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Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes
Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes
Sepsis-induced myocardial dysfunction (SIMD) may contribute to the poor prognosis of septic patients. Carvacrol (2-methyl-...
Correction: Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Correction: Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation
Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation
Transfer RNA-derived small RNAs (tsRNAs) are a newly discovered class of small noncoding RNAs (sncRNAs) that include tRNA-...
Clinical, pharmacology and in vivo studies of QingDai (indigo naturalis) promotes mucosal healing and symptom improvement in ulcerative colitis by regulating the AHR-Th17/Treg pathway
Clinical, pharmacology and in vivo studies of QingDai (indigo naturalis) promotes mucosal healing and symptom improvement in ulcerative colitis by regulating the AHR-Th17/Treg pathway
Qingdai (QD), derived from various plant sources, is commonly used in traditional Chinese medicine for ulcerative colitis ...
Regulatory role of microRNAs in virus-mediated inflammation
Regulatory role of microRNAs in virus-mediated inflammation
Viral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and e...
Profile of immune response during nasal challenge with dermatophagoides pteronyssinus in subjects with allergic airway diseases
Profile of immune response during nasal challenge with dermatophagoides pteronyssinus in subjects with allergic airway diseases
T lymphocyte helper (Th) 2 plays the main role in pathogenesis of allergic airway diseases (AAD). Recent studies showed th...
Influence and distinctions of particulate matter exposure across varying etiotypes in chronic obstructive pulmonary disease (COPD) mouse model
Influence and distinctions of particulate matter exposure across varying etiotypes in chronic obstructive pulmonary disease (COPD) mouse model
Air pollution, notably particulate matter (PM), significantly impacts chronic respiratory disease such chronic obstructive...
Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsis
Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsis
Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of term...
Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain
Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain
Lipopolysaccharide (LPS) challenge in mice has been used to identify the mechanisms and therapeutics for neuroinflammation...
Correction: Disulfiram Alleviates Acute Lung Injury and Related Intestinal Mucosal Barrier Impairment by Targeting GSDMD-Dependent Pyroptosis
Correction: Disulfiram Alleviates Acute Lung Injury and Related Intestinal Mucosal Barrier Impairment by Targeting GSDMD-Dependent Pyroptosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Circ_001653 alleviates sepsis associated-acute kidney injury by recruiting BUD13 to regulate KEAP1/NRF2/HO-1 signaling pathway
Circ_001653 alleviates sepsis associated-acute kidney injury by recruiting BUD13 to regulate KEAP1/NRF2/HO-1 signaling pathway
The kidney is exceptionally vulnerable during sepsis, often resulting in sepsis-associated acute kidney injury (SA-AKI), a...
Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis
Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis
Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequenc...
Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model
Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model
Sonic Hedgehog (Shh), extensively researched for its role in early neurogenesis and brain development, has recently been r...
Correction: PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Correction: PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The effects of chronic, continuous β-funaltrexamine pre-treatment on lipopolysaccharide-induced inflammation and behavioral deficits in C57BL/6J mice
The effects of chronic, continuous β-funaltrexamine pre-treatment on lipopolysaccharide-induced inflammation and behavioral deficits in C57BL/6J mice
Inflammation and neuroinflammation are integral to the progression and severity of many diseases and are strongly associat...
MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation
MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation
Transforming Growth Factor Beta1 (TGF-β1) signaling is upregulated in Chronic Obstructive Pulmonary disease (COPD), s...
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways
Intervertebral disc degeneration (IVDD) is a common spine disease with inflammation as its main pathogenesis. Mulberroside...
Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation
Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation
Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation...
Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model
Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model
Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic aller...
Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
Atherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular di...
Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
Intestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protect...
MAP3K8 is a potential therapeutic target in airway epithelial inflammation
MAP3K8 is a potential therapeutic target in airway epithelial inflammation
We have previously discovered clusters of sequentially negative and positive modulators of acute inflammation during cytok...
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis
Microcirculatory disturbance in acute liver injury is triggered by IFNγ-CD40 axis
Acute liver failure (ALF) is a life-threatening disorder that progresses from self-limiting acute liver injury (ALI). Micr...
YTHDC1 inhibits autophagy-dependent NF-κB signaling by stabilizing Beclin1 mRNA in macrophages
YTHDC1 inhibits autophagy-dependent NF-κB signaling by stabilizing Beclin1 mRNA in macrophages
YTHDC1, a key m(6)A nuclear reader, plays a crucial role in regulating mRNA splicing, export, and stability. However, the ...
Correction: Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death
Correction: Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus
Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus
Autoimmune diseases are caused by an imbalance in the immune system, producing autoantibodies that cause inflammation lead...
The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis
The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis
Atherosclerosis (AS) formation is enhanced by different mechanisms including cytokine generation, vascular smooth muscle c...
Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages
Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages
Worldwide, more than 125 million people are infected with Shigella each year and develop shigellosis. In our prev...
Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages
Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages
The transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reac...
Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation
Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation
Neutrophils are a heterogeneous population capable of antimicrobial functions associated with pre-activation/activation an...
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