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Racial disparity in prostate cancer: an outlook in genetic and molecular landscape
Racial disparity in prostate cancer: an outlook in genetic and molecular landscape
Prostate cancer (PCa) incidence, morbidity, and mortality rates are significantly impacted by racial disparities. Despite ...
The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
Glucagon-like peptide-1 receptor (GLP-1R) agonists have garnered significant attention for their therapeutic potential in ...
Healthcare disparities, screening, and molecular testing in the changing landscape of non–small cell lung cancer in the United States: a review
Healthcare disparities, screening, and molecular testing in the changing landscape of non–small cell lung cancer in the United States: a review
Inequitable access to care continues to hinder improvements in diagnosis and treatment of lung cancer. This review describ...
Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine
Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine
Cellular plasticity refers to the ability of cells to change their identity or behavior, which can be advantageous in some...
The roles of PD-L1 in the various stages of tumor metastasis
The roles of PD-L1 in the various stages of tumor metastasis
The interaction between tumor programmed death ligand 1 (PD-L1) and T-cell programmed cell death 1 (PD-1) has long been ac...
Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor initiation, progression, and metast...
In vivo manufacture and manipulation of CAR-T cells for better druggability
In vivo manufacture and manipulation of CAR-T cells for better druggability
The current CAR-T cell therapy products have been hampered in their druggability due to the personalized preparation requi...
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
Metastasis is a major contributor to treatment failure and death in urological cancers, representing an important biomedic...
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicat...
Glioblastoma stem cell metabolism and immunity
Glioblastoma stem cell metabolism and immunity
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire...
OX40/OX40 ligand and its role in precision immune oncology
OX40/OX40 ligand and its role in precision immune oncology
Immune checkpoint inhibitors have changed the treatment landscape for various malignancies; however, their benefit is limi...
Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics
Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics
Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on dru...
Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance
Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance
There has been a surge of interest in recent years in understanding the intricate mechanisms underlying cancer progression...
The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas
We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, charac...
TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer
TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer
Tumor suppressor genes and proto-oncogenes comprise most of the complex genomic landscape associated with cancer, with a m...
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (C...
Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?
Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?
Metabolic reprogramming, a hallmark of cancer, allows cancer cells to adapt to their specific energy nee...
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Nasopharyngeal carcinoma (NPC) is characterised by its remarkable geographical and ethnic distribution. The interplay betw...
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Atezolizumab (TECENTRIQ®) and nivolumab (OPDIVO®) are both immunotherapeutic indications targeting programmed ce...
Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation
Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation
Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early stages and high metastatic pot...
Clusterin: a marker and mediator of chemoresistance in colorectal cancer
Clusterin: a marker and mediator of chemoresistance in colorectal cancer
Intra-tumoural heterogeneity and cancer cell plasticity in colorectal cancer (CRC) have been key challenges to effective t...
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plast...
Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance
Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance
Circular RNAs (circRNAs) are a member of non-coding RNAs with no ability in encoding proteins and their aberrant dysregula...
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
T cells, a key component of cancer immunotherapy, undergo a variety of histone modifications and DNA methylation changes s...
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and ep...
The emerging roles of histone demethylases in cancers
The emerging roles of histone demethylases in cancers
Modulation of histone methylation status is regarded as an important mechanism of epigenetic regulation and has substantia...
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs cellular shape and function change...
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Cellular plasticity and therapy resistance are critical features of pancreatic cancer, a highly aggressive and fatal disea...
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitoch...
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
We describe here the molecular basis of the complex formation of PRUNE1 with the tumor metastasis suppressors NME1 and NME...
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