Modulation of autophagy by melatonin and its receptors: implications in brain disorders

Debnath J, Gammoh N, Ryan KM. Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol. 2023;24:560–75.

Article  CAS  PubMed  Google Scholar 

Chung C, Seo W, Silwal P, Jo EK. Crosstalks between inflammasome and autophagy in cancer. J Hematol Oncol. 2020;13:100.

Article  PubMed  PubMed Central  Google Scholar 

Roohbakhsh A, Shamsizadeh A, Hayes AW, Reiter RJ, Karimi G. Melatonin as an endogenous regulator of diseases: the role of autophagy. Pharmacol Res. 2018;133:265–76.

Article  CAS  PubMed  Google Scholar 

Stavoe AKH, Holzbaur ELF. Autophagy in neurons. Annu Rev Cell Dev Biol. 2019;35:477–500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez D, Torres CA, Setlik W, Cebrián C, Mosharov EV, Tang G, et al. Regulation of presynaptic neurotransmission by macroautophagy. Neuron. 2012;74:277–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Compans B, Camus C, Kallergi E, Sposini S, Martineau M, Butler C, et al. NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95. Nat Commun. 2021;12:2849.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kallergi E, Daskalaki AD, Kolaxi A, Camus C, Ioannou E, Mercaldo V, et al. Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice. Nat Commun. 2022;13:680.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keary KM 3rd, Gu QH, Chen J, Li Z. Dendritic distribution of autophagosomes underlies pathway-selective induction of LTD. Cell Rep. 2023;42:112898.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li YY, Qin ZH, Sheng R. The multiple roles of autophagy in neural function and diseases. Neurosci Bull. 2023;40:363–82.

Galluzzi L, Bravo-San Pedro JM, Levine B, Green DR, Kroemer G. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov. 2017;16:487–511.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML. MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharm Toxicol. 2016;56:361–83.

Article  CAS  Google Scholar 

Hardeland R. Melatonin and inflammation–Story of a double-edged blade. J Pineal Res. 2018;65:e12525.

Article  PubMed  Google Scholar 

Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L. Melatonin as an antioxidant: under promises but over delivers. J Pineal Res. 2016;61:253–78.

Article  CAS  PubMed  Google Scholar 

Hossain MF, Wang N, Chen R, Li S, Roy J, Uddin MG, et al. Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology. Ageing Res Rev. 2021;67:101304.

Article  CAS  PubMed  Google Scholar 

Boga JA, Caballero B, Potes Y, Perez-Martinez Z, Reiter RJ, Vega-Naredo I, et al. Therapeutic potential of melatonin related to its role as an autophagy regulator: A review. J Pineal Res. 2019;66:e12534.

Article  PubMed  Google Scholar 

Wongprayoon P, Govitrapong P. Melatonin attenuates methamphetamine-induced neurotoxicity. Curr Pharm Des. 2016;22:1022–32.

Article  CAS  PubMed  Google Scholar 

Ali T, Rahman SU, Hao Q, Li W, Liu Z, Ali Shah F, et al. Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation. J Pineal Res. 2020;69:e12667.

Article  CAS  PubMed  Google Scholar 

Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, et al. Impairment of macroautophagy in dopamine neurons has opposing effects on Parkinsonian pathology and behavior. Cell Rep. 2019;29:920–31.e7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang S, Park D, Manning L, Hill SE, Cao M, Xuan Z, et al. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Neuron. 2022;110:824–40.e10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, et al. Bassoon controls presynaptic autophagy through Atg5. Neuron. 2017;93:897–913.e7.

Article  CAS  PubMed  Google Scholar 

Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, et al. The GTPase Rab26 links synaptic vesicles to the autophagy pathway. eLife. 2015;4:e05597.

Article  PubMed  PubMed Central  Google Scholar 

Shen H, Zhu H, Panja D, Gu Q, Li Z. Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling. Nat Commun. 2020;11:2979.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan Y, He X, Li C, Li Y, Li W, Zhang H, et al. Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD. Cell Rep. 2021;36:109398.

Article  CAS  PubMed  Google Scholar 

Hui KK, Takashima N, Watanabe A, Chater TE, Matsukawa H, Nekooki-Machida Y, et al. GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA(A) receptor trafficking and social behavior. Sci Adv. 2019;5:eaau8237.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoue K, Rispoli J, Yang L, Macleod D, Beal MF, Klann E, et al. Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. PLoS Genet. 2013;9:e1003845.

Article  PubMed  PubMed Central  Google Scholar 

Overhoff M, Tellkamp F, Hess S, Tolve M, Tutas J, Faerfers M, et al. Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse. EMBO J. 2022;41:e110963.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lieberman OJ, Frier MD, McGuirt AF, Griffey CJ, Rafikian E, Yang M, et al. Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy. eLife. 2020;9:e50843.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron. 1994;13:1177–85.

Article  CAS  PubMed  Google Scholar 

Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci USA. 1995;92:8734–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klosen P, Lapmanee S, Schuster C, Guardiola B, Hicks D, Pevet P, et al. MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations. J Pineal Res. 2019;67:e12575.

Article  PubMed  Google Scholar 

Lacoste B, Angeloni D, Dominguez-Lopez S, Calderoni S, Mauro A, Fraschini F, et al. Anatomical and cellular localization of melatonin MT1 and MT2 receptors in the adult rat brain. J Pineal Res. 2015;58:397–417.

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