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An exosomal strategy for targeting cancer-associated fibroblasts mediated tumors desmoplastic microenvironments
An exosomal strategy for targeting cancer-associated fibroblasts mediated tumors desmoplastic microenvironments
Tumors desmoplastic microenvironments are characterized by abundant stromal cells and extracellular matrix (ECM) depositio...
Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer
Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer
Heat shock protein 90 (HSP90) is overexpressed in numerous cancers, promotes the maturation of numerous oncoproteins and f...
Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling
Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation, causing substantial dis...
A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects
A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects
Considering the high recrudescence and the long-lasting unhealed large-sized wound that affect the aesthetics and cause dy...
Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy
Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy
Androgen deprivation therapy (ADT) is a crucial and effective strategy for prostate cancer, while systemic administration ...
Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells
Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells
Exosomes assume a pivotal role as essential mediators of intercellular communication within tumor microenvironments. Withi...
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia
Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized by overexuberant inflammator...
Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics
Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics
Several studies suggest that topographical patterns influence nerve cell fate. Efforts have been made to improve nerve cel...
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment
Pyroptosis, a novel type of programmed cell death (PCD), which provides a feasible therapeutic option for the treatment of...
Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms
Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms
Rare earth nanomaterials (RE NMs), which are based on rare earth elements, have emerged as remarkable biomaterials for use...
Macrophages as carriers of boron carbide nanoparticles dedicated to boron neutron capture therapy
Macrophages as carriers of boron carbide nanoparticles dedicated to boron neutron capture therapy
The use of cells as carriers for the delivery of nanoparticles is a promising approach in anticancer therapy, mainly due t...
The application of phenylboronic acid pinacol ester functionalized ROS-responsive multifunctional nanoparticles in the treatment of Periodontitis
The application of phenylboronic acid pinacol ester functionalized ROS-responsive multifunctional nanoparticles in the treatment of Periodontitis
Periodontitis is an inflammatory disease induced by the complex interactions between the host immune system and the microb...
Developing hydrogels for gene therapy and tissue engineering
Developing hydrogels for gene therapy and tissue engineering
Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers ...
A pH-responsive nanoplatform with dual-modality imaging for enhanced cancer phototherapy and diagnosis of lung metastasis
A pH-responsive nanoplatform with dual-modality imaging for enhanced cancer phototherapy and diagnosis of lung metastasis
To address the limitations of traditional photothermal therapy (PTT)/ photodynamic therapy (PDT) and real-time cancer meta...
Mesoporous silica coated spicules for photodynamic therapy of metastatic melanoma
Mesoporous silica coated spicules for photodynamic therapy of metastatic melanoma
We report on the fabrication of mesoporous silicon dioxide coated Haliclona sp. spicules (mSHS) to enhance the delivery of...
Biomimetic MDSCs membrane coated black phosphorus nanosheets system for photothermal therapy/photodynamic therapy synergized chemotherapy of cancer
Biomimetic MDSCs membrane coated black phosphorus nanosheets system for photothermal therapy/photodynamic therapy synergized chemotherapy of cancer
Photothermal therapy is favored by cancer researchers due to its advantages such as controllable initiation, direct killin...
New frontiers in salivary extracellular vesicles: transforming diagnostics, monitoring, and therapeutics in oral and systemic diseases
New frontiers in salivary extracellular vesicles: transforming diagnostics, monitoring, and therapeutics in oral and systemic diseases
Salivary extracellular vesicles (EVs) have emerged as key tools for non-invasive diagnostics, playing a crucial role in th...
Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19
Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19
Angiotensin-converting enzyme 2 (ACE2) and AXL tyrosine kinase receptor are known to be involved in the SARS-CoV-2 entry o...
Macrophage membrane-camouflaged pH-sensitive nanoparticles for targeted therapy of oral squamous cell carcinoma
Macrophage membrane-camouflaged pH-sensitive nanoparticles for targeted therapy of oral squamous cell carcinoma
Oral cancer is the most common malignant tumor of the head and neck, and 90% of cases are oral squamous cell carcinoma (OS...
Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE−/− Mice
Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE−/− Mice
Clearance of apoptotic cells by efferocytosis is crucial for prevention of atherosclerosis progress, and impaired efferocy...
Agomir-122-loaded nanoparticles coated with cell membrane of activated fibroblasts to treat frozen shoulder based on homologous targeting
Agomir-122-loaded nanoparticles coated with cell membrane of activated fibroblasts to treat frozen shoulder based on homologous targeting
As a common musculoskeletal disorder, frozen shoulder is characterized by thickened joint capsule and limited range of mot...
A thermoresponsive nanocomposite integrates NIR-II-absorbing small molecule with lonidamine for pyroptosis-promoted synergistic immunotherapy
A thermoresponsive nanocomposite integrates NIR-II-absorbing small molecule with lonidamine for pyroptosis-promoted synergistic immunotherapy
Photothermal immunotherapy is regarded as the ideal cancer therapeutic modality to against malignant solid tumors; however...
The development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
The development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
Plasma proteins are considered the most informative source of biomarkers for disease diagnosis and monitoring. Mass spectr...
Alkylated EDTA potentiates antibacterial photodynamic activity of protoporphyrin
Alkylated EDTA potentiates antibacterial photodynamic activity of protoporphyrin
Antibiotic resistance has garnered significant attention due to the scarcity of new antibiotics in development. Protoporph...
Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness
Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness
Dry eye disease (DED) is associated with ocular hyperosmolarity and inflammation. The marketed topical eye drops for DED t...
Anti-EGFR ScFv functionalized exosomes delivering LPCAT1 specific siRNAs for inhibition of lung cancer brain metastases
Anti-EGFR ScFv functionalized exosomes delivering LPCAT1 specific siRNAs for inhibition of lung cancer brain metastases
Brain metastasis (BM) is one of the leading causes of cancer-related deaths in patients with advanced non-small cell lung ...
Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the “microbiota-gut-joint” axis
Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the “microbiota-gut-joint” axis
Osteoarthritis (OA) is a common degenerative joint disease that can cause severe pain, motor dysfunction, and even disabil...
Kilogram scale facile synthesis and systematic characterization of a Gd-macrochelate as T1-weighted magnetic resonance imaging contrast agent
Kilogram scale facile synthesis and systematic characterization of a Gd-macrochelate as T1-weighted magnetic resonance imaging contrast agent
To overcome the problems of commercial magnetic resonance imaging (MRI) contrast agents (CAs) (i.e., small molecule Gd che...
Correction: Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery
Correction: Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Multifunctional fucoidan-loaded Zn-MOF-encapsulated microneedles for MRSA-infected wound healing
Multifunctional fucoidan-loaded Zn-MOF-encapsulated microneedles for MRSA-infected wound healing
Infected wound healing remains a challenging task in clinical practice due to several factors: (I) drug-resistant infectio...
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