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Interplay between the DNA damage response and the life cycle of DNA tumor viruses
Interplay between the DNA damage response and the life cycle of DNA tumor viruses
Approximately 20 % of human cancers are associated with virus infection. DNA tumor viruses can induce tumor formation in h...
Construction of a diagnostic model for hepatitis B-related hepatocellular carcinoma using machine learning and artificial neural networks and revealing the correlation by immunoassay
Construction of a diagnostic model for hepatitis B-related hepatocellular carcinoma using machine learning and artificial neural networks and revealing the correlation by immunoassay
HBV infection profoundly escalates hepatocellular carcinoma (HCC) susceptibility, responsible for a majority of HCC cases....
Identification and characterisation of novel potential phospho-acceptor sites in HPV-16 E7
Identification and characterisation of novel potential phospho-acceptor sites in HPV-16 E7
Several studies have described functional regulation of high-risk human papillomaviruses (HPVs), E6 and E7 oncoproteins vi...
Association of two genomic variants with HPV type-specific risk of cervical cancer
ProblemHuman papillomavirus infection is integral to developing invasive cervical cancer in the majority of patients. In a...
The human Papillomavirus twilight zone – Latency, immune control and subclinical infection
The incorporation of HPV DNA testing into cervical screening programs has shown that many HPV-positive women are cytologic...
Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia?
The International Papillomavirus Conference was held in Washington DC in April 2023 and encompassed wide ranging basic, cl...
Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus
KeywordsMerkel cell polyomavirusMerkel cell carcinomaHuman papillomavirusOropharyngeal squamous cell carcinomaEnhancer of ...
Characterization of HPV subtypes in invasive cervical cancer in Botswana patients using a pan-pathogen microarray technology
Human papillomavirus (HPV) plays a significant role in the development of cervical cancers in the setting of co-infection ...
Diversity of cervicovaginal human papillomavirus (HPV) genotypes and naturally occurring E6/E7 DNA polymorphisms of HPV-16 in Ghana
KeywordsHuman papillomavirusGenotypingHPV E6/E7 DNA sequence PolymorphismsCervical cancerHPV-16 variantsAbbreviationsCINce...
Tegument proteins of Epstein-Barr virus: Diverse functions, complex networks, and oncogenesis
The tegument is the structure between the envelope and nucleocapsid of herpesvirus particles. Viral (and cellular) protein...
Elevated iNOS and 3′-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model
Kaposi's Sarcoma (KS) is a heterogenous, multifocal vascular malignancy caused by the human herpesvirus 8 (HHV8), also kno...
Human papillomavirus genomics: Understanding carcinogenicity
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other anatomical sites in both men an...
Association of PNPLA3 (rs738409) & TM6SF2 (rs58542926) and ATG16L1 (rs2241880) genetic variants with susceptibility to hepatocellular carcinoma in a group of Egyptian patients with HCV-induced liver cirrhosis
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Molecular dissection of the E6 PBM identifies essential residues regulating Chk1 phosphorylation and subsequent 14-3-3 recognition
Previous studies have shown that the high-risk HPV E6 oncoprotein PDZ binding motifs (PBMs) can interact with PDZ proteins...
Exploring monitoring strategies for population surveillance of HPV vaccine impact using primary HPV screening
Australia's cervical screening program transitioned from cytology to HPV-testing with genotyping for HPV16/18 in Dec’2017....
The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro
The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypeptides, defined as E4or...
Unresolved issues in the management of human papillomavirus-associated mucosal high-grade pre-cancers
This article reviews human papillomavirus-associated mucosal high-grade pre-cancers and their management. It examines pre-...
Synonymous nucleotide changes drive papillomavirus evolution
Papillomaviruses have been evolving alongside their hosts for at least 450 million years. This review will discuss some of...
Programmed death-ligand 1 (PD-L1) polymorphisms as predictive biomarkers for the development of liver cirrhosis and hepatocellular carcinoma in HCV Egyptian patients
BackgroundConsidering the immune evasion role of programmed death-ligand 1 (PD-L1) in cancer development, the genomic vari...
Differences in integration frequencies and APOBEC3 profiles of five high-risk HPV types adheres to phylogeny
Persistent infection with Human Papillomavirus (HPV) is responsible for almost all cases of cervical cancers, and HPV16 an...
Synergistic targeting of the PI3K/mTOR and MAPK/ERK pathways in Merkel cell carcinoma
Volume 14, December 2022, 200244AbstractMerkel cell carcinoma (MCC) is an aggressive type of skin cancer, which is caused ...
The oncogenic gamma herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) hijack retinoic acid-inducible gene I (RIG-I) facilitating both viral and tumour immune evasion
Available online 20 August 2022, 200246AbstractHerpesviruses evade host immunity to establish persistent lifelong infectio...
HPV and head and neck cancers: Towards early diagnosis and prevention
Available online 13 August 2022, 200245AbstractHead and neck squamous cell carcinoma (HNSCC) is the sixth most common canc...
Detection of high-risk HPV in FFPE specimens of various tumours using the BD Onclarity™ HPV Assay
Available online 15 June 2022, 200243AbstractAnalysis of high-risk HPV status on formalin-fixed paraffin-embedded (FFPE) t...
Women with a positive high-risk human papillomavirus (HPV) test remain at increased risk of HPV infection and cervical precancer ≥15 years later
Available online 28 May 2022, 200240AbstractLittle is known about the long-term association between high-risk human papill...
Small DNA tumor viruses and human cancer: Preclinical models of virus infection and disease
Available online 27 May 2022, 200239AbstractHuman tumor viruses cause various human cancers that account for at least 15% ...
Human papillomavirus seroprevalence and seroconversion following baseline detection of nine human papillomavirus types in young women
Available online 4 May 2022, 200236Highlights•Research on humoral immune responses to HPV infection are limited.•HPV-relat...
Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults
Available online 20 April 2022, 200237AbstractBackgroundHIV has been shown to increase the likelihood of oral HPV infectio...
Cervical cancer therapies: current challenges and future perspectives
Available online 20 April 2022, 200238AbstractCervical cancer is the fourth most common female cancer worldwide and result...
Provider Preferences for Anal Cancer Prevention Screening: Results of the International Anal Neoplasia Society Survey
Available online 17 February 2022, 200235AbstractObjectiveThis study explores provider preferences regarding anal cancer s...
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