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Biography—Mikhail Kolonin
Biography—Mikhail Kolonin
Mikhail Kolonin, Ph.D., is a tenured professor and the Harry E. Bovay, Jr. Distinguished University Chair in Metabolic Dis...
Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases
Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases
Obesity is an established risk factor for several human cancers. Given the association between excess body weight and canc...
Immunotherapy for triple negative breast cancer: the end of the beginning or the beginning of the end?
Immunotherapy for triple negative breast cancer: the end of the beginning or the beginning of the end?
Won, K. A., & Spruck, C. (2020). Triple-negative breast cancer therapy: Current and future perspectives (Review). Inte...
Obesity: a perfect storm for carcinogenesis
Obesity: a perfect storm for carcinogenesis
Obesity-related cancers account for 40% of the cancer cases observed in the USA and obesity is overtaking smoking as the m...
The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer
The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer
The significant increase in the incidence of obesity represents the next global health crisis. As a result, scientific res...
Obesity, cancer risk, and time-restricted eating
Obesity, cancer risk, and time-restricted eating
Obesity and the associated metabolic syndrome is considered a pandemic whose prevalence is steadily increasing in many cou...
The adipocyte microenvironment and cancer
The adipocyte microenvironment and cancer
Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors develop, crosstalk between adip...
p73 isoforms meet evolution of metastasis
p73 isoforms meet evolution of metastasis
Cancer largely adheres to Darwinian selection. Evolutionary forces are prominent during metastasis, the final and incurabl...
Clinical interventions to break the obesity and cancer link: a narrative review
Clinical interventions to break the obesity and cancer link: a narrative review
Excess body weight is a significant risk factor for the development and recurrence of many types of cancer. Patients with ...
White adipose tissue-derived factors and prostate cancer progression: mechanisms and targets for interventions
White adipose tissue-derived factors and prostate cancer progression: mechanisms and targets for interventions
Obesity represents an important risk factor for prostate cancer, driving more aggressive disease, chemoresistance, and inc...
The timing of adiposity and changes in the life course on the risk of cancer
The timing of adiposity and changes in the life course on the risk of cancer
Excess body weight has been established as a risk factor for at least twelve cancer sites, though questions remain as to t...
The multifaceted mechanisms of malignant glioblastoma progression and clinical implications
The multifaceted mechanisms of malignant glioblastoma progression and clinical implications
With the application of high throughput sequencing technologies at single-cell resolution, studies of the tumor microenvir...
The gut microbiome, immune check point inhibition and immune-related adverse events in non-small cell lung cancer
The gut microbiome, immune check point inhibition and immune-related adverse events in non-small cell lung cancer
Systemic treatment options for patients with lung cancer have expanded in recent years, with a number of immunotherapeutic...
The role of obesity and bariatric surgery-induced weight loss in breast cancer
The role of obesity and bariatric surgery-induced weight loss in breast cancer
Obesity is a complex metabolic condition considered a worldwide public health crisis, and a deeper mechanistic understandi...
Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance
Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance
Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system development by regulating angiogenes...
The obesity-breast cancer link: a multidisciplinary perspective
The obesity-breast cancer link: a multidisciplinary perspective
Obesity, exceptionally prevalent in the USA, promotes the incidence and progression of numerous cancer types including bre...
Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression
Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression
Glucocorticoids (GCs), mostly dexamethasone (dex), are routinely administered as adjuvant therapy to manage side effects i...
The role of bone marrow adipocytes in cancer progression: the impact of obesity
The role of bone marrow adipocytes in cancer progression: the impact of obesity
Bone marrow adipose tissues (BMATs) and their main cellular component, bone marrow adipocytes (BMAds), are found within th...
Oncogenic functions of the FOXC2 transcription factor: a hallmarks of cancer perspective
Oncogenic functions of the FOXC2 transcription factor: a hallmarks of cancer perspective
Epigenetic regulation of gene expression is a fundamental determinant of molecular and cellular function, and epigenetic r...
Targeting lipid metabolism in cancer: neuroblastoma
Targeting lipid metabolism in cancer: neuroblastoma
Maris, J.M., Hogarty, M.D., Bagatell, R., & Cohn, S.L. (2007). Neuroblastoma. Lancet (London, England), 369(9579), 210...
Notch signaling in malignant gliomas: supporting tumor growth and the vascular environment
Notch signaling in malignant gliomas: supporting tumor growth and the vascular environment
Glioblastoma is the most malignant form of glioma, which is the most commonly occurring tumor of the central nervous syste...
De- “bug”-ing the microbiome in lung cancer
De- “bug”-ing the microbiome in lung cancer
The identification of microbes enriched in the healthy lung has led to the compelling discovery that microbes may contribu...
Correction to: Connecting the human microbiome and pancreatic cancer
Correction to: Connecting the human microbiome and pancreatic cancer
Department of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 4100 John R, Detroit, MI, 48...
Microbes and cancer: disease drivers, passengers, biomarkers, or therapeutics?
Microbes and cancer: disease drivers, passengers, biomarkers, or therapeutics?
O’Keefe, S. J., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., et al. (2015). Fat, fibre and cancer risk in Af...
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of...
Oncobiology and treatment of breast cancer in young women
Oncobiology and treatment of breast cancer in young women
Female breast cancer emerged as the leading cancer type in terms of incidence globally in 2020. Although mortality due to ...
The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor
The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor
Inositol is an essential nutrient, obtained either by uptake from the environment or by de novo synthesis from glucose. In...
The cure from within? a review of the microbiome and diet in melanoma
The cure from within? a review of the microbiome and diet in melanoma
Therapy for cutaneous melanoma, the deadliest of the skin cancers, is inextricably linked to the immune system. Once thoug...