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Regulation and targeting of SREBP-1 in hepatocellular carcinoma
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is associated with enhanced lipogenesis...
Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
This comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, with a primary focus on m...
Metastasis suppressor genes and their role in the tumor microenvironment
Metastasis suppressor genes and their role in the tumor microenvironment
The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells a...
Clonal tracking in cancer and metastasis
Clonal tracking in cancer and metastasis
The eradication of many cancers has proven challenging due to the presence of functionally and genetically heterogeneous c...
Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer
Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer
Air pollutants are increasingly emitted into the atmosphere because of the high dependency of humans on fossil-derived fue...
Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer
Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer
Cancer is a major public health concern because it is one of the main causes of morbidity and mortality worldwide. As a re...
From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
MYB transcription factors are encoded by a large family of highly conserved genes from plants to vertebrates. There are th...
Tumor ablation induced anti-tumor immunity: destruction of the tumor in situ with the aim to evoke a robust anti-tumor immune response
Tumor ablation induced anti-tumor immunity: destruction of the tumor in situ with the aim to evoke a robust anti-tumor immune response
Coley, W. B. (1893). The treatment of malignant tumors by repeated inoculations of erysipelas: With a report of ten origin...
Epigenetic regulation of breast cancer metastasis
Epigenetic regulation of breast cancer metastasis
Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among w...
Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications
Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications
Extracellular vesicles (EVs) are small lipid bilayer–enclosed vesicles that mediate vital cellular communication by ...
Sam68 is a druggable vulnerability point in cancer stem cells
Sam68 is a druggable vulnerability point in cancer stem cells
Sam68 (Src associated in mitosis of 68 kDa) is an RNA-binding and multifunctional protein extensively characteriz...
Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. A...
Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and is implicated in the mult...
Cancer cell plasticity, stem cell factors, and therapy resistance: how are they linked?
Cancer cell plasticity, stem cell factors, and therapy resistance: how are they linked?
Cellular plasticity can occur naturally in an organism and is considered an adapting mechanism during the developmental st...
Epithelial-to-mesenchymal transition in cancer progression: unraveling the immunosuppressive module driving therapy resistance
Epithelial-to-mesenchymal transition in cancer progression: unraveling the immunosuppressive module driving therapy resistance
Cancer cells undergo phenotypic switching (cancer cell plasticity) in response to microenvironmental cues, including expos...
Next-generation immune checkpoint inhibitors as promising functional molecules in cancer therapeutics
Next-generation immune checkpoint inhibitors as promising functional molecules in cancer therapeutics
Cancer is a devastating disease that demands expensive treatment and follow-up patien...
Metastasis suppressor genes in clinical practice: are they druggable?
Metastasis suppressor genes in clinical practice: are they druggable?
Since the identification of NM23 (now called NME1) as the first metastasis suppressor gene (MSG), a small number of other ...
B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention
B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention
B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory protein expressed in immune cells, antigen-pr...
The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
Resistance to therapeutic agents is one of the major challenges in cancer therapy. Generally, the focus is given to the ge...
Epigenetic control of pancreatic cancer metastasis
Epigenetic control of pancreatic cancer metastasis
Surgical resection, when combined with chemotherapy, has been shown to significantly improve the survival rate of patients...
New progress of tuberculosis scar carcinoma
New progress of tuberculosis scar carcinoma
It has been demonstrated that scar tissue and fibrosis may increase the likelihood of developing malignancies. Specificall...
A perspective on the metastasis suppressor field
A perspective on the metastasis suppressor field
Metastasis is the leading cause of cancer patient mortality. Metastasis suppressors are genes that, upon reexpression in m...
The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell prolife...
Metastasis suppressors: a paradigm shift in cancer biology
Metastasis suppressors: a paradigm shift in cancer biology
It was when I visited Lance Liotta’s lab at the NCI in the mid-1980s that I met his p...
Is cancer an intelligent species?
Is cancer an intelligent species?
Some relevant emerging properties of intelligent systems are “adaptation to a changing environment,” “re...
Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance
Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance
The tumor microenvironment (TME) plays a pivotal role in cancer development and progression. In this line, revealing the p...
Resveratrol as sensitizer in colorectal cancer plasticity
Resveratrol as sensitizer in colorectal cancer plasticity
Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide...
Targeting miRNA and using miRNA as potential therapeutic options to bypass resistance in pancreatic ductal adenocarcinoma
Targeting miRNA and using miRNA as potential therapeutic options to bypass resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor prognosis due to early metastasis, low di...
Helicobacter pylori–activated fibroblasts as a silent partner in gastric cancer development
Helicobacter pylori–activated fibroblasts as a silent partner in gastric cancer development
The discovery of Helicobacter pylori (Hp) infection of gastric mucosa leading to active chronic gastritis, gastroduodenal ...
Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance
Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance
The metastasis is a multistep process in which a small proportion of cancer cells are detached from the colony to enter in...
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