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Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical co...
Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of t...
MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence
MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence
Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Acc...
Epidemiological trends in psoriatic arthritis: a comprehensive population-based study
Epidemiological trends in psoriatic arthritis: a comprehensive population-based study
Psoriatic arthritis (PsA) is a chronic, potentially debilitating inflammatory arthritis often associated with psoriasis. U...
Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in...
Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study
Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study
Epidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. ...
Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis
Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis
Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the infl...
Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states
Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states
This study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Eryth...
The role of M1/M2 macrophage polarization in primary Sjogren’s syndrome
The role of M1/M2 macrophage polarization in primary Sjogren’s syndrome
The purpose of this study was to investigate the role of macrophage polarization in the pathogenesis of primary Sjogren...
Early identification of macrophage activation syndrome secondary to systemic lupus erythematosus with machine learning
Early identification of macrophage activation syndrome secondary to systemic lupus erythematosus with machine learning
The macrophage activation syndrome (MAS) secondary to systemic lupus erythematosus (SLE) is a severe and life-threatening ...
Efficacy and safety study of targeted small-molecule drugs in the treatment of systemic lupus erythematosus
Efficacy and safety study of targeted small-molecule drugs in the treatment of systemic lupus erythematosus
Targeted small-molecule drugs in the treatment of systemic lupus erythematosus (SLE) have attracted increasing attention f...
Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice
Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice
Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inh...
Plasma mtDNA as a possible contributor to and biomarker of inflammation in rheumatoid arthritis
Plasma mtDNA as a possible contributor to and biomarker of inflammation in rheumatoid arthritis
Neutrophil extracellular trap formation and cell-free DNA (cfDNA) contribute to the inflammation in rheumatoid arthritis (...
Rheumatoid arthritis disease activity significantly impacts on the severity of interstitial lung disease
Rheumatoid arthritis disease activity significantly impacts on the severity of interstitial lung disease
Rheumatoid arthritis (RA) related interstitial lung disease (ILD) impacts on the treatment strategy and its prognosis in p...
Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthrit...
Osteoarthritis and hypertension: observational and Mendelian randomization analyses
Osteoarthritis and hypertension: observational and Mendelian randomization analyses
The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and...
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify po...