Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, et al. GPCR-mediated beta-arrestin activation deconvoluted with single-molecule precision. Cell. 2022;185:1661–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma TL, Zhou Y, Zhang CY, Gao ZA, Duan JX. The role and mechanism of beta-arrestin2 in signal transduction. Life Sci. 2021;275:119364.

Article  CAS  PubMed  Google Scholar 

Zhou WJ, Wang DD, Tao J, Tai Y, Zhou ZW, Wang Z, et al. Deficiency of beta-arrestin2 exacerbates inflammatory arthritis by facilitating plasma cell formation. Acta Pharmacol Sin. 2021;42:755–66.

Article  CAS  PubMed  Google Scholar 

Pydi SP, Barella LF, Zhu L, Meister J, Rossi M, Wess J. beta-Arrestins as important regulators of glucose and energy homeostasis. Annu Rev Physiol. 2022;84:17–40.

Article  CAS  PubMed  Google Scholar 

Goertzen CG, Dragan M, Turley E, Babwah AV, Bhattacharya M. KISS1R signaling promotes invadopodia formation in human breast cancer cell via beta-arrestin2/ERK. Cell Signal. 2016;28:165–76.

Article  CAS  PubMed  Google Scholar 

Jean-Charles PY, Zhang L, Wu JH, Han SO, Brian L, Freedman NJ, et al. Ubiquitin-specific protease 20 regulates the reciprocal functions of beta-arrestin2 in toll-like receptor 4-promoted nuclear factor kappaB (NF-kappaB) activation. J Biol Chem. 2016;291:7450–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han C, Li Y, Wang Y, Cui D, Luo T, Zhang Y, et al. Development of inflammatory immune response-related drugs based on G protein-coupled receptor kinase 2. Cell Physiol Biochem. 2018;51:729–45.

Article  CAS  PubMed  Google Scholar 

Argenziano M, Tortora C, Bellini G, Di Paola A, Punzo F, Rossi F. The endocannabinoid system in pediatric inflammatory and immune diseases. Int J Mol Sci. 2019;20:5875.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anchang CG, Xu C, Raimondo MG, Atreya R, Maier A, Schett G, et al. The potential of OMICs technologies for the treatment of immune-mediated inflammatory diseases. Int J Mol Sci. 2021;22:7506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moller B, Villiger PM. Inhibition of IL-1, IL-6, and TNF-alpha in immune-mediated inflammatory diseases. Springer Semin Immunopathol. 2006;27:391–408.

Article  PubMed  Google Scholar 

Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, et al. Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem. 1992;267:17882–90.

Hilger D, Masureel M, Kobilka BK. Structure and dynamics of GPCR signaling complexes. Nat Struct Mol Biol. 2018;25:4–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peterson YK, Luttrell LM. The diverse roles of arrestin scaffolds in G protein-coupled receptor signaling. Pharmacol Rev. 2017;69:256–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scheerer P, Sommer ME. Structural mechanism of arrestin activation. Curr Opin Struct Biol. 2017;45:160–9.

Article  CAS  PubMed  Google Scholar 

Kim K, Chung KY. Many faces of the GPCR-arrestin interaction. Arch Pharm Res. 2020;43:890–9.

Article  CAS  PubMed  Google Scholar 

Yun Y, Ji J, Lee HH. Dissecting the structural features of beta-arrestins as multifunctional proteins. Biochim Biophys Acta Proteins Proteom. 2021;1869:140603.

Article  CAS  PubMed  Google Scholar 

Chen Q, Tesmer JJG. G protein-coupled receptor interactions with arrestins and GPCR kinases: the unresolved issue of signal bias. J Biol Chem. 2022;298:102279.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma D, Parameswaran N. Multifaceted role of beta-arrestins in inflammation and disease. Genes Immun. 2015;16:499–513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan H. beta-Arrestins 1 and 2 are critical regulators of inflammation. Innate Immun. 2014;20:451–60.

Article  PubMed  Google Scholar 

Wess J, Oteng AB, Rivera-Gonzalez O, Gurevich EV, Gurevich VV. beta-Arrestins: structure, function, physiology, and pharmacological perspectives. Pharmacol Rev. 2023;75:854–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maharana J, Banerjee R, Yadav MK, Sarma P, Shukla AK. Emerging structural insights into GPCR-beta-arrestin interaction and functional outcomes. Curr Opin Struct Biol. 2022;75:102406.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu YJ, Sun WY, Zhang S, Wu JJ, Wei W. The emerging roles of beta-arrestins in fibrotic diseases. Acta Pharmacol Sin. 2015;36:1277–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, et al. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science. 2000;290:1574–77.

Article  CAS  PubMed  Google Scholar 

Sun Y, Cheng Z, Ma L, Pei G. Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation. J Biol Chem. 2002;277:49212–9.

Article  CAS  PubMed  Google Scholar 

Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172:409–22.e21

Article  CAS  PubMed  Google Scholar 

Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999;283:655–61.

Article  CAS  PubMed  Google Scholar 

Tao J, Jiang C, Guo P, Chen H, Zhu Z, Su T, et al. A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation. Biomed Pharmacother. 2023;157:113997.

Article  CAS  PubMed  Google Scholar 

Cheng H, Guo P, Su T, Jiang C, Zhu Z, Wei W, et al. G protein-coupled receptor kinase type 2 and beta-arrestin2: Key players in immune cell functions and inflammation. Cell Signal. 2022;95:110337.

Article  CAS  PubMed  Google Scholar 

Jeljeli MM, Adamopoulos IE. Innate immune memory in inflammatory arthritis. Nat Rev Rheumatol. 2023;19:627–39.

Article  PubMed  Google Scholar 

Parkin J, Cohen B. An overview of the immune system. Lancet. 2001;357:1777–89.

Article  CAS  PubMed  Google Scholar 

Drareni K, Gautier JF, Venteclef N, Alzaid F. Transcriptional control of macrophage polarisation in type 2 diabetes. Semin Immunopathol. 2019;41:515–29.

Article  PubMed  Google Scholar 

Tardito S, Martinelli G, Soldano S, Paolino S, Pacini G, Patane M, et al. Macropha