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Epigenetic modification of miR-217 promotes intervertebral disc degeneration by targeting the FBXO21-ERK signalling pathway
Epigenetic modification of miR-217 promotes intervertebral disc degeneration by targeting the FBXO21-ERK signalling pathway
Numerous potential therapeutic alternatives for intervertebral disc degeneration (IDD) have been investigated, the most pr...
Four emerging immune cellular blood phenotypes associated with disease duration and activity established in Psoriatic Arthritis
Four emerging immune cellular blood phenotypes associated with disease duration and activity established in Psoriatic Arthritis
Psoriatic Arthritis (PsA) is an immune-mediated disease with heterogenous symptoms indicating differences in the underlyin...
Autologous hematopoietic stem cell transplantation improves long-term survival—data from a national registry
Autologous hematopoietic stem cell transplantation improves long-term survival—data from a national registry
Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell ther...
Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage
Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage
To investigate the occurrence and frequency of anti-citrullinated protein antibodies (ACPA) to cyclic citrullinated type I...
EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis
EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis
EC-18, a synthetic monoacetyldiaglyceride, exhibits protective effects against lung inflammation, allergic asthma, and abd...
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients
Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients
Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsivene...
Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications
Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications
To evaluate the levels of periostin in patients with systemic sclerosis (SSc) and their association with features of syste...
Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease
Macrophage polarization toward M1 phenotype through NF-κB signaling in patients with Behçet’s disease
Macrophages are key innate immune cells implicated in the pathogenesis of Behçet’s disease (BD), and macrophage...
PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment
PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment
The cytoskeletal protein, PSTPIP2, is associated with inflammation and is predominantly expressed in macrophages. Previous...
Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model
Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model
Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study i...
Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference
Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference
With great interest, we have read the recent article “Age at menarche, age at natural menopause, and risk of rheumat...
Methotrexate improves endothelial function in early rheumatoid arthritis patients after 3 months of treatment
Methotrexate improves endothelial function in early rheumatoid arthritis patients after 3 months of treatment
Endothelial dysfunction contributes to increased cardiovascular (CV) disease in rheumatoid arthritis (RA). Angiogenic T ce...
Impact of cardiovascular risk on the diagnostic accuracy of the ultrasound Halo Score for giant cell arteritis
Impact of cardiovascular risk on the diagnostic accuracy of the ultrasound Halo Score for giant cell arteritis
To evaluate the impact of cardiovascular risk (CVR) on the diagnostic accuracy of the ultrasonographic (US) Halo Score in ...
Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis
Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is characterized by the presence of disease-specific autoreactive B cell responses, in particula...
Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study
Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study
Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even ...
Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK: a latent class analysis
Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK: a latent class analysis
Osteoarthritis (OA) is a common chronic condition but its association with other chronic conditions and mortality is large...