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Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration
Osteoarthritis (OA) is the most common disease in aging joints and has characteristics of cartilage destruction and inflam...
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reac...
Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens
Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens
In the post-COVID-19 era, drug-resistant bacterial infections emerge as one of major death causes, where multidrug-resista...
Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment
Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment
Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious t...
Biomimetic astrocyte cell membrane-fused nanovesicles for protecting neurovascular units in hypoxic ischemic encephalopathy
Biomimetic astrocyte cell membrane-fused nanovesicles for protecting neurovascular units in hypoxic ischemic encephalopathy
Hypoxic ischemic encephalopathy (HIE) refers to neonatal hypoxic brain injury caused by severe asphyxia during the perinat...
Astragali radix vesicle-like nanoparticles improve energy metabolism disorders by repairing the intestinal mucosal barrier and regulating amino acid metabolism in sleep-deprived mice
Astragali radix vesicle-like nanoparticles improve energy metabolism disorders by repairing the intestinal mucosal barrier and regulating amino acid metabolism in sleep-deprived mice
Sleep disorder is widespread and involves a variety of intricate factors in its development. Sleep deprivation is a manife...
3D cryo-printed hierarchical porous scaffolds provide immobilization of surface-functionalized sleep-inspired small extracellular vesicles: synergistic therapeutic strategies for vascularized bone regeneration based on macrophage phenotype modulation and angiogenesis-osteogenesis coupling
3D cryo-printed hierarchical porous scaffolds provide immobilization of surface-functionalized sleep-inspired small extracellular vesicles: synergistic therapeutic strategies for vascularized bone regeneration based on macrophage phenotype modulation and angiogenesis-osteogenesis coupling
Bone defect healing is a multi-factorial process involving the inflammatory microenvironment, bone regeneration and the fo...
Development and evaluation of a single domain antibody targeting folate receptor alpha for radioligand therapy
Development and evaluation of a single domain antibody targeting folate receptor alpha for radioligand therapy
Folate receptor alpha (FRα) overexpression is seen in many cancers. Radioligand therapy (RLT) has emerged as a promis...
HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability
HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability
Immunotherapy for colorectal cancer (CRC) with microsatellite stability (MSS) and mismatch repair proficiency (pMMR) has s...
Engineering extracellular vesicles to transiently permeabilize the blood–brain barrier
Engineering extracellular vesicles to transiently permeabilize the blood–brain barrier
Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studie...
A green, versatile, and facile strategy for anti-biofouling surface with ultra-high graft density polyethylene glycol
A green, versatile, and facile strategy for anti-biofouling surface with ultra-high graft density polyethylene glycol
Implantable catheters are susceptible to severe complications due to non-specific protein adhesion on their surfaces. Poly...
A minimalist multifunctional nano-prodrug for drug resistance reverse and integration with PD-L1 mAb for enhanced immunotherapy of hepatocellular carcinoma
A minimalist multifunctional nano-prodrug for drug resistance reverse and integration with PD-L1 mAb for enhanced immunotherapy of hepatocellular carcinoma
Clinical treatment of hepatocellular carcinoma (HCC) with 5-fluorouracil (5-FU), the primary anticancer agent, remains uns...
A supervised machine learning tool to predict the bactericidal efficiency of nanostructured surface
A supervised machine learning tool to predict the bactericidal efficiency of nanostructured surface
The emergence and rapid spread of multidrug-resistant bacterial strains is a growing concern of public health. Inspired by...
Novel cocktail therapy based on multifunctional supramolecular hydrogel targeting immune-angiogenesis-nerve network for enhanced diabetic wound healing
Novel cocktail therapy based on multifunctional supramolecular hydrogel targeting immune-angiogenesis-nerve network for enhanced diabetic wound healing
Diabetes-associated chronic skin wounds present a formidable challenge due to inadequate angiogenesis and nerve regenerati...
Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease
Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease
The damnification of mitochondrion is often considered to be an important culprit of inflammatory bowel disease (IBD), how...
