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Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis
Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis
Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequenc...
Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model
Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model
Sonic Hedgehog (Shh), extensively researched for its role in early neurogenesis and brain development, has recently been r...
Correction: PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Correction: PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The effects of chronic, continuous β-funaltrexamine pre-treatment on lipopolysaccharide-induced inflammation and behavioral deficits in C57BL/6J mice
The effects of chronic, continuous β-funaltrexamine pre-treatment on lipopolysaccharide-induced inflammation and behavioral deficits in C57BL/6J mice
Inflammation and neuroinflammation are integral to the progression and severity of many diseases and are strongly associat...
MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation
MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation
Transforming Growth Factor Beta1 (TGF-β1) signaling is upregulated in Chronic Obstructive Pulmonary disease (COPD), s...
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways
Intervertebral disc degeneration (IVDD) is a common spine disease with inflammation as its main pathogenesis. Mulberroside...
Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation
Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation
Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation...
Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model
Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model
Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic aller...
Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
Atherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular di...
Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
Intestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protect...
MAP3K8 is a potential therapeutic target in airway epithelial inflammation
MAP3K8 is a potential therapeutic target in airway epithelial inflammation
We have previously discovered clusters of sequentially negative and positive modulators of acute inflammation during cytok...
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis
Acute liver failure (ALF) is a life-threatening disorder that progresses from self-limiting acute liver injury (ALI). Micr...
YTHDC1 inhibits autophagy-dependent NF-κB signaling by stabilizing Beclin1 mRNA in macrophages
YTHDC1 inhibits autophagy-dependent NF-κB signaling by stabilizing Beclin1 mRNA in macrophages
YTHDC1, a key m(6)A nuclear reader, plays a crucial role in regulating mRNA splicing, export, and stability. However, the ...
Correction: Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death
Correction: Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus
Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus
Autoimmune diseases are caused by an imbalance in the immune system, producing autoantibodies that cause inflammation lead...
The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis
The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis
Atherosclerosis (AS) formation is enhanced by different mechanisms including cytokine generation, vascular smooth muscle c...
Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages
Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages
Worldwide, more than 125 million people are infected with Shigella each year and develop shigellosis. In our prev...
Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages
Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages
The transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reac...
Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation
Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation
Neutrophils are a heterogeneous population capable of antimicrobial functions associated with pre-activation/activation an...
Coarse particulate matter (PM10) induce an inflammatory response through the NLRP3 activation
Coarse particulate matter (PM10) induce an inflammatory response through the NLRP3 activation
PM exposure can induce inflammatory and oxidative responses; however, differences in these adverse effects have been repor...
Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex
The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) ...
Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD
Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD
Exposure to noxious particles, including cigarette smoke and fine particulate matter (PM2.5), is a risk factor for chronic...
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Asthma is a prevalent respiratory inflammatory disease. Abnormal apoptosis of bronchial epithelial cells is one of the maj...
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
Interplay between systemic inflammation and programmed cell death contributes to the pathogenesis of acute lung injury (AL...
EGFR of platelet regulates macrophage activation and bacterial phagocytosis function
EGFR of platelet regulates macrophage activation and bacterial phagocytosis function
Beyond their crucial role in hemostasis, platelets possess the ability to regulate inflammation and combat infections thro...
Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis
Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associate...
Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores
Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores
Sepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major ch...
Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications
Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications
Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-co...
The preventive effects of Lactobacillus casei 03 on Escherichia coli-induced mastitis in vitro and in vivo
The preventive effects of Lactobacillus casei 03 on Escherichia coli-induced mastitis in vitro and in vivo
Lactobacillus casei possesses many kinds of bioactivities, such as anti-inflammation and anti-oxidant, and has been applie...
Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation
Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation
Tissue-plasminogen activator (tPA) is a serine protease well known for its fibrinolytic function. Recent studies indicate ...
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