Roh YS, Choi J, Sutaria N, Kwatra SG. Itch: Epidemiology, clinical presentation, and diagnostic workup. J Am Acad Dermatol. 2022;86:1–14.
Steinhoff M, Al-Khawaga S, Buddenkotte J. Itch in elderly patients: Origin, diagnostics, management. J Allergy Clin Immunol. 2023;152:42–49.
Hawro T, Hawro M, Zalewska-Janowska A, Weller K, Metz M, Maurer M. Pruritus and sleep disturbances in patients with psoriasis. Arch Dermatol Res. 2020;312:103–11.
Leader B, Carr CW, Chen SC. Pruritus epidemiology and quality of life. Handb Exp Pharmacol. 2015;226:15–38.
Article CAS PubMed Google Scholar
Weisshaar E, Szepietowski JC, Dalgard FJ, Garcovich S, Gieler U, Giménez-Arnau AM, et al. European S2k guideline on chronic pruritus. Acta Derm Venereol. 2019;99:469–506.
Stefaniak AA, Krajewski PK, Bednarska-Chabowska D, Bolanowski M, Mazur G, Szepietowski JC. Itch in adult population with type 2 diabetes mellitus: clinical profile, pathogenesis and disease-related burden in a cross-sectional study. Biology. 2021;10:1332.
Article PubMed PubMed Central Google Scholar
Hu X, Sang Y, Yang M, Chen X, Tang W. Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients: A meta-analysis of cross-sectional studies. Medicine. 2018;97:e10633.
Article PubMed PubMed Central Google Scholar
Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001;106:619–32.
Article CAS PubMed Google Scholar
Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009;139:1353–65.
Article PubMed PubMed Central Google Scholar
Lembo PM, Grazzini E, Groblewski T, O’Donnell D, Roy MO, Zhang J, et al. Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs. Nat Neurosci. 2002;5:201–9.
Article CAS PubMed Google Scholar
Heller D, Doyle JR, Raman VS, Beinborn M, Kumar K, Kopin AS. Novel probes establish Mas-related G protein-coupled receptor X1 variants as receptors with loss or gain of function. J Pharmacol Exp Ther. 2016;356:276–83.
Article CAS PubMed Google Scholar
Klein A, Solinski HJ, Malewicz NM, Ieong HF, Sypek EI, Shimada SG, et al. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. Elife. 2021;10:e64506.
Article CAS PubMed PubMed Central Google Scholar
Liu Q, Weng HJ, Patel KN, Tang Z, Bai H, Steinhoff M, et al. The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal. 2011;4:ra45.
Article CAS PubMed PubMed Central Google Scholar
Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ, Dong X. Mas-related G-protein-coupled receptors inhibit pathological pain in mice. Proc Natl Acad Sci USA. 2010;107:15933–8.
Article CAS PubMed PubMed Central Google Scholar
Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, et al. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain. 2014;155:1613–21.
Article CAS PubMed PubMed Central Google Scholar
Zylka MJ, Rice FL, Anderson DJ. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005;45:17–25.
Article CAS PubMed Google Scholar
Shinohara T, Harada M, Ogi K, Maruyama M, Fujii R, Tanaka H, et al. Identification of a G protein-coupled receptor specifically responsive to beta-alanine. J Biol Chem. 2004;279:23559–64.
Article CAS PubMed Google Scholar
Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, et al. Mechanisms of itch evoked by β-alanine. J Neurosci. 2012;32:14532–7.
Article CAS PubMed PubMed Central Google Scholar
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, et al. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain. 2014;137:1039–50.
Article PubMed PubMed Central Google Scholar
Chompunud Na Ayudhya C, Roy S, Thapaliya M, Ali H. Roles of a mast cell-specific receptor MRGPRX2 in host defense and inflammation. J Dent Res. 2020;99:882–90.
Article CAS PubMed PubMed Central Google Scholar
Thapaliya M, Chompunud Na Ayudhya C, Amponnawarat A, Roy S, Ali H. Mast cell-specific MRGPRX2: a key modulator of neuro-immune interaction in allergic diseases. Curr Allergy Asthma Rep. 2021;21:3.
Article CAS PubMed PubMed Central Google Scholar
Meixiong J, Anderson M, Limjunyawong N, Sabbagh MF, Hu E, Mack MR, et al. Activation of mast-cell-expressed Mas-related G-protein-coupled receptors drives non-histaminergic itch. Immunity. 2019;50:1163–71.e5.
Article CAS PubMed PubMed Central Google Scholar
Jia T, Che D, Zheng Y, Zhang H, Li Y, Zhou T, et al. Mast cells initiate type 2 inflammation through tryptase released by MRGPRX2/MRGPRB2 activation in atopic dermatitis. J Invest Dermatol. 2024;144:53–62.e2.
Article CAS PubMed Google Scholar
Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z, et al. MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife. 2019;8:e48431.
Article CAS PubMed PubMed Central Google Scholar
Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, et al. Identification of a bilirubin receptor that may mediate a component of cholestatic itch. Elife. 2019;8:e44116.
Article PubMed PubMed Central Google Scholar
Meixiong J, Vasavda C, Snyder SH, Dong X. MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus. Proc Natl Acad Sci USA. 2019;116:10525–30.
Article CAS PubMed PubMed Central Google Scholar
Zhang L, Taylor N, Xie Y, Ford R, Johnson J, Paulsen JE, et al. Cloning and expression of MRG receptors in macaque, mouse, and human. Brain Res Mol Brain Res. 2005;133:187–97.
Article CAS PubMed Google Scholar
Bender E, Buist A, Jurzak M, Langlois X, Baggerman G, Verhasselt P, et al. Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc Natl Acad Sci USA. 2002;99:8573–8.
Article CAS PubMed PubMed Central Google Scholar
Cox PJ, Pitcher T, Trim SA, Bell CH, Qin W, Kinloch RA. The effect of deletion of the orphan G-protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice. Mol Pain. 2008;4:2.
Article PubMed PubMed Central Google Scholar
Shen Q, Han Y, Wu K, He Y, Jiang X, Liu P, et al. MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling. Signal Transduct Target Ther. 2022;7:147.
留言 (0)