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Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies
Sexual dimorphism significantly influences cancer incidence and prognosis. Notably, females exhibit a lower risk and favor...
Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton
Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton
Prenatal alcohol exposure (PAE) can result in lifelong disabilities known as foetal alcohol spectrum disorder (FASD) and i...
Sex and gender differences in adverse events following influenza and COVID-19 vaccination
Sex and gender differences in adverse events following influenza and COVID-19 vaccination
Active and passive surveillance studies have found that a greater proportion of females report adverse events (AE) followi...
Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Sex hormones and sex chromosomes play a vital role in cardiovascular disease. Testosterone plays a crucial role in menR...
Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
Past research suggests that low testosterone levels relate to poorer cognitive function and higher Alzheimer’s disea...
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
The outcomes of traumatic brain injury (TBI) exhibit variance contingent upon biological sex. Although female sex hormones...
Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
Differences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune dise...
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by the presence of hepatic steatosis, detected...
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Early life adversity impairs hippocampal development and function across diverse species. While initial evidence indicated...
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea
Obstructive sleep apnea (OSA) affects 10–26% of adults in the United States with known sex differences in prevalence...
Sex differences of post-Covid patients undergoing outpatient pulmonary rehabilitation
Sex differences of post-Covid patients undergoing outpatient pulmonary rehabilitation
Following years of pandemic severe acute respiratory syndrome coronavirus 2 infections labelled Covid-19, long lasting imp...
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes
The lateral habenula (LHb) is an epithalamus nucleus that is evolutionarily conserved and involved in various physiologica...
Treating sex and gender differences as a continuous variable can improve precision cancer treatments
Treating sex and gender differences as a continuous variable can improve precision cancer treatments
The significant sex and gender differences that exist in cancer mechanisms, incidence, and survival, have yet to impact cl...
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses
Recently implemented research policies requiring the inclusion of females and males have created an urgent need for effect...
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex
The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into...
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring
Offspring of hypertensive disorders of pregnancy are at an increased risk of developing neurodevelopmental and neurobehavi...
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in wom...
Resting heart rate associations with violence exposure and posttraumatic stress symptoms: sex differences in children
Resting heart rate associations with violence exposure and posttraumatic stress symptoms: sex differences in children
Traumatic events experienced in childhood can lead to increased risk of cardiovascular disorders in adulthood. Black Ameri...
Integrative multi-omics characterization reveals sex differences in glioblastoma
Integrative multi-omics characterization reveals sex differences in glioblastoma
Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with limited treatment modalities and poor...
Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer
Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer
There is an ongoing debate on whether sex affects immune-suppressive tumor microenvironment and immunotherapy. Here, we ex...
Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns
Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns
Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual respon...
Consideration of sex as a biological variable in diabetes research across twenty years
Consideration of sex as a biological variable in diabetes research across twenty years
Sex differences exist in the risk of developing type 1 and type 2 diabetes, and in the risk of developing diabetes-associa...
Sex-specific modulation of early life vocalization and cognition by Fmr1 gene dosage in a mouse model of Fragile X Syndrome
Sex-specific modulation of early life vocalization and cognition by Fmr1 gene dosage in a mouse model of Fragile X Syndrome
Pup-dam ultrasonic vocalizations (USVs) are essential to cognitive and socio-emotional development. In autism and Fragile ...
Different mechanisms underlie compulsive alcohol self-administration in male and female rats
Different mechanisms underlie compulsive alcohol self-administration in male and female rats
Sex is an important factor in the progression and treatment of alcohol addiction, and therapeutic approaches may have to b...