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Effect of ambrisentan in patients with systemic sclerosis and mild pulmonary arterial hypertension: long-term follow-up data from EDITA study
Effect of ambrisentan in patients with systemic sclerosis and mild pulmonary arterial hypertension: long-term follow-up data from EDITA study
In the EDITA trial, patients with systemic sclerosis (SSc) and mild pulmonary vascular disease (PVD) treated with ambrisen...
Stabilizing the integrity of intestinal barrier to control arthritis
Stabilizing the integrity of intestinal barrier to control arthritis
With great interest, we have read the recent article “Expression of HIF1α in intestinal epithelium restricts ar...
Risk factors of mortality in patients with rheumatoid arthritis-associated interstitial lung disease: a single-centre prospective cohort study
Risk factors of mortality in patients with rheumatoid arthritis-associated interstitial lung disease: a single-centre prospective cohort study
To determine the risk factors for mortality in Korean patients with rheumatoid arthritis (RA)-associated interstitial lung...
JAK inhibitors attenuate hyperactivation of nonswitched memory B cells in rheumatoid arthritis patients in remission
JAK inhibitors attenuate hyperactivation of nonswitched memory B cells in rheumatoid arthritis patients in remission
To investigate the distribution and activation of B-cell subpopulations in rheumatoid arthritis (RA) patients treated with...
Serum GM-CSF level is a predictor of treatment response to tocilizumab in rheumatoid arthritis patients: a prospective observational cohort study
Serum GM-CSF level is a predictor of treatment response to tocilizumab in rheumatoid arthritis patients: a prospective observational cohort study
The aim of this prospective observational cohort study was to unveil the predictors of treatment response to tocilizumab (...
The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection – a novel disease-modifying osteoarthritis drug
The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection – a novel disease-modifying osteoarthritis drug
Despite the extensive research to provide a disease-modifying osteoarthritis drug (DMOAD), there is still no approved DMOA...
TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis
TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis
Association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years, but still remains unexplained. We recentl...
A novel method to monitor rheumatoid arthritis prevalence using hospital and medication databases
A novel method to monitor rheumatoid arthritis prevalence using hospital and medication databases
Most estimates of rheumatoid arthritis (RA) prevalence, including all official figures in Australia and many other countri...
Clinical relevance of positively determined myositis antibodies in rheumatology: a retrospective monocentric analysis
Clinical relevance of positively determined myositis antibodies in rheumatology: a retrospective monocentric analysis
The increased availability of myositis autoantibodies represents new possibilities and challenges in clinical practice (Lu...
Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes
Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes
Kinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA)...
Rituximab in the treatment of progressive interstitial lung disease associated with the antisynthetase syndrome
Rituximab in the treatment of progressive interstitial lung disease associated with the antisynthetase syndrome
To assess the real-world, long-term effectiveness of rituximab (RTX) as a rescue therapy in patients with antisynthetase s...
Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons
Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons
Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies s...
The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation
The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation
In gout, monosodium urate crystals are taken up by macrophages, triggering the activation of the NLRP3 inflammasome and th...
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical co...
Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of t...
Effectiveness of janus kinase inhibitors in relapsing giant cell arteritis in real-world clinical practice and review of the literature
Effectiveness of janus kinase inhibitors in relapsing giant cell arteritis in real-world clinical practice and review of the literature
A substantial proportion of patients with giant cell arteritis (GCA) relapse despite standard therapy with glucocorticoids...
A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis
A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis
The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑0...
Exploration of the combined role of immune checkpoints and immune cells in the diagnosis and treatment of ankylosing spondylitis: a preliminary study immune checkpoints in ankylosing spondylitis
Exploration of the combined role of immune checkpoints and immune cells in the diagnosis and treatment of ankylosing spondylitis: a preliminary study immune checkpoints in ankylosing spondylitis
Immune checkpoints have emerged as promising therapeutic targets for autoimmune diseases. However, the specific roles of i...
Predictive models of radiographic progression and pain progression in patients with knee osteoarthritis: data from the FNIH OA biomarkers consortium project
Predictive models of radiographic progression and pain progression in patients with knee osteoarthritis: data from the FNIH OA biomarkers consortium project
The progression of knee osteoarthritis (OA) can be defined as either radiographic progression or pain progression. This st...
Microstructural changes of the white matter in systemic lupus erythematosus patients without neuropsychiatric symptoms: a multi-shell diffusion imaging study
Microstructural changes of the white matter in systemic lupus erythematosus patients without neuropsychiatric symptoms: a multi-shell diffusion imaging study
Diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) provide more comprehensive...
MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence
MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence
Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Acc...
The prognosis and management of reclassified systemic lupus erythematosus associated pulmonary arterial hypertension according to 2022 ESC/ERS guidelines
The prognosis and management of reclassified systemic lupus erythematosus associated pulmonary arterial hypertension according to 2022 ESC/ERS guidelines
The 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) guideline has recently revised the hemodyna...
Investigating protease-mediated peptides of inflammation and tissue remodeling as biomarkers associated with flares in psoriatic arthritis
Investigating protease-mediated peptides of inflammation and tissue remodeling as biomarkers associated with flares in psoriatic arthritis
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. PsA disease involves flares, which are a...
Epidemiological trends in psoriatic arthritis: a comprehensive population-based study
Epidemiological trends in psoriatic arthritis: a comprehensive population-based study
Psoriatic arthritis (PsA) is a chronic, potentially debilitating inflammatory arthritis often associated with psoriasis. U...
Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in...
Time to improvement of pain, morning stiffness, fatigue, and disease activity in patients with ankylosing spondylitis treated with tofacitinib: a post hoc analysis
Time to improvement of pain, morning stiffness, fatigue, and disease activity in patients with ankylosing spondylitis treated with tofacitinib: a post hoc analysis
Tofacitinib is an oral Janus kinase inhibitor for treatment of ankylosing spondylitis (AS). Time to improvement in core do...
Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study
Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study
Epidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. ...
Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis
Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis
Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the infl...
Dystrophic calcinosis: structural and morphological composition, and evaluation of ethylenediaminetetraacetic acid (‘EDTA’) for potential local treatment
Dystrophic calcinosis: structural and morphological composition, and evaluation of ethylenediaminetetraacetic acid (‘EDTA’) for potential local treatment
To perform a detailed morphological analysis of the inorganic portion of two different clinical presentations of calcium-b...
Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation
Identification and verification of a novel signature that combines cuproptosis-related genes with ferroptosis-related genes in osteoarthritis using bioinformatics analysis and experimental validation
Exploring the pathogenesis of osteoarthritis (OA) is important for its prevention, diagnosis, and treatment. Therefore, we...
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