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Sex differences in the human brain related to visual motion perception
Sex differences in the human brain related to visual motion perception
Previous studies have found that the temporal duration required for males to perceive visual motion direction is significa...
A call for inclusive research, policies, and leadership to close the global women’s health gap
A call for inclusive research, policies, and leadership to close the global women’s health gap
Women comprise approximately half of the world’s population, yet they are often underrepresented and inadequately co...
Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment
Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment
Chronic cigarette smokers report withdrawal symptomology, including affective dysfunction and cognitive deficits. While th...
Sex dimorphism and tissue specificity of gene expression changes in aging mice
Sex dimorphism and tissue specificity of gene expression changes in aging mice
Aging is a complex process that involves all tissues in an organism and shows sex dimorphism. While transcriptional change...
Human-specific protein-coding and lncRNA genes cast sex-biased genes in the brain and their relationships with brain diseases
Human-specific protein-coding and lncRNA genes cast sex-biased genes in the brain and their relationships with brain diseases
Gene expression shows sex bias in the brain as it does in other organs. Since female and male humans exhibit noticeable di...
Quantitative proteomic profiling reveals sexual dimorphism in the retina and RPE of C57BL6 mice
Quantitative proteomic profiling reveals sexual dimorphism in the retina and RPE of C57BL6 mice
Sex as a biological variable is not a common consideration in molecular mechanistic or preclinical studies of retinal dise...
The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation
The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation
The Four Core Genotypes (FCG) mouse model has become a valuable model to study the mechanistic basis for biological sex di...
The influence of sex on neuroimmune communication, pain, and physiology
The influence of sex on neuroimmune communication, pain, and physiology
With the National Institutes of Health’s mandate to consider sex as a biological variable (SABV), there has been a s...
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity
Male sex has been identified as a risk factor for worse COVID-19 outcomes. This sex difference has been mostly attributed ...
Age, sex, and cell type-resolved hypothalamic gene expression across the pubertal transition in mice
Age, sex, and cell type-resolved hypothalamic gene expression across the pubertal transition in mice
The hypothalamus plays a central role in regulating puberty. However, our knowledge of the postnatal gene regulatory netwo...
Sex Differences in Human Brain Structure at Birth
Sex Differences in Human Brain Structure at Birth
Sex differences in human brain anatomy have been well-documented, though remain significantly underexplored during early d...
Isolated during adolescence: long-term impact on social behavior, pain sensitivity, and the oxytocin system in male and female rats
Isolated during adolescence: long-term impact on social behavior, pain sensitivity, and the oxytocin system in male and female rats
Adolescent social isolation (ASI) has profound long-term effects on behavioral and neural development. Despite this, the s...
Sex differences in prelimbic cortex calcium dynamics during stress and fear learning
Sex differences in prelimbic cortex calcium dynamics during stress and fear learning
In recent years, research has progressively increased the importance of considering sex differences in stress and fear mem...
Sex-specific phenotypical, functional and metabolic profiles of human term placenta macrophages
Sex-specific phenotypical, functional and metabolic profiles of human term placenta macrophages
Placental macrophages, Hofbauer cells (HBC) are the only fetal immune cell population within the stroma of healthy placent...
Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development
Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development
46,XX testicular disorder/difference of sex development (46,XX DSD) is a rare congenital condition, characterized by a com...
Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?
Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?
Systemic lupus erythematosus (SLE or lupus) is an immune-mediated disease associated with substantial medical burden. Nota...
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats
Adolescent stress and alcohol exposure increase the risk of maladaptive behaviors and mental disorders in adulthood, with ...
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin
Sex differences exist in the prevalence and progression of major glomerular diseases. Podocytes are the essential cell-typ...
Application and insights of targeted next-generation sequencing in a large cohort of 46,XY disorders of sex development in Chinese
Application and insights of targeted next-generation sequencing in a large cohort of 46,XY disorders of sex development in Chinese
46,XY disorders of sex development (46,XY DSD) are characterized by incomplete masculinization of genitalia with reduced a...
Histological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis
Histological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis
Blotched snakehead (Channa maculata) displays significant sexual dimorphism, with males exhibiting faster growth rates and...
Sex-specific associations of Notch signaling with chronic HBV infection: a study from Taiwan Biobank
Sex-specific associations of Notch signaling with chronic HBV infection: a study from Taiwan Biobank
Hepatitis B, a liver infection caused by the hepatitis B virus (HBV), can develop into a chronic infection that puts patie...
Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs
Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs
Differences of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypica...
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic
Lowering LDL-cholesterol is a fundamental goal for both primary and secondary prevention of atherosclerotic cardiovascular...
MetaFun: unveiling sex-based differences in multiple transcriptomic studies through comprehensive functional meta-analysis
MetaFun: unveiling sex-based differences in multiple transcriptomic studies through comprehensive functional meta-analysis
While sex-based differences in various health scenarios have been thoroughly acknowledged in the literature, we lack suffi...
SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers
SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers
Sexual differences across molecular levels profoundly impact cancer biology and outcomes. Patient gender significantly inf...
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors
Cardiovascular disease is a leading cause of death worldwide. Rates of cardiovascular disease vary both across the lifespa...
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta
Fetal sex and placental development impact pregnancy outcomes and fetal–maternal health, but the critical timepoint ...
Fetal endocrine axes mRNA expression levels are related to sex and intrauterine position
Fetal endocrine axes mRNA expression levels are related to sex and intrauterine position
The hypothalamic–pituitary–adrenal (HPA) and -gonadal (HPG) axes are two major pathways that connect the neura...
Gene regulatory networks reveal sex difference in lung adenocarcinoma
Gene regulatory networks reveal sex difference in lung adenocarcinoma
Lung adenocarcinoma (LUAD) has been observed to have significant sex differences in incidence, prognosis, and response to ...
The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies
The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies
Schizophrenia is a severe neuropsychiatric disorder characterized by altered perception, mood, and behavior that profoundl...
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