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Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthrit...
Osteoarthritis and hypertension: observational and Mendelian randomization analyses
Osteoarthritis and hypertension: observational and Mendelian randomization analyses
The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and...
Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study
Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study
We aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy...
Urate-lowering therapy, serum urate, inflammatory biomarkers, and renal function in patients with gout following pegloticase discontinuation
Urate-lowering therapy, serum urate, inflammatory biomarkers, and renal function in patients with gout following pegloticase discontinuation
Little is known about long-term clinical outcomes or urate-lowering (ULT) therapy use following pegloticase disco...
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify po...
Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
Immunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often developing gastrointestina...
Canakinumab treatment real world evidence in 3 monogenic periodic fever syndromes in 2009–2022: an interim analysis using the French JIR cohort database
Canakinumab treatment real world evidence in 3 monogenic periodic fever syndromes in 2009–2022: an interim analysis using the French JIR cohort database
Our study aimed to provide real-world evidence on the treatment patterns, effectiveness and safety of canakinumab in Franc...
Usability and preliminary effectiveness of an app-based physical activity and education program for people with hip or knee osteoarthritis – a pilot randomized controlled trial
Usability and preliminary effectiveness of an app-based physical activity and education program for people with hip or knee osteoarthritis – a pilot randomized controlled trial
Hip and knee osteoarthritis (OA) are highly prevalent worldwide. The guidelines recommend physical activity and education ...
Anxiety and depression symptoms in adolescents and young adults with juvenile idiopathic arthritis: results of an outpatient screening
Anxiety and depression symptoms in adolescents and young adults with juvenile idiopathic arthritis: results of an outpatient screening
Previous studies have shown that growing up with rheumatic conditions can fuel dissatisfaction and psychological distress,...
Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies
Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies
Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous group diseases, and their treatment is not full...
Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence
Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence
Transitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the appl...
Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation
Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation
Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understo...
Patients with systemic sclerosis and low CD4 numbers after autologous stem cell transplantation have a favorable outcome
Patients with systemic sclerosis and low CD4 numbers after autologous stem cell transplantation have a favorable outcome
Treatment with high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (aHSCT) is an intensi...
Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis...
Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis
Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis
Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nocice...
Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet’s syndrome
Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet’s syndrome
Autoimmune responses have been suggested to involvement in patients with Behcet’s syndrome (BS). There has been grow...
The prevalence of sarcopenia in spondyloarthritis patients: a meta-analysis
The prevalence of sarcopenia in spondyloarthritis patients: a meta-analysis
Spondyloarthritis (SpA) is a chronic inflammatory disorder that affects sacroiliac joints and spine, resulting in substant...
Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis
Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis
Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not cor...
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis
Transferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is u...
Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection
Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection
To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as ...
Concomitant Sjögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss clinical quality management cohort
Concomitant Sjögren’s disease as a biomarker for treatment effectiveness in rheumatoid arthritis - results from the Swiss clinical quality management cohort
To investigate the clinical phenotype and treatment response in patients with rheumatoid arthritis (RA) with and without c...
Antiphospholipid antibodies as potential predictors of disease severity and poor prognosis in systemic lupus erythematosus-associated thrombocytopenia: results from a real-world CSTAR cohort study
Antiphospholipid antibodies as potential predictors of disease severity and poor prognosis in systemic lupus erythematosus-associated thrombocytopenia: results from a real-world CSTAR cohort study
To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombo...
Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations
Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populations
CRISPR-Cas9-based genome engineering represents a powerful therapeutic tool for cartilage tissue engineering and for under...
Low CD4 + T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
Low CD4 + T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus ery...
Effect of remission, clinical remission with active serology, and glucocorticoid dosage on the pregnancy outcome of pregnant patients with systemic lupus erythematosus
Effect of remission, clinical remission with active serology, and glucocorticoid dosage on the pregnancy outcome of pregnant patients with systemic lupus erythematosus
Remission is a key treatment target in systemic lupus erythematosus (SLE) management. Given the direct correlation between...
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options ...
B cell receptor repertoire analysis in primary Sjogren’s syndrome salivary glands identifies repertoire features associated with clinical activity
B cell receptor repertoire analysis in primary Sjogren’s syndrome salivary glands identifies repertoire features associated with clinical activity
Primary Sjogren’s syndrome (pSS) is a complex autoimmune disease featuring damage to salivary and lacrimal glands, w...
Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies
Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies
This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE). We systemat...
Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis
Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis
Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are ...
Distinct uric acid trajectories are associated with incident cardiac conduction block
Distinct uric acid trajectories are associated with incident cardiac conduction block
The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify...
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