Rios JL. Chemical constituents and pharmacological properties of Poria cocos. Planta Med. 2011;77:681–91.

Article  CAS  PubMed  Google Scholar 

Wang YZ, Zhang J, Zhao YL, Li T, Shen T, Li JQ, et al. Mycology, cultivation, traditional uses, phytochemistry and pharmacology of Wolfiporia cocos (Schwein.) Ryvarden et Gilb.: a review. J Ethnopharmacol. 2013;147:265–76.

Article  CAS  PubMed  Google Scholar 

Chen L, Cao G, Wang M, Feng YL, Chen DQ, Vaziri ND, et al. The matrix metalloproteinase-13 inhibitor poricoic acid ZI ameliorates renal fibrosis by mitigating epithelial-mesenchymal transition. Mol Nutr Food Res. 2019;63:e1900132.

Article  PubMed  Google Scholar 

Zhao YY, Feng YL, Bai X, Tan XJ, Lin RC, Mei Q. Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism. PLoS One. 2013;8:e59617.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kobira S, Atsumi T, Kakiuchi N, Mikage M. Difference in cultivation characteristics and genetic polymorphism between Chinese and Japanese strains of Wolfiporia cocos Ryvarden et Gilbertson (Poria cocos Wolf). J Nat Med. 2012;66:493–9.

Article  CAS  PubMed  Google Scholar 

Feng YL, Lei P, Tian T, Yin L, Chen DQ, Chen H, et al. Diuretic activity of some fractions of the epidermis of Poria cocos. J Ethnopharmacol. 2013;150:1114–8.

Article  PubMed  Google Scholar 

Zhao YY, Lei P, Chen DQ, Feng YL, Bai X. Renal metabolic profiling of early renal injury and renoprotective effects of Poria cocos epidermis using UPLC Q-TOF/HSMS/MSE. J Pharm Biomed Anal. 2013;81-82:202–9.

Article  CAS  PubMed  Google Scholar 

Wang M, Chen DQ, Chen L, Cao G, Zhao H, Liu D, et al. Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis. Br J Pharmacol. 2018;175:2689–708.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giner-Larza EM, Máñez S, Giner-Pons RM, Carmen Recio M, Ríos JL. On the anti-inflammatory and anti-phospholipase A2 activity of extracts from lanostane-rich species. J Ethnopharmacol. 2000;73:61–69.

Article  CAS  PubMed  Google Scholar 

Ahn YM, Cho KW, Kang DG, Lee HS. Oryeongsan (Wulingsan), a traditional Chinese herbal medicine, induces natriuresis and diuresis along with an inhibition of the renin-angiotensin-aldosterone system in rats. J Ethnopharmacol. 2012;141:780–5.

Article  PubMed  Google Scholar 

Li L, Zuo ZT, Wang YZ. The traditional usages, chemical components and pharmacological activities of Wolfiporia cocos: a review. Am J Chin Med. 2022;50:389–440.

Article  CAS  PubMed  Google Scholar 

Zhao S, Li H, Jing X, Zhang X, Li R, Li Y, et al. Identifying subgroups of patients with type 2 diabetes based on real-world traditional Chinese medicine electronic medical records. Front Pharmacol. 2023;14:1210667.

Article  PubMed  PubMed Central  Google Scholar 

Zhao J, Li Y, Xin L, Sun M, Yu C, Shi G, et al. Clinical features and rules of chinese herbal medicine in diabetic peripheral neuropathy patients. Evid Based Complement Altern Med. 2020;2020:5795264.

Article  Google Scholar 

Kanematsu A, Natori S. Triterpenoids of Hoelen (fuling), sclerotia of Poria cocos (Schw.) Wolf. I. Yakugaku Zasshi. 1970;90:475–9.

Article  CAS  PubMed  Google Scholar 

Kikuchi T, Uchiyama E, Ukiya M, Tabata K, Kimura Y, Suzuki T, et al. Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos. J Nat Prod. 2011;74:137–44.

Article  CAS  PubMed  Google Scholar 

Tai T, Shingu T, Kikuchi T, Tezuka Y, Akahori A. Triterpenes from the surface layer of Poria cocos. Phytochemistry. 1995;39:1165–9.

