Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds

Article title

Abstract

Keywords

Introduction

Garlic as therapeutic agent in cancer hallmarks

Replicative immortality: Targeting telomerase and CDKs with garlic compounds

Clinical relevance

Mechanisms of action

Tumor dysregulated metabolism

Tumor-promoting inflammation

Angiogenesis

Cell migration and tumor metastasis

Immune evasion

Sustained proliferative signaling

Antigrowth signaling evasion

Resistance to apoptosis: targeting anti-growth signaling pathways

Garlic’s role in targeting signaling pathways: balancing proliferative and anti-growth signaling

Role of garlic in induction of apoptosis

Role of garlic in replicative immortality

Role of garlic in tumor dysregulated metabolism

Role of garlic in Tumor-promoting inflammation

Role of garlic in angiogenesis inhibition

Role of garlic in preventing tissue Invasion and Metastasis

Role of garlic in tumor associated immune evasion

Conclusion

References

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