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Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking
Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking
Social behaviour plays a key role in mental health and wellbeing, and developing greater understanding of mechanisms under...
Sex differences in airway disease: estrogen and airway surface liquid dynamics
Sex differences in airway disease: estrogen and airway surface liquid dynamics
Biological sex differences exist for many airway diseases in which females have either worse or better health outcomes. In...
MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome
MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS), the most common endocrine disorder in premenopausal women, is associated with increased ...
Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice
Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice
The transition from childhood to adulthood, or adolescence, a developmental stage, is characterized by psychosocial and bi...
Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
Scientific evidence highlights the influence of biological sex on the relationship between stress and metabolic dysfunctio...
Sex-specific differences in the mechanisms for enhanced thromboxane A2-mediated vasoconstriction in adult offspring exposed to prenatal hypoxia
Sex-specific differences in the mechanisms for enhanced thromboxane A2-mediated vasoconstriction in adult offspring exposed to prenatal hypoxia
Prenatal hypoxia, a common pregnancy complication, leads to impaired cardiovascular outcomes in the adult offspring. It re...
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies
Sexual dimorphism significantly influences cancer incidence and prognosis. Notably, females exhibit a lower risk and favor...
Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton
Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton
Prenatal alcohol exposure (PAE) can result in lifelong disabilities known as foetal alcohol spectrum disorder (FASD) and i...
Sex and gender differences in adverse events following influenza and COVID-19 vaccination
Sex and gender differences in adverse events following influenza and COVID-19 vaccination
Active and passive surveillance studies have found that a greater proportion of females report adverse events (AE) followi...
Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Sex hormones and sex chromosomes play a vital role in cardiovascular disease. Testosterone plays a crucial role in menR...
Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
Past research suggests that low testosterone levels relate to poorer cognitive function and higher Alzheimer’s disea...
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
The outcomes of traumatic brain injury (TBI) exhibit variance contingent upon biological sex. Although female sex hormones...
Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
Differences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune dise...
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by the presence of hepatic steatosis, detected...
Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex
Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex
Recent studies have shown that prenatal BPA exposure altered the transcriptome profiles of autism-related genes in the off...
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Early life adversity impairs hippocampal development and function across diverse species. While initial evidence indicated...
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea
Obstructive sleep apnea (OSA) affects 10–26% of adults in the United States with known sex differences in prevalence...
Sex differences of post-Covid patients undergoing outpatient pulmonary rehabilitation
Sex differences of post-Covid patients undergoing outpatient pulmonary rehabilitation
Following years of pandemic severe acute respiratory syndrome coronavirus 2 infections labelled Covid-19, long lasting imp...
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes
The lateral habenula (LHb) is an epithalamus nucleus that is evolutionarily conserved and involved in various physiologica...
Treating sex and gender differences as a continuous variable can improve precision cancer treatments
Treating sex and gender differences as a continuous variable can improve precision cancer treatments
The significant sex and gender differences that exist in cancer mechanisms, incidence, and survival, have yet to impact cl...
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Children with pregnancy-associated plasma protein-A2 (PAPP-A2) mutations resulting in low levels of bioactive insulin-like...
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses
Recently implemented research policies requiring the inclusion of females and males have created an urgent need for effect...
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex
The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into...
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
Following in vitro ischemia, the nerve growth factor receptor TrkB is activated in the presence of the TrkB agonist 7,8-DH...
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring
Offspring of hypertensive disorders of pregnancy are at an increased risk of developing neurodevelopmental and neurobehavi...
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in wom...
Resting heart rate associations with violence exposure and posttraumatic stress symptoms: sex differences in children
Resting heart rate associations with violence exposure and posttraumatic stress symptoms: sex differences in children
Traumatic events experienced in childhood can lead to increased risk of cardiovascular disorders in adulthood. Black Ameri...
Reprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development
Reprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development
Disorders/differences of sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal,...
Integrative multi-omics characterization reveals sex differences in glioblastoma
Integrative multi-omics characterization reveals sex differences in glioblastoma
Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with limited treatment modalities and poor...
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner
Differences in male vs. female immune responses are well-documented and have significant clinical implications. While the ...
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