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Post-transcriptional regulation of the transcriptional apparatus in neuronal development
Introduction Alternative splicing (AS) plays a major role in expanding proteomic diversity by allowing a limited number ...
Characterization of 3,3′-iminodipropionitrile (IDPN) damaged utricle transcriptome in the adult mouse utricle
Introduction Utricle is one of the important vestibular organs detecting linear acceleration through its sensory hair ce...
Comparative analysis of gut microbiota in metabolic syndrome and obese children from Southeastern China
Introduction Obesity, defined as an excess of adipose tissue, is widespread globally and affects individuals of all age ...
Clinical review and drug sensitivity test of Corynebacterium kroppenstedtii complex isolates in non-lactating patients with severe mastitis
1 Introduction Non-puerperal mastitis (NPM) is a group of benign, non-specific inflammatory diseases of unknown etiology,...
Deciphering dengue: novel RNA barcoding segments for enhanced serotype-specific identification and global surveillance of dengue viruses
Highlights • We standardized the framework for RNA barcoding technology and optimized the existing barcode segment valida...
WhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium
1 Introduction The regulation of housekeeping gene expression in simple organisms is of particular interest in synthetic...
Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations
1 Introduction The rapid emergence and global dissemination of Acinetobacter spp. as a major nosocomial pathogen is rema...
dna2bit: high performance genomic distance estimation software for microbial genome analysis
Background Metagenome analysis has emerged as a standard approach for the examination of microbial genomes. Initiatives s...
A human monoclonal antibody isolated from Japanese encephalitis virus vaccine-vaccinated volunteer neutralizing various flaviviruses
Introduction Flaviviruses are positive-sense, single-stranded RNA viruses that include dengue virus (DV, classified into...
Isolation and characterization of cellulose-mineralizing haloalkaliphilic bacteria from Siberian soda lakes
Introduction Soda lakes are unique inland saline habitats, characterized by brines with extremely high and stable pH val...
Microbial optimization for improved charring of agricultural solid waste: a cutting-edge technology across the life cycle
The resource utilization of agricultural solid waste plays a crucial role in environmental pollution prevention and agricu...
Evolution of community-associated MRSA: a 20-year genomic and epidemiological study in Region Örebro County, Sweden
Introduction The opportunistic gram-positive bacterium Staphylococcus aureus is one of the most common infectious agents ...
Physiological and intestinal microbiota responses of sea cucumber Apostichopus japonicus to various stress and signatures of intestinal microbiota dysbiosis
1 Introduction As the global population continues to rise and the demand for sustainable aquaculture increases, the indu...
Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-glucosidase and α-amylase
1 Introduction Coconut sap, commonly known as Neera, is a naturally sweet liquid harvested from the unopened flower buds...
Calorimetric measurement of energy and nutrient stimulation of microorganisms from the continental deep subsurface
1 Introduction Despite being Earth’s largest microbial habitat, the subsurface remains understudied due to its inaccessi...
Can there be calm during a cytokine storm? Immune checkpoint pathways affecting the severity of COVID-19 disease
Introduction The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2...
Effect of conjugative transfer of antibiotic resistance genes mediated by plasmids on the microecology of different intestinal segments
Introduction In humans and other vertebrates, the gut microbial ecosystem is closely related to several basic host funct...
Sodium butyrate prevents lipopolysaccharide induced inflammation and restores the expression of tight junction protein in human epithelial Caco-2 cells
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New insights into roles of IL-7R gene as a diagnostic biomarker for post-stroke depression
1 IntroductionPost-stroke depression (PSD) is a mental disorder characterized by emotional disturbances after a stroke, af...
Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprograming of the tumour microenvironment
Highlights● What is already known on this topic: miRNA expression is critical in driving macrophage polarisation by simult...
Cutoffs on severity metrics for minimal manifestations or better status in patients with generalized myasthenia gravis
1 IntroductionIn the treatment of generalized myasthenia gravis (gMG), high-dose chronic oral steroid therapy has reduced ...
Editorial: Regulatory T cells in immune-mediated diseases
During the 1970s and 1980s, research in murine models suggested the existence of CD8 + I-J + T cells as suppressor cells. ...
Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors
IntroductionColorectal cancer (CRC) is a heterogeneous disease with different underlying mechanisms leading to different m...
The innate defenders: a review of natural killer cell immunotherapies in cancer
1 IntroductionCancer, a well-documented disease, has likely afflicted humans throughout history. The oldest records of thi...
Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review
Primary small cell neuroendocrine carcinoma of the prostate is extremely rare, highly aggressive, and has a very poor prog...
The role of APOE gene polymorphisms in lung adenocarcinoma susceptibility and lipid profile
1 IntroductionThe apolipoprotein E (APOE) gene, located on chromosome 19q13.32, encodes the 34 KDa glycoprotein known as A...
Enhancing cell-mediated immunity through dendritic cell activation: the role of Tri-GalNAc-modified PLGA-PEG nanoparticles encapsulating SR717
Graphical Abstract. M. Tuberculosis fusion proteins (TP) and the STING agonist SR717 are co-encapsulated within Triante...
The role of PPAR in fungal keratitis
1 IntroductionThe treatment of fungal infections is an important part of global public health. Fungi is the most important...
Endostatin as a biomarker of systemic sclerosis: insights from a systematic review and meta-analysis
IntroductionVascular dysfunction and ineffective angiogenesis play a critical pathophysiological role in systemic sclerosi...
Efficacy and safety of chimeric antigen receptor T cells targeting BCMA and GPRC5D in relapsed or refractory multiple myeloma
IntroductionMultiple myeloma (MM) is a malignant plasma cell neoplasm, constituting approximately 10% of all hematological...
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