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Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
Chemotherapy can cause severe pain for patients, but there are currently no satisfactory methods of pain relief. Enhancing...
Visualization of microRNA therapy in cancers delivered by small extracellular vesicles
Visualization of microRNA therapy in cancers delivered by small extracellular vesicles
MicroRNA (miRNA) delivery by extracellular vesicles (EVs) has recently inspired tremendous developments in cancer treatmen...
Extracellular vesicles in venous thromboembolism and pulmonary hypertension
Extracellular vesicles in venous thromboembolism and pulmonary hypertension
Venous thromboembolism (VTE) is a multifactorial disease, and pulmonary hypertension (PH) is a serious condition character...
Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but...
Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus
Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus
The outbreak of the monkeypox virus (MPXV) worldwide in 2022 highlights the need for a rapid and low-cost MPXV detection t...
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration
Photoreceptor apoptosis is an important pathogenesis of retinal degeneration and a primary cause of vision loss with limit...
Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis
Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis
Sepsis is defined as a life-threatening organ dysfunction caused by excessive formation of reactive oxygen species (ROS) a...
Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds
Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds
Bacterial infection, complex wound microenvironment and persistent inflammation cause delayed wound healing and scar forma...
Ultrasmall PtMn nanoparticles as sensitive manganese release modulator for specificity cancer theranostics
Ultrasmall PtMn nanoparticles as sensitive manganese release modulator for specificity cancer theranostics
Manganese-based nanomaterials (Mn-nanomaterials) hold immense potential in cancer diagnosis and therapies. However, most M...
Correction: Nano-immunotherapy: overcoming delivery challenge of immune checkpoint therapy
Correction: Nano-immunotherapy: overcoming delivery challenge of immune checkpoint therapy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway
Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway
The implementation of pyroptosis exhibits significant potential as a tactic to enhance tumor immune microenvironments. Pre...
Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation
Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation
Atopic dermatitis (AD) is a common skin disease involving important immune mechanisms. There is an unmet need for a treatm...
Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy
Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy
Tumor treatment still remains a clinical challenge, requiring the development of biocompatible and efficient anti-tumor na...
Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis
Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis
Osteoarthritis (OA) is an age-related disease characterised by the accumulation of senescent chondrocytes, which drives it...
Size and charge effects of metal nanoclusters on antibacterial mechanisms
Size and charge effects of metal nanoclusters on antibacterial mechanisms
Nanomaterials, specifically metal nanoclusters (NCs), are gaining attention as a promising class of antibacterial agents. ...
Surface curvature-induced oriented assembly of sushi-like Janus therapeutic nanoplatform for combined chemodynamic therapy
Surface curvature-induced oriented assembly of sushi-like Janus therapeutic nanoplatform for combined chemodynamic therapy
Chemodynamic therapy (CDT) based on Fenton/Fenton-like reaction has emerged as a promising cancer treatment strategy. Yet,...
A candidate nanoparticle vaccine comprised of multiple epitopes of the African swine fever virus elicits a robust immune response
A candidate nanoparticle vaccine comprised of multiple epitopes of the African swine fever virus elicits a robust immune response
The African swine fever (ASF) pandemics pose a significant threat to the global swine industry, and the development of saf...
Synergetic regulation of cancer cells and exhausted T cells to fight cold tumors with a fluorinated EGCG-based nanocomplex
Synergetic regulation of cancer cells and exhausted T cells to fight cold tumors with a fluorinated EGCG-based nanocomplex
Immune therapy that targets PD-L1 (programmed cell death-ligand 1) is attractive to augment immune response by breaking th...