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Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis
Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis
Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. H...
Influence of the timing of biological treatment initiation on Juvenile Idiopathic Arthritis long-term outcomes
Influence of the timing of biological treatment initiation on Juvenile Idiopathic Arthritis long-term outcomes
Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. ...
Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years
Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years
This study aimed to investigate the long-term effect of vitamin D supplementation compared to placebo over 5 year...
Unveiling difficult-to-treat rheumatoid arthritis: long-term impact of biologic or targeted synthetic DMARDs from the KOBIO registry
Unveiling difficult-to-treat rheumatoid arthritis: long-term impact of biologic or targeted synthetic DMARDs from the KOBIO registry
While the availability of biological or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) has improve...
Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats
Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats
Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. ...
Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis
Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis
Uncontrolled T-cell activation plays a key role in systemic sclerosis (SSc). Arsenic trioxide (ATO) has immunological effe...
Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8
Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8
Osteoarthritis (OA) is a degenerative joint disease associated with aging, which often leads to joint stiffness and disabi...
Causal associations of Sjögren’s syndrome with cancers: a two-sample Mendelian randomization study
Causal associations of Sjögren’s syndrome with cancers: a two-sample Mendelian randomization study
Several observational studies have explored the associations between Sjögren’s syndrome (SS) and certain cancer...
Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study
Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study
Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve Me...
Anti-Ro52 positivity is associated with progressive interstitial lung disease in systemic sclerosis—an exploratory study
Anti-Ro52 positivity is associated with progressive interstitial lung disease in systemic sclerosis—an exploratory study
Interstitial lung disease (ILD) is the most common cause of death in patients with systemic sclerosis (SSc). Prognostic bi...
CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis
CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis
Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by s...
A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis
A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis
Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs,...
Cellular characterisation of advanced osteoarthritis knee synovium
Cellular characterisation of advanced osteoarthritis knee synovium
Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the...
Iguratimod attenuated fibrosis in systemic sclerosis via targeting early growth response 1 expression
Iguratimod attenuated fibrosis in systemic sclerosis via targeting early growth response 1 expression
The early growth response 1 (EGR1) is a central transcription factor involved in systemic sclerosis (SSc) pathogenesis. Ig...
A prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA
A prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA
While it is known that klotho has negative regulatory effects in a variety of diseases such as metabolic disorders and kid...
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
In addition to decreasing the level of cholesterol, proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has pleiotrop...