Article  CAS  Google Scholar 

Tai T, Shingu T, Kikuchi T, Tezuka Y, Akahori A. Isolation of lanostane-type triterpene acids having an acetoxyl group from sclerotia of Poria cocos. Phytochemistry. 1995;40:225–31.

Article  CAS  Google Scholar 

Nukaya H, Yamashiro H, Fukazawa H, Ishida H, Tsuji K. Isolation of inhibitors of TPA-induced mouse ear edema from Hoelen, Poria cocos. Chem Pharm Bull. 1996;44:847–9.

Article  CAS  Google Scholar 

Ukiya M, Akihisa T, Tokuda H, Hirano M, Oshikubo M, Nobukuni Y, et al. Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos. J Nat Prod. 2002;65:462–5.

Article  CAS  PubMed  Google Scholar 

Yasukawa K, Kaminaga T, Kitanaka S, Tai T, Nunoura Y, Natori S, et al. 3β-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect. Phytochemistry. 1998;48:1357–60.

Article  CAS  PubMed  Google Scholar 

Akihisa T, Nakamura Y, Tokuda H, Uchiyama E, Suzuki T, Kimura Y, et al. Triterpene acids from Poria cocos and their anti-tumor-promoting effects. J Nat Prod. 2007;70:948–53.

Article  CAS  PubMed  Google Scholar 

Akihisa T, Uchiyama E, Kikuchi T, Tokuda H, Suzuki T, Kimura Y. Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. J Nat Prod. 2009;72:1786–92.

Article  CAS  PubMed  Google Scholar 

Lai KH, Lu MC, Du YC, El-Shazly M, Wu TY, Hsu YM, et al. Cytotoxic lanostanoids from Poria cocos. J Nat Prod. 2016;79:2805–13.

Article  CAS  PubMed  Google Scholar 

Cai TG, Cai Y. Triterpenes from the fungus Poria cocos and their inhibitory activity on nitric oxide production in mouse macrophages via blockade of activating protein-1 pathway. Chem Biodivers. 2011;8:2135–43.

Article  CAS  PubMed  Google Scholar 

Zheng Y, Yang XW. Poriacosones A and B: two new lanostane triterpenoids from Poria cocos. J Asian Nat Prod Res. 2008;10:645–51.

PubMed  Google Scholar 

Dong H, Wu P, Yan R, Xu Q, Li H, Zhang F, et al. Enrichment and separation of antitumor triterpene acids from the epidermis of Poria cocos by pH-zone-refining counter-current chromatography and conventional high-speed counter-current chromatography. J Sep Sci. 2015;38:1977–82.

Article  CAS  PubMed  Google Scholar 

Lee D, Lee S, Shim SH, Lee HJ, Choi Y, Jang TS, et al. Protective effect of lanostane triterpenoids from the sclerotia of Poria cocos Wolf against cisplatin-induced apoptosis in LLC-PK1 cells. Bioorg Med Chem Lett. 2017;27:2881–5.

Article  CAS  PubMed  Google Scholar 

Tai T, Akahori A, Shingu T. Triterpenes of Poria cocos. Phytochemistry. 1993;32:1239–44.

Article  CAS  Google Scholar 

Zhou L, Zhang Y, Gapter LA, Ling H, Agarwal R, Ng KY. Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. Chem Pharm Bull. 2008;56:1459–62.

Article  CAS  Google Scholar 

Akihisa T, Mizushina Y, Ukiya M, Oshikubo M, Kondo S, Kimura Y, et al. Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase α and β. Biosci Biotechnol Biochem. 2004;68:448–50.

Article  CAS  PubMed  Google Scholar 

Bao TR, Long GQ, Wang Y, Wang Q, Liu XL, Hu GS, et al. Newl anostane-type triterpenes with anti-inflammatory activity from the epidermis of Wolfiporia cocos. J Agric Food Chem. 2022;70:4418–33.

Article  CAS  PubMed  Google Scholar 

Jiang TT, Ding LF, Nie W, Wang LY, Lei T, Wu XD, et al. Tetranorlanostane and lanostane triterpenoids with cytotoxic activity from the epidermis of Poria cocos. Chem Biodivers. 2021;18:e2100196.

Article  CAS  PubMed