery of lipophagy i...
A high-salt diet promotes atherosclerosis by altering haematopoiesis
A high-salt diet promotes atherosclerosis by altering haematopoiesis
Excessive salt intake is a known risk factor for cardiovascular disease commonly associated with hypertension. However, we...
AI outperforms sonographers at diagnosing cardiac function on echocardiography
An artificial intelligence-guided workflow for initial evaluation of left ventricular ejection fraction in echocardiograph...
The bidirectional association between atrial fibrillation and myocardial infarction
The bidirectional association between atrial fibrillation and myocardial infarction
Atrial fibrillation (AF) is associated with an increased risk of myocardial infarction (MI) and vice versa. This bidirecti...
Novel and future lipid-modulating therapies for the prevention of cardiovascular disease
Novel and future lipid-modulating therapies for the prevention of cardiovascular disease
Lowering the levels of LDL cholesterol in the plasma has been shown to reduce the risk of atherosclerotic cardiovascular d...
Improving the cardiovascular health care of transgender and non-binary persons
Improving the cardiovascular health care of transgender and non-binary persons
Research consistently shows that gender-affirming practices improve markers of cardiovascular health. Consequently, the fo...
Increased degradation of desmosomal proteins in ACM
Increased degradation of desmosomal proteins in ACM
Desmosomal protein degradation that occurs via a mechanism involving the ubiquitin–proteasome system might underlie ...
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale
Factor XIa inhibitors are being tested in clinical trials, with the assumption that these agents are as effective as direc...
Current concepts and novel targets for antiplatelet therapy
Current concepts and novel targets for antiplatelet therapy
Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control of platelet hyper-reactivity ha...
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce
Establishing and enforcing LGBTQ-inclusive policies at the national, state and institutional level are essential for advan...
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action
Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders characterized by excess cardiovascular risk. Glucagon-...
Bempedoic acid prevents cardiovascular events in statin-intolerant patients
Bempedoic acid prevents cardiovascular events in statin-intolerant patients
In the CLEAR Outcomes trial, bempedoic acid lowered plasma LDL-cholesterol levels and reduced the incidence of major adver...
Transcatheter repair for severe tricuspid regurgitation
Tricuspid transcatheter edge-to-edge repair in patients with severe tricuspid regurgitation improved quality of life and r...
A wearable sensor to measure troponin I levels
A wrist-worn, transdermal sensor can be used to measure plasma levels of cardiac troponin I, potentially facilitating the ...
Intravascular imaging improves outcomes
In patients with complex coronary lesions, percutaneous coronary intervention guided by intravascular imaging improved car...
Oral PCSK9 inhibitor is effective and safe
MK-0616, an oral inhibitor of PCSK9, safely and effectively lowers plasma levels of LDL cholesterol in a dose-dependent ma...
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