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The LDL cumulative exposure hypothesis: evidence and practical applications
The LDL cumulative exposure hypothesis: evidence and practical applications
The trapping of LDL and other apolipoprotein B-containing lipoproteins within the artery wall causes atherosclerosis. As m...
Consequences of ionizing radiation exposure to the cardiovascular system
Consequences of ionizing radiation exposure to the cardiovascular system
Ionizing radiation is widely used in various industrial and medical applications, resulting in increased exposure for cert...
Functional control of myosin motors in the cardiac cycle
Functional control of myosin motors in the cardiac cycle
Contraction of the heart is driven by cyclical interactions between myosin and actin filaments powered by ATP hydrolysis. ...
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight
For more than 60 years, humans have travelled into space. Until now, the majority of astronauts have been professional, go...
Cardiac involvement in Chagas disease and African trypanosomiasis
Cardiac involvement in Chagas disease and African trypanosomiasis
Trypanosomiases are diseases caused by various species of protozoan parasite in the genus Trypanosoma, each presenting wit...
Dietary patterns to promote cardiometabolic health
Dietary patterns to promote cardiometabolic health
Multiple professional societies recommend the Mediterranean and/or Dietary Approaches to Stop Hypertension dietary pattern...
Transcatheter treatment of pure aortic regurgitation
Transcatheter treatment of pure aortic regurgitation
Preliminary experience with the use of transcatheter aortic valve implantation (TAVI) to treat non-calcific aortic regurgi...
Autoimmune diseases and atherosclerotic cardiovascular disease
Autoimmune diseases and atherosclerotic cardiovascular disease
Autoimmune diseases are associated with a dramatically increased risk of atherosclerotic cardiovascular disease and its cl...
Pulsed-field ablation: a revolution in atrial fibrillation therapy
The advent of pulsed-field ablation — a series of ultra-rapid, high-energy pulses that result in non-thermal cell de...
Global epidemiology of heart failure
Global epidemiology of heart failure
Heart failure (HF) is a heterogeneous clinical syndrome marked by substantial morbidity and mortality. The natural history...
Suture-to-scan: ultrasonography-guided induction of heart injury
Suture-to-scan: ultrasonography-guided induction of heart injury
In this Tools of the Trade article, Berkeley and Thomson describe the use of a minimally invasive strategy to standardize ...
Proximity-based labelling for proteomic mapping
Proximity-based labelling for proteomic mapping
In this Tools of the Trade article, Jablonska describes the use of proximity-based labelling for the proteomic profiling o...
Epigenetic changes in HSCs contribute to HF and comorbidities
Epigenetic changes in HSCs contribute to HF and comorbidities
Findings from a new study published in Science Immunology suggest that epigenetic changes in haematopoietic stem cells pro...
RNA interference lowers triglyceride levels
Data from the phase IIb MUIR and ARCHES-2 trials show that RNA interference approaches that target either apolipoprotein C...
Characterization of the F8 gene: a silver lining in a dark cloud
Haemophilia A is caused by variants in the gene that encodes coagulation factor VIII (FVIII). Sequencing of this gene in t...
Insights into endothelial metabolic heterogeneity
Corey McAleese describes the study that identified the presence of metabolic heterogeneity in endothelial cells from diffe...
Phase separation of protein kinase A: a new paradigm in cardiac regulation?
Milda Folkmanaite and Manuela Zaccolo highlight a study that demonstrates a role for phase-separated condensates of protei...
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF
In patients with type 2 diabetes mellitus and obesity, bariatric metabolic surgery is associated with a lower risk of the ...
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications
Atrial fibrillation (AF) is a continually growing health-care burden that often presents together with metabolic disorders...
Aficamten reduces symptoms in obstructive hypertrophic cardiomyopathy
Aficamten reduces symptoms in obstructive hypertrophic cardiomyopathy
Data from the SEQUOIA-HCM trial show that aficamten, a cardiac myosin inhibitor, increases exercise capacity and improves ...
A distinct platelet differentiation pathway is involved in age-related thrombocytosis
A distinct platelet differentiation pathway is involved in age-related thrombocytosis
Poscablo and colleagues identify a distinct haematopoietic platelet differentiation pathway that is enriched in ageing mic...
Bile acid receptor protects against diabetic cardiomyopathy
Bile acid receptor protects against diabetic cardiomyopathy
Activation of the bile acid receptor TGR5 inhibits CD36-mediated fatty acid uptake in cardiomyocytes and protects against ...
Artificially transplanted mitochondria in endothelial cells promote mitophagy
Artificially transplanted mitochondria in endothelial cells promote mitophagy
A study in Nature describes a single-cell-type strategy for vascular cell therapies that involves the artificial transplan...
Efferocytosis in atherosclerosis
Efferocytosis in atherosclerosis
Cardiovascular disease is the leading cause of death worldwide, and it commonly results from atherosclerotic plaq...
Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention?
Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention?
This Perspective article is a form of ‘pastiche’, inspired by the 1993 review by Lincoff and Topol entitled &#...
No benefit of apoA-I infusion after myocardial infarction
No benefit of apoA-I infusion after myocardial infarction
In the AEGIS-II trial, infusion of apolipoprotein A-I to increase cholesterol efflux capacity did not improve outcomes in ...
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease
In the Review by Talasaz et al. (Optimizing antithrombotic therapy in patients with coexisting cardio...
Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’
Competing interests B.B. reports that he was a consulting expert, on behalf of t...
Stress and cardiovascular disease: an update
Stress and cardiovascular disease: an update
Psychological stress is generally accepted to be associated with an increased risk of cardiovascular disease (CVD), but re...
Targeting immune cell recruitment in atherosclerosis
Targeting immune cell recruitment in atherosclerosis
Atherosclerosis is the primary underlying cause of myocardial infarction and stroke. Atherosclerotic cardiovascular diseas...
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