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Biography—Dr. David Gewirtz
Biography—Dr. David Gewirtz
Dr. David Gewirtz received his Ph.D. from the Mt. Sinai School of Medicine/The City University of New York in 1978 in Phys...
Tumor dormancy and disease recurrence
Tumor dormancy and disease recurrence
Wyld, L., Bellantuono, I., Tchkonia, T., Morgan, J., Turner, O., Foss, F., George, J., Danson, S., & Kirkland, J. L. (...
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
Every sixth person in the world dies due to cancer, making it the second leading severe cause of death after cardiovascula...
Regulation of dormancy during tumor dissemination: the role of the ECM
Regulation of dormancy during tumor dissemination: the role of the ECM
The study of the metastatic cascade has revealed the complexity of the process and the multiple cellular states that disse...
Newly identified form of phenotypic plasticity of cancer: immunogenic mimicry
Newly identified form of phenotypic plasticity of cancer: immunogenic mimicry
Cancer plasticity is now a recognized new hallmark of cancer which is due to disturbances of cell differentiation programs...
Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution
Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution
The biological complexity of cancer represents a tremendous clinical challenge, resulting in the frequent failure of curre...
Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?
Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?
Uncontrolled inflammation giving rise to excessive tissue inflammation can lead to chronic inflammation that enhances tiss...
Autophagy, molecular chaperones, and unfolded protein response as promoters of tumor recurrence
Autophagy, molecular chaperones, and unfolded protein response as promoters of tumor recurrence
Tumor recurrence is a paradoxical function of a machinery, whereby a small proportion of the cancer cell population enters...
The genetic profile and molecular subtypes of human pseudomyxoma peritonei and appendiceal mucinous neoplasms: a systematic review
The genetic profile and molecular subtypes of human pseudomyxoma peritonei and appendiceal mucinous neoplasms: a systematic review
Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing neoplastic condition which is poorly understood, with ...
Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers
Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers
Hepatocellular carcinoma (HCC) is a common malignancy and one of the leading causes of cancer-related death. The biologica...
Could senescence phenotypes strike the balance to promote tumor dormancy?
Could senescence phenotypes strike the balance to promote tumor dormancy?
After treatment and surgery, patient tumors can initially respond followed by a rapid relapse, or respond well and seeming...
KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?
KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?
Present therapeutic approaches do not effectively target metastatic cancers, often limited by their inability to eliminate...
The role of cancer cell bioenergetics in dormancy and drug resistance
The role of cancer cell bioenergetics in dormancy and drug resistance
While anti-cancer drug treatments are often effective for the clinical management of cancer, these treatments frequently l...
Tetrahydrocannabinols: potential cannabimimetic agents for cancer therapy
Tetrahydrocannabinols: potential cannabimimetic agents for cancer therapy
Tetrahydrocannabinols (THCs) antagonize the CB1 and CB2 cannabinoid receptors, whose signaling to the endocannabinoid syst...
Involvement of redox signalling in tumour cell dormancy and metastasis
Involvement of redox signalling in tumour cell dormancy and metastasis
Decades of research on oncogene-driven carcinogenesis and gene-expression regulatory networks only started to unveil the c...
Dormancy in cancer metastasis: keys to moving forward
Dormancy in cancer metastasis: keys to moving forward
If diagnosed prior to spread, surgical removal of cancer is curative. If metastases already e...
Insights into the role of senescence in tumor dormancy: mechanisms and applications
Insights into the role of senescence in tumor dormancy: mechanisms and applications
One of the most formidable challenges in oncology and tumor biology research is to provide an accurate understanding of tu...
Role of myeloid-derived suppressor cells in tumor recurrence
Role of myeloid-derived suppressor cells in tumor recurrence
The establishment of primary tumor cells in distant organs, termed metastasis, is the principal cause of cancer mortality ...
Mesenchymal stromal cell senescence in haematological malignancies
Mesenchymal stromal cell senescence in haematological malignancies
Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple myeloma (MM) are age-related haematologic...
Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors
Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors
Cancer is one of the three leading causes of death worldwide. Even after successful therapy and achieving remission, the r...
Dormant cancer cells: programmed quiescence, senescence, or both?
Dormant cancer cells: programmed quiescence, senescence, or both?
Metastasis is the overwhelming driver of cancer mortality, accounting for the majority of cancer deaths. Many patients pre...
The genomic regulation of metastatic dormancy
The genomic regulation of metastatic dormancy
The genomics and pathways governing metastatic dormancy are critically important drivers of long-term patient survival giv...
Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities
Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities
Hepatocellular carcinoma (HCC) is one of the most common cancers with a relatively high cancer-related mortality. The unco...
Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets
Circadian disruption: from mouse models to molecular mechanisms and cancer therapeutic targets
The circadian clock is a timekeeping system for numerous biological rhythms that contribute to the regulation of numerous ...
Natural compounds targeting nuclear receptors for effective cancer therapy
Natural compounds targeting nuclear receptors for effective cancer therapy
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatial...
The vulnerable primed cancer stem cells in disguise: demystifying the role of Maspin
The vulnerable primed cancer stem cells in disguise: demystifying the role of Maspin
Epithelial-specific Maspin is widely known as a tumor suppressor. However, while the level of maspin expression is inverse...
Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry
Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry
Tumour vascularisation is vital for cancer sustainment representing not only the main source of nutrients and oxygen suppl...
The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options
The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options
Hormonal therapy plays a vital part in the treatment of estrogen receptor–positive (ER +) breast cancer. ER ca...
The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy
The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy
Despite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account f...
Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling
Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling
The dense cancer microenvironment is a significant barrier that limits the penetration of anticancer agents, thereby restr...
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