From dansyl-modified biofilm disruptors to β-cyclodextrin-optimized multifunctional supramolecular nanovesicles: their improved treatment for plant bacterial diseases
From dansyl-modified biofilm disruptors to β-cyclodextrin-optimized multifunctional supramolecular nanovesicles: their improved treatment for plant bacterial diseases
Bacterial diseases caused by phytopathogenic Xanthomonas pose a significant threat to global agricultural production, caus...
Accurate HER2 determination in breast cancer: a prominent COF-immobilized enzyme-enhanced electrochemical aptasensor employing 4-acetamidophenol as an efficient mediator
Accurate HER2 determination in breast cancer: a prominent COF-immobilized enzyme-enhanced electrochemical aptasensor employing 4-acetamidophenol as an efficient mediator
An effective strategy for enzyme-enhanced electrochemical detection of human epidermal growth factor receptor 2 (HER2) is ...
Albumin-seeking near-infrared-II probe evaluating blood–brain barrier disruption in stroke
Albumin-seeking near-infrared-II probe evaluating blood–brain barrier disruption in stroke
Blood-brain barrier (BBB) disruption after stroke is closely associated with brain tissue edema and neuronal injury, which...
Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites
Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites
Triple-negative breast cancer (TNBC) is an aggressive cancer type that lacks targeted treatment options. Ferroptosis, a no...
Time-series metabolomic analysis revealed altered metabolism of cynomolgus monkeys after injecting exosomes
Time-series metabolomic analysis revealed altered metabolism of cynomolgus monkeys after injecting exosomes
Recent years, exosomes have been increasing used to treat diseases, but there is little research on how exosomes affect th...
Dendritic mesoporous silica-delivered siRNAs nano insecticides to prevent Sogatella furcifera by inhibiting metabolic detoxification and reproduction
Dendritic mesoporous silica-delivered siRNAs nano insecticides to prevent Sogatella furcifera by inhibiting metabolic detoxification and reproduction
Migratory insect infestation caused by Sogatella furcifera is a serious threat to rice production. The most effective meth...
Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules
Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules
Amidst the burgeoning field of cancer nanomedicine, dense extracellular matrices and anomalous vascular structures in the ...
Multifunctional nanocomposites utilizing ruthenium (II) complex/manganese (IV) dioxide nanoparticle for synergistic reinforcing radioimmunotherapy
Multifunctional nanocomposites utilizing ruthenium (II) complex/manganese (IV) dioxide nanoparticle for synergistic reinforcing radioimmunotherapy
Radiotherapy (RT) stands as a frontline treatment modality in clinical breast oncology, yet challenges like ROS reduction,...
Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model
Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model
Pathological scars (PS) are one of the most common complications in patients with trauma and burns, leading to functional ...
Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles
Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles
Probiotics can colonize both the human and animal bodies and consist of active microorganisms that are beneficial to healt...
ROS-responsive nanoparticles for bioimaging and treating acute lung injury by releasing dexamethasone and improving alveolar macrophage homeostasis
ROS-responsive nanoparticles for bioimaging and treating acute lung injury by releasing dexamethasone and improving alveolar macrophage homeostasis
Acute lung injury (ALI) triggers the activation of pulmonary macrophages, which in turn produce excessive amounts of react...
Radionuclide-labelled nanoparticles for cancer combination therapy: a review
Radionuclide-labelled nanoparticles for cancer combination therapy: a review
Radionuclide therapy (RT) is widely used to advanced local cancers. However, its therapeutic efficacy is limited to the ra...
Polydopamine(PDA)-coated diselenide-bridged mesoporous silica-based nanoplatform for neuroprotection by reducing oxidative stress and targeting neuroinflammation in intracerebral hemorrhage
Polydopamine(PDA)-coated diselenide-bridged mesoporous silica-based nanoplatform for neuroprotection by reducing oxidative stress and targeting neuroinflammation in intracerebral hemorrhage
Oxidative stress (OS) and neuroinflammation are critical pathological processes in secondary brain injury (SBI) after intr...
Mechanism of cold exposure delaying wound healing in mice
Mechanism of cold exposure delaying wound healing in mice
Cold temperatures have been shown to slow skin wound healing. However, the specific mechanisms underlying cold-induced imp...
Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration
Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration
The regeneration of osteoporotic bone defects remains challenging as the critical stem cell function is impaired by inflam...
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