Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 2009;459:356–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sriram K, Insel PA. G protein-coupled receptors as targets for approved drugs: how many targets and how many drugs? Mol Pharmacol. 2018;93:251–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Derynck R, Zhang Y, Feng XH. Transcriptional activators of TGF-β responses: Smads. Cell. 1998;95:737–40.

Article  CAS  PubMed  Google Scholar 

Ankeny RF, Thourani VH, Weiss D, Vega JD, Taylor WR, Nerem RM, et al. Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves–association with low BMP antagonists and SMAD6. PLoS One. 2011;6:e20969.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuchida K, Nakatani M, Hitachi K, Uezumi A, Sunada Y, Ageta H, et al. Activin signaling as an emerging target for therapeutic interventions. Cell Commun Signal. 2009;7:15.

Article  PubMed  PubMed Central  Google Scholar 

Shen MM. Nodal signaling: developmental roles and regulation. Development. 2007;134:1023–34.

Article  CAS  PubMed  Google Scholar 

Macias-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL. MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell. 1996;87:1215–24.

Article  CAS  PubMed  Google Scholar 

Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, et al. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell. 1996;86:543–52.

Article  CAS  PubMed  Google Scholar 

Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R. Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. Science. 1993;262:900–2.

Article  CAS  PubMed  Google Scholar 

Feng XH, Derynck R. A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. EMBO J. 1997;16:3912–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Massague J. TGF-beta signal transduction. Annu Rev Biochem. 1998;67:753–91.

Article  CAS  PubMed  Google Scholar 

Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev. 2005;19:2783–810.

Article  CAS  PubMed  Google Scholar 

Massague J. TGFbeta in cancer. Cell. 2008;134:215–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. Mechanism of activation of the TGF-beta receptor. Nature. 1994;370:341–7.

Article  CAS  PubMed  Google Scholar 

Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 1998;95:779–91.

Article  CAS  PubMed  Google Scholar 

Kamato D, Do BH, Osman N, Ross BP, Mohamed R, Xu S, et al. Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling. Cell Mol Life Sci. 2020;77:243–51.

Article  CAS  PubMed  Google Scholar 

Kamato D, Thach L, Getachew R, Burch M, Hollenberg MD, Zheng W, et al. Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cell Signal. 2016;28:110–9.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Little PJ, Cao Y, Ta HT, Kamato D. Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing genes XYLT1 and CHST3. Biochim Biophys Acta Mol Cell Res. 2020;1867:118848.

Article  CAS  PubMed  Google Scholar 

Buskohl PR, Sun MJ, Thompson RP, Butcher JT. Serotonin potentiates transforming growth factor-beta3 induced biomechanical remodeling in avian embryonic atrioventricular valves. PLoS One. 2012;7:e42527.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M, Egido J, Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation. 2005;111:2509–17.

Article  CAS  PubMed  Google Scholar 

Babaahmadi-Rezaei H, Mohamed R, Dayati P, Mehr RN, Seif F, Sharifat N, et al. Endothelin-1 dependent expression of GAG genes involves NOX and p38 mediated Smad linker region phosphorylation. Clin Exp Pharmacol Physiol. 2022;49:710–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Afroz R, Zhou Y, Little PJ, Xu S, Mohamed R, Stow J, et al. Toll-like receptor 4 stimulates gene expression via Smad2 linker region phosphorylation in vascular smooth muscle cells. ACS Pharm Transl Sci. 2020;3:524–34.

Article  CAS  Google Scholar 

Afroz R, Kumarapperuma H, Nguyen QVN, Mohamed R, Little PJ, Kamato D. Lipopolysaccharide acting via toll-like receptor 4 transactivates the TGF-beta receptor in vascular smooth muscle cells. Cell Mol Life Sci. 2022;79:121.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsuzaki K, Kitano C, Murata M, Sekimoto G, Yoshida K, Uemura Y, et al. Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer. Cancer Res. 2009;69:5321–30.

Article  CAS  PubMed  Google Scholar 

Sekimoto G, Matsuzaki K, Yoshida K, Mori S, Murata M, Seki T, et al. Reversible Smad-dependent signaling between tumor suppression and oncogenesis. Cancer Res. 2007;67:5090–6.

Article  CAS  PubMed  Google Scholar 

Kamato D, Burch ML, Piva TJ, Rezaei HB, Rostam MA, Xu S, et al. Transforming growth factor-beta signalling: Role and consequences of Smad linker region phosphorylation. Cell Signal. 2013;25:2017–24.

Article  CAS  PubMed  Google Scholar 

Rezaei HB, Kamato D, Ansari G, Osman N, Little PJ. Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle. Clin Exp Pharmacol Physiol. 2012;39:661–7.

Article  CAS  PubMed  Google Scholar 

Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685–700.

Article  CAS  PubMed  Google Scholar 

Miyazono K, Kusanagi K, Inoue H. Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol. 2001;187:265–76.

Article  CAS  PubMed  Google Scholar 

Rostam MA, Kamato D, Piva TJ, Zheng W, Little PJ, Osman N. The role of specific Smad linker region phosphorylation in TGF-beta mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cell Signal. 2016;28:956–66.

Article  CAS  PubMed