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Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain
Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain
Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9–10% in the general population, severely ...
Dysregulated endothelial cell markers in systemic lupus erythematosus: a systematic review and meta-analysis
Dysregulated endothelial cell markers in systemic lupus erythematosus: a systematic review and meta-analysis
To perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregu...
PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucida...
Neutrophil extracellular traps in acute coronary syndrome
Neutrophil extracellular traps in acute coronary syndrome
Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart ...
First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation
First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation
The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorde...
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study
Osteoarthritis (OA) is a common joint disease and is the main cause of physical disability in the elderly. Currently, ther...
Efficacy of CU06-1004 via regulation of inflammation and endothelial permeability in LPS-induced acute lung injury
Efficacy of CU06-1004 via regulation of inflammation and endothelial permeability in LPS-induced acute lung injury
Acute lung injury (ALI) is a life-threatening condition that fundamentally results from inflammation and edema in the lung...
Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS
Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS
Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation...
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-1...
Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model
Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model
Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammat...
Components of the sympathetic nervous system as targets to modulate inflammation – rheumatoid arthritis synovial fibroblasts as neuron-like cells?
Components of the sympathetic nervous system as targets to modulate inflammation – rheumatoid arthritis synovial fibroblasts as neuron-like cells?
Catecholamines are major neurotransmitters of the sympathetic nervous system (SNS) and they are of pivotal importance in r...
Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ
Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ
Chronic low-grade inflammation has been identified as a major contributor in the development of atherosclerosis. Nuclear F...
Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation
Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chr...
C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice
C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice
Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a ...
Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway
Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway
Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity...
Anti-inflammatory effects of β-FNA are sex-dependent in a pre-clinical model of LPS-induced inflammation
Anti-inflammatory effects of β-FNA are sex-dependent in a pre-clinical model of LPS-induced inflammation
Inflammation is present in neurological and peripheral disorders. Thus, targeting inflammation has emerged as a viable opt...
Neutrophil extracellular traps and pulmonary fibrosis: an update
Neutrophil extracellular traps and pulmonary fibrosis: an update
Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a sig...
Progranulin (PGRN) as a regulator of inflammation and a critical factor in the immunopathogenesis of cardiovascular diseases
Progranulin (PGRN) as a regulator of inflammation and a critical factor in the immunopathogenesis of cardiovascular diseases
Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). N...
Correction: Evaluation of asthma–chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease
Correction: Evaluation of asthma–chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19
Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19
Hypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our pre...
Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts
Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts
Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since th...
Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration
Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration
The heterodimer interleukin (IL)-17A/F is elevated in the lungs in chronic respiratory disease such as severe asthma, alon...
Evaluation of asthma–chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease
Evaluation of asthma–chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease
Features of asthma and chronic obstructive pulmonary disease (COPD) can coexist in the same patient, in a condition termed...
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages
Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that c...
The immunological function of CXCR2 in the liver during sepsis
The immunological function of CXCR2 in the liver during sepsis
The chemokine receptor CXCR2 and its ligands, especially CXCL8, are crucial mediators for the progression of liver inflamm...
Neutrophil reverse migration
Neutrophil reverse migration
The behavior of neutrophils is very important for the resolution of inflammation and tissue repair. People have used advan...
The antigen CD300e drives T cell inflammation in adipose tissue and elicits an antibody response predictive of the insulin sensitivity recovery in obese patients
The antigen CD300e drives T cell inflammation in adipose tissue and elicits an antibody response predictive of the insulin sensitivity recovery in obese patients
Obesity and insulin resistance (IR), the key features of metabolic syndrome, are closely associated with a state of chroni...
Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype
Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype
Macrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury a...
Induction of pyroptotic cell death as a potential tool for cancer treatment
Induction of pyroptotic cell death as a potential tool for cancer treatment
Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restrict...
Extracellular vesicles isolated from hyperuricemia patients might aggravate airway inflammation of COPD via senescence-associated pathway
Extracellular vesicles isolated from hyperuricemia patients might aggravate airway inflammation of COPD via senescence-associated pathway
Chronic obstructive pulmonary disease (COPD) is a major health issue resulting in significant mortality worldwide. Due to ...
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