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Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally d...
Comparing immunogenicity and safety following transition from reference rituximab to biosimilar rituximab (DRL_RI) in patients with rheumatoid arthritis: a randomized, double-blind, phase 3 study
Comparing immunogenicity and safety following transition from reference rituximab to biosimilar rituximab (DRL_RI) in patients with rheumatoid arthritis: a randomized, double-blind, phase 3 study
To assess immunogenicity and safety in patients with active rheumatoid arthritis (RA) transitioning from rituximab [US-lic...
KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus
KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus
Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening in...
Quantitative 18F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis
Quantitative 18F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis
This study aimed to assess the quantitative uptake of 18F-FDG PET-CT in the lungs of patients with early severe diffuse cu...
Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement
Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement
To investigate the levels of plasma neutrophil extracellular traps (NETs) and free thiols, the latter reflecting systemic ...
Efficacy and safety of tofacitinib in an open-label, long-term extension study in patients with psoriatic arthritis who received adalimumab or tofacitinib in a Phase 3 randomized controlled study: a post hoc analysis
Efficacy and safety of tofacitinib in an open-label, long-term extension study in patients with psoriatic arthritis who received adalimumab or tofacitinib in a Phase 3 randomized controlled study: a post hoc analysis
Data on treatment switching directly from tumor necrosis factor inhibitors to tofacitinib in psoriatic arthritis (PsA) are...
A non-invasive model for diagnosis of primary Sjogren’s disease based on salivary biomarkers, serum autoantibodies, and Schirmer’s test
A non-invasive model for diagnosis of primary Sjogren’s disease based on salivary biomarkers, serum autoantibodies, and Schirmer’s test
Minor salivary gland (MSG) biopsy is a critical but invasive method for the classification of primary Sjögren’s...
Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis
Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis
In the murine K/BxN serum transfer rheumatoid arthritis (RA) model, tactile allodynia persists after resolution of inflamm...
Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study
Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study
The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on ...
Clonal T cell populations scarcely impair patients with rheumatic diseases: a prospective long-term follow up study
Clonal T cell populations scarcely impair patients with rheumatic diseases: a prospective long-term follow up study
Clonal T cell populations are frequently detected in patients with rheumatic diseases. The relevance of this finding is of...
Impact of the digital health application ViViRA on spinal mobility, physical function, quality of life and pain perception in spondyloarthritides patients: a randomized controlled trial
Impact of the digital health application ViViRA on spinal mobility, physical function, quality of life and pain perception in spondyloarthritides patients: a randomized controlled trial
Spondyloarthritides (SpAs) are a group of common rheumatic diseases that often cause limited mobility and lower back pain....
Impact of systemic inflammation and disease activity on the incidence of interstitial lung disease in patients with rheumatoid arthritis – a nested case-control study within the German biologics register RABBIT
Impact of systemic inflammation and disease activity on the incidence of interstitial lung disease in patients with rheumatoid arthritis – a nested case-control study within the German biologics register RABBIT
To investigate the association between the development of incident interstitial lung disease (ILD) in patients with rheuma...
Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases
Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases
This study investigates the causal role of metabolites mediating immune cells in rheumatoid arthritis (RA) and ankylosing ...
Correction: Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome
Correction: Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome
Antonella Notarnicola, Charlotta Preger, Ingrid E. Lundberg and Cátia Fernandes-Cerqueira contributed equally to this work...
Automatic knee osteoarthritis severity grading based on X-ray images using a hierarchical classification method
Automatic knee osteoarthritis severity grading based on X-ray images using a hierarchical classification method
This study aims to develop a hierarchical classification method to automatically assess the severity of knee osteoarthriti...
Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study
Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study
Knee osteoarthritis (KOA) is characterized by mitochondrial damage and increased inflammation. Circulating cell-free mitoc...
Therapeutic effects of extracellular vesicles derived from mesenchymal stem cells primed with disease-conditioned-immune cells in systemic lupus erythematosus
Therapeutic effects of extracellular vesicles derived from mesenchymal stem cells primed with disease-conditioned-immune cells in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an incurable chronic autoimmune disease of unknown etiology. Therefore, the developm...
Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus
Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus
Previously, we reported that serum Semaphorin 5 A (Sema5A) levels were increased in systemic lupus erythematosus ...
Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls
Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls
Gout is caused by the response of the innate immune system to monosodium urate (MSU) crystals. A recent gout GWAS identifi...
Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis refractory to biologic therapy: 2-year clinical and radiographic results from the open-label extension of the SELECT-AXIS 2 study
Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis refractory to biologic therapy: 2-year clinical and radiographic results from the open-label extension of the SELECT-AXIS 2 study
The efficacy and safety of upadacitinib in patients with ankylosing spondylitis (AS) and inadequate response/intolerance t...
Investigation of GPM6B as a novel therapeutic target in Osteoarthritis
Investigation of GPM6B as a novel therapeutic target in Osteoarthritis
Osteoarthritis (OA) is the most common motor system disease in older people, characterized by a high incidence and signifi...
Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA)
Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA)
Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in patients undergoing immunosuppressive therapy, suc...
Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway
Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway
Osteoarthritis (OA) is a degenerative joint disease caused by the breakdown of joint cartilage and adjacent bone. Joint in...
Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis
Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis
Serum protein abundance was assessed in adult and juvenile dermatomyositis (DM and JDM) patients to determine differential...
Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study
Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study
Patient trust plays a central role in the patient-physician relationship. This study aimed to determine whether the number...
Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus
Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal gut microbiome sequencing to ...
Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study
Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study
Neuropsychiatric manifestations, such as cognitive impairment, are relatively prevalent in systemic sclerosis (SSc) patien...
Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat
Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat
To investigate the frequency of difficult-to-treat (D2T) rheumatoid arthritis (RA) in patients early escalated to biologic...
Prevalence of and trends in hyperuricemia by race and ethnicity among US adolescents, 1999–2018
Prevalence of and trends in hyperuricemia by race and ethnicity among US adolescents, 1999–2018
Our objective was to ascertain the most recent prevalence and trends of hyperuricemia among adolescents, stratified by sex...
Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis
Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis
Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have t...
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