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Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis refractory to biologic therapy: 2-year clinical and radiographic results from the open-label extension of the SELECT-AXIS 2 study
Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis refractory to biologic therapy: 2-year clinical and radiographic results from the open-label extension of the SELECT-AXIS 2 study
The efficacy and safety of upadacitinib in patients with ankylosing spondylitis (AS) and inadequate response/intolerance t...
Investigation of GPM6B as a novel therapeutic target in Osteoarthritis
Investigation of GPM6B as a novel therapeutic target in Osteoarthritis
Osteoarthritis (OA) is the most common motor system disease in older people, characterized by a high incidence and signifi...
Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA)
Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA)
Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in patients undergoing immunosuppressive therapy, suc...
Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway
Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway
Osteoarthritis (OA) is a degenerative joint disease caused by the breakdown of joint cartilage and adjacent bone. Joint in...
Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis
Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis
Serum protein abundance was assessed in adult and juvenile dermatomyositis (DM and JDM) patients to determine differential...
Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study
Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study
Patient trust plays a central role in the patient-physician relationship. This study aimed to determine whether the number...
Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus
Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal gut microbiome sequencing to ...
Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study
Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study
Neuropsychiatric manifestations, such as cognitive impairment, are relatively prevalent in systemic sclerosis (SSc) patien...
Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat
Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat
To investigate the frequency of difficult-to-treat (D2T) rheumatoid arthritis (RA) in patients early escalated to biologic...
Prevalence of and trends in hyperuricemia by race and ethnicity among US adolescents, 1999–2018
Prevalence of and trends in hyperuricemia by race and ethnicity among US adolescents, 1999–2018
Our objective was to ascertain the most recent prevalence and trends of hyperuricemia among adolescents, stratified by sex...
Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis
Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis
Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have t...
Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery
Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primaril...
Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis
Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis
Patients with diffuse cutaneous systemic sclerosis (dcSSc) frequently show spontaneous improvement of skin fibrosis. Our a...
Infiltrations of plasma cells in synovium predict inadequate response to Adalimumab in Rheumatoid Arthritis patients
Infiltrations of plasma cells in synovium predict inadequate response to Adalimumab in Rheumatoid Arthritis patients
Rheumatoid arthritis (RA) is a clinically heterogeneous and complex autoimmune disease, making the prediction of therapeut...
Integrated multi-omics revealed that dysregulated lipid metabolism played an important role in RA patients with metabolic diseases
Integrated multi-omics revealed that dysregulated lipid metabolism played an important role in RA patients with metabolic diseases
Patients with rheumatoid arthritis (RA) commonly experience a high prevalence of multiple metabolic diseases (MD), leading...
Increased serum level of IL-6 predicts poor prognosis in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease
Increased serum level of IL-6 predicts poor prognosis in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease
Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-positvie DM) is a subtype ...
Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus
Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus
To investigate the roles of Ca2+ influx-regulated circular RNAs (circRNAs) in T cells from patients with systemic lupus er...
Oxysterols contribute to immune cell recruitment in SLE skin lesions
Oxysterols contribute to immune cell recruitment in SLE skin lesions
Abnormal oxysterol metabolism has been observed in the peripheral blood of SLE patients, but its role in systemic...
Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clinical analysis
Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clinical analysis
Low-dose IL-2 (Ld-IL2) has shown favorable therapeutic effects in systemic lupus erythematosus (SLE) therapy. However, pre...
WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis
WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis
Neuropsychiatric systemic lupus erythematosus (NPSLE) often manifests as cognitive deterioration, with activated microglia...
Long-term outcome of autologous haematopoietic stem cell transplantation in patients with systemic sclerosis: a comparison with patients treated with rituximab and with traditional immunosuppressive agents
Long-term outcome of autologous haematopoietic stem cell transplantation in patients with systemic sclerosis: a comparison with patients treated with rituximab and with traditional immunosuppressive agents
Autologous haematopoietic stem cell transplantation (AHSCT) is more effective than conventional immunosuppressive therapie...
Cardiovascular health metrics and all-cause mortality in osteoarthritis, inflammatory arthritis, and unclassified arthritis patients: a national prospective cohort study
Cardiovascular health metrics and all-cause mortality in osteoarthritis, inflammatory arthritis, and unclassified arthritis patients: a national prospective cohort study
Arthritis notably elevates mortality risk. It remains unclear whether the cardiovascular health (CVH) metrics improves the...
Methotrexate promotes the release of granulocyte–macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling
Methotrexate promotes the release of granulocyte–macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling
Activated fibroblast-like synoviocytes (FLS) are drivers of synovitis and structural joint damage in rheumatoid arthritis ...
Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy
Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy
Mechanobiological mechanisms of osteoarthritis (OA) are unclear. Our objectives were to explore: 1) changes in knee joint ...
Incidence rate of recurrent cardiovascular events in patients with radiographic axial spondyloarthritis and the effect of tumor necrosis factor inhibitors
Incidence rate of recurrent cardiovascular events in patients with radiographic axial spondyloarthritis and the effect of tumor necrosis factor inhibitors
Patients with radiographic axial spondyloarthritis (r-axSpA) are at increased risk of incident cardiovascular events. Tumo...
Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritis (RA)
Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritis (RA)
CXC chemokine CXCL12 is involved in the pathological development of rheumatoid arthritis (RA) through abnormal migration o...
Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort
Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort
Based on the recent evidence of IL-1 inhibition in patients with rheumatoid arthritis (RA) and concomitant type 2 diabetes...
Patients’ recollection about the onset of Sjögren’s disease – a mixed methods study on the patients’ perspective
Patients’ recollection about the onset of Sjögren’s disease – a mixed methods study on the patients’ perspective
Little is known about the symptoms at the onset of Sjögren’s Disease (SjD) and it is unclear whether SjD starts...
Novel endothelial progenitor cells populations as biomarkers of damage and remission in systemic lupus erythematosus
Novel endothelial progenitor cells populations as biomarkers of damage and remission in systemic lupus erythematosus
Endothelial progenitor cells (EPCs) are essential for maintenance of vascular homeostasis and stability, key processes in ...
Effects of chronic ankle instability after grade I ankle sprain on the post-traumatic osteoarthritis
Effects of chronic ankle instability after grade I ankle sprain on the post-traumatic osteoarthritis
Untreated acute ankle sprains often result in chronic ankle instability (CAI) and can ultimately lead to the development o...
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