Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential

Guan XJ, Deng ZQ, Liu J, Su CF, Tong BC, Zhu Z, et al. Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Abeta pathology in Alzheimer’s disease models. Acta Pharmacol Sin. 2024;45:900–13.

Article  CAS  PubMed  Google Scholar 

Fleming A, Bourdenx M, Fujimaki M, Karabiyik C, Krause GJ, Lopez A, et al. The different autophagy degradation pathways and neurodegeneration. Neuron. 2022;110:935–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. Selective autophagy as a potential therapeutic target for neurodegenerative disorders. Lancet Neurol. 2018;17:802–15.

Article  PubMed  PubMed Central  Google Scholar 

Kaushik S, Cuervo AM. The coming of age of chaperone-mediated autophagy. Nat Rev Mol Cell Biol. 2018;19:365–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffey CJ, Yamamoto A. Macroautophagy in CNS health and disease. Nat Rev Neurosci. 2022;23:411–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Klionsky DJ, Shen HM. The emerging mechanisms and functions of microautophagy. Nat Rev Mol Cell Biol. 2023;24:186–203.

Article  CAS  PubMed  Google Scholar 

Li YY, Qin ZH, Sheng R. The multiple roles of autophagy in neural function and diseases. Neurosci Bull. 2024;40:363–82.

Article  PubMed  Google Scholar 

Gao L, She H, Li W, Zeng J, Zhu J, Jones DP, et al. Oxidation of survival factor MEF2D in neuronal death and Parkinson’s disease. Antioxid Redox Signal. 2014;20:2936–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science. 2004;305:1292–5.

Article  CAS  PubMed  Google Scholar 

Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696–714.e25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, et al. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson’s disease. J Neuroinflammation. 2021;18:295.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiao L, Ma J, Zhang Z, Sui W, Zhai C, Xu D, et al. Deficient chaperone-mediated autophagy promotes inflammation and atherosclerosis. Circ Res. 2021;129:1141–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomez-Sintes R, Arias E. Chaperone-mediated autophagy and disease: Implications for cancer and neurodegeneration. Mol Asp Med. 2021;82:101025.

Article  CAS  Google Scholar 

Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Bartholdy BA, et al. Proteome-wide analysis of chaperone-mediated autophagy targeting motifs. PLoS Biol. 2019;17:e3000301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Hu B, You Y, Yang Z, Liu L, Tang H, et al. Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of colorectal cancer through regulating chaperone-mediated autophagy degradation of p21(Cip1/WAF1). Cancer Lett. 2018;419:116–27.

Article  CAS  PubMed  Google Scholar 

Agarraberes FA, Dice JF. A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci. 2001;114:2491–9.

Article  CAS  PubMed  Google Scholar 

Cuervo AM, Dice JF. Unique properties of lamp2a compared to other lamp2 isoforms. J Cell Sci. 2000;113:4441–50.

Article  CAS  PubMed  Google Scholar 

Cuervo AM, Dice JF. A receptor for the selective uptake and degradation of proteins by lysosomes. Science. 1996;273:501–3.

Article  CAS  PubMed  Google Scholar 

Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo AM. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol. 2008;28:5747–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol Rev. 2018;98:1169–203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valdor R, Mocholi E, Botbol Y, Guerrero-Ros I, Chandra D, Koga H, et al. Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat Immunol. 2014;15:1046–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013;9:374–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cuervo AM. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. EMBO J. 2003;22:47–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiffin R, Kaushik S, Zeng M, Bandyopadhyay U, Zhang C, Massey AC, et al. Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age. J Cell Sci. 2007;120:782–91.

Article  CAS  PubMed  Google Scholar 

Rodriguez-Navarro JA, Kaushik S, Koga H, Dall’Armi C, Shui G, Wenk MR, et al. Inhibitory effect of dietary lipids on chaperone-mediated autophagy. Proc Natl Acad Sci USA. 2012;109:E705–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arias E, Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM. Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy. Mol Cell. 2015;59:270–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiang HL, Terlecky SR, Plant CP, Dice JF. A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science. 1989;246:382–5.

Article  CAS  PubMed  Google Scholar 

Kaushik S, Massey AC, Mizushima N, Cuervo AM. Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell. 2008;19:2179–92.

Article  CAS  PubMed  PubMed Central 

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