A derivative of tanshinone IIA and salviadione, 15a, inhibits inflammation and alleviates DSS-induced colitis in mice by direct binding and inhibition of RIPK2

Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002;347:417–29.

Article  CAS  PubMed  Google Scholar 

Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474:307–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu P, Ishimoto T, Fu L, Zhang J, Zhang Z, Liu Y. The gut microbiota in inflammatory bowel disease. Front Cell Infect Microbiol. 2022;12:733992.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. Diversity of the human intestinal microbial flora. Science. 2005;308:1635–8.

Article  PubMed  PubMed Central  Google Scholar 

Kaplan GG, Ng SC. Understanding and preventing the global increase of inflammatory bowel disease. Gastroenterology. 2017;152:313–21.e2.

Article  PubMed  Google Scholar 

Saez A, Herrero-Fernandez B, Gomez-Bris R, Sanchez-Martinez H, Gonzalez-Granado JM. Pathophysiology of inflammatory bowel disease: innate immune system. Int J Mol Sci. 2023;24:1526.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448:427–34.

Article  CAS  PubMed  Google Scholar 

Xiao YT, Yan WH, Cao Y, Yan JK, Cai W. Neutralization of IL-6 and TNF-alpha ameliorates intestinal permeability in DSS-induced colitis. Cytokine. 2016;83:189–92.

Article  CAS  PubMed  Google Scholar 

Aardoom MA, Veereman G, de Ridder L. A Review on the use of anti-TNF in children and adolescents with inflammatory bowel disease. Int J Mol Sci. 2019;20:2529.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verstockt B, Ferrante M, Vermeire S, Van Assche G. New treatment options for inflammatory bowel diseases. J Gastroenterol. 2018;53:585–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashall L, Horton CA, Nelson DE, Paszek P, Harper CV, Sillitoe K, et al. Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science. 2009;324:242–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mukherjee T, Kumar N, Chawla M, Philpott DJ, Basak S. The NF-kappaB signaling system in the immunopathogenesis of inflammatory bowel disease. Sci Signal. 2024;17:eadh1641.

Article  CAS  PubMed  Google Scholar 

Taniguchi K, Karin M. NF-kappaB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18:309–24.

Article  CAS  PubMed  Google Scholar 

Strober W, Murray PJ, Kitani A, Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol. 2006;6:9–20.

Article  CAS  PubMed  Google Scholar 

Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity. 2011;34:637–50.

Article  CAS  PubMed  Google Scholar 

Pham AT, Ghilardi AF, Sun L. Recent advances in the development of RIPK2 modulators for the treatment of inflammatory diseases. Front Pharmacol. 2023;14:1127722.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hofmann SR, Girschick L, Stein R, Schulze F. Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity. Clin Immunol. 2021;223:108648.

Article  CAS  PubMed  Google Scholar 

Jun JC, Cominelli F, Abbott DW. RIP2 activity in inflammatory disease and implications for novel therapeutics. J Leukoc Biol. 2013;94:927–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Morris-Natschke SL, Lee KH. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med Res Rev. 2007;27:133–48.

Article  PubMed  Google Scholar 

Xu M, Dong MQ, Cao FL, Liu ML, Wang YX, Dong HY, et al. Tanshinone IIA reduces lethality and acute lung injury in LPS-treated mice by inhibition of PLA2 activity. Eur J Pharmacol. 2009;607:194–200.

Article  CAS  PubMed  Google Scholar 

Guo R, Li L, Su J, Li S, Duncan SE, Liu Z, et al. Pharmacological activity and mechanism of tanshinone IIA in related diseases. Drug Des Devel Ther. 2020;14:4735–48.

Article  PubMed  PubMed Central  Google Scholar 

Hao H, Wang G, Cui N, Li J, Xie L, Ding Z. Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. Curr Drug Metab. 2007;8:137–49.

Article  CAS  PubMed  Google Scholar 

Don MJ, Shen CC, Lin YL, Syu WJ, Ding YH, Sun CM. Nitrogen-containing compounds from Salvia miltiorrhiza. J Nat Prod. 2005;68:1066–70.

Article  CAS  PubMed  Google Scholar 

Ding C, Chen H, Liang B, Jiao M, Liang G, Zhang A. Biomimetic synthesis of the natural product salviadione and its hybrids: discovery of tissue-specific anti-inflammatory agents for acute lung injury. Chem Sci. 2019;10:4667–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Ding C, Zou C, Xiong Z, Zhu W, Qian J, et al. A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappaB-mediated inflammatory responses. Toxicol Appl Pharmacol. 2020;409:115322.

Article  CAS  PubMed  Google Scholar 

Ananthakrishnan AN. Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol. 2015;12:205–17.

Article  PubMed  Google Scholar 

Qu C, Yuan ZW, Yu XT, Huang YF, Yang GH, Chen JN, et al. Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism. Pharm Res. 2017;121:70–82.

Article  CAS  Google Scholar 

Nielsen OH, Munck LK. Drug insight: aminosalicylates for the treatment of IBD. Nat Clin Pr Gastroenterol Hepatol. 2007;4:160–70.

Article  CAS  Google Scholar 

Katsandegwaza B, Horsnell W, Smith K. Inflammatory bowel disease: a review of pre-clinical murine models of human disease. Int J Mol Sci. 2022;23:9344.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honjo H, Watanabe T, Kamata K, Minaga K, Kudo M. RIPK2 as a new therapeutic target in inflammatory bowel diseases. Front Pharmacol. 2021;12:650403.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larochelle J, Tishko RJ, Yang C, Ge Y, Phan LT, Gunraj RE, et al. Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators. J Neuroinflammation. 2023;20:221.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif