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Tumor necrosis factor superfamily signaling: life and death in cancer
Tumor necrosis factor superfamily signaling: life and death in cancer
Immune checkpoint inhibitors have shaped the landscape of cancer treatment. However, many patients either do not respond o...
Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets
Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets
The mitochondrion is an essential cell organelle known as the powerhouse of the cell. Mitochondrial ribosomal proteins (MR...
Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis
Functional links between the microbiome and the molecular pathways of colorectal carcinogenesis
Colorectal cancer (CRC) is a common cancer, with a concerning rise in early-onset CRC cases, signalling a shift in disease...
CAR T-cells for pediatric solid tumors: where to go from here?
CAR T-cells for pediatric solid tumors: where to go from here?
Despite the great success that chimeric antigen receptor (CAR) T-cells have had in patients with B-cell malignancies and m...
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and ...
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
The biological function of extracellular vesicles in prostate cancer and their clinical application as diagnostic and prognostic biomarkers
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and main causes of cancer-related deaths worldwid...
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cells in solid tumors and metastasis: paving the way forward
CAR T cell therapy, hailed as a breakthrough in cancer treatment due to its remarkable outcomes in hematological malignanc...
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives
Natural killer (NK) cells have multifaceted roles within the complex tumor milieu. They are pivotal components of innate i...
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases
MCM10 plays a vital role in genome duplication and is crucial for DNA replication initiation, elongation, and termination....
Lost at SCLC: a review of potential platinum sensitizers
Lost at SCLC: a review of potential platinum sensitizers
The expression “lost at sea” means to be confused or perplexed. By extension, lost at SCLC references the curr...
Tissue factor pathway inhibitor-2 (TFPI-2)—an underappreciated partaker in cancer and metastasis
Tissue factor pathway inhibitor-2 (TFPI-2)—an underappreciated partaker in cancer and metastasis
The coagulation system is known to play an important role in cancer development and metastasis, but the precise mechanisms...
Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications
Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications
Solitary fibrous tumor (SFT) is a rare fibroblastic mesenchymal neoplasm. The current classification has merged SFT and he...
Molecular and cellular mechanisms of chemoresistance in paediatric pre–B cell acute lymphoblastic leukaemia
Molecular and cellular mechanisms of chemoresistance in paediatric pre–B cell acute lymphoblastic leukaemia
Paediatric patients with relapsed B cell acute lymphoblastic leukaemia (B-ALL) have poor prognosis, as relapse-causing clo...
Role of MARCH E3 ubiquitin ligases in cancer development
Role of MARCH E3 ubiquitin ligases in cancer development
Membrane-associated RING-CH (MARCH) E3 ubiquitin ligases, a family of RING-type E3 ubiquitin ligases, have garnered increa...
Failure to progress: breast and prostate cancer cell lines in developing targeted therapies
Failure to progress: breast and prostate cancer cell lines in developing targeted therapies
Developing anticancer drugs from preclinical to clinical takes approximately a decade in a cutting-edge biomedical lab and...
Electrical excitability of cancer cells—CELEX model updated
Electrical excitability of cancer cells—CELEX model updated
The normal functioning of every cell in the body depends on its bioelectric properties and many diseases are caused by gen...
Functional and clinical roles of stromal PDGF receptors in tumor biology
Functional and clinical roles of stromal PDGF receptors in tumor biology
PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal ...
Striated muscle: an inadequate soil for cancers
Striated muscle: an inadequate soil for cancers
Many organs of the body are susceptible to cancer development. However, striated muscles—which include skeletal and ...
Cancer treatments as paradoxical catalysts of tumor awakening in the lung
Cancer treatments as paradoxical catalysts of tumor awakening in the lung
Much of the fatality of tumors is linked to the growth of metastases, which can emerge months to years after apparently su...
Classification of anticancer drugs: an update with FDA- and EMA-approved drugs
Classification of anticancer drugs: an update with FDA- and EMA-approved drugs
Anticancer systemic therapy comprises a complex and growing group of drugs. Some of the new agents with novel mechanisms o...
Mechanical deformation and death of circulating tumor cells in the bloodstream
Mechanical deformation and death of circulating tumor cells in the bloodstream
The circulation of tumor cells through the bloodstream is a significant step in tumor metastasis. To better understand the...
Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies
Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies
Cancer is a significant global health concern associated with multiple distinct factors, including microbial and viral inf...
Racial disparity in prostate cancer: an outlook in genetic and molecular landscape
Racial disparity in prostate cancer: an outlook in genetic and molecular landscape
Prostate cancer (PCa) incidence, morbidity, and mortality rates are significantly impacted by racial disparities. Despite ...
The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
Glucagon-like peptide-1 receptor (GLP-1R) agonists have garnered significant attention for their therapeutic potential in ...
Healthcare disparities, screening, and molecular testing in the changing landscape of non–small cell lung cancer in the United States: a review
Healthcare disparities, screening, and molecular testing in the changing landscape of non–small cell lung cancer in the United States: a review
Inequitable access to care continues to hinder improvements in diagnosis and treatment of lung cancer. This review describ...
Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine
Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine
Cellular plasticity refers to the ability of cells to change their identity or behavior, which can be advantageous in some...
The roles of PD-L1 in the various stages of tumor metastasis
The roles of PD-L1 in the various stages of tumor metastasis
The interaction between tumor programmed death ligand 1 (PD-L1) and T-cell programmed cell death 1 (PD-1) has long been ac...
Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor initiation, progression, and metast...
In vivo manufacture and manipulation of CAR-T cells for better druggability
In vivo manufacture and manipulation of CAR-T cells for better druggability
The current CAR-T cell therapy products have been hampered in their druggability due to the personalized preparation requi...
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
The role of circular RNA during the urological cancer metastasis: exploring regulatory mechanisms and potential therapeutic targets
Metastasis is a major contributor to treatment failure and death in urological cancers, representing an important biomedic...
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