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Genetics and mechanisms of thoracic aortic disease
Genetics and mechanisms of thoracic aortic disease
Aortic disease has many forms including aortic aneurysm and dissection, aortic coarctation or abnormalities in aortic func...
Cardiovascular benefits of statins outweigh small risk of muscle pain
Cardiovascular benefits of statins outweigh small risk of muscle pain
A new meta-analysis indicates that statin therapy causes a small excess of mostly mild muscle pain and that this risk is o...
Oxygen and BP targets for OHCA
Among patients in a coma after resuscitation for out-of-hospital cardiac arrest, a restrictive versus liberal oxygenation ...
Polypills for the secondary prevention of MACE
Polypills for the secondary prevention of MACE
In the SECURE trial, a polypill containing aspirin, ramipril and atorvastatin taken within 6 months after myocardial infar...
Acetazolamide improves decongestion in acute heart failure
Acetazolamide improves decongestion in acute heart failure
The addition of acetazolamide to loop diuretic therapy improves the success of decongestion in patients with acute decompe...
Black In Cardio: promoting diversity and representation in the cardiovascular field
Globally, Black people have some of the highest rates of cardiovascular disease. Racial inequities in cardiovascular healt...
Women in cardiology in Brazil: an expected and necessary future
Women in cardiology in Brazil: an expected and necessary future
As a Brazilian female cardiologist who has held leadership positions since my 40s, I understand the difficulties that wome...
No benefit of PCI in ischaemic LV dysfunction
In patients with severe ischaemic left ventricular (LV) systolic dysfunction receiving optimal medical therapy (OMT), the ...
Vitamin K antagonists for RHD-associated AF
In patients with rheumatic heart disease (RHD) and atrial fibrillation (AF), vitamin K antagonists (VKAs) reduce the rate ...
Dapagliflozin improves outcomes in HFmrEF and HFpEF
Dapagliflozin improves outcomes in HFmrEF and HFpEF
In patients with heart failure (HF) with mildly reduced or preserved ejection fraction, the SGLT2 inhibitor dapagliflozin ...
Extravascular ICDs are safe and effective
Extravascular implantable cardioverter–defibrillators are safe and effective at detecting and terminating ventricula...
CVD screening trial in older men misses primary end point but suggests benefits
An invitation to undergo comprehensive cardiovascular screening in men aged 65–74 years did not lower the incidence ...
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically significant cardiac rhythm dist...
Functional testing after PCI in high-risk patients
In high-risk patients who have undergone percutaneous coronary intervention (PCI), a follow-up strategy of routine functio...
Overcoming challenges as a female cardiologist in the Middle East
Overcoming challenges as a female cardiologist in the Middle East
When I have encountered obstacles in the three decades of my career, I have found that self-confidence and courage are the...
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults
The epidemiology of congenital heart disease (CHD) has changed in the past 50 years as a result of an increase in the prev...
Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure
Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure
Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of cardiac function by degrading cAMP an...
Branched-chain amino acids in cardiovascular disease
Branched-chain amino acids in cardiovascular disease
Research conducted in the past 15 years has yielded crucial insights that are reshaping our understanding of the systems p...
Gout flares can precede cardiovascular events
According to observational data, patients with gout might be at increased risk of cardiovascular events in the days after ...
Ethnic disparities in age of onset of hypertension
In a cross-sectional study using the NHANES database from the USA, a total of 9,627 participants reported a diagnosis of h...
LIPC variant in combined hypocholesterolaemia
Using next-generation sequencing, researchers have discovered a dominant, gain-of-function variant in LIPC that underlies ...
ASGR1 inhibition stimulates cholesterol excretion
ASGR1 inhibition stimulates cholesterol excretion
Inhibition of asialoglycoprotein receptor 1 (ASGR1) reduces cholesterol levels by promoting cholesterol excretion to bile ...
Donor macrophages influence rejection of transplanted hearts
Donor macrophages influence rejection of transplanted hearts
In mouse transplanted hearts, donor CCR2+ macrophages promote allograft rejection, whereas donor CCR2− macroph...
Implementing an anti-bullying culture in cardiology
Bullying is common in cardiology and can have substantial adverse effects. However, bullying can be addressed by substanti...
Age-related loss of Y chromosome in leukocytes linked to cardiac fibrosis
Age-related loss of Y chromosome in leukocytes linked to cardiac fibrosis
Haematopoietic mosaic loss of the Y chromosome, a phenomenon that frequently occurs with age, directly contributes to card...
Sulfide regulation of cardiovascular function in health and disease
Sulfide regulation of cardiovascular function in health and disease
Hydrogen sulfide (H2S) has emerged as a gaseous signalling molecule with crucial implications for cardiovascular health. H...
Pregnancy among cardiologists: challenges and recommendations
Childbearing cardiologists face a number of challenges before, during and after pregnancy, including radiation concerns, i...
Macrophages and neutrophils modulate arrhythmia risk after myocardial infarction
Macrophages and neutrophils modulate arrhythmia risk after myocardial infarction
In a new mouse model of spontaneous ventricular tachycardia after myocardial infarction, cardiac neutrophils increased the...
AIMing 2 treat atherosclerosis
AIMing 2 treat atherosclerosis
The AIM2 inflammasome is activated by host and pathogen DNA. Work from the past 5 years indicates that the AIM2 inflammaso...