G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner

Fabbri L, Chakraborty A, Robert C, Vagner S. The plasticity of mRNA translation during cancer progression and therapy resistance. Nat Rev Cancer. 2021;21:558–77.

PubMed  Google Scholar 

Labrie M, Brugge JS, Mills GB, Zervantonakis IK. Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer. Nat Rev Cancer. 2022;22:323–39.

PubMed  PubMed Central  Google Scholar 

De Santis MC, Gozzelino L, Margaria JP, Costamagna A, Ratto E, Gulluni F, et al. Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer. Gut. 2023;72:360–71.

PubMed  Google Scholar 

Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jimenez JA, McCarthy A, et al. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nat Cancer. 2022;3:1386–403.

PubMed  PubMed Central  Google Scholar 

Jain V, Amaravadi RK. Pumping iron: ferritinophagy promotes survival and therapy resistance in pancreatic cancer. Cancer Discov. 2022;12:2023–5.

PubMed  PubMed Central  Google Scholar 

Park W, Chawla A, O’Reilly EM. Pancreatic cancer: a review. JAMA. 2021;326:851–62.

PubMed  PubMed Central  Google Scholar 

Lavalee M, Curdy N, Laurent C, Fournie JJ, Franchini DM. Cancer cell adaptability: turning ribonucleoprotein granules into targets. Trends Cancer. 2021;7:902–15.

PubMed  Google Scholar 

Kedersha N, Ivanov P, Anderson P. Stress granules and cell signaling: more than just a passing phase? Trends Biochem Sci. 2013;38:494–506.

PubMed  Google Scholar 

Xing F, Qin Y, Xu J, Wang W, Zhang B. Stress granules dynamics and promising functions in pancreatic cancer. Biochim Biophys Acta Rev Cancer. 2023;1878:188885.

PubMed  Google Scholar 

Wang X, Chen T, Li C, Li W, Zhou X, Li Y, et al. CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR. J Hematol Oncol. 2022;15:122.

PubMed  PubMed Central  Google Scholar 

Grabocka E, Bar-Sagi D. Mutant KRAs enhances tumor cell fitness by upregulating stress granules. Cell. 2016;167:1803–13. e1812

PubMed  PubMed Central  Google Scholar 

Mukhopadhyay S, Goswami D, Adiseshaiah PP, Burgan W, Yi M, Guerin TM, et al. Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers. Cancer Res. 2020;80:1630–43.

PubMed  PubMed Central  Google Scholar 

Fonteneau G, Redding A, Hoag-Lee H, Sim ES, Heinrich S, Gaida MM, et al. Stress granules determine the development of obesity-associated pancreatic cancer. Cancer Discov. 2022;12:1984–2005.

PubMed  PubMed Central  Google Scholar 

Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, et al. G3BP1 is a tunable switch that triggers phase separation to assemble stress granules. Cell. 2020;181:325–45. e328

PubMed  PubMed Central  Google Scholar 

Jin G, Zhang Z, Wan J, Wu X, Liu X, Zhang W. G3BP2: Structure and function. Pharmacol Res. 2022;186:106548.

PubMed  Google Scholar 

Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, et al. Competing protein-RNA interaction networks control multiphase intracellular organization. Cell. 2020;181:306–24. e328

PubMed  PubMed Central  Google Scholar 

Ratnadiwakara M, Anko ML. mRNA stability assay using transcription inhibition by actinomycin D in mouse pluripotent stem cells. Bio Protoc. 2018;8:e3072.

PubMed  PubMed Central  Google Scholar 

Icard P, Fournel L, Wu Z, Alifano M, Lincet H. Interconnection between metabolism and cell cycle in cancer. Trends Biochem Sci. 2019;44:490–501.

PubMed  Google Scholar 

Sidibe H, Dubinski A, Vande Velde C. The multi-functional RNA-binding protein G3BP1 and its potential implication in neurodegenerative disease. J Neurochem. 2021;157:944–62.

PubMed  PubMed Central  Google Scholar 

Jones RJ, Baladandayuthapani V, Neelapu S, Fayad LE, Romaguera JE, Wang M, et al. HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma. Blood. 2011;118:4140–9.

PubMed  PubMed Central  Google Scholar 

Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR, et al. Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo. Clin Cancer Res. 2009;15:1730–40.

PubMed  PubMed Central  Google Scholar 

Ko E, Kim JS, Ju S, Seo HW, Chang Y, Kang JA, et al. Oxidatively modified protein-disulfide isomerase-associated 3 promotes dyskerin pseudouridine synthase 1-mediated malignancy and survival of hepatocellular carcinoma cells. Hepatology. 2018;68:1851–64.

PubMed  Google Scholar 

Raffenne J, Nicolle R, Puleo F, Le Corre D, Boyez C, Marechal R, et al. hENT1 testing in pancreatic ductal adenocarcinoma: are we ready? a multimodal evaluation of hENT1 status. Cancers (Basel). 2019;11:1808.

PubMed  Google Scholar 

Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci USA. 2017;114:1033–8.

PubMed  PubMed Central  Google Scholar 

Mizrahi JD, Surana R, Valle JW, Shroff RT. Pancreatic cancer. Lancet. 2020;395:2008–20.

PubMed  Google Scholar 

Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature. 2016;531:47–52.

PubMed  Google Scholar 

Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet. 2016;388:73–85.

PubMed  Google Scholar 

Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, et al. Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2020;13:130.

PubMed  PubMed Central  Google Scholar 

Tempero MA, Malafa MP, Al-Hawary M, Behrman SW, Benson AB, Cardin DB, et al. Pancreatic adenocarcinoma, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2021;19:439–57.

PubMed  Google Scholar 

Grasso C, Jansen G, Giovannetti E. Drug resistance in pancreatic cancer: impact of altered energy metabolism. Crit Rev Oncol Hematol. 2017;114:139–52.

PubMed  Google Scholar 

Kan G, Wang Z, Sheng C, Chen G, Yao C, Mao Y, et al. Dual inhibition of DKC1 and MEK1/2 synergistically restrains the growth of colorectal cancer cells. Adv Sci (Weinh). 2021;8:2004344.

PubMed  Google Scholar 

Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohee L, et al. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021;184:655–74. e627

PubMed  PubMed Central  Google Scholar 

Wippich F, Bodenmiller B, Trajkovska MG, Wanka S, Aebersold R, Pelkmans L. Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell. 2013;152:791–805.

PubMed  Google Scholar 

Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, et al. QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism. Cell. 2023;186:3208–26. e3227

PubMed  PubMed Central  Google Scholar 

Protter DSW, Parker R. Principles and properties of stress granules. Trends Cell Biol. 2016;26:668–79.

PubMed  PubMed Central  Google Scholar 

Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, et al. YTHDF1 mitigates acute kidney injury via safeguarding m6A-methylated mRNAs in stress granules of renal tubules. Redox Biol. 2023;67:102921.

PubMed  PubMed Central  Google Scholar 

Pederiva C, Trevisan DM, Peirasmaki D, Chen S, Savage SA, Larsson O, et al. Control of protein synthesis through mRNA pseudouridylation by dyskerin. Sci Adv. 2023;9:eadg1805.

PubMed  PubMed Central  Google Scholar 

Kaehler C, Isensee J, Hucho T, Lehrach H, Krobitsch S. 5-Fluorouracil affects assembly of stress granules based on RNA incorporation. Nucleic Acids Res. 2014;42:6436–47.

PubMed  PubMed Central  Google Scholar 

Diep CH, Munoz RM, Choudhary A, Von Hoff DD, Han H. Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cells. Clin Cancer Res. 2011;17:2744–56.

PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif