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TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells
Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of ...
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank
There is conflicting evidence around the role of sex hormones with cardiovascular outcomes. The aim of this study was to e...
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males
Although sex bias has been reported in the development and progression of renal cell carcinoma (RCC), the underlying mecha...
Sex differences in muscle protein expression and DNA methylation in response to exercise training
Sex differences in muscle protein expression and DNA methylation in response to exercise training
Exercise training elicits changes in muscle physiology, epigenomics, transcriptomics, and proteomics, with males and femal...
The mixed legacy of the rat estrous cycle
The mixed legacy of the rat estrous cycle
The rat estrous cycle first characterized by Long and Evans in 1922 profoundly affected the course of endocrine research. ...
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain
Aromatase catalyzes the synthesis of estrogens from androgens. Knowledge on its regional expression in the brain is of rel...
Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core
Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core
Glutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. Alth...
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampa...
Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury
Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury
Bronchopulmonary dysplasia (BPD) is characterized by an arrest in lung development and is a leading cause of morbidity in ...
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries
Behavioral sex differences are widespread in the animal world. These differences can be qualitative (i.e., behavior presen...
Coronary artery calcification and aortic valve calcification in patients with kidney failure: a sex-disaggregated study
Coronary artery calcification and aortic valve calcification in patients with kidney failure: a sex-disaggregated study
Chronic kidney disease (CKD) is linked to an increased cardiovascular disease (CVD) burden. Albeit underappreciated, sex d...
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years
Physical weakness is a key component of frailty, and is highly prevalent in older adults. While females have a higher prev...
Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats
Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats
Biological factors are known to influence disease trajectories and treatment effectiveness in alcohol addiction and precli...
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
The development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) fu...
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
Clinical trials investigating efficacy of immune checkpoint inhibitors (ICI) revealed sex-specific divergent outcomes in u...
Breast cancer: the first comparative evaluation of oncobiome composition between males and females
Breast cancer: the first comparative evaluation of oncobiome composition between males and females
Emerging evidence suggests that breast microbiota dysbiosis contributes to cancer initiation, progression, prognosis and t...
Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
Sex differences play a critical role in the incidence and severity of cardiovascular diseases, whereby men are at a higher...
Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease
Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease
Alzheimer’s disease (AD) can be characterised in vivo by biomarkers reflecting amyloid-β (Aβ) and tau path...