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Clonal expansion of CD8+ T cells in aged mice linked to pro-atherogenic phenotype
In aged mice, but not young mice, with atherosclerosis, depletion of CD8+ T cells significantly reduces atherosclerotic le...
Levothyroxine supplementation does not improve heart transplantation from brain-dead donors
The use of intravenous levothyroxine does not increase the likelihood of hearts being transplanted from haemodynamically u...
Mosaic loss of chromosome Y and cardiovascular disease
Mosaic loss of chromosome Y and cardiovascular disease
Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells los...
Anticoagulation in patients with atrial high-rate episodes
Anticoagulation in patients with atrial high-rate episodes
The risk of stroke in patients with atrial high-rate episodes (AHREs) depends on age, comorbidities and AHRE burden. Two r...
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials
Representation of Black patients in cardiovascular clinical trials remains dismally low, reflective of systemic and struct...
Author Correction: Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Department of Cardiology, Maria Cecilia Hospital, GVM Care & Research, Cotignola, ItalyMattia GalliDepartment of Cardi...
Base editing therapy corrects long QT syndrome in mice
Gene therapy involving adenine base editing can correct a pathogenic variant in the Scn5a gene and alleviate arrhythmia ph...
The case for eliminating racial and ethnic cardiovascular disparities in the USA
Racial and ethnic disparities in cardiovascular health in the USA result in a persistent mortality gap between white and B...
PCI for stable angina
PCI for stable angina
In the ORBITA-2 trial, percutaneous coronary intervention was associated with a lower angina symptom score compared with a...
Non-invasive ultrasound therapy for calcified aortic valve stenosis
In patients with severe calcified aortic valve stenosis, treatment with transthoracically delivered non-invasive ultrasoun...
MINT trial signals potential benefit of liberal transfusion strategy in MI with anaemia
A liberal strategy of blood transfusion might improve outcomes in patients with acute myocardial infarction and anaemia, a...
SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes
SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes
Treatment with the glucagon-like peptide 1 receptor agonist semaglutide, administered subcutaneously at a dose of 2.4̴...
New insights into dietary cholesterol absorption
New insights into dietary cholesterol absorption
Aster proteins are involved in the non-vesicular transport of cholesterol derived from dietary lipids in the small intesti...
Self-monitoring strategy reduces postpartum hypertension and cardiac remodelling
In women with elevated levels of blood pressure during pregnancy, the use of a physician-guided remote telemonitoring prog...
Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Despite prompt epicardial recanalization in patients presenting with ST-segment elevation myocardial infarction (STEMI), c...
Aspirin exclusion in patients with an LVAD
Data from the ARIES-HM3 trial show that excluding aspirin from the antithrombotic regimen in patients with advanced heart ...
Long non-coding RNAs in cardiac hypertrophy and heart failure: functions, mechanisms and clinical prospects
Long non-coding RNAs in cardiac hypertrophy and heart failure: functions, mechanisms and clinical prospects
The surge in reports describing non-coding RNAs (ncRNAs) has focused attention on their possible biological roles and effe...
Long-term outcomes and device failure after TAVI
Long-term outcomes and device failure after TAVI
Transcatheter aortic valve implantation (TAVI) has become an important treatment option for aortic stenosis, even among yo...
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-ischaemic injury to the myocardium. ...
Patisiran is beneficial for the treatment of TTR cardiac amyloidosis
Patisiran is beneficial for the treatment of TTR cardiac amyloidosis
Treatment with the small interfering RNA patisiran preserves functional capacity and improves health status and quality of...
Drug-eluting resorbable scaffolds are superior to angioplasty for infrapopliteal artery disease
Drug-eluting resorbable scaffolds are superior to angioplasty for infrapopliteal artery disease
In the LIFE-BTK trial, treatment with an everolimus-eluting resorbable scaffold was superior to angioplasty in improving c...
Lipoprotein(a), platelet function and cardiovascular disease
Lipoprotein(a), platelet function and cardiovascular disease
Lipoprotein(a) (Lp(a)) is associated with atherothrombosis through several mechanisms, including putative antifibrinolytic...
Disrupting a cell-specific miRNA–CXCR4 interaction is atheroprotective in mice
An approach that increases the expression of the chemokine receptor CXCR4 in vascular cells by targeting a microRNA-based ...
Explaining how a cardiac reflex causes syncope
Explaining how a cardiac reflex causes syncope
Activation of a specific set of vagal sensory neurons connecting the ventricular wall of the heart to the area postrema in...
Revealing the structure of the cardiac myosin filament
Revealing the structure of the cardiac myosin filament
Two new studies using cryo-electron microscopy describe the structure and conformation of myosin in the cardiac thick fila...
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention
Aortic blood flow patterns are closely linked to the morphology and function of the left ventricle, aortic valve and aorta...
Defining iron deficiency in patients with heart failure
Defining iron deficiency in patients with heart failure
For patients with heart failure and reduced left ventricular ejection fraction, intravenous iron is likely to deliver clin...
Depolarization of fibroblasts in scar tissue drives cardiac excitation
In a study published in Science, Wang and colleagues show that excited cardiomyocytes couple to fibroblasts via gap-juncti...
Oxidized phospholipids in cardiovascular disease
Oxidized phospholipids in cardiovascular disease
Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic inflammation. OxPLs are present in ath...
Sirtuin 2 protects against cardiac ageing
NAD-dependent protein deacetylase sirtuin 2 is a key protective mediator against cardiac ageing, according to a study in n...
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