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Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
Ropivacaine-loaded hydrogels for prolonged relief of chemotherapy-induced peripheral neuropathic pain and potentiated chemotherapy
Chemotherapy can cause severe pain for patients, but there are currently no satisfactory methods of pain relief. Enhancing...
Visualization of microRNA therapy in cancers delivered by small extracellular vesicles
Visualization of microRNA therapy in cancers delivered by small extracellular vesicles
MicroRNA (miRNA) delivery by extracellular vesicles (EVs) has recently inspired tremendous developments in cancer treatmen...
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells
Reduced supplies of oxygen and nutrients caused by vascular injury lead to difficult-to-heal pressure ulcers (PU) in clini...
Extracellular vesicles in venous thromboembolism and pulmonary hypertension
Extracellular vesicles in venous thromboembolism and pulmonary hypertension
Venous thromboembolism (VTE) is a multifactorial disease, and pulmonary hypertension (PH) is a serious condition character...
Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles
Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles
This study aims to investigate the mechanism by which biomimetic composite hydrogels loaded with bone marrow mesenchymal s...
Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF-κB/NLRP3 pathways in inflammatory endothelial cells
Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF-κB/NLRP3 pathways in inflammatory endothelial cells
Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque formation, is one of the most prominent c...
Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but...
Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration
Transplantation of active nucleus pulposus cells with a keep-charging hydrogel microsphere system to rescue intervertebral disc degeneration
Cell transplantation has been demonstrated as a promising approach in tissue regeneration. However, the reactive oxygen sp...
Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus
Fluorescence-enhanced dual signal lateral flow immunoassay for flexible and ultrasensitive detection of monkeypox virus
The outbreak of the monkeypox virus (MPXV) worldwide in 2022 highlights the need for a rapid and low-cost MPXV detection t...
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration
Photoreceptor apoptosis is an important pathogenesis of retinal degeneration and a primary cause of vision loss with limit...
Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis
Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis
Sepsis is defined as a life-threatening organ dysfunction caused by excessive formation of reactive oxygen species (ROS) a...
Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway
Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway
Spinal cord injury (SCI) remains a significant health concern, with limited available treatment options. This condition po...
Micro electrical fields induced MSC-sEVs attenuate neuronal cell apoptosis by activating autophagy via lncRNA MALAT1/miR-22-3p/SIRT1/AMPK axis in spinal cord injury
Micro electrical fields induced MSC-sEVs attenuate neuronal cell apoptosis by activating autophagy via lncRNA MALAT1/miR-22-3p/SIRT1/AMPK axis in spinal cord injury
Spinal cord injury (SCI) is a traumatic condition of the central nervous system that causes paralysis of the limbs. Micro ...
Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds
Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds
Bacterial infection, complex wound microenvironment and persistent inflammation cause delayed wound healing and scar forma...
Ultrasmall PtMn nanoparticles as sensitive manganese release modulator for specificity cancer theranostics
Ultrasmall PtMn nanoparticles as sensitive manganese release modulator for specificity cancer theranostics
Manganese-based nanomaterials (Mn-nanomaterials) hold immense potential in cancer diagnosis and therapies. However, most M...
Correction: Nano-immunotherapy: overcoming delivery challenge of immune checkpoint therapy
Correction: Nano-immunotherapy: overcoming delivery challenge of immune checkpoint therapy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway
Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway
The implementation of pyroptosis exhibits significant potential as a tactic to enhance tumor immune microenvironments. Pre...
Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation
Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation
Atopic dermatitis (AD) is a common skin disease involving important immune mechanisms. There is an unmet need for a treatm...
Hollow manganese dioxide-chitosan hydrogel for the treatment of atopic dermatitis through inflammation-suppression and ROS scavenging
Hollow manganese dioxide-chitosan hydrogel for the treatment of atopic dermatitis through inflammation-suppression and ROS scavenging
Atopic dermatitis (AD) is a chronic inflammatory disease associated with immune dysfunction. High levels of reactive oxyge...
Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy
Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy
Tumor treatment still remains a clinical challenge, requiring the development of biocompatible and efficient anti-tumor na...
Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis
Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis
Osteoarthritis (OA) is an age-related disease characterised by the accumulation of senescent chondrocytes, which drives it...
Metal-organic framework-modulated Fe3O4 composite au nanoparticles for antibacterial wound healing via synergistic peroxidase-like nanozymatic catalysis
Metal-organic framework-modulated Fe3O4 composite au nanoparticles for antibacterial wound healing via synergistic peroxidase-like nanozymatic catalysis
Bacterial wound infections are a serious threat due to the emergence of antibiotic resistance. Herein, we report an innova...
Size and charge effects of metal nanoclusters on antibacterial mechanisms
Size and charge effects of metal nanoclusters on antibacterial mechanisms
Nanomaterials, specifically metal nanoclusters (NCs), are gaining attention as a promising class of antibacterial agents. ...
Surface curvature-induced oriented assembly of sushi-like Janus therapeutic nanoplatform for combined chemodynamic therapy
Surface curvature-induced oriented assembly of sushi-like Janus therapeutic nanoplatform for combined chemodynamic therapy
Chemodynamic therapy (CDT) based on Fenton/Fenton-like reaction has emerged as a promising cancer treatment strategy. Yet,...
A candidate nanoparticle vaccine comprised of multiple epitopes of the African swine fever virus elicits a robust immune response
A candidate nanoparticle vaccine comprised of multiple epitopes of the African swine fever virus elicits a robust immune response
The African swine fever (ASF) pandemics pose a significant threat to the global swine industry, and the development of saf...
Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy
Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy
Despite being a common malignant tumor, the molecular mechanism underlying the initiation and progression of triple-negati...
Biomineralized tetramethylpyrazine-loaded PCL/gelatin nanofibrous membrane promotes vascularization and bone regeneration of rat cranium defects
Biomineralized tetramethylpyrazine-loaded PCL/gelatin nanofibrous membrane promotes vascularization and bone regeneration of rat cranium defects
Conventional electrospinning produces nanofibers with smooth surfaces that limit biomineralization ability. To overcome th...
Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats
Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats
Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance in the cardiac autonomic nervous system, chara...
Synergetic regulation of cancer cells and exhausted T cells to fight cold tumors with a fluorinated EGCG-based nanocomplex
Synergetic regulation of cancer cells and exhausted T cells to fight cold tumors with a fluorinated EGCG-based nanocomplex
Immune therapy that targets PD-L1 (programmed cell death-ligand 1) is attractive to augment immune response by breaking th...
Correction: The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces
Correction: The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